dr. M. (Monique) Nijhuis

dr. M. (Monique) Nijhuis

Associate Professor
dr. M. (Monique) Nijhuis
  • Department of Medical Microbiology

Research Programs

Infection & Immunity



Monique Nijhuis studied Molecular Biology and obtained her PhD in 1999 at the University of Utrecht on the investigation of the impact of antiretroviral therapy on HIV fitness. Following postdoctoral research training in respiratory viruses she initiated her own research line and became an associate Professor of Virology at the University Medical Center Utrecht in The Netherlands. She is heading the Translational Virology group which performs research at the interface between fundamental and clinical virology. Her research is centered on (I) Viral entry, transmission and pathogenesis (II) Mechanisms of antiviral resistance and viral evolution and (III) Viral-reservoirs and eradication. Monique Nijhuis was granted by the Netherlands Organization for Scientific Research (NWO) with the VIDI and ASPASIA award. She is a member of the IAS HIV Cure International Scientific Working Group and the scientific advisory board of the Dutch Aidsfonds and associate editor of Retrovirology. She has published over 100 papers in peer-reviewed journals and has guided technicians, PhD student, and Postdoctoral Fellows. 

She is teaching Virology in the Bachelor Biomedical Sciences and several Master and PhD programs. She has mentored numerous Bachelor and Graduate students. She is heading the Biological Safety Committee supervising several Biosafety Level III laboratories.

Research Output (132)

Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19

Rümke Lidewij W., Smit Wouter L., Bossink Ailko, Limonard Gijs J.M., Muilwijk Danya, Haas Lenneke E.M., Reusken Chantal, van der Wal Sanne, Thio Bing J., van Os Yvonne M.G., Gremmels Hendrik, Beekman Jeffrey M., Nijhuis Monique, Wensing Annemarie M.J., Heron Michiel, Thijsen Steven F.T. Apr 2023, In: Frontiers in Immunology. 14 9 p.

Point-of-Care Tenofovir Urine Testing for the Prediction of Treatment Failure and Drug Resistance During Initial Treatment for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Hermans Lucas E., Umunnakwe Chijioke N., Lalla-Edward Samanta T., Hebel Shane K., Tempelman Hugo A., Nijhuis Monique, Venter Willem D.F., Wensing Annemarie M.J. 8 Feb 2023, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 76 , p. e553-e560

In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

Jensen Björn Erik Ole, Knops Elena, Cords Leon, Lübke Nadine, Salgado Maria, Busman-Sahay Kathleen, Estes Jacob D., Huyveneers Laura E.P., Perdomo-Celis Federico, Wittner Melanie, Gálvez Cristina, Mummert Christiane, Passaes Caroline, Eberhard Johanna M., Münk Carsten, Hauber Ilona, Hauber Joachim, Heger Eva, De Clercq Jozefien, Vandekerckhove Linos, Bergmann Silke, Dunay Gábor A., Klein Florian, Häussinger Dieter, Fischer Johannes C., Nachtkamp Kathrin, Timm Joerg, Kaiser Rolf, Harrer Thomas, Luedde Tom, Nijhuis Monique, Sáez-Cirión Asier, Schulze zur Wiesch Julian, Wensing Annemarie M.J., Martinez-Picado Javier, Kobbe Guido 2023, In: Nature Medicine. 29 , p. 583-587 5 p.

Shock and kill within the CNS:A promising HIV eradication approach?

Nühn Marieke M., Gumbs Stephanie B.H., Buchholtz Ninée V.E.J., Jannink Lisanne M., Gharu Lavina, de Witte Lot D., Wensing Annemarie M.J., Lewin Sharon R., Nijhuis Monique, Symons Jori Nov 2022, In: Journal of Leukocyte Biology. 112 , p. 1297-1315 19 p.

Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells

Huyveneers Laura E.P., Bruns Anke, Stam Arjen, Ellerbroek Pauline, de Jong Dorien, Nagy Noémi A., Gumbs Stephanie B.H., Tesselaar Kiki, Bosman Kobus, Salgado Maria, Hütter Gero, Brosens Lodewijk A.A., Kwon Mi, Diez Martin Jose, van der Meer Jan T.M., de Kort Theun M., Sáez-Cirión Asier, Schulze zur Wiesch Julian, Boelens Jaap Jan, Martinez-Picado Javier, Kuball Jürgen H.E., Wensing Annemarie M.J., Nijhuis Monique, 17 Sep 2022, In: Viruses. 14

A randomized study of intensified antiretroviral treatment monitoring versus standard-of-care for prevention of drug resistance and antiretroviral treatment switch:week 96 results of the ITREMA trial

Hermans Lucas E., Ter Heine Rob, Schuurman Rob, Tempelman Hugo A., Burger David M., Vervoort Sigrid C.J.M., Deville Walter L.J.M., De Jong Dorien, Venter Willem D.F., Nijhuis Monique, Wensing Annemarie M.J. 11 Aug 2022, In: AIDS (London, England). 36 , p. 1959-1968 10 p.

Evaluation of a commercial SARS-CoV-2 multiplex PCR genotyping assay for variant identification in resource-scarce settings

Umunnakwe Chijioke N., Makatini Zinhle N., Maphanga Mathapelo, Mdunyelwa Anele, Mlambo Khamusi M., Manyaka Puseletso, Nijhuis Monique, Wensing Annemarie, Tempelman Hugo A. 24 Jun 2022, In: PLoS ONE. 17 , p. 1-14

HIV-1 pretreatment drug resistance negatively impacts outcomes of first-line antiretroviral treatment

Hermans Lucas E., Hofstra Laura M., Schuurman Rob, Ter Heine Rob, Burger David M., Talboom Stijn A.J., De Jong Dorien, Tempelman Hugo A., Venter Willem D.F., Nijhuis Monique, Wensing Annemarie M.J. 1 Jun 2022, In: AIDS. 36 , p. 923-931 9 p.

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

Gumbs Stephanie B.H., Berdenis van Berlekom Amber, Kübler Raphael, Schipper Pauline J., Gharu Lavina, Boks Marco P., Ormel Paul R., Wensing Annemarie M.J., de Witte Lot D., Nijhuis Monique 16 Apr 2022, In: Viruses. 14 , p. 1-20

Prolonged SARS-CoV-2 RNA shedding in a young man recovering from traumatic pneumothorax

Umunnakwe C. N., Makatini Z. N., Mdunyelwa A., Maphanga M., Nijhuis M., Wensing A., Tempelman H. A. 1 Feb 2022, In: South African Medical Journal. 112 5 p.

All research output

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