prof. dr. H.E. (Hilleke) Hulshoffpol

Full Professor

  • Psychiatry

prof. dr. H.E. (Hilleke) Hulshoffpol

Research Programs


Hilleke Hulshoff Pol completed her MS degree in psychophysiology with Rien Verbaten in Utrecht (1987), her internship in neuropsychology and neuroimaging with Nelson Butters at the University of California in San Diego (1988), and subsequently her PhD degree in Utrecht (September 25, 1995) with Jan van Ree (neuropharmacology), Max Viergever (imaging), and Cees Tulleken (neurosurgery). Topic of her thesis was memory processes in the frontal cortex of the human brain. Between 1996 and 2006 she set up and headed the brain imaging research lab at the Department of Psychiatry in Utrecht. Since 2007 she is full professor of neuroscience in particular of psychiatric disorders at the Brain Center Rudolf Magnus.

Her research focuses on structural and functional brain plasticity throughout life in health and in psychiatric disease, and the influences of genes and environment on brain plasticity. For this purpose she studies individuals and their (twin) family members, using magnetic resonance imaging at (ultra) high field. She has received a VIDI award from the Netherlands Scientific Organization NWO, and a High Potential award from the Utrecht University. Her work was published in >220 publications, her current h-index is 64, and has been cited >15.800 times.

Research line

Brain plasticity

Most recent key publications

1:Teeuw J., Brouwer R.M., Guimarães, J.P.O.F.T., Brandner, P., Koenis M., Swagerman S., Verwoert, M., Boomsma D.I., Hulshoff Pol H.E. (2019) Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls. Neuroimage. doi: 10.1016/j.neuroimage.2019.116073

2:Brouwer RM Panizzon MS Glahn DC, Hibar DP, Hua X, Jahanshad N, Abramovic L, de Zubicaray GI Franz CE, Hansell NK, Hickie IB, Koenis MMG, Martin NG, Mather KA, McMahon KL, Schnack HG, Strike LT, Swagerman SC, Thalamuthu A, Wen W, Gilmore JH, Gogtay N, Kahn RS, Sachdev PS, Wright MJ, Boomsma DI, Kremen WS, Thompson PM, Hulshoff Pol HE. (2017). Genetic influences on longitudinal changes in global and subcortical brain volumes: results of the ENIGMA Plasticity Working Group. Hum Brain Mapp. 38(9):4444-4458

3:Bohlken MM, Brouwer RM, Mandl RC, Van den Heuvel MP, Hedman AM, De Hert M, Cahn W, Kahn RS, Hulshoff Pol HE. (2016). Structural Brain Connectivity as a Genetic Marker for Schizophrenia. JAMA Psychiatry. 73(1):11-9.

4:Svatkova A, Mandl RC, Scheewe TW, Cahn W, Kahn RS, Hulshoff Pol HE. (2015). Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls. Schizophr Bull.41(4):869-78.

5:Schnack HG, van Haren NE, Brouwer RM, Evans A, Durston S, Boomsma DI, Kahn RS, Hulshoff Pol HE. (2015). Changes in thickness and surface area of the human cortex and their relationship with intelligence. Cereb Cortex. 25(6):1608-17.

6:Marsman A, Mandl RC, Klomp DW, Bohlken MM, Boer VO, Andreychenko A, Cahn W, Kahn RS, Luijten PR, Hulshoff Pol HE. (2014). GABA and glutamate in schizophrenia: a 7 T ¹H-MRS study. Neuroimage Clin. 15;6:398-407.

Side Activities

  • None

Fellowship and Awards

  • Alzheimer's Association Zenith Award Program (subaward PI) 2020

    NWA Ideas Generator (one of the PIs) 2020

    NIH ENIGMA World Aging Center (subward PI) 2018

    NWA NeuroLabNL (subward PI) 2018

    Dutch Brain Foundation (subaward PI) 2018

    NWO National Roadmap BBMRI-NL2.0 (one of the PIs) 2014

    NWO Gravitation Grant CID (one of the PIs), 2012

    NWO  NIHC Brain and Cognition, programmes of excellence (PI), 2010

    High Potential Program Utrecht University (one of the two PIs), 2007

    Marie Curie research training network (PI for Utrecht), 2007

    NWO ZON-MW VIDI program (PI), 2004

Research Output (269)

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal Claudia L., Adams Hieab H.H., Hibar Derrek P., White Charles C., Knol Maria J., Stein Jason L., Scholz Markus, Sargurupremraj Muralidharan, Jahanshad Neda, Roshchupkin Gennady V., Smith Albert V., Bis Joshua C., Jian Xueqiu, Luciano Michelle, Hofer Edith, Teumer Alexander, van der Lee Sven J., Yang Jingyun, Yanek Lisa R., Lee Tom V., Li Shuo, Hu Yanhui, Koh Jia Yu, Eicher John D., Desrivières Sylvane, Arias-Vasquez Alejandro, Chauhan Ganesh, Athanasiu Lavinia, Rentería Miguel E., Kim Sungeun, Hoehn David, Armstrong Nicola J., Chen Qiang, Holmes Avram J., den Braber Anouk, Kloszewska Iwona, Andersson Micael, Abramovic Lucija, Bohlken Marc M., Klein Marieke, Boks Marco P., van Eijk Kristel R., Cahn Wiepke, Hulshoff Pol Hilleke E., Ikram M. Kamran, Brouwer Rachel M., Kahn René S., Ophoff Roel A., van Haren Neeltje E.M., Schmidt Reinhold, 1 nov 2019, In: Nature Genetics. 51 , p. 1624-1636 13 p.

