dr. E.M. (Evelyn) Monninkhof

dr. E.M. (Evelyn) Monninkhof

Assistant Professor
dr. E.M. (Evelyn) Monninkhof
  • Epi Kanker Team C
  • Julius Center Research Program Cancer

Research Programs

Strategic Program Cancer



Evelyn Monninkhof studied Biomedical Health Sciences at the Catholic University Nijmegen. In 1998, she obtained her Master’s degree in Epidemiology. In 1999, she started a PhD project at Medisch Spectrum Twente hospital in Enschede and the Department of Epidemiology at the University Medical Center Nijmegen. In February 2004, she completed her thesis on ‘Medical and behavioural interventions in COPD: the COPE study’. Since October 2003, she is working at the Julius Center for Health Sciences and Primary care as a postdoc researcher in the field of cancer epidemiology, obesity and physical activity. Furthermore, she is a teacher in Epidemiology & Evidence Based Medicine and methodological consultant for the department of Radiotherapy.

Interests and Focus

Main research interest of Evelyn Monninkhof is directed towards physical activity, obesity and (breast) cancer risk. She has been coordinating/ involved in several randomised controlled trials studying the effect of exercise on breast cancer risk or outcome after breast cancer diagnosis:

  • The SHAPE-1 study examined the effects of a 1-year exercise programme on endogenous hormone levels (associated with breast cancer among 189 sedentary postmenopausal women.
  • The SHAPE-2 study examined the effect of weight loss mainly driven by exercise compared to equivalent weight loss due to a calorie restricted diet only on sex hormone levels. In addition, the role of total body fat and intra-abdominal fat was explored.
  • The UMBRELLA- Fit trial: a trial investigating the effects of physical activity in breast cancer patients applying a new study design (the cmRCT design)
  • The PAM (Physical Activity & Exercise) study. This study investigates the effects of exercise on cognitive function in breast cancer patients with complaints in this area after chemotherapy treatment.

Besides above mentioned trials, Evelyn is also involved in the DENSE trial: a very large trial studying the cost-effectiveness of biennial screening with MRI + mammography compared to mammography alone in women aged 50-75 years with extremely dense breasts. At the radiotherapy department, she is involved in the FLAME trial. This trial invetsigates standard fractionated external beam radiotherapy (EBRT) with and without an additional integrated boost to the macroscopically visible tumour in patients with localized prostate cancer on disease-free survival and side effects.

Side Activities

-         Member (methodologist) of the Medical Ethical Committee of the UMC Utrecht

-         Member of the tracer pool of the UMC Utrecht

-         Consultant at the Julius Support office

Fellowship and Awards


Research Output (132)

Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Groen Veerle H., Zuithoff Nicolaas P.A., van Schie Marcel, Monninkhof Evelyn M., Kunze-Busch Martina, de Boer Hans C.J., van der Voort van Zyp Jochem, Pos Floris J., Smeenk Robert Jan, Haustermans Karin, Isebaert Sofie, Draulans Cédric, Depuydt Tom, Verkooijen Helena M., van der Heide Uulke A., Kerkmeijer Linda G.W. 29 jun 2021, In: Radiotherapy and Oncology. 162 , p. 98-104 7 p.

Supplemental Breast MRI for Women with Extremely Dense Breasts:Results of the Second Screening Round of the DENSE Trial

Veenhuizen Stefanie G A, de Lange Stéphanie V, Bakker Marije F, Pijnappel Ruud M, Mann Ritse M, Monninkhof Evelyn M, Emaus Marleen J, de Koekkoek-Doll Petra K, Bisschops Robertus H C, Lobbes Marc B I, de Jong Mathijn D F, Duvivier Katya M, Veltman Jeroen, Karssemeijer Nico, de Koning Harry J, van Diest Paul J, Mali Willem P T M, van den Bosch Maurice A A J, van Gils Carla H, Veldhuis Wouter B, 16 mrt 2021, In: Radiology. 299 , p. 278-286 9 p.

Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer:Results From the FLAME Randomized Phase III Trial

Kerkmeijer Linda G W, Groen Veerle H, Pos Floris J, Haustermans Karin, Monninkhof Evelyn M, Smeenk Robert Jan, Kunze-Busch Martina, de Boer Johannes C J, van der Voort van Zijp Jochem, van Vulpen Marco, Draulans Cédric, van den Bergh Laura, Isebaert Sofie, van der Heide Uulke A 20 jan 2021, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 39 , p. 787-796 10 p.

