dr. M.I. (Mirjam) Geerlings

Associate Professor

  • Department of Epidemiology
  • Julius Center Research Program Cardiovascular Epidemiology

dr. M.I. (Mirjam) Geerlings

Research Programs


Mirjam Geerlings received her MSc degree in Neuropsychology (1994) and her PhD degree in Epidemiology (2000) from the VU medical center Amsterdam, the Netherlands, both of which were awarded for the best thesis. From 2000 until 2002 she worked as a post-doc at the Erasmus Medical Center, Rotterdam (Dept Epidemiology & Biostatistics) where she studied steroid hormones as risk factors for dementia using data from the Rotterdam Study. Since 2002, she works at the University Medical Center Utrecht (Julius Center for Health Sciences and Primary Care). In 2006, she obtained an Innovational Research Incentives (VIDI) grant and ASPASIA grant to study depression and stress hormones as risk factors for hippocampal atrophy and Alzheimer disease and was appointed Associate Professor Neuro-epidemiology. In 2006 (Apr-Sep), she worked at the Sergievsky Center of Columbia University, New York (S Small and R Mayeux). From Oct 2011 to Oct 2012 she worked at the National Institute on Aging, Lab of Epidemiology, Demography, and Biometry (chief Dr LJ Launer), Bethesda, Md, USA. In 2012, she was nominated for AcademiaNet, a database of excellent female reserachers. Since 2014, she is leader of the theme ‘Brain’, one of the 3 strategic themes of the Cardiovascular Epidemiology programme of the Julius Center.

Research line

Epidemiology of the aging brain

Most recent key publications

Geerlings MI & Gerritsen L. Late-life Depression, Hippocampal Volumes, and Hypothalamic-Pituitary-Adrenal Axis Regulation: A Systematic Review and Meta-analysis. Biol Psychiatry 2017, Jan 27 [epub ahead of print]. PMID: 28318491

Buddeke J, Kooistra M, Zuithoff NP, Gerritsen L, Biessels GJ, van der Graaf Y, Geerlings MI; SMART Study Group. Hippocampal volume and the course of depressive symptoms over eight years of follow-up. Acta Psychiatr Scand 2017;135:78-85.[2016 Nov 1 Epub ahead of print]. PMID: 27800603

Ghaznawi R, de Bresser J, van der Graaf Y, Zwartbol MH, Witkamp TD, Geerlings MI, Hendrikse J; SMART Study Group. Detection and characterization of small infarcts in the caudate nucleus on 7 tesla MRI: The SMART-MR study. J Cereb Blood Flow Metab 2017; Jan 1 [Epub ahead of print].

Wisse LEM, Kuijf HJ, Honingh AM, Wang H, Pluta JB, Das SR, Wolk DA, Zwanenburg JJM, Yushkevich PA, Geerlings, MI. Automated hippocampal subfield segmentation at 7 tesla MRI. AJNR Am J Neuroradiol 2016;37:1050-1057. PMID: 26846925

Kooistra M, van der Graaf Y, Grool AM, Zuithoff NP, Biessels GJ, Geerlings MI. The natural course of elevated levels of depressive symptoms in patients with vascular disease over eight years of follow-up. The SMART-Medea study. J Affect Disord 2016;202:95-101. PMID: 27259081

Geerlings MI, Sigurdsson S, Eiriksdottir G, Garcia ME, Harris TB, Gudnason V, Launer LJ. Salivary cortisol, brain volumes, and cognition in community-dwelling elderly without dementia. Neurology 2015;85:976-83. PMID: 26291281

Gerritsen L, van Velzen L, Schmaal L, van der Graaf Y, van der Wee N, van Tol MJ, Penninx B, Geerlings M. Childhood maltreatment modifies the relationship of depression with hippocampal volume. Psychol Med 2015;45:3517-3526. PMID: 26204801