Sexual dimorphism in cortisol production and metabolism throughout pubertal development: a longitudinal study

van Keulen Britt, Dolan Conor, van der Voorn Bibian, Andrew Ruth, Walker Brian, Boomsma Dorret, Hulshoff-Pol Hilleke, Rotteveel Joost, Finken Martijn sep 2019, In: Hormone Research in Paediatrics. 91 , p. 59-60

Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls

Teeuw Jalmar, Brouwer Rachel M, Guimarães João P O F T, Brandner Philip, Koenis Marinka M G, Swagerman Suzanne C, Verwoert Maxime, Boomsma Dorret I, Hulshoff Pol Hilleke E 3 aug 2019, In: NeuroImage. 202 16 p.

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

Walton E., Hibar D., Yilmaz Z., Jahanshad N., Cheung J., Batury V. -L., Seitz J., Bulik C. M., Thompson P. M., Ehrlich Stefan, Hibar Derrek P., Stein Jason L., Renteria Miguel E., Arias-Vasquez Alejandro, Desrivieres Sylvane, Jahanshad Neda, Toro Roberto, Wittfeld Katharina, Abramovic Lucija, Andersson Micael, Aribisala Benjamin S., Armstrong Nicola J., Bernard Manon, Bohlken Marc M., Boks Marco P., Bralten Janita, Brown Andrew A., Chakravarty M. Mallar, Chen Qiang, Ching Christopher R. K., Cuellar-Partida Gabriel, Den Braber Anouk, Giddaluru Sudheer, Goldman Aaron L., Grimm Oliver, Guadalupe Tulio, Hass Johanna, Woldehawariat Girma, Klein Marieke, van Eijk Kristel R., Cahn Wiepke, Kahn Rene S., van Haren Neeltje E. M., Brouwer Rachel M., Pol Hilleke E. Hulshoff, Ophoff Roel, Adan Roger, Kas Martien, Koeleman Bobby, Ophoff Roel, 1 jul 2019, In: Molecular Neurobiology. 56 , p. 5146-5156 11 p.

The Association Between Familial Risk and Brain Abnormalities Is Disease Specific:An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

de Zwarte Sonja M C, Brouwer Rachel M, Agartz Ingrid, Alda Martin, Aleman André, Alpert Kathryn I, Bearden Carrie E, Bertolino Alessandro, Bois Catherine, Bonvino Aurora, Bramon Elvira, Buimer Elizabeth E L, Cahn Wiepke, Cannon Dara M, Cannon Tyrone D, Caseras Xavier, Castro-Fornieles Josefina, Chen Qiang, Chung Yoonho, De la Serna Elena, Di Giorgio Annabella, Doucet Gaelle E, Eker Mehmet Cagdas, Erk Susanne, Fears Scott C, Foley Sonya F, Frangou Sophia, Frankland Andrew, Fullerton Janice M, Glahn David C, Goghari Vina M, Goldman Aaron L, Gonul Ali Saffet, Gruber Oliver, de Haan Lieuwe, Hajek Tomas, Hawkins Emma L, Heinz Andreas, Hillegers Manon H J, Hulshoff Pol Hilleke, Hultman Christina M, Ingvar Martin, Johansson Viktoria, Jönsson Erik G, Kane Fergus, Kempton Matthew J, Koenis Marinka M G, van Os Jim, Kahn René, van Haren Neeltje E M, 13 jun 2019, In: Biological Psychiatry. 86 , p. 545-556 12 p.


Legind Christian, Broberg Brian, Brouwer Rachel, Mandl Rene, Ebdrup Bjorn H., Anhoj Simon, Jensen Maria H., Hilker Rikke Prime, Fagerlund Birgitte, Pol Hilleke Hulshoff, Glenthoj Birte, Rostrup Egill apr 2019, In: Schizophrenia Bulletin. 45 , p. S311-S311


Gangadin Shiral, Cahn Wiepke, Scheeuwe Thomas, Pol Hilleke Hulshoff, Bossong Matthijs apr 2019, In: Schizophrenia Bulletin. 45 , p. S288-S288

Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders:A Pseudo-continuous Arterial Spin Labeling Twin Study

Legind Christian S, Broberg Brian V, Brouwer Rachel, Mandl René C W, Ebdrup Bjørn H, Anhøj Simon J, Jensen Maria H, Hilker Rikke, Fagerlund Birgitte, Hulshoff Pol Hilleke E, Glenthøj Birte Y, Rostrup Egill 18 feb 2019, In: Schizophrenia Bulletin. 45 , p. 1231-1241 11 p.

Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data

Kochunov Peter, Patel Binish, Ganjgahi Habib, Donohue Brian, Ryan Meghann, Hong Elliot L., Chen Xu, Adhikari Bhim, Jahanshad Neda, Thompson Paul M., Van’t Ent Dennis, den Braber Anouk, de Geus Eco J.C., Brouwer Rachel M., Boomsma Dorret I., Hulshoff Pol Hilleke E., de Zubicaray Greig I., McMahon Katie L., Martin Nicholas G., Wright Margaret J., Nichols Thomas E. 7 feb 2019, In: Frontiers in Neuroinformatics [E]. 13

Running in the Family?:Structural Brain Abnormalities and IQ in Offspring, Siblings, Parents, and Co-twins of Patients with Schizophrenia

De Zwarte Sonja M.C., Brouwer Rachel M., Tsouli Andromachi, Cahn Wiepke, Hillegers Manon H.J., Hulshoff Pol Hilleke E., Kahn René S., Van Haren Neeltje E.M. 28 dec 2018, In: Schizophrenia Bulletin. 45 , p. 1209-1217 9 p.

All Research Output (269)