dr. M. (Monique) Nijhuis

Associate Professor

  • Department of Medical Microbiology

dr. M. (Monique) Nijhuis

Research Programs


Monique Nijhuis studied Molecular Biology and obtained her PhD in 1999 at the University of Utrecht on the investigation of the impact of antiretroviral therapy on HIV fitness. Following postdoctoral research training in respiratory viruses she initiated her own research line and became an associate Professor of Virology at the University Medical Center Utrecht in The Netherlands. She is heading the Translational Virology group which performs research at the interface between fundamental and clinical virology. Her research is centered on (I) Viral entry, transmission and pathogenesis (II) Mechanisms of antiviral resistance and viral evolution and (III) Viral-reservoirs and eradication. Monique Nijhuis was granted by the Netherlands Organization for Scientific Research (NWO) with the VIDI and ASPASIA award. She is a member of the IAS HIV Cure International Scientific Working Group and the scientific advisory board of the Dutch Aidsfonds and associate editor of Retrovirology. She has published over 100 papers in peer-reviewed journals and has guided technicians, PhD student, and Postdoctoral Fellows. 

She is teaching Virology in the Bachelor Biomedical Sciences and several Master and PhD programs. She has mentored numerous Bachelor and Graduate students. She is heading the Biological Safety Committee supervising several Biosafety Level III laboratories.

Research Output (113)

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

Eberhard Johanna M., Angin Mathieu, Passaes Caroline, Salgado Maria, Monceaux Valerie, Knops Elena, Kobbe Guido, Jensen Björn, Christopeit Maximilian, Kröger Nicolaus, Vandekerckhove Linos, Badiola Jon, Bandera Alessandra, Raj Kavita, van Lunzen Jan, Hütter Gero, Kuball Jürgen H.E., Martinez-Laperche Carolina, Balsalobre Pascual, Kwon Mi, Díez-Martín José L., Nijhuis Monique, Wensing Annemarie, Martinez-Picado Javier, Schulze Zur Wiesch Julian, Sáez-Cirión Asier 6 mei 2020, In: Science translational medicine. 12 13 p.

Virological suppression and clinical management in response to viremia in South African HIV treatment program:A multicenter cohort study

Hermans Lucas E, Carmona Sergio, Nijhuis Monique, Tempelman Hugo A, Richman Douglas D, Moorhouse Michelle, Grobbee Diederick E, Venter Willem D F, Wensing Annemarie M J 25 feb 2020, In: PLoS Medicine. 17 18 p.

A trip down memory lane with Retrovirology

Benkirane Monsef, Berkhout Ben, Borrow Persephone, Fassati Ariberto, Fujii Masahiro, Garcia-Martinez J Victor, Margolis D, Nijhuis Monique, Parent Leslie, Strebel Klaus, Venter François, Kirchhoff Frank, Lever Andrew, Ross Susan, Mak Johnson 21 aug 2019, In: Retrovirology. 16 , p. 22 3 p.

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

Gupta Ravindra K., Abdul-Jawad Sultan, McCoy Laura E., Mok Hoi Ping, Peppa Dimitra, Salgado Maria, Martinez-Picado Javier, Nijhuis Monique, Wensing Annemarie M.J., Lee Helen, Grant Paul, Nastouli Eleni, Lambert Jonathan, Pace Matthew, Salasc Fanny, Monit Christopher, Innes Andrew J., Muir Luke, Waters Laura, Frater John, Lever Andrew M.L., Edwards Simon G., Gabriel Ian H., Olavarria Eduardo 11 apr 2019, In: Nature. 568 , p. 244-248 5 p.

Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Verheyen Jens, Thielen Alexander, Lübke Nadine, Dirks Miriam, Widera Marek, Dittmer Ulf, Kordelas Lambros, Däumer Martin, De Jong Dorien C.M., Wensing Annemarie M.J., Kaiser Rolf, Nijhuis Monique, Esser Stefan 15 feb 2019, In: Clinical Infectious Diseases. 68 , p. 684-687 4 p.

All-printed cell counting chambers with on-chip sample preparation for point-of-care CD4 counting

Wasserberg Dorothee, Zhang Xichen, Breukers Christian, Connell Bridgette J., Baeten Ellen, van den Blink Dorine, Solà Benet Èlia, Bloem Andries C., Nijhuis Monique, Wensing Annemarie M.J., Terstappen Leon W.M.M., Beck Markus 15 okt 2018, In: Biosensors and Bioelectronics. 117 , p. 659-668 10 p.

Development of sensitive ddPCR assays to reliably quantify the proviral DNA reservoir in all common circulating HIV subtypes and recombinant forms

Bosman Kobus J., Wensing Annemarie M. J., Pijning Aster E., van Snippenberg Wilco J., van Ham Petra M., de Jong Dorien M. C., Hoepelman Andy I. M., Nijhuis Monique 14 sep 2018, In: Journal of the International AIDS Society [E]. 21

The antiretroviral CCR5-inhibitor maraviroc effectively reverses HIV latency by phosphorylation of Nf-kappa B

Symons J., vanLelyveld S. F. L., deSpiegelaere W., Wensing A. M. J., Zerbato J. M., vanHam P. M., Drylewicz J., Middel A., Hoepelman A. I. M., Cameron P. U., Lu H. K., Dantanarayana A. I., Borghans J. A. M., Vandekerckhove L., Lewin S. R., Tesselaar K., Nijhuis M. jul 2018, In: Journal of the International AIDS Society [E]. 21 , p. 29-30

Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

Fun Axel, Leitner Thomas, Vandekerckhove Linos, Däumer Martin, Thielen Alexander, Buchholz Bernd, Hoepelman Andy I.M., Gisolf Elizabeth H., Schipper Pauline J., Wensing Annemarie M.J., Nijhuis Monique 5 jan 2018, In: Retrovirology. 15 13 p.

A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape

Lebbink Robert Jan, de Jong Dorien C M, Wolters Femke, Kruse Elisabeth M, van Ham Petra M, Wiertz Emmanuel J H J, Nijhuis Monique 8 feb 2017, In: Scientific Reports. 7

All Research Output (113)