dr. L.P.G. (Lennie) Derde

dr. L.P.G. (Lennie) Derde

Assistant Professor - medical
dr. L.P.G. (Lennie) Derde
  • Intensive Care Medicine

Research Programs

Infection & Immunity



Lennie is an ICU consultant with a background in infectious diseases and epidemiology. She obtained her Ph.D. after successfully defending her thesis "Controlling antibiotic resistance in the ICU" in 2013. Her research focuses on innovative trial design, mainly in sepsis and severe infections. She is the immediate past chair of the International Trial Steering Committee of REMAP-CAP, an Adaptive Platform Trial investigating the best treatment for pneumonia, including Covid-19. Lennie is a co-applicant and work package leader on EU-funded projects RECOVER and ECRAID-Base, and co-applicant on several international collaborative grants. 

Research Output (57)

Cohort profile of PLUTO:a perioperative biobank focusing on prediction and early diagnosis of postoperative complications

de Mul Nikki, Verlaan Diede, Ruurda Jelle P, van Grevenstein Wilhelmina M U, Hagendoorn Jeroen, de Borst Gert-Jan, Vriens Menno R, de Bree Remco, Zweemer Ronald P, Vogely Charles, Haitsma Mulier Jelle L G, Vernooij Lisette M, Reitsma Johannes B, de Zoete Marcel R, Top Janetta, Kluijtmans Jan A J, Hoefer Imo E, Noordzij Peter, Rettig Thijs, Marsman Marije, de Smet Anne Marie G A, Derde Lennie, van Waes Judith, Rijsdijk Mienke, Schellekens Willem Jan M, Bonten Marc J M, Slooter Arjen J C, Cremer Olaf L 19 Apr 2023, In: BMJ Open. 13 16 p.

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

Higgins Alisa M, Berry Lindsay R, Lorenzi Elizabeth, Murthy Srinivas, McQuilten Zoe, Mouncey Paul R, Al-Beidh Farah, Annane Djillali, Arabi Yaseen M, Beane Abi, van Bentum-Puijk Wilma, Bhimani Zahra, Bonten Marc J M, Bradbury Charlotte A, Brunkhorst Frank M, Burrell Aiden, Buzgau Adrian, Buxton Meredith, Charles Walton N, Cove Matthew, Detry Michelle A, Estcourt Lise J, Fagbodun Elizabeth O, Fitzgerald Mark, Girard Timothy D, Goligher Ewan C, Goossens Herman, Haniffa Rashan, Hills Thomas, Horvat Christopher M, Huang David T, Ichihara Nao, Lamontagne Francois, Marshall John C, McAuley Daniel F, McGlothlin Anna, McGuinness Shay P, McVerry Bryan J, Neal Matthew D, Nichol Alistair D, Parke Rachael L, Parker Jane C, Parry-Billings Karen, Peters Sam E C, Reyes Luis F, Rowan Kathryn M, Saito Hiroki, Santos Marlene S, Saunders Christina T, Derde Lennie P G, Leavis HL, 16 Dec 2022, In: JAMA - The Journal of The American Medical Association. 329 , p. 39-51 13 p.

The Renin-Angiotensin System in Acute Lung Injury∗

Lawler Patrick R., Derde Lennie P.G., Mcverry Bryan J., Russell James A., Van De Veerdonk Frank L. 1 Sep 2022, In: Critical care medicine. 50 , p. 1411-1415 5 p.

Updated competency-based training in intensive care:next step towards a healthcare union in Europe?

Póvoa Pedro, Martin-Loeches Ignacio, Duska Frantisek, Hästbacka Johanna, Gomes Ernestina, Le Roy Anne, Matsa Ramprasad, Derde Lennie, Hein Lars, Castellanos Álvaro, Roten Hans Ulrich, Aug 2022, In: Intensive Care Medicine. 48 , p. 1093-1094 2 p.

Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19:A network meta-analysis

Godolphin Peter J., Fisher David J., Berry Lindsay R., Derde Lennie P.G., Diaz Janet V., Gordon Anthony C., Lorenzi Elizabeth, Marshall John C., Murthy Srinivas, Shankar-Hari Manu, Sterne Jonathan A.C., Tierney Jayne F., Vale Claire L. Jul 2022, In: PLoS ONE. 17

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients with COVID-19:A Randomized Clinical Trial

Bradbury Charlotte A, Lawler Patrick R, Stanworth Simon J, McVerry Bryan J, McQuilten Zoe, Higgins Alisa M, Mouncey Paul R, Al-Beidh Farah, Rowan Kathryn M, Berry Lindsay R, Lorenzi Elizabeth, Zarychanski Ryan, Arabi Yaseen M, Annane Djillali, Beane Abi, van Bentum-Puijk Wilma, Bhimani Zahra, Bihari Shailesh, Bonten Marc J M, Brunkhorst Frank M, Buzgau Adrian, Buxton Meredith, Carrier Marc, Cheng Allen C, Cove Matthew, Detry Michelle A, Estcourt Lise J, Fitzgerald Mark, Girard Timothy D, Goligher Ewan C, Goossens Herman, Haniffa Rashan, Hills Thomas, Huang David T, Horvat Christopher M, Hunt Beverley J, Ichihara Nao, Lamontagne Francois, Leavis Helen L, Linstrum Kelsey M, Litton Edward, Marshall John C, McAuley Daniel F, McGlothlin Anna, McGuinness Shay P, Middeldorp Saskia, Montgomery Stephanie K, Morpeth Susan C, Murthy Srinivas, Derde Lennie P G, 22 Mar 2022, In: JAMA - The Journal of The American Medical Association. 327 , p. 1247-1259 13 p.

Thrombosis pathways in COVID-19 vs. influenza-associated ARDS:a targeted proteomics approach

Rademaker Emma, Doorduijn Dennis J, Kusadasi Nuray, Maas Coen, Drylewicz Julia, Huisman Albert, Hoefer Imo E, Bonten Marc J M, Derde Lennie P G, Rooijakkers Suzan H M, Cremer Olaf L 12 Feb 2022, In: Journal of thrombosis and haemostasis : JTH. 20 , p. 1206-1212 7 p.

Randomised clinical trials in critical care:past, present and future

Granholm Anders, Alhazzani Waleed, Derde Lennie P.G., Angus Derek C., Zampieri Fernando G., Hammond Naomi E., Sweeney Rob Mac, Myatra Sheila N., Azoulay Elie, Rowan Kathryn, Young Paul J., Perner Anders, Møller Morten Hylander Feb 2022, In: Intensive Care Medicine. 48 , p. 164-178 15 p.

A guide to immunotherapy for COVID-19

van de Veerdonk Frank L., Giamarellos-Bourboulis Evangelos, Pickkers Peter, Derde Lennie, Leavis Helen, van Crevel Reinout, Engel Job J., Wiersinga W. Joost, Vlaar Alexander P.J., Shankar-Hari Manu, van der Poll Tom, Bonten Marc, Angus Derek C., van der Meer Jos W.M., Netea Mihai G. 21 Jan 2022, In: Nature Medicine. 28 , p. 39-50 12 p.

The European clinical research response to optimise treatment of patients with COVID-19:lessons learned, future perspective, and recommendations

Goossens Herman, Derde Lennie, Horby Peter, Bonten Marc 21 Dec 2021, In: The Lancet Infectious Diseases. 22 , p. e153-e158

All research output

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