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prof. dr. P.A.F.M. (Pieter A.) Doevendans

Full Professor
prof. dr. P.A.F.M. (Pieter A.) Doevendans
  • Division of Heart & Lungs

Biography

Biography

Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books

Side Activities

                                   

  • Member of the Scientific Board, Netherlands Heart Institute                                                                                         
  • Chairman Steering committee Heart and Vascular Center                                                                             

Fellowship and Awards

 

Honors

  • Fellow of the European Society of Cardiology, 2000
  • Honorary Professor Yantai Yuhuangding Hospital, China, 2007
  • Visiting Professor Harvard University, USA, 2007-2009
  • Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
  • Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014

 

Research grants obtained 

  • NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
  • The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".

  • NIH: "The role of the min K gene". Grant with R.S. Kass.

  • The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.

  • The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)

  • The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.

  • Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)

  • The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)

  • ICIN: Molecular genetic basis of cardiovascular disease (2000)

  • ICIN: Human genetics and cardiovascular developement (2000)

  • NHS: Dekker program: Vanessa van Empel (2001-2004)

  • STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)

  • BSIK: Weefsel op maat (2003)

  • Bekales Research Grant – Cardiology 2004, candidature.

  • Bekales Research Grant (2005)

  • NHS: Translational medicine: stem cell applications (2006)

  • ICIN: Stem cells from patients with genetic cardiac disease (2007)

  • BMM: SMARTCARE: cardiac repair with microtissues (2008)

  • NIRM: Stem cells as disease models (2009)

  • ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
    Phase A1 preclinical PL €300.000 (total project  €2.0M)

  • CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
    (Total project 0,5M)

  • CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)

  • Leducq (Total project 6 M€) (2018)

  • RegMed: Cardiovascular Moonshot (4 M€) (2018)

Research Output (939)

Discovering and Visualizing Disease-specific Electrocardiogram Features Using Deep Learning:Proof-of-concept in Phospholamban Gene Mutation Carriers

van de Leur Rutger, Taha Karim, Bos Max N, van der Heijden Jeroen F, Gupta Deepak, Cramer Maarten J, Hassink Rutger J, van der Harst Pim, Doevendans Pieter A, Asselbergs Folkert W, van Es René 2021, In: Circulation. Arrhythmia and electrophysiology. 14 , p. 138-147

Minimally Invasive Ways of Determining Circadian Rhythms in Humans

Crnko Sandra, Schutte Hilde, Doevendans Pieter, Sluijter Joost P G, van Laake Linda W 16 dec 2020, In: Physiology (Bethesda, Md.). 36 , p. 7-20 14 p.

Damage-Associated Molecular Patterns in Myocardial Infarction and Heart Transplantation:The Road to Translational Success

Silvis Max J M, Kaffka Genaamd Dengler Selma E, Odille Clémence A, Mishra Mudit, van der Kaaij Niels P, Doevendans Pieter, Sluijter Joost P G, de Kleijn Dominique P V, de Jager Saskia C A, Bosch Lena, van Hout Gerardus P J 8 dec 2020, In: Frontiers in Immunology. 11

Big Data and Artificial Intelligence:Opportunities and Threats in Electrophysiology

van de Leur Rutger R, Boonstra Machteld J, Bagheri Ayoub, Roudijk Rob W, Sammani Arjan, Taha Karim, Doevendans Pieter Afm, van der Harst Pim, van Dam Peter M, Hassink Rutger J, van Es René, university Folkert W nov 2020, In: Arrhythmia & electrophysiology review. 9 , p. 146-154 9 p.

In vivo analysis of the origin and characteristics of gaseous microemboli during catheter-mediated irreversible electroporation

Groen Marijn H A, van Es René, van Klarenbosch Bas R, Stehouwer Marco, Loh Peter, Doevendans Pieter, Wittkampf Fred H, Neven Kars 28 okt 2020, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 23 , p. 139-146 8 p.

Pulmonary Vein Isolation With Single Pulse Irreversible Electroporation:A First in Human Study in 10 Patients With Atrial Fibrillation

Loh Peter, van Es René, Groen Marijn H A, Neven Kars, Kassenberg Wil, Wittkampf Fred H M, Doevendans Pieter A okt 2020, In: Circulation. Arrhythmia and electrophysiology. 13 , p. 1083-1091 9 p.

Induced Pluripotent Stem Cells

van Mil Alain, Neef Klaus, Balk Geerthe Margriet, Buikema Jan Willem, Sluijter Joost P.G., Doevendans PA sep 2020, 2020 , p. 439-455 17 p.

Cellular and Molecular Mechanism of Cardiac Regeneration:A Comparison of Newts, Zebrafish, and Mammals

de Wit Lousanne, Fang Juntao, Neef Klaus, Xiao Junjie, A Doevendans Pieter, Schiffelers Raymond M, Lei Zhiyong, Sluijter Joost P G 19 aug 2020, In: Biomolecules. 10 20 p.

Angiotensin Converting Enzyme Inhibitors (ACEIs) Decrease the Progression of Cardiac Fibrosis in Rheumatic Heart Disease Through the Inhibition of IL-33/sST2

Ambari Ade M, Setianto Budhi, Santoso Anwar, Radi Basuni, Dwiputra Bambang, Susilowati Eliana, Tulrahmi Fadilla, Doevendans Pieter A, Cramer Maarten J 28 jul 2020, In: Frontiers in cardiovascular medicine. 7 , p. 115

In memory of Hein Wellens:unique scientist, teacher, doctor and friend

Gorgels A P M, Doevendans P A, Wilde A A M 13 jul 2020, In: Netherlands Heart Journal. 28 , p. 439-440 2 p.

All research output

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