dr. C.W. Helsper

dr. C.W. Helsper

Assistant Professor
dr. C.W. Helsper
  • Department of General Practice
  • Julius Center Research Program Cancer

Research Programs

Strategic Program Cancer



Main focus


Research coordinator: oncology in primary care - research projects;

Early diagnosis;

  • Dickens: duration of the cancer diagnostic pathway & potential to improve
  • Dickens II: Impact of COVID on the diagnostic pathway for cancer 
  • ABE: case finding of increased cancer risk - ovarian cancer
  • Risk perception and policy among GPs in different stages of their career


Shared decision making (SDM)

  • GRIP - the effects of SDM support by GPs after a cancer diagnosis
  • Choose Wisely -  optimal shared decision making support by the GP
  • Meaningful choice - role of the GP in hospital choice 


Structured primary care guidance during and after treatment

  • GRIP I (RCT) - Effects of strutured primary care guidance during cancer treatment
  • GRIP II - Optimal implementation of strutured primary care guidance during cancer treatment
  • Blanket (RCT) - Effects of treatment of fear of cancer recurrence in primary care



Lecturer at GP-specialty training and Utrecht University 

  • Evidence Based Medicine in clinical pratice
  • Primary care oncology
  • Teach the teachrer programs




  • MD: with a background in General practice (AIOTHO)
  • PhD: casefinding strategies for hepatitis C infection
  • MSc: Clinical Epidemiology



Biographical Sketch

Charles Helsper was born on the 9th of March 1980 in Pullman Washington (USA). After graduating from the Atheneum at the ‘Bisschop Bekkers College’ in Eindhoven and the first year of Health Sciences at Maastricht University, he studied Medicine at Utrecht University. During these studies he developed an interest for both the practice and research of primary care and prevention.

To put this interest into practice he combined the GP-specialty training with a PhD programme at the Julius Center for Health Sciences and Primary Care at the Utrecht Medical Center. His PhD programme addressed identification strategies for hepatitis C infection from a primary care point of view.

During this combined programme he also successfully finished a Prestige Master in Epidemiology, worked as a lecturer at the GP specialty training, at Utrecht University and as an invited lecturer at the Centre for Research in Evidence-Based Practice at Bond University (Australia).

Currently he is working as a senior researcher at the Julius Center for Health Sciences and Primary Care, with a focus on cancer in primary care. In addition, he works at the Utrecht GP specialty training and Utrecht University, with a main focus on improving the use and education of scientific evidence in primary care practice.




Side Activities

THINC.  Advisor - The Health Care Innovation Centre

THINC (The Healthcare Innovation Center)., as part of the UMC Utrecht Julius Center, contributes to the continuous development of scientific knowledge at the service of healthcare innovation. We combine state of the art scientific expertise in the fields of HTA (Health Technology Assessment), clinical epidemiology, public health, ethics, primary care and implementation. From the early innovation stages THINC can inform innovators on the anticipated working mechanism (causal pathways), usability, validity and (cost-effectiveness). THINC aims at a broad range of healthcare innovations including medical technology, devices, mHealth, eHealth and care pathways.   

Fellowship and Awards

- SBOH academiseringsprijs - artikel: Primary care management of women with breast cancer-related concerns-a dynamic cohort study using a network database. Sollie A, Helsper CW, Ader RJ, Ausems MG, van der Wouden JC, Numans ME. Eur J Cancer Care (Engl). 2016 Nov;25(6):1005-1014


- Academic GP Award 2012. Utrechtse prijs academische huisartsgeneeskunde. Universitair medisch centrum Utrecht


- Future Research Star Award 2010. European Society for Primary Care Gastroenterology

Research Output (39)

Effects of structured involvement of the primary care team versus standard care after a cancer diagnosis on patient satisfaction and healthcare use:the GRIP randomised controlled trial

