dr. dr.h.c.mult A.L.G. (Alexander) Leemans

Associate Professor

  • Image Sciences Institute

dr. dr.h.c.mult A.L.G. (Alexander) Leemans

Research Programs


Alexander Leemans is a physicist who received his Ph.D. in 2006 at the University of Antwerp, Belgium. From 2007 to 2009, he worked as a postdoctoral researcher at the Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Wales, United Kingdom. In 2009, he joined the Image Sciences Institute (ISI), University Medical Center Utrecht, the Netherlands, where he currently holds a tenured faculty position as Associate Professor. His current research interests include modeling, processing, visualizing and analyzing diffusion MRI data for investigating microstructural and architectural tissue organization. He heads the PROVIDI Lab and is the developer of ExploreDTI, which is a graphical toolbox for investigating diffusion MRI data.

Research line

Diffusion MRI

Most recent key publications

1: C. Lebel, L. Walker, A. Leemans, L. Phillips, C. Beaulieu, "Microstructural Maturation of the Human Brain from Childhood to Adulthood", NeuroImage, 2008, nr. 3, vol. 40, pp. 1044-1055
2: A. Leemans, D.K. Jones, "The B-matrix must be rotated when correcting for subject motion in DTI data", Magnetic Resonance in Medicine, 2009, nr. 1, vol. 62, pp. 1336-1349
3: J.D. Tournier, S. Mori, A. Leemans, "Diffusion tensor imaging and beyond", Magnetic Resonance in Medicine, 2011, nr. 6, vol. 65, pp. 1532-1556
4: B. Jeurissen, A. Leemans, J.D. Tournier, D.K. Jones, J. Sijbers, "Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion MRI", Human Brain Mapping, 2013, nr. 11, vol. 34, pp. 2747-2766
5: S.B. Vos, D.K. Jones, M.A. Viergever, A. Leemans, "Partial volume effect as a hidden covariate in DTI analyses", NeuroImage, 2011, nr. 4, vol. 55, pp. 1566-1576

Fellowship and Awards

  • VIDI (NWO)

    FC-EW (NWO)


    PhD fellowship (IWT)

    Honorary Doctorate (Chubut)

    Young Investigator Award (BHPA)

    Outstanding Teacher Award (ISMRM)

Research Output (226)

Effect of radiation therapy on cerebral cortical thickness in glioma patients:Treatment-induced thinning of the healthy cortex

Nagtegaal Steven H J, David Szabolcs, Snijders Tom J, Philippens Marielle E P, Leemans Alexander, Verhoeff Joost J C 10 jul 2020, In: Neuro-oncology advances. 2 8 p.

Automated characterization of noise distributions in diffusion MRI data

St-Jean SJGRY, de Luca A, Tax Chantal, Viergever Max A., Leemans Alexander 17 jun 2020, In: Medical Image Analysis. 65

Generalized Richardson-Lucy (GRL) for analyzing multi-shell diffusion MRI data

Guo Fenghua, Leemans Alexander, Viergever Max A, Dell'Acqua Flavio, De Luca Alberto 16 mei 2020, In: NeuroImage. 218 16 p.

Perinatal thalamic injury: MRI predictors of electrical status epilepticus in sleep and long-term neurodevelopment

van den Munckhof Bart, Zwart Anne F, Weeke Lauren C, Claessens Nathalie H P, Plate Joost D J, Leemans Alexander, Kuijf Hugo J, van Teeseling Heleen C, Leijten Frans S S, Benders Manon J N, Braun Kees P J, de Vries Linda S, Jansen Floor E 25 feb 2020, In: NeuroImage. Clinical. 26 9 p.

Indirect frontocingulate structural connectivity predicts clinical response to accelerated rTMS in major depressive disorder

Klooster Deborah C.W., Vos Iris N., Caeyenberghs Karen, Leemans Alexander, David Szabolcs, Besseling René M.H., Aldenkamp Albert P., Baeken Chris 28 jan 2020, In: Journal of Psychiatry and Neuroscience. 45 , p. 243-252 10 p.

