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dr. S.G. (Sjoerd) Elias Associate Professor

  • Department of Epidemiology
  • Julius Center Research Program Cancer
  • Julius Center Research Program Cancer

S.G. Elias

Contact

Research Programs

Biography

I obtained my MSc in Clinical Epidemiology (2002) at the Netherlands Institute for Health Sciences, and my PhD at Utrecht University (2003). Following graduation from Medical School in 2005 I worked as a resident in radiology (Gelre Ziekenhuizen Apeldoorn, the Netherlands, 2006-2007). A personal Dutch Cancer Society Research Fellowship (2009-2013) enabled me to work as a visiting scientist at the Molecular Imaging Program at Stanford (professor SS Gambhir), the Department of Radiology and Biomedical Imaging at the University of California San Francisco (professor NM Hylton), and the Department of Molecular Pathology at the Netherlands Cancer Institute (professor LJ van't Veer). Since 2008, I work as a Clinical Epidemiologist in the research programs Cancer and Methodology at the Julius Center for Health Sciences and Primary Care, since 2018 as Associate Professor. Furthermore, I teach several courses in clinical epidemiology, both nationally as well as internationally.

Interests and Focus

My main research focus is on the clinical evaluation and translation of biomarkers, particularly for cancer classification (i.e. diagnostic, prognostic, and predictive markers). These markers include emerging imaging technologies such as molecular imaging, omics-based tests, and organoids. I have both experience in preclinical research as well as applied clinical science, and have expertise in the design and analysis of studies spanning all (translation) phases of biomarker development.

Side Activities

  • Advisor to the scientific counsel of PLCRC (Prospectief Landelijk CRC cohort).
    Member of BOOG (the Dutch breast cancer research group).
    Methodological member of the IRB (Medisch Etische Toetsings Commissie) of UMC Utrecht.
    Member of the Dutch Association for Epidemiology (Vereniging voor Epidemiologie), Registration as Senior Epidemiologist (B) (SMBWO, 2006).

Fellowship and Awards

  • 2014: Epidemiology teacher of the year, Epidemiology department, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht.
    2014: Voted best lecturer of the year by the Selective Utrecht Medical Master program students, Utrecht University.
    2013: UMC Utrecht Research Talent Program.
    2012: Invitee, 2nd Inspire2Live annual conference at the Royal Netherlands Academy of Arts and Sciences (meeting of talented young international cancer scientists).
    2011: René Vogels Foundation travel grant.
    2009: Dutch Cancer Society Research Fellowship (four year personal grant).

Research Output (99)

The Changing Role of Gene-Expression Profiling in the Era of De-escalating Adjuvant Chemotherapy in Early-Stage Breast Cancer

van Steenhoven J E C, Kuijer A, Schreuder K, Elias S G, van Diest P J, van der Wall E, Siesling S, van Dalen T okt 2019, In: Annals of Surgical Oncology. 26 , p. 3495-3501 7 p.

Lesion detection by [89Zr]Zr-DFO-girentuximab and [18F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma

Verhoeff Sarah R, van Es Suzanne C, Boon Eline, van Helden Erik, Angus Lindsay, Elias Sjoerd G, Oosting Sjoukje F, Aarntzen Erik H, Brouwers Adrienne H, Kwee Thomas C, Heskamp Sandra, Hoekstra Otto S, Verheul Henk, van der Veldt Astrid A M, de Vries Elisabeth G E, Boerman Otto C, van der Graaf Winette T A, Oyen Wim J G, van Herpen Carla M L 1 aug 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46 , p. 1931-1939 9 p.

Regional Recurrence Risk Following a Negative Sentinel Node Procedure Does Not Approximate the False-Negative Rate of the Sentinel Node Procedure in Breast Cancer Patients Not Receiving Radiotherapy or Systemic Treatment

Roos Marleen M., van Steenhoven Julia E.C., Aalders Kim C., Schreuder Kay, Burgmans Josephina P.J., Siesling Sabine, Elias Sjoerd, van Dalen Thijs 15 feb 2019, In: Annals of Surgical Oncology. 26 , p. 372-378 7 p.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers Gitte, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Dekkers Johanna F, de Winter-de Groot Karin M, Arets Hubertus G M, Marck-van der Wilt Rozemarijn E P, Dijkema Jasper S, Vanderschuren Maaike M, Houwen Roderick H J, Heijerman Harry G M, van de Graaf Eduard A, Elias Sjoerd G, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Bakker Marleen, Janssens Hettie M, van der Meer Renske, Vries Robert G J, Clevers Hans C, de Jonge Hugo R, Beekman Jeffrey M, van der Ent Cornelis K 12 feb 2019, In: Cell Reports. 26 , p. 1701-1708.e3

Effect of diet with or without exercise on abdominal fat in postmenopausal women - a randomised trial

van Gemert Willemijn A, Peeters Petra H, May Anne M, Doornbos Adriaan J H, Elias Sjoerd G, van der Palen Job, Veldhuis Wouter, Stapper Maaike, Schuit Jantine A, Monninkhof Evelyn M 11 feb 2019, In: BMC Public Health. 19 , p. 174

Choosing the right strategy based on individualized treatment effect predictions:combination versus sequential chemotherapy in patients with metastatic colorectal cancer

Kwakman Johannes J.M., van Kruijsdijk Rob C.M., Elias Sjoerd G., Seymour Matthew T., Meade Angela M., Visseren Frank L.J., Punt Cornelis J.A., Koopman Miriam 1 jan 2019, In: Acta Oncologica. 58 , p. 326-333 8 p.

89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

Bensch Frederike, van der Veen Elly L., Lub-de Hooge Marjolijn N., Jorritsma-Smit Annelies, Boellaard Ronald, Kok Iris C., Oosting Sjoukje F., Schröder Carolina P., Hiltermann T. Jeroen N., van der Wekken Anthonie J., Groen Harry J.M., Kwee Thomas C., Elias Sjoerd G., Gietema Jourik A., Bohorquez Sandra Sanabria, de Crespigny Alex, Williams Simon Peter, Mancao Christoph, Brouwers Adrienne H., Fine Bernard M., de Vries Elisabeth G.E. dec 2018, In: Nature Medicine. 24 , p. 1852-1858 7 p.

Integrating molecular nuclear imaging in clinical research to improve anticancer therapy

de Vries Elisabeth G E, Kist de Ruijter Laura, Lub-de Hooge Marjolijn N, Dierckx Rudi A, Elias Sjoerd G, Oosting Sjoukje F 27 nov 2018, In: Nature Reviews Clinical Oncology. 16 , p. 241-255 15 p.

Caloric restriction reduces age at menopause:the effect of the 1944-1945 Dutch famine

Elias Sjoerd G., van Noord Paulus A.H., Peeters Petra H.M., Tonkelaar Isolde den, Grobbee Diederick E. 1 nov 2018, In: Menopause (New York, N.Y.). 25 , p. 1232-1237 6 p.

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as biomarker of CFTR function

de Winter-de Groot Karin M, Janssens Hettie M, van Uum Rick T, Dekkers Johanna F, Berkers Gitte, Vonk Annelotte, Kruisselbrink Evelien, Oppelaar Hugo, Vries Robert, Clevers Hans, Houwen Roderick H J, Escher Johanna C, Elias Sjoerd G, de Jonge Hugo R, de Rijke Yolanda B, Tiddens Harm A W M, van der Ent Cornelis K, Beekman Jeffrey M 30 aug 2018, In: European Respiratory Journal. 52

All Research Output (99)
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