Perfors I. A.A., Helsper C. W., Noteboom E. A., Visserman E. A., van Dorst E. B.L., van Dalen T., Verhagen M. A.M.T., Witkamp A. J., Koelemij R., Flinterman A. E., Pruissen-Peeters K. A.B.M., Schramel F. M.N.H., van Rens M. T.M., Ernst M. F., Moons L. M.G., van der Wall E., de Wit N. J., May A. M. 4 Jun 2022, In: BMC Primary Care. 23 , p. 1-14

Patients' preferred and perceived level of involvement in decision making for cancer treatment:A systematic review

Noteboom Eveline A., May Anne M., van der Wall Elsken, de Wit Niek J., Helsper Charles W. 28 Jun 2021, In: Psycho-Oncology. 30 , p. 1663-1679 17 p.

Cancer suspicion, referral to cancer patient pathway and primary care interval:a survey and register study exploring 10 different types of abdominal cancer

Jessen Nanna H., Jensen Henry, Helsper Charles W., Falborg Alina Z., Glerup Henning, Gronbaek Henning, Vedsted Peter 27 Apr 2021, In: Family Practice. 38 , p. 589-597 9 p.

Developing a regional transmural care database:A roadmap

Vermond Debbie, Helsper Charles W, Kortekaas Marlous F, Boekema Nicole, de Groot Esther, de Wit Niek J, Zwart Dorien L M 16 Jan 2021, In: International Journal of Medical Informatics. 148 , p. 1-7

Treatment decision-making and the added value of the general practitioner:A qualitative exploration of cancer patients' perspectives

Noteboom Eveline A, Vervoort Sigrid C J M, May Anne M, van Dorst Eleonora B L, van Lindert Anne S R, van Elst Maarten W, Bijlsma Rhodé M, van der Wall Elsken, de Wit Niek J, Helsper Charles W 2021, In: European Journal of Cancer Care. 30

GP involvement after a cancer diagnosis; patients' call to improve decision support

Noteboom Eveline A, Perfors Ietje A A, May Anne M, Stegmann Mariken E, Duijts Saskia F A, Visserman Ella A, Vivian Engelen, Richel Carol, van der Wall Elsken, de Wit Niek, Helsper Charles W 8 Dec 2020, In: BJGP Open. 5 , p. 1-10 10 p.

Cancer has not gone away:A primary care perspective to support a balanced approach for timely cancer diagnosis during COVID-19

Helsper Charles W, Campbell Christine, Emery Jon, Neal Richard D, Li Li, Rubin Greg, van Weert Henk, Vedsted Peter, Walter Fiona M, Weller David, Nekhlyudov Larissa 7 Jul 2020, In: European Journal of Cancer Care. 29

Time to diagnosis of symptomatic gastric and oesophageal cancer in the Netherlands:Where is the room for improvement?

van Erp N. F., Helsper C. W., Slottje P., Brandenbarg D., Büchner F. L., van Asselt K. M., Muris J. W.M., Kortekaas M. F., Peeters P. H.M., de Wit N. J. Jun 2020, In: United European Gastroenterology Journal. 8 , p. 607-620 14 p.

Sneller verwijzen bij darmkanker

van Erp Nicole, Helsper Charles, Olyhoek Saskia, Janssen Ramon, Winsveen Amber, Peeters Petra, de Wit N. J. 4 Apr 2020, In: Huisarts en Wetenschap. 63 , p. 14-17 4 p.

Effects of a time out consultation with the general practitioner on cancer treatment decision-making:a randomised controlled trial: Time out with the general practitioner and cancer treatment decision

Perfors Ietje A A, Noteboom Eveline A, de Wit Niek J, van der Wall Elsken, Visserman Ella A, van Dalen Thijs, Verhagen Marc A M T, Witkamp Arjen J, Koelemij Ron, Flinterman Annebeth E, van Dorst Eleonora B L, Pruissen-Peeters Kim A B M, Moons Leon M G, Schramel Franz M N H, van Rens Marcel T M, Ernst Miranda F, May Anne M, Helsper Charles W 2020, In: Psycho-Oncology. 30 , p. 571-580 10 p.

All research output

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