prof. dr. J. (Judith) Klumperman Full Professor
- Cell Biology
Contact
jklumper@umcutrecht.nl
Research Programs
Biography
Since 2001 Judith Klumperman is professor of Cell Biology and since 2008 chair of the Department of Cell Biology at the UMC Utrecht. She is also head of the Cell Microscopy Core of the UMC Utrecht, which is widely recognized as one of the best expertise centers in the world for immuno-electron microscopy. On a yearly basis the UMC Utrechts trains and assist over 40 scientists from the Netherlands and 15-20 international guests.She is often asked for expert microscopy advise and participate(d) in a large number of international collaborations.
Her research focus on understanding the molecular basis of human diseases, with an emphasis on diseases of the endo-lysosomal system. Diseases specifically addressed in my work are: Lysosomal storage disorders (Pompe disease; Mucolipidosis II/I-Cell disease) – Alzheimer disease – Hermansky Pudlak Syndrome (pigmentation bleeding disorder) - Cancer – virus and bacterial infections – ARC syndrome –Microvillar inclusion Disease. In addition, her work has elucidated fundamental concepts of endosome and lysosome biogenesis, of which the most recent finding is a novel pathway for the delivery of lysosomal membrane proteins to the lysosomes.
Side Activities
Regular (>10) member or chair of Appointment Advisory Committee’s for new professors.
Regular (>20) member of chair of thesis assessment committee’s (Universities of Utrecht, Leiden, Rotterdam, Amsterdam, Nijmegen, Leuven (Belgium), Copenhagen (Denmark)).
ESFRI initiative EuroBioImaging. 2010-2014: Steering Committee (member). 2009-2014: WP4: Coordinator for Correlative Light Electron Microscopy.
Utrecht PhD program ‘Biomembranes’. 2004-2006: Board member. 2007-2010: Chair. 2010 – now: Board member
NL-BioImaging-AM. Dutch Roadmap initiative for Research Infrastructure for Advanced Microscopy. 2011-present: Vice-chair of the Project Management Team
Dutch Technology Centre (DTL).2011-present: Member of the Core group
Associate editor: Molecular Biology of the Cell. Editorial boards: Traffic, Histochemistry and Cell Biology, Biology of the Cell, PeerJ. Section editor: Current Opinion in Cell Biology. Member of FACULTY F1000
Fellowship and Awards
2007: 20th Foundation lecture, Center for Cell and Molecular Biology, Hyderabad, India.
2004: VICI Award (1.25M€) from the Netherlands Organisation for Scientific Research.
1998: UMC Utrecht award: Attraction and maintenance of female talent.
Research Output (135)
Honkoop Hessel, de Bakker Dennis Em, Aharonov Alla, Kruse Fabian, Shakked Avraham, Nguyen Phong D, de Heus Cecilia, Garric Laurence, Muraro Mauro J, Shoffner Adam, Tessadori Federico, Peterson Joshua Craiger, Noort Wendy, Bertozzi Alberto, Weidinger Gilbert, Posthuma George, Grun Dominic, van der Laarse Willem J, Klumperman Judith, Jaspers Richard T, Poss Kenneth D, van Oudenaarden Alexander, Tzahor Eldad, Bakkers Jeroen 23 dec 2019, In: eLife. 8
Koerver Lisa, Papadopoulos Chrisovalantis, Liu Bin, Kravic Bojana, Rota Giulia, Brecht Lukas, Veenendaal Tineke, Polajnar Mira, Bluemke Anika, Ehrmann Michael, Klumperman Judith, Jäättelä Marja, Behrends Christian, Meyer Hemmo 4 okt 2019, In: EMBO Reports. 20
van Rijn Jorik M, van Hoesel Marliek, de Heus Cecilia, van Vugt Anke H M, Klumperman Judith, Nieuwenhuis Edward, Houwen Roderick H J, Middendorp Sabine 17 jul 2019, In: Journal of Lipid Research. 60 , p. 1787-1800 14 p.
Wijers Melinde, Zanoni Paolo, Liv Nalan, Vos Dyonne Y, Jäckstein Michelle Y, Smit Marieke, Wilbrink Sanne, Wolters Justina C, van der Veen Ydwine T, Huijkman Nicolette, Dekker Daphne, Kloosterhuis Niels, van Dijk Theo H, Billadeau Daniel D, Kuipers Folkert, Klumperman Judith, von Eckardstein Arnold, Kuivenhoven Jan Albert, van de Sluis Bart 6 jun 2019, In: JCI Insight. 4
van der Beek Jan, Jonker Caspar, van der Welle Reini, Liv Nalan, Klumperman Judith 15 mei 2019, In: Journal of Cell Science. 132
Gao Xinxin, De Mazière Ann, Iaea David B, Arthur Christopher P, Klumperman Judith, Ciferri Claudio, Hannoush Rami N 6 mei 2019, In: Scientific Reports. 9
Khundadze Mukhran, Ribaudo Federico, Hussain Adeela, Rosentreter Jan, Nietzsche Sandor, Thelen Melanie, Winter Dominic, Hoffmann Birgit, Afzal Muhammad Awais, Hermann Tanja, de Heus Cecilia, Piskor Eva-Maria, Kosan Christian, Franzka Patricia, von Kleist Lisa, Stauber Tobias, Klumperman Judith, Damme Markus, Proikas-Cezanne Tassula, Hübner Christian A 28 mrt 2019, In: Neurobiology of Disease. 127 , p. 419-431 13 p.
Mohammadian Sajjad, Fokkema Jantina, Agronskaia Alexandra V, Liv Nalan, de Heus Cecilia, van Donselaar Elly, Blab Gerhard A, Klumperman Judith, Gerritsen Hans C 1 mrt 2019, In: Scientific Reports. 9
Dejanovic Borislav, Huntley Melanie A., De Mazière Ann, Meilandt William J., Wu Tiffany, Srinivasan Karpagam, Jiang Zhiyu, Gandham Vineela, Friedman Brad A., Ngu Hai, Foreman Oded, Carano Richard A.D., Chih Ben, Klumperman Judith, Bakalarski Corey, Hanson Jesse E., Sheng Morgan 19 dec 2018, In: Neuron. 100 , p. 1322-1336.e7
Fokkema Jantina, Fermie Job, Liv Nalan, van den Heuvel Dave J., Konings Tom O.M., Blab Gerhard A., Meijerink Andries, Klumperman Judith, Gerritsen Hans C. 1 dec 2018, In: Scientific Reports. 8 10 p.