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prof. dr. R.M. (Rick M.) Dijkhuizen

Full Professor
prof. dr. R.M. (Rick M.) Dijkhuizen
  • Biomedical MR Imaging and Spectroscopy Group

Research Programs

Biography

Biography

Rick Dijkhuizen received his Ph.D. at Utrecht University in 1998 (thesis title: 'Magnetic Resonance Imaging and Spectroscopy in Experimental Cerebral Ischemia'). From 1999 until 2002 he worked at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School (Charlestown/Boston, MA, USA), first as Postdoctoral Fellow and later as Instructor. There his research focused on elucidating spontaneous and therapy-induced recovery after cerebrovascular injury (e.g. stroke) with different MRI techniques in patients and experimental models. In 2002 he became head of the Biomedical MR Imaging and Spectroscopy group, part of the Center for Image Sciences, at the University Medical Center Utrecht. He was a Visiting Associate Professor at the Department of Radiology at Stanford University School of Medicine from 2013 until 2014.

His current research interests include multiparametric imaging of brain structure and function in health and disease, with a particular focus on i) development of tools for improved diagnosis of brain pathophysiology, ii) characterization of neural network (re)organization, and iii) monitoring of neuroprotective and -restorative therapies. He has recently initiated a translational research project that aims to establish safe and effective modulation of neural networks to enhance functional recovery after stroke through non-invasive brain stimulation in stroke animal models and patients.

He has teamed up with different colleagues of the UMCU Brain Center for preclinical imaging studies on stroke, epilepsy and neurodevelopmental disorders, and he collaborates with various national and international institutions on topics such as brain plasticity and molecular imaging. Rick Dijkhuizen has been workpackage leader in two EU-FP7 research programs (EUSTROKE and TACTICS). He served/serves on the Board of Directors of the International Society for Cerebral Blood Flow and Metabolism, and the Editorial Boards of the Journal of Cerebral Blood Flow and Metabolism, Translational Stroke Research, and Stroke. He is Associate Editor of Frontiers in Neurology|Stroke and the Journal of Cerebral Blood Flow and Metabolism.

Research line

Experimental and Translational Neuroimaging

Most recent key publications

1: Otte WM, van der Marel K, van Meer MP, van Rijen PC, Gosselaar PH, Braun KP, Dijkhuizen RM. Altered contralateral sensorimotor system organization after experimental hemispherectomy: a structural and functional connectivity study. J Cereb Blood Flow Metab. 2015;35:1358-67.
2: Dijkhuizen RM, Zaharchuk G, Otte WM. Assessment and modulation of resting-state neural networks after stroke. Curr Opin Neurol. 2014;27:637-43.
3: Dijkhuizen RM. Imaging neuronal loss and recovery in compromised but viable brain tissue. Brain. 2013;136:1689-91.
4: van Meer MP, Otte WM, van der Marel K, Nijboer CH, Kavelaars A, van der Sprenkel JW, Viergever MA, Dijkhuizen RM. Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity. J Neurosci. 2012;32:4495-507.
5: Schaechter JD, van Oers CA, Groisser BN, Salles SS, Vangel MG, Moore CI, Dijkhuizen RM. Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients. Neurorehabil Neural Repair. 2012;26:325-34.

Side Activities

Member of the Editorial Board of Translational Stroke Research

Member of the Editorial Board of Stroke

Associate Editor of Frontiers in Neurology|Stroke

Associate Editor of the Journal for Cerebral Blood Flow and Metabolism

Fellowship and Awards

VICI award, Netherlands Organization for Scientific Research (2013)

‘High Potential’ award, Utrecht University (2007)

VIDI award, Netherlands Organization for Scientific Research (2006)

Royal Netherlands Academy of Arts and Sciences (KNAW) Fellowship (2002)

Postdoctoral Fellowship Award (New England Affiliate), American Heart Association (2000)

Talent Fellowship Award, Netherlands Organization for Scientific Research (1998)

Research Output (164)

Activation response and functional connectivity change in rat cortex after bilateral transcranial direct current stimulation—An exploratory study

Boonzaier Julia, Straathof Milou, Ardesch Dirk Jan, van der Toorn Annette, van Vliet Gerard, van Heijningen Caroline L., Otte Willem M., Dijkhuizen Rick M. 2021, In: Journal of Neuroscience Research. 99 , p. 1377-1389 13 p.

Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain

Straathof Milou, Sinke Michel R T, Roelofs Theresia J M, Blezer Erwin L A, Sarabdjitsingh R Angela, van der Toorn Annette, Schmitt Oliver, Otte Willem M, Dijkhuizen Rick M 1 dec 2020, In: Scientific Reports. 10 14 p.