Tractography reproducibility challenge with empirical data (TraCED):The 2017 ISMRM diffusion study group challenge

Nath Vishwesh, Schilling Kurt G., Parvathaneni Prasanna, Huo Yuankai, Blaber Justin A., Hainline Allison E., Barakovic Muhamed, Romascano David, Rafael-Patino Jonathan, Frigo Matteo, Girard Gabriel, Thiran Jean Philippe, Daducci Alessandro, Rowe Matt, Rodrigues Paulo, Prčkovska Vesna, Aydogan Dogu B., Sun Wei, Shi Yonggang, Parker William A., Ould Ismail Abdol A., Verma Ragini, Cabeen Ryan P., Toga Arthur W., Newton Allen T., Wasserthal Jakob, Neher Peter, Maier-Hein Klaus, Savini Giovanni, Palesi Fulvia, Kaden Enrico, Wu Ye, He Jianzhong, Feng Yuanjing, Paquette Michael, Rheault Francois, Sidhu Jasmeen, Lebel Catherine, Leemans Alexander, Descoteaux Maxime, Dyrby Tim B., Kang Hakmook, Landman Bennett A. 1 jan 2020, In: Journal of Magnetic Resonance Imaging. 51 , p. 234-249 16 p.

Regions of white matter abnormalities in the arcuate fasciculus in veterans with anger and aggression problems

David Szabolcs, Heesink Lieke, Geuze Elbert, Gladwin Thomas, van Honk Jack, Kleber Rolf, Leemans Alexander 27 dec 2019, In: Brain structure & function. 225 , p. 1401-1411 11 p.

On the sensitivity of the diffusion MRI signal to brain activity in response to a motor cortex paradigm

De Luca Alberto, Schlaffke Lara, Siero Jeroen C.W., Froeling Martijn, Leemans Alexander 1 dec 2019, In: Human Brain Mapping. 40 , p. 5069-5082 14 p.

Early prediction of unilateral cerebral palsy in infants at risk:MRI versus the hand assessment for infants

Wagenaar Nienke, Verhage Cornelia H, de Vries Linda S, van Gasselt Bram P L, Koopman-Esseboom Corine, Leemans Alexander, Groenendaal Floris, Benders Manon J N L, van der Aa Niek E 13 nov 2019, In: Pediatric Research. 87 , p. 932-939 8 p.

Author Correction:The challenge of mapping the human connectome based on diffusion tractography (Nature Communications, (2017), 8, 1, (1349), 10.1038/s41467-017-01285-x)

Maier-Hein Klaus H., Neher Peter F., Houde Jean Christophe, Côté Marc Alexandre, Garyfallidis Eleftherios, Zhong Jidan, Chamberland Maxime, Yeh Fang Cheng, Lin Ying Chia, Ji Qing, Reddick Wilburn E., Glass John O., Chen David Qixiang, Feng Yuanjing, Gao Chengfeng, Wu Ye, Ma Jieyan, He Renjie, Li Qiang, Westin Carl Fredrik, Deslauriers-Gauthier Samuel, González J. Omar Ocegueda, Paquette Michael, St-Jean Samuel, Girard Gabriel, Rheault François, Sidhu Jasmeen, Tax Chantal M.W., Guo Fenghua, Mesri Hamed Y., Dávid Szabolcs, Froeling Martijn, Heemskerk Anneriet M., Leemans Alexander, Boré Arnaud, Pinsard Basile, Bedetti Christophe, Desrosiers Matthieu, Brambati Simona, Doyon Julien, Sarica Alessia, Vasta Roberta, Cerasa Antonio, Quattrone Aldo, Yeatman Jason, Khan Ali R., Hodges Wes, Alexander Simon, Romascano David, Barakovic Muhamed 4 nov 2019, In: Nature Communications. 10

All Research Output (226)