Wij zijn onze website aan het vernieuwen.

Ontdekt u nog een pagina die niet klopt of hebt u een goede suggestie, laat het ons dan weten via webmedia@umcutrecht.nl.

Deze website maakt gebruik van cookies

Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Lees meer over het cookiebeleid.

prof. dr. O.W. Kranenburg Full Professor

  • Lab Translational Oncology

O.W. Kranenburg

Contact

Research Programs

Biography

Onno Kranenburg received his PhD in 1995 from Leiden University (Prof Lex van der Eb). He then studied RAS and RHO small GTPase signaling in cancer in the Netherlands Cancer Institute (Prof Wouter Moolenaar). In 2000 he became senior Post-Doc in the Dept of Medical Oncology in the UMC Utrecht (Prof Emile Voest) where he started his translational studies on the mechanism of action of anti-angiogenic drugs. In 2003 he became Assistant Professor and PI at the Dept. of Surgery (Prof Inne Borel Rinkes) and started to work on the mechanisms of colon cancer metastasis, initially focusing on the role of the K-RAS oncogene.  In 2006 he became Associate Professor, head of the Surgery Lab and staff member at the Dept. of Surgery. In 2012 he became coordinator of the PhD research school Clinical and Translational Oncology. In 2015 he was appointed Professor of Surgical and Translational Tumor Biology at the Cancer Center UMC Utrecht where he continues to design and test novel strategies for the prevention and treatment of colon cancer metastasis. 

Side Activities

Fellowship and Awards

  • 1. KWF2015-8088. Targeting mesenchymal-tyope colon cancer by aggravating oxidative damage. €573.500. 
    2. Scope: Modulation of chemotherapy efficacy and toxicity by nutrition in metastatic colorectal cancer. €586.000.
    3. ZonMw 2014: PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymal-type colon cancer: A window trial. €108.000
    4. Gieskes-Strijbis Fonds 2014: The relationship between primary colorectal tumors and their liver metastases: Biological subgroups and therapy response. €290.000
    5. Vrienden UMC Utrecht 2013. Title: Targeting colon tumors at their root: Elimination of Cancer Stem Cells. €217.000   
    6. KWF UU2011-5226 Title: LIMK1 control of CD95 function in colorectal cancer. €553.300   
    7. KWF UU2011-5135. Suppression of LIMK1 by oncogenic KRAS and RAF1: A critical survival pathway in colorectal cancer? €560.000
    8. KWF UU2009-4417. The contribution of CD95 signalling to recurrence of colorectal liver metastases following radiofrequency ablation. €592.100   

Research Output (80)

Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin:Protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial

De Boer Nadine Leonie, Brandt-Kerkhof Alexandra R.M., Madsen Eva V.E., DIepeveen Marjolein, Van Meerten Esther, Van Eerden Ruben A.G., De Man Femke M., Bouamar Rachida, Koolen Stijn L.W., De Hingh Ignace H.J.T., Bakkers Checca, Rovers Koen P., Creemers Geert Jan M., Deenen Maarten J., Kranenburg Onno W., Constantinides Alexander, Mathijssen Ron H.J., Verhoef Cornelis, Burger Jacobus W.A. 8 dec 2019, In: BMJ Open. 9 , p. e034508

Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures

van der Waals Lizet M, Laoukili Jamila, Jongen Jennifer M J, Raats Danielle A, Borel Rinkes Inne H M, Kranenburg Onno 1 dec 2019, In: Scientific Reports. 9

Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy

Ubink I., Bolhaqueiro A. C. F., Elias S. G., Raats D. A. E., Constantinides A., Peters N. A., Wassenaar E. C. E., de Hingh I. H. J. T., Rovers K. P., van Grevenstein W. M. U., Lacle M. M., Kops G. J. P. L., Rinkes I. H. M. Borel, Kranenburg O. sep 2019, In: British Journal of Surgery. 106 , p. 1404-1414 11 p.