Wisse LE, Biessels GJ, Stegenga BT, Kooistra M, van der Veen PH, Zwanenburg JJ, van der Graaf Y, Geerlings MI. Major depressive episodes over the course of 7 years and hippocampal subfield volumes at 7 tesla MRI: the PREDICT-MR study. J Affect Disord 2015;175:1-7. PMID: 25589378

Jochemsen HM, Muller M, Bots ML, Scheltens Ph, Vincken KL, Mali WPTM, van der Graaf Y, Geerlings MI. Arterial stiffness and progression of structural brain changes. The SMART-MR study. Neurology 2015;84:448-455. PMID: 25552578

Kooistra M, Zuithoff NP, Grool AM, Zinsmeester M, Biessels GJ, van der Graaf Y, Geerlings MI. Cognitive performance and the course of depressive symptoms over 7 years of follow-up: The SMART-MR Study. Psychol Med 2015;45:1741-1750. PMID: 25499398

van der Veen PH, Muller M, Vincken KL, Hendrikse J, Mali WP, van der Graaf Y, Geerlings MI; SMART Study Group. Longitudinal relationship between cerebral small-vessel disease and cerebral blood flow: the second manifestations of arterial disease-magnetic resonance study. Stroke 2015;46:1233-1238. PMID: 25804924

De Cocker LJ, Kloppenborg RP, van der Graaf Y, Luijten PR, Hendrikse J, Geerlings MI; SMART Study Group. Cerebellar Cortical Infarct Cavities: Correlation With Risk Factors and MRI Markers of Cerebrovascular Disease. Stroke 2015;46:3154-3160. PMID:26382175. Correction in: Stroke 2016;47:e38. PMID: 26811333

Wisse LEM, Biessels GJ, Heringa SM, Kuijf HJ, Koek HL, Luijten PR, Geerlings MI. Hippocampal subfield volumes at 7T in early Alzheimer disease and normal aging. Neurobiol Aging 2014;35:2039-2045. PMID: 24684788

Geerlings MI, Sigurdsson S, Eiriksdottir G, Garcia ME, Harris TB, Sigurdsson T, Gudnason V, Launer LJ. Associations of current and remitted major depressive disorder with brain atrohpy: the AGES-Reykjavik Study. Psychol Med 2013;43:317-28. PMID: 22647536

Geerlings MI, Brickman AM, Schupf N, Devanand DP, Luchsinger JA, Mayeux R, Small SA. Depressive symptoms, antidepressant use, and brain volumes on MRI in a population-based cohort of old persons without dementia. J Alzheimers Dis 2012;30:75-82. PIMD 22377782

Fellowship and Awards

  • VIDI (2005)
    ASPASIA (2006)
    University Medical Center Utrecht, Program Internationalisation Research (2006)
    University Medical Center Utrecht, Program Internationalisation Research (2010)
    Prize for the best PhD thesis of the research school CARE (2000)

Research Output (205)

Association of hippocampal calcification and cardiovascular risk factors in two patient cohorts

van der Knaap Marije J.A., Peters Melissa E.M., Lucci Carlo, Geerlings Mirjam I., de Jong Pim A., Ruigrok Ynte M., van der Graaf Y., Grobbee D. E., Rutten G. E.H.M., Visseren F. L.J., de Borst G. J., Kappelle L. J., Leiner T., Doevendans P. A., 1 mei 2019, In: Atherosclerosis: X. 1

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Chauhan Ganesh, Adams Hieab H H, Satizabal Claudia L, Bis Joshua C, Teumer Alexander, Sargurupremraj Muralidharan, Hofer Edith, Trompet Stella, Hilal Saima, Smith Albert Vernon, Jian Xueqiu, Malik Rainer, Traylor Matthew, Pulit Sara L, Amouyel Philippe, Mazoyer Bernard, Zhu Yi-Cheng, Kaffashian Sara, Schilling Sabrina, Beecham Gary W, Montine Thomas J, Schellenberg Gerard D, Kjartansson Olafur, Guðnason Vilmundur, Knopman David S, Griswold Michael E, Windham B Gwen, Gottesman Rebecca F, Mosley Thomas H, Schmidt Reinhold, Saba Yasaman, Schmidt Helena, Takeuchi Fumihiko, Yamaguchi Shuhei, Nabika Toru, Kato Norihiro, Rajan Kumar B, Aggarwal Neelum T, De Jager Philip L, Evans Denis A, Psaty Bruce M, Rotter Jerome I, Rice Kenneth, Lopez Oscar L, Liao Jiemin, Uh Hae-Won, Geerlings Mirjam I, van der Graaf Yolanda, de Bakker Paul I W, Asselbergs Folkert W, 16 jan 2019, In: Neurology. 92 , p. E486-E503