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

Priem Bram, van Leent Mandy M.T., Teunissen Abraham J.P., Sofias Alexandros Marios, Mourits Vera P., Willemsen Lisa, Klein Emma D., Oosterwijk Roderick S., Meerwaldt Anu E., Munitz Jazz, Prévot Geoffrey, Vera Verschuur Anna, Nauta Sheqouia A., van Leeuwen Esther M., Fisher Elizabeth L., de Jong Karen A.M., Zhao Yiming, Toner Yohana C., Soultanidis Georgios, Calcagno Claudia, Bomans Paul H.H., Friedrich Heiner, Sommerdijk Nico, Reiner Thomas, Duivenvoorden Raphaël, Zupančič Eva, Di Martino Julie S., Kluza Ewelina, Rashidian Mohammad, Ploegh Hidde L., Dijkhuizen Rick M., Hak Sjoerd, Pérez-Medina Carlos, Bravo-Cordero Jose Javier, de Winther Menno P.J., Joosten Leo A.B., van Elsas Andrea, Fayad Zahi A., Rialdi Alexander, Torre Denis, Guccione Ernesto, Ochando Jordi, Netea Mihai G., Griffioen Arjan W., Mulder Willem J.M. 29 okt 2020, In: Cell. 183 , p. 786-801.e19

Exploring the experiences of stroke patients treated with transcranial magnetic stimulation for upper limb recovery:A qualitative study

Van Lieshout Eline C.C., Jacobs Lilliane D., Pelsma Maike, Dijkhuizen Rick M., Visser-Meily Johanna M.A. 6 okt 2020, In: BMC Neurology. 20 , p. 365

Does upper limb strength play a prominent role in health-related quality of life in stroke patients discharged from inpatient rehabilitation?

Lieshout Eline C.C.van, van de Port Ingrid G., Dijkhuizen Rick M., Visser-Meily Johanna M.A. 2 okt 2020, In: Topics in Stroke Rehabilitation. 27 , p. 525-533 9 p.

Active Recharge Burst and Tonic Spinal Cord Stimulation Engage Different Supraspinal Mechanisms:A Functional Magnetic Resonance Imaging Study in Peripherally Injured Chronic Neuropathic Rats

Meuwissen Koen P.V., van der Toorn Annette, Gu Jianwen Wendy, Zhang Tianhe C., Dijkhuizen Rick M., Joosten Elbert A.J. 1 jun 2020, In: Pain Practice. 20 , p. 510-521 12 p.

Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

Senders Max L., Meerwaldt Anu E., van Leent Mandy M.T., Sanchez-Gaytan Brenda L., van de Voort Jan C., Toner Yohana C., Maier Alexander, Klein Emma D., Sullivan Nathaniel A.T., Sofias Alexandros Marios, Groenen Hannah, Faries Christopher, Oosterwijk Roderick S., van Leeuwen Esther M., Fay Francois, Chepurko Elena, Reiner Thomas, Duivenvoorden Raphael, Zangi Lior, Dijkhuizen Rick M., Hak Sjoerd, Swirski Filip K., Nahrendorf Matthias, Pérez-Medina Carlos, Teunissen Abraham J.P., Fayad Zahi A., Calcagno Claudia, Strijkers Gustav J., Mulder Willem J.M. 1 mei 2020, In: Nature nanotechnology. 15 , p. 398-405 8 p.

Comparison of self-reported vs observational clinical measures of improvement in upper limb capacity in patients after stroke

Van Lieshout Eline C.C., Visser-Meily Johanna M.A., Nijland Rinske H.M., Dijkhuizen Rick M., Kwakkel Gert 22 apr 2020, In: Journal of Rehabilitation Medicine. 52 , p. jrm00051 7 p.

Design and Evaluation of a Rodent-Specific Transcranial Magnetic Stimulation Coil:An In Silico and In Vivo Validation Study

Boonzaier Julia, Petrov Petar I., Otte Willem M., Smirnov Nickolay, Neggers Sebastiaan F.W., Dijkhuizen Rick M. 1 apr 2020, In: Neuromodulation. 23 , p. 324-334 11 p.

Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Straathof Milou, Blezer Erwin L.A., van Heijningen Caroline, Smeele Christel E., van der Toorn Annette, Buitelaar Jan K., de Ruiter Saskia, Naaijen Jilly, Akkermans Sophie, Mennes Maarten, Zwiers Marcel, Ilbegi Shahrzad, Hennissen Leonie, Glennon Jeffrey C., van de Vondervoort Ilse, Kapusta Katarzyna, Bielczyk Na AAtalia, Amiri Houshang, Havenith Martha, Franke Barbara, Poelmans Geert, Bralten Janita, Heskes Tom, Sokolova Elena, Groot Perry, Williams Steven, Murphy De AAclan, Lythgoe David, Bruchhage Muriel, Dud Iulia, Voinescu Bogdan, Dittmann Ralf, Banaschewski Tobias, Brandeis Daniel, Mechler Konstantin, Berg Ruth, Wolf Isabella, Häge Alexander, Landauer Michael, Hohmann Sarah, Schlier Regina Boecker, Ruff Matthias, Mandl René, Dijkhuizen Rick, Blezer Erwin, Mol Wouter, Otte Willem, Durston Sarah, Oranje Bob, Dijkhuizen Rick, 1 apr 2020, In: European Neuropsychopharmacology. 33 , p. 58-70 13 p.

All research output

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