prof. dr. D.W.J. Klomp
prof. dr. D.W.J. Klomp
- 7T Group
In my research team, we are investigating novel methods to enable imaging of metabolism and physiology of diseases and treatments non-invasively to aid clinical decision making. Using ultra-high magnetic fields, we demonstrated feasibility of imaging metabolism with magnetic resonance in the human body at clinically relevant spatial resolutions. Observing physiology and metabolism will provide a more direct and therefore faster and accurate means to characterize diseases and responses to treatments when compared to conventional morphologic imaging as known from cell studies. In fact, we have recently proven that metabolic images can predict efficacy of neoadjuvant chemotherapy in breast cancer much better and faster than any morphologic imaging technique could. The results have motivated public-private partnerships in translating the technology for clinical studies involving metabolic MRI throughout the body.
Compared to a few morpholic imaging contrasts conventionally available in radiology, potentially hundred of different metabolite levels could soon be imaged. Our innovation therefore brings radiology into the world of biochemistry and visa versa, creating a new bridge between research groups in identifying what non-invasively detectable metabolites would be useful for aiding clinic. In parallel, acceleration techniques in imaging are being investigated to maximize metabolic and physiologic information within a single scan session for each patient. These incorporate high density receiver array and even novel ways in gradient coil designs that speed up (metabolic) MRI with an anticiptated acceleration of an order of magnitude.
The very first prototype worldwide of metabolic MRI dedicated for clinical use will become available at the UMCU and clinical projects are being compiled for the focus areas of cancer, heart/vasculature, regenerative medicine, child, infections, brain. Teams from Dutch UMCU’s will use our system, while plans have been compiled to take the scientific lead of the next 8 systems positioned worldwide (3 already confirmed) prior to FDA approval.
Non executive board member Tesla Engingeering (no shareholder); advisor in MRI technology, August 2019 - August 2050
Research Output (181)
van Ooijen I. M., Annink K. V., Benders M. J.N.L., Dudink J., Alderliesten T., Groenendaal F., Tataranno M. L., Lequin M. H., Hoogduin J. M., Visser F., Raaijmakers A. J.E., Klomp D. W.J., Wiegers E. C., Wijnen J. P., van der Aa N. E. Jun 2023, In: Neuroimage: Reports. 3 6 p.
Dai Jiying, Gosselink Mark, van der Velden Tijl Antonius, Meliadò Ettore Flavio, Raaijmakers Alexander Jan Eberhard, Klomp Dennis Wilhelmus Johannes May 2023, In: Magnetic Resonance in Medicine. 89 , p. 2131-2141 11 p.
van den Wildenberg Lieke, Gursan Ayhan, Seelen Leonard W.F., van der Velden Tijl A., Gosselink Mark W.J.M., Froeling Martijn, van der Kemp Wybe J.M., Klomp Dennis W.J., Prompers Jeanine J. May 2023, In: NMR in Biomedicine. 36
Bates Steve, Dumoulin Serge O, Folkers Paul J M, Formisano Elia, Goebel Rainer, Haghnejad Aidin, Helmich Rick C, Klomp Dennis, van der Kolk Anja G, Li Yi, Nederveen Aart, Norris David G, Petridou Natalia, Roell Stefan, Scheenen Tom W J, Schoonheim Menno M, Voogt Ingmar, Webb Andrew 10 Apr 2023, In: Magma - Magnetic Resonance Materials In Physics Biology And Medicine. 36 , p. 211-225 15 p.
Harrevelt Seb D, Roos Thomas H M, Klomp Dennis W J, Steensma Bart R, Raaijmakers Alexander J E Apr 2023, In: Magma - Magnetic Resonance Materials In Physics Biology And Medicine. 36 , p. 245-255 11 p.
Gursan Ayhan, Hendriks Arjan D, Welting Dimitri, de Jong Pim A, Klomp Dennis W J, Prompers Jeanine J 16 Mar 2023, In: NMR in Biomedicine. 36 , p. 1-14
Nam Kyung Min, Gursan Ayhan, Bhogal Alex A, Wijnen Jannie P, Klomp Dennis W J, Prompers Jeanine J, Hendriks Arjan D 2023, In: Magnetic Resonance in Medicine. 90 , p. 863-874 12 p.
van der Kemp W J M, Grinde M T, Malvik J O, van Laarhoven H W M, Prompers J J, Klomp D W J, Burgering B M T, Bathen T F, Moestue S A 30 Nov 2022, In: NMR in Biomedicine. 36
Versteeg Edwin, Klomp Dennis W.J., Siero Jeroen C.W. Oct 2022, In: Magnetic Resonance in Medicine. 88 , p. 1785-1793 9 p.
Nam Kyung Min, Hendriks Arjan D, Boer Vincent O, Klomp Dennis W J, Wijnen Jannie P, Bhogal Alex A Oct 2022, In: NMR in Biomedicine. 35