Kidney Function and the Risk of Stroke and Dementia:The Rotterdam Study

Koop-Nieuwelink Carolien, Sedaghat Sanaz, Mutlu Unal, Licher Silvan, Franco Oscar H, Ikram M Arfan, Geerlings Mirjam I, Ikram M Kamran, Bos Daniel 14 jan 2019, In: Journal of Alzheimer's Disease. 67 , p. 821-826

Intracranial Vessel Wall Lesions on 7T MRI (Magnetic Resonance Imaging):Occurrence and vascular risk factors: The SMART-MR study

Zwartbol Maarten H.T., van der Kolk Anja G., Ghaznawi Rashid, van der Graaf Yolanda, Hendrikse Jeroen, Geerlings Mirjam I., 1 jan 2019, In: Stroke. 50 , p. 88-94 7 p.

MRI phenotypes of the brain are related to future stroke and mortality in patients with manifest arterial disease:The SMART-MR study

Jaarsma-Coes Myriam G, Ghaznawi Rashid, Hendrikse Jeroen, Slump Cornelis, Witkamp Theo D, van der Graaf Yolanda, Geerlings Mirjam I, de Bresser Jeroen, 14 dec 2018, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 354-364 11 p.

The association between lacunes and white matter hyperintensity features on MRI:The SMART-MR study

Ghaznawi Rashid, Geerlings Mirjam I, Jaarsma-Coes Myriam G, Zwartbol Maarten Ht, Kuijf Hugo J, van der Graaf Yolanda, Witkamp Theo D, Hendrikse Jeroen, de Bresser Jeroen, 11 sep 2018, In: Journal of Cerebral Blood Flow and Metabolism. 39 , p. 2486-2496 11 p.

Hippocampal calcifications:Risk factors and association with cognitive function

De Brouwer Esther J.M., Kockelkoren Remko, Claus Jules J., De Jonghe Annemarieke, Geerlings Mirjam I., Jongsma Thomas E.F., Mali Willem P.T.M., Hendrikse Jeroen, De Jong Pim A., Koek Huiberdina L. 12 jun 2018, In: Radiology. 288 , p. 815-820 6 p.

Automated Multi-Atlas Segmentation of Hippocampal and Extrahippocampal Subregions in Alzheimer's Disease at 3T and 7T:What Atlas Composition Works Best?

Xie Long, Shinohara Russell T, Ittyerah Ranjit, Kuijf Hugo J, Pluta John B, Blom Kim, Kooistra Minke, Reijmer Yael D, Koek Huiberdina L, Zwanenburg Jaco J M, Wang Hongzhi, Luijten Peter R, Geerlings Mirjam I, Das Sandhitsu R, Biessels Geert Jan, Wolk David A, Yushkevich Paul A, Wisse Laura E M 1 jan 2018, In: Journal of Alzheimer's Disease. 63 , p. 217-225 9 p.

White Matter Hyperintensities and Cognition in Mild Cognitive Impairment and Alzheimer's Disease:A Domain-Specific Meta-Analysis

Van Den Berg Esther, Geerlings Mirjam I., Biessels Geert Jan, Nederkoorn Paul J., Kloppenborg Raoul P. 1 jan 2018, In: Journal of Alzheimer's Disease. 63 , p. 515-527 13 p.

All Research Output (205)