prof. dr. F. (Frank) Miedema

prof. dr. F. (Frank) Miedema

Full Professor
prof. dr. F. (Frank) Miedema
  • UMC Utrecht Academy



Frank Miedema studied biochemistry at the University of Groningen, specializing in immunology. As Divisional Manager at the Central Laboratory of the Blood Transfusion Service (CLB) he was responsible for such things as education and research, before going on to become Director of Sanquin Research. Miedema was affiliated with the University of Amsterdam as professor of Immunology of AIDS. In 2004 he became head of the Immunology department at UMC Utrecht. Miedema is a member of various national and international scientific organizations and advisory committees. He has published hundreds of articles in medical journals, including Nature, Science and Lancet, and is one of the initiators of The initiators of Science in Transition believe that the scientific system is in need of fundamental reform. Science should be appreciated for the added value it contributes to society and stakeholders in society must participate in decisions regarding the production of knowledge.

Side Activities

Secretary of Dondersfonds Foundation
Board member of Talma Eijckman Foundation
Member of the supervisory board of Hubrecht Institute
Member of the supervisory board of UU Holding BV
Member of the supervisory board of AIDS Fonds
Member of the supervisory board of Utrecht Science Park

Research Output (94)

Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome

Duffy Fergal J., Weiner January, Hansen Scott, Tabb David L., Suliman Sara, Thompson Ethan, Maertzdorf Jeroen, Shankar Smitha, Tromp Gerard, Parida Shreemanta, Dover Drew, Axthelm Michael K., Sutherland Jayne S., Dockrell Hazel M., Ottenhoff Tom H.M., Scriba Thomas J., Picker Louis J., Walzl Gerhard, Kaufmann Stefan H.E., Zak Daniel E., Golinski R., Jacobson M., McEwen G., Walzl G., Black G. F., Van Der Spuy G., Stanley K., Kriel M., DuPlessis N., Nene N., Loxton A. G., Chegou N. N., Fisher M., Mahomed H., Hughes J., Downing K., Penn-Nicholson A., Mulenga H., Abel B., Bowmaker M., Kagina B., Kwong W., Hanekom C. W., Klein M. R., Haks M. C., F ranken K. L., Van Baarle D., Miedema F., Thiel B., Muller S., 22 mrt 2019, In: Frontiers in Immunology. 10 , p. 527

Toll-like receptor 7-adapter complex modulates interferon-α production in HIV-stimulated plasmacytoid dendritic cells

Patamawenu Andy A, Wright Nathaniel E, Shofner Tulley, Evans Sean, Manion Maura M, Doria-Rose Nicole, Migueles Stephen A, Mendoza Daniel, Peterson Bennett, Wilhelm Christopher, Rood Julia, Berkley Amy, Cogliano Nancy A, Liang C Jason, Tesselaar Kiki, Miedema Frank, Bess Julian, Lifson Jeffrey, Connors Mark 1 jan 2019, In: PLoS ONE. 14 14 p.

Four-gene pan-African blood signature predicts progression to tuberculosis

Suliman Sara, Thompson Ethan, Sutherland Jayne, Weiner Rd January, Ota Martin O C, Shankar Smitha, Penn-Nicholson Adam, Thiel Bonnie, Erasmus Mzwandile, Maertzdorf Jeroen, Duffy Fergal J, Hill Philip C, Hughes E Jane, Stanley Kim, Downing Katrina, Fisher Michelle L, Valvo Joe, Parida Shreemanta K, van der Spuy Gian, Tromp Gerard, Adetifa Ifedayo M O, Donkor Simon, Howe Rawleigh, Mayanja-Kizza Harriet, Boom W Henry, Dockrell Hazel, Ottenhoff Tom H M, Hatherill Mark, Aderem Alan, Hanekom Willem A, Scriba Thomas J, Kaufmann Stefan He, Zak Daniel E, Walzl Gerhard, , van Baarle D, Miedema F 1 mei 2018, In: American Journal of Respiratory and Critical Care Medicine. 197 , p. 1198-1208 11 p.

Fewer numbers, better science

Benedictus Rinze, Miedema Frank, Ferguson Mark W.J. 26 okt 2016, In: Nature. 538 , p. 453-455 3 p.

Quantification of naive and memory T-cell turnover during HIV-1 infection

Vrisekoop N, Drylewicz J, van Gent R., Mugwagwa T., van Lelyveld SFL, Veel E.M., Otto S.A., Ackermans M.T., Vermeulen J.N., Huidekoper H.H., Prins J.M., Miedema F, de Boer Rob J., Tesselaar NA, Borghans JAM okt 2015, In: AIDS. 29 , p. 2071-2080

Dialoog tussen wetenschap en maatschappij is hard nodig:Reactie van Science in transition op de Wetenschapsvisie 2025 van het Ministerie van VWS,

Mijnhardt W.W., Miedema F, Benedictus R., Dijstelbloem Huub, Huisman FG 2014, In: Science in transition . 2 p.

Wetenschap in transitie. Zeven zorgen voor de universiteit.

Dijstelbloem H.M., Huisman F.G., Miedema F., Mijnhardt W.W. 2014, p. 111-124 14 p.

Differential characteristics of cytotoxic T lymphocytes restricted by the protective HLA alleles B*27 and B*57 in HIV-1 infection

Schellens I.M.M., Spits H.B., Navis M., Westerlaken G.H.A., Nanlohy N.M., Coffeng L.E., Kootstra N., Miedema F., Schuitemaker H., Borghans J.A.M., van Baarle D. 2014, In: Journal of Acquired Immune Deficiency Syndromes. 67 , p. 236-245 10 p.

Science in transition, stand van zaken. Debat, beweging en aanbevelingen.

Dijstelbloem H., Huisman F.G., Miedema F., Mijnhardt W.W. 2014, 40 p.

Immune activation and collateral damage in aids pathogenesis

Miedema F., Hazenberg M., Tesselaar K., van Baarle D., de Boer R.J., Borghans J.A.M. sep 2013, In: Frontiers in Immunology [E]. 4 1 p.

All research output

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