Prognostic value of microvessel density in stage II and III colon cancer patients:a retrospective cohort study

den Uil Sjoerd H, van den Broek Evert, Coupé Veerle M H, Vellinga Thomas T, Delis-van Diemen Pien M, Bril Herman, Belt Eric J Th, Kranenburg Onno, Stockmann Hein B A C, Belien Jeroen A M, Meijer Gerrit A, Fijneman Remond J A 16 aug 2019, In: BMC Gastroenterology. 19

Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC)

Rovers Koen P., Lurvink Robin J., Wassenaar Emma C. E., Kootstra Thomas J. M., Scholten Harm J., Tajzai Rudaba, Deenen Maarten J., Nederend Joost, Lahaye Max J., Huysentruyt Clement J. R., van't Erve Iris, Fijneman Remond J. A., Constantinides Alexander, Kranenburg Onno, Los Maartje, Thijs Anna M. J., Creemers Geert-Jan M., Burger Jacobus W. A., Wiezer Marinus J., Boerma Djamila, Nienhuijs Simon W., de Hingh Ignace H. J. T. 1 jul 2019, In: BMJ Open. 9 , p. e030408

Oral mucosal organoids as a potential platform for personalized cancer therapy

Driehuis Else, Kolders Sigrid, Spelier Sacha, Lõhmussaar Kadi, Willems Stefan M., Devriese Lot A., de Bree Remco, de Ruiter Emma J., Korving Jeroen, Begthel Harry, van Es Johan H., Geurts Veerle, He Gui Wei, van Jaarsveld Richard H., Oka Rurika, Muraro Mauro J., Vivié Judith, Zandvliet Maurice M.J.M., Hendrickx Antoni P.A., Iakobachvili Nino, Sridevi Priya, Kranenburg Onno, van Boxtel Ruben, Kops Geert J.P.L., Tuveson David A., Peters Peter J., van Oudenaarden Alexander, Clevers Hans 3 mei 2019, In: Cancer Discovery. 9 , p. 852-871 20 p.

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases:protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

Rovers Koen P, Bakkers Checca, Simkens Geert A A M, Burger Jacobus W A, Nienhuijs Simon W, Creemers Geert-Jan M, Thijs Anna M J, Brandt-Kerkhof Alexandra R M, Madsen Eva V E, Ayez Ninos, de Boer Nadine L, van Meerten Esther, Tuynman Jurriaan B, Kusters Miranda, Sluiter Nina R, Verheul Henk M W, van der Vliet Hans J, Wiezer Marinus J, Boerma Djamila, Wassenaar Emma C E, Los Maartje, Hunting Cornelis B, Aalbers Arend G J, Kok Niels F M, Kuhlmann Koert F D, Boot Henk, Chalabi Myriam, Kruijff Schelto, Been Lukas B, van Ginkel Robert J, de Groot Derk Jan A, Fehrmann Rudolf S N, de Wilt Johannes H W, Bremers Andreas J A, de Reuver Philip R, Radema Sandra A, Herbschleb Karin H, van Grevenstein Wilhelmina M U, Witkamp Arjen J, Koopman Miriam, Haj Mohammad Nadia, van Duyn Eino B, Mastboom Walter J B, Mekenkamp Leonie J M, Nederend Joost, Lahaye Max J, Snaebjornsson Petur, Verhoef Cornelis, van Laarhoven Hanneke W M, Kranenburg Onno, 25 apr 2019, In: BMC Cancer. 19

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

Mullenders Jasper, de Jongh Evelien, Brousali Anneta, Roosen Mieke, Blom Jan P. A., Begthel Harry, Korving Jeroen, Jonges Trudy, Kranenburg Onno, Meijer Richard, Clevers Hans C. 5 mrt 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 4567-4574

Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions

Trumpi Kari, Frenkel Nicola, Peters Timo, Korthagen Nicoline M., Jongen Jennifer M.J., Raats Daniëlle, van Grevenstein Helma, Backes Yara, Moons Leon M., Lacle Miangela M., Koster Jan, Zwijnenburg Danny, Rinkes Inne H.M.Borel, Kranenburg Onno 13 apr 2018, In: Oncotarget. 9 , p. 19490-19507 18 p.

Histopathological and molecular classification of colorectal cancer and corresponding peritoneal metastases

Ubink I., van Eden W. J., Snaebjornsson P., Kok N. F.M., van Kuik J., van Grevenstein W. M.U., Laclé M. M., Sanders J., Fijneman R. J.A., Elias S. G., Borel Rinkes I. H.M., Aalbers A. G.J., Kranenburg O. 1 jan 2018, In: British Journal of Surgery. 105 , p. e204-e211

All Research Output (80)
To top