dr. F. (Floris) Groenendaal

dr. F. (Floris) Groenendaal

Associate Professor - medical
dr. F. (Floris) Groenendaal
  • Birth Center Neonatology - Medical



Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.

Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.

In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic  strategies have been developed and tested in animal models.

He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.

He is member of many professional societies.

Research line

Neonatal neuroprotection

Most recent key publications

1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575

Side Activities

•          Invited speaker on many international courses and symposia

•          Co-inventor of 2-iminobiotin for neonatal neuroprotection

•          Expert witness in several legal cases

•          Reviewer for many international scientific journals

Fellowship and Awards

- Ter Meulen Fonds, KNAW, Amsterdam 1993

- Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995

- NWO AGIKO-stipendium 920-03-039

- Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07

- Dr.W.M.Phelps-Stichting voor Spastici 03.016

- Wilhelmina Kinderziekenhuis Onderzoekfonds 2003

- NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022

- Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.

- NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002

- NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103

- ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005

- ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes.  50-50200-98-060

Research Output (631)

A Population Model of Time-Dependent Changes in Serum Creatinine in (Near)term Neonates with Hypoxic-Ischemic Encephalopathy During and After Therapeutic Hypothermia

Krzyzanski Wojciech, Wintermark Pia, Annaert Pieter, Groenendaal Floris, Şahin Suzan, Öncel Mehmet Yekta, Armangil Didem, Koc Esin, Battin Malcolm R, Gunn Alistair J, Frymoyer Adam, Chock Valerie Y-L, Keles Elif, Mekahli Djalila, van den Anker John, Smits Anne, Allegaert Karel Feb 2024, In: The AAPS Journal. 26 11 p.

Cranial MRI beyond the Neonatal Period and Neurodevelopmental Outcomes in Neonatal Encephalopathy Due to Perinatal Asphyxia:A Systematic Review

Parmentier Corline E J, Kropman Tobias, Groenendaal Floris, Lequin Maarten H, de Vries Linda S, Benders Manon J N L, Alderliesten Thomas 6 Dec 2023, In: Journal of Clinical medicine. 12 18 p.

Opportunities and Challenges of Prognostic Models for Extremely Preterm Infants

de Boer Angret, van Beek Pauline E, Andriessen Peter, Groenendaal Floris, Hogeveen Marije, Meijer Julia S, Obermann-Borst Sylvia A, Onland Wes, Scheepers Liesbeth H C J, Vermeulen Marijn J, Verweij E J T Joanne, De Proost Lien, Geurtzen Rosa 21 Oct 2023, In: Children (Basel, Switzerland). 10 10 p.

Proceedings of the 14th International Newborn Brain Conference:Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc

Ali Sanoj et al. 17 Aug 2023, In: Journal of neonatal-perinatal medicine. 16 , p. S63-S73

Introduction of ultra-high-field MR brain imaging in infants:vital parameters, temperature and comfort

van Ooijen I. M., Annink K. V., Benders M. J.N.L., Dudink J., Alderliesten T., Groenendaal F., Tataranno M. L., Lequin M. H., Hoogduin J. M., Visser F., Raaijmakers A. J.E., Klomp D. W.J., Wiegers E. C., Wijnen J. P., van der Aa N. E. Jun 2023, In: Neuroimage: Reports. 3 6 p.

Prediction of fetal and neonatal outcomes after preterm manifestations of placental insufficiency:systematic review of prediction models

Kleuskens D G, van Veen C M C, Groenendaal F, Ganzevoort W, Gordijn S J, van Rijn B B, Lely A T, Schuit E, Kooiman J 9 May 2023, In: Ultrasound in Obstetrics and Gynecology. 62 , p. 644-652 9 p.

Do we need a brain MRI once or twice in infants treated with hypothermia?

de Vries Linda S, Groenendaal Floris 29 Apr 2023, In: Pediatric Research. 94 , p. 870-872 3 p.

Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia

van der Veer Marlotte A A, de Haan Timo R, Franken Linda G W, Hodiamont Caspar J, Groenendaal Floris, Dijk Peter H, de Boode Willem P, Simons Sinno, Dijkman Koen P, van Straaten Henrica L M, Rijken Monique, Cools Filip, Nuytemans Debbie H G M, van Kaam Anton H, Bijleveld Yuma A, Mathôt Ron A A 3 Apr 2023, In: Antimicrobial Agents and Chemotherapy. 67

OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE):study protocol of a multicentre, retrospective cohort study

van de Meent Mette, Kleuskens Dianne G, Ganzevoort Wessel, Gordijn Sanne J, Kooi Elisabeth M W, Onland Wes, van Rijn Bas B, Duvekot Johannes J, Kornelisse René F, Al-Nasiry Salwan, Jellema Reint K, Knol H Marieke, Manten Gwendolyn T R, Mulder-de Tollenaer Susanne M, Derks Jan B, Groenendaal Floris, Bekker Mireille N, Schuit Ewoud, Lely A Titia, Kooiman Judith 17 Mar 2023, In: BMJ Open. 13

Susceptibility weighted imaging can be a sensitive sequence to detect brain damage in neonates with kernicterus:a case report

Lequin Maarten, Groenendaal Floris, Dudink Jeroen, Govaert Paul 11 Mar 2023, In: BMC Neurology. 23

All research output

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