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dr. B. (Bob) Oranje Associate Professor

  • Psychiatry

B. Oranje

Contact

Research Programs

Biography

Bob Oranje is vice director of NICHE, University Medical Center Utrecht (UMC-U), Holland, as well as senior researcher and head of the psychophysiological department of the Center for Neuropsychiatric Schizophrenia Research [CNSR], Glostrup, Denmark. Since 2009 he is lector at the Faculty of Health and Medical Sciences, Dept. of Neurology, Psychiatry, and Sensory Sciences, Copenhagen University, Denmark. Furthermore, since 2012 he is UHD at the department of Psychiatry, UMC-U, Holland, where he opened a new electrophysiological and neurocognitive lab in 2017. BO has developed a psychophysiological test-battery, the Copenhagen Psychophysiological Test Battery [CPTB]. The CPTB consists of five psychophysiological paradigms specifically designed for research on psychiatric disorders and plays a central role in the projects that he has initiated. His research primarily focusses on improving/developing medical treatment for patients with schizophrenia, autism and ADHD. Secondary goals are developing animal models for schizophrenia and determining vulnerability indicators (endophenotypes) for psychosis, schizophrenia and autism in children and adolescents, in order to try and prevent these individuals from developing these disorders later in life. As such, BO has initiated several projects, including pharmacological challenge studies in healthy volunteers, treatment studies in patients with schizophrenia, studies in children and  adolescents with developmental disorders, translational studies in animals, and a project using concurrent EEG and fMRI methodology. In addition, BO collaborates in many national and international projects. Currently, his research has been sponsored by a large number of major and minor research grants, both in Denmark and in Holland. He has been promotor, co-promotor and project-leader of a large number of preclinical and clinical projects in both Holland and Denmark.

Research line

Electrophysiologically mediated improvement of treatment for psychotic as well as developmental disorders

Most recent key publications

1: B. Oranje, B. Aggernaes, H. Rasmussen, B. H. Ebdrup, and B. Y. Glenthoj. Selective attention and mismatch negativity in antipsychotic-naive, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy. Psychol.Med.:1-11, 2017.

2: C. Vlaskamp, B. Oranje, G. F. Madsen, J. R. Mollegaard Jepsen, S. Durston, C. Cantio, B. Glenthoj, and N. Bilenberg. Auditory processing in autism spectrum disorder: Mismatch negativity deficits. Autism Res., 2017.

3: G. F. Madsen, N. Bilenberg, J. R. Jepsen, B. Y. Glenthøj, C. Cantio, and B. Oranje. Normal P50 gating in children with autism, yet attenuated P50 amplitude in the Asperger subcategory. Autism Res. Epub, 2015.

4: L. Witten, J. F. Bastlund, B. Y. Glenthoj, C. Bundgaard, B. Steiniger-Brach, A. Mork, and B. Oranje. Comparing Pharmacological Modulation of Sensory Gating in Healthy Humans and Rats: The Effects of Reboxetine and Haloperidol. Neuropsychopharmacology, 2015.

5: N. Bak and B. Oranje. Psychophysiology-Informed (Multimodal) Imaging. Curr.Top.Behav.Neurosci. 21:371-385, 2014.

Fellowship and Awards

  • 1: ZonMW Goed Gebruik Geneesmiddelen (GGG, 2013 & 2015)

    2: Lundbeck foundation grants (main applicant personal salary 2009, 2010)

    3: Lundbeck Foundation Center for Neurovascular signaling

    4: Førskningsrådet for Sundhed of Sygdom (FSS) (co-applicant for postdoctoral researcher)

    5: The Capital region of Psychiatry 2012

Research Output (85)

No evidence of differences in cognitive control in children with autism spectrum disorder or obsessive-compulsive disorder:An fMRI study

Gooskens Bram, Bos Dienke J., Mensen Vincent T., Shook Devon A., Bruchhage Muriel M.K., Naaijen Jilly, Wolf Isabella, Brandeis Daniel, Williams Steven C.R., Buitelaar Jan K., Oranje Bob, Durston Sarah, 1 jan 2018, In: Developmental Cognitive Neuroscience. 36

XKR4 Gene Effects on Cerebellar Development Are Not Specific to ADHD

Shook Devon, Brouwer Rachel, de Zeeuw Patrick, Oranje Bob, Durston Sarah 12 dec 2017, In: Frontiers in Cellular Neuroscience [E]. 11

Bumetanide as a candidate treatment for behavioral problems in tuberous sclerosis complex

Vlaskamp Chantal, Poil Simon Shlomo, Jansen Floor, Linkenkaer-Hansen Klaus, Durston Sarah, Oranje Bob, Bruining Hilgo 8 sep 2017, In: Frontiers in Neurology. 8

Selective attention and mismatch negativity in antipsychotic-naïve, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy

Oranje B., Aggernaes B., Rasmussen Hans, Ebdrup Bjorn H., Glenthoj Birte Y. 1 sep 2017, In: Psychological Medicine. 47 , p. 2155-2165 11 p.

Deficient prepulse inhibition of the startle reflex in schizophrenia using a cross-modal paradigm

Haß Katharina, Bak Nikolaj, Szycik Gregor R., Glenthøj Birte Y., Oranje Bob 1 sep 2017, In: Biological Psychology. 128 , p. 112-116 5 p.

Testing a decades’ old assumption:Are individuals with lower sensory gating indeed more easily distracted?

Bak Nikolaj, Mann J.J., Fagerlund B., Glenthøj Birte Y., Jepsen Jens Richardt M., Oranje B. 1 sep 2017, In: Psychiatry Research. 255 , p. 387-393 7 p.

The EU-AIMS Longitudinal European Autism Project (LEAP):Clinical characterisation

Charman Tony et al. 23 jun 2017, In: Molecular Autism [E]