Knowledge-Based Assessment of Focal Dose Escalation Treatment Plans in Prostate Cancer

van Schie Marcel A, Janssen Tomas M, Eekhout Dave, Walraven Iris, Pos Floris J, de Ruiter Peter, Kotte Alexis N T J, Monninkhof Evelyn M, Kerkmeijer Linda G W, Draulans Cédric, de Roover Robin, Haustermans Karin, Kunze-Busch Martina, Smeenk Robert Jan, van der Heide Uulke A 15 nov 2020, In: International Journal of Radiation Oncology Biology Physics. 108 , p. 1055-1062 8 p.

Health-related quality of life after ultrafocal salvage high-dose-rate brachytherapy for radiorecurrent prostate cancer:reporting the patient's perspective

van Son Marieke, Monninkhof Evelyn, Peters Max, Lagendijk Jan, van der Voort van Zyp Jochem nov 2020, In: Clinical and translational radiation oncology. 25 , p. 81-87 7 p.

Primary endpoint analysis of the multicentre phase II hypo-FLAME trial for intermediate and high risk prostate cancer

Draulans Cédric, van der Heide Uulke A, Haustermans Karin, Pos Floris J, van der Voort van Zyp Jochem, De Boer Hans, Groen Veerle H, Monninkhof Evelyn M, Smeenk Robert J, Kunze-Busch Martina, De Roover Robin, Depuydt Tom, Isebaert Sofie, Kerkmeijer Linda G W jun 2020, In: Radiotherapy & Oncology. 147 , p. 92-98 7 p.

Meerwaarde van MRI-screening bij zeer dicht borstweefsel in het bevolkingsonderzoek borstkanker

de Lange Stéphanie V., Bakker Marije F., Pijnappel Ruud M., Mann Ritse M., Peeters Petra H.M., Monninkhof Evelyn M., Emaus Marleen J., Loo Claudette E., Bisschops Robertus H.C., Lobbes Marc B.I., de Jong Mathijn D.F., Duvivier Katya M., Veltman Jeroen, Karssemeijer Nico, de Koning Harry J., van Diest Paul J., Mali Willem P.T.M., van den Bosch Maurice A.A.J., Veldhuis Wouter B., van Gils Carla H. apr 2020, In: Nederlands Tijdschrift voor Geneeskunde. 164 10 p.

Theoretical potential for endometrial cancer prevention through primary risk factor modification:Estimates from the EPIC cohort

Fortner Renée T, Hüsing Anika, Dossus Laure, Tjønneland Anne, Overvad Kim, Dahm Christina C, Arveux Patrick, Fournier Agnès, Kvaskoff Marina, Schulze Matthias B, Bergmann Manuela, Trichopoulou Antonia, Karakatsani Anna, La Vecchia Carlo, Masala Giovanna, Pala Valeria, Mattiello Amalia, Tumino Rosario, Ricceri Fulvio, van Gils Carla H, Monninkhof Evelyn M, Bonet Catalina, Quirós José Ramón, Sanchez Maria-Jose, Rodríguez-Palacios Daniel-Ángel, Gurrea Aurelio B, Amiano Pilar, Allen Naomi E, Travis Ruth C, Gunter Marc J, Viallon Vivian, Weiderpass Elisabete, Riboli Elio, Kaaks Rudolf 3 feb 2020, In: International Journal of Cancer. 147 , p. 1325-1333 9 p.

Physical activity and risks of breast and colorectal cancer:a Mendelian randomisation analysis

Papadimitriou Nikos et al. 30 jan 2020, In: Nature Communications. 11 10 p.

Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases:a multinational cohort study

Freisling Heinz, Viallon Vivian, Lennon Hannah, Bagnardi Vincenzo, Ricci Cristian, Butterworth Adam S, Sweeting Michael, Muller David, Romieu Isabelle, Bazelle Pauline, Kvaskoff Marina, Arveux Patrick, Severi Gianluca, Bamia Christina, Kühn Tilman, Kaaks Rudolf, Bergmann Manuela, Boeing Heiner, Tjønneland Anne, Olsen Anja, Overvad Kim, Dahm Christina C, Menéndez Virginia, Agudo Antonio, Sánchez Maria-Jose, Amiano Pilar, Santiuste Carmen, Gurrea Aurelio Barricarte, Tong Tammy Y N, Schmidt Julie A, Tzoulaki Ioanna, Tsilidis Konstantinos K, Ward Heather, Palli Domenico, Agnoli Claudia, Tumino Rosario, Ricceri Fulvio, Panico Salvatore, Picavet H Susan J, Bakker Marije, Monninkhof Evelyn, Nilsson Peter, Manjer Jonas, Rolandsson Olov, Thysell Elin, Weiderpass Elisabete, Jenab Mazda, Riboli Elio, Vineis Paolo, Danesh John, Wareham Nick J, Gunter Marc J, Ferrari Pietro 10 jan 2020, In: BMC Medicine. 18 11 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet