dr. M. (Monique) Nijhuis

dr. M. (Monique) Nijhuis

Associate Professor
dr. M. (Monique) Nijhuis
  • Department of Medical Microbiology

Research Programs

Infection & Immunity



Monique Nijhuis studied Molecular Biology and obtained her PhD in 1999 at the University of Utrecht on the investigation of the impact of antiretroviral therapy on HIV fitness. Following postdoctoral research training in respiratory viruses she initiated her own research line and became an associate Professor of Virology at the University Medical Center Utrecht in The Netherlands. She is heading the Translational Virology group which performs research at the interface between fundamental and clinical virology. Her research is centered on (I) Viral entry, transmission and pathogenesis (II) Mechanisms of antiviral resistance and viral evolution and (III) Viral-reservoirs and eradication. Monique Nijhuis was granted by the Netherlands Organization for Scientific Research (NWO) with the VIDI and ASPASIA award. She is a member of the IAS HIV Cure International Scientific Working Group and the scientific advisory board of the Dutch Aidsfonds and associate editor of Retrovirology. She has published over 100 papers in peer-reviewed journals and has guided technicians, PhD student, and Postdoctoral Fellows. 

She is teaching Virology in the Bachelor Biomedical Sciences and several Master and PhD programs. She has mentored numerous Bachelor and Graduate students. She is heading the Biological Safety Committee supervising several Biosafety Level III laboratories.

Research Output (122)

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

Gumbs Stephanie B.H., Berdenis van Berlekom Amber, Kübler Raphael, Schipper Pauline J., Gharu Lavina, Boks Marco P., Ormel Paul R., Wensing Annemarie M.J., de Witte Lot D., Nijhuis Monique 16 Apr 2022, In: Viruses. 14 , p. 1-20

In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center

Rümke Lidewij W, Groenveld Femke C, van Os Yvonne M G, Praest Patrique, Tanja Anniek A N, de Jong Dorien T C M, Symons Jori, Schuurman Rob, Reinders Tessa, Hofstra L Marije, Nierkens Stefan, Thijsen Steven F T, Heron Michiel, Lebbink Robert-Jan, Beekman Jeffrey M, Nijhuis Monique, Wensing Annemarie M J Jan 2022, In: Open forum infectious diseases. 9 , p. 1-6

A public–private partnership model for COVID-19 diagnostics

Krijger Peter H.L., Hoek Tim A., Boersma Sanne, Donders Lieke I.P.M., Broeders Maaike M.C., Pieterse Mark, Toonen Pim W., Logister Ive, Verhagen Bram M.P., Verstegen Marjon J.A.M., van Ravesteyn Thomas W., Roymans Rene J.T.M., Mattiroli Francesca, Vandesompele Jo, Nijhuis Monique, Meijer Stefan, van Weert Anton, Dekker Edwin, Dom Fred J., Ruijtenbeek Rob, van der Velden Lieven B.J., van de Bovenkamp Jeroen H.B., Bosch Martijn, de Laat Wouter, Tanenbaum Marvin E. Oct 2021, In: Nature Biotechnology. 39 , p. 1182-1184 3 p.

Point-of-Care Detection of Nonadherence to Antiretroviral Treatment for HIV-1 in Resource-Limited Settings Using Drug Level Testing for Efavirenz, Lopinavir, and Dolutegravir:A Validation and Pharmacokinetic Simulation Study

Hermans Lucas E., Nijhuis Monique, Tempelman Hugo A., Houts Tom, Schuurman Rob, Burger David M., Wensing Annemarie M.J., Heine Rob Ter 1 Aug 2021, In: Journal of acquired immune deficiency syndromes (1999). 87 , p. 1072-1078 7 p.

Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

Connell Bridgette J., Hermans Lucas E., Wensing Annemarie M.J., Schellens Ingrid, Schipper Pauline J., van Ham Petra M., de Jong Dorien T.C.M., Otto Sigrid, Mathe Tholakele, Moraba Robert, Borghans José A.M., Papathanasopoulos Maria A., Kruize Zita, Venter Francois W.D., Kootstra Neeltje A., Tempelman Hugo, Tesselaar Kiki, Nijhuis Monique 28 Sep 2020, In: Scientific Reports. 10 , p. 1-10

Drug level testing as a strategy to determine eligibility for drug resistance testing after failure of ART:a retrospective analysis of South African adult patients on second-line ART

Hermans Lucas E., Steegen Kim, ter Heine Rob, Schuurman Rob, Tempelman Hugo A., Moraba Robert, van Maarseveen Erik, Nijhuis Monique, Pillay Taryn, Legg-E’Silva Derryn, Snyman Tracy, Schapiro Jonathan M., Burger David M., Carmona Sergio, Wensing Annemarie M.J. 1 Jun 2020, In: Journal of the International AIDS Society. 23 , p. 1-10

An inkjet-printed polysaccharide matrix for on-chip sample preparation in point-of-care cell counting chambers

Zhang Xichen, Wasserberg Dorothee, Breukers Christian, Connell Bridgette J., Schipper Pauline J., van Dalum Joost, Baeten Ellen, van den Blink Dorine, Bloem Andries C., Nijhuis Monique, Wensing Annemarie M.J., Terstappen Leon W.M.M., Beck Markus 12 May 2020, In: RSC Advances. 10 , p. 18062-18072 11 p.

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

Eberhard Johanna M., Angin Mathieu, Passaes Caroline, Salgado Maria, Monceaux Valerie, Knops Elena, Kobbe Guido, Jensen Björn, Christopeit Maximilian, Kröger Nicolaus, Vandekerckhove Linos, Badiola Jon, Bandera Alessandra, Raj Kavita, van Lunzen Jan, Hütter Gero, Kuball Jürgen H.E., Martinez-Laperche Carolina, Balsalobre Pascual, Kwon Mi, Díez-Martín José L., Nijhuis Monique, Wensing Annemarie, Martinez-Picado Javier, Schulze Zur Wiesch Julian, Sáez-Cirión Asier 6 May 2020, In: Science translational medicine. 12 13 p.

Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report

Gupta Ravindra Kumar, Peppa Dimitra, Hill Alison L., Gálvez Cristina, Salgado Maria, Pace Matthew, McCoy Laura E., Griffith Sarah A., Thornhill John, Alrubayyi Aljawharah, Huyveneers Laura E.P., Nastouli Eleni, Grant Paul, Edwards Simon G., Innes Andrew J., Frater John, Nijhuis Monique, Wensing Anne Marie J., Martinez-Picado Javier, Olavarria Eduardo May 2020, In: The Lancet HIV. 7 , p. e340-e347

Virological suppression and clinical management in response to viremia in South African HIV treatment program:A multicenter cohort study

Hermans Lucas E, Carmona Sergio, Nijhuis Monique, Tempelman Hugo A, Richman Douglas D, Moorhouse Michelle, Grobbee Diederick E, Venter Willem D F, Wensing Annemarie M J 25 Feb 2020, In: PLoS Medicine. 17 18 p.

All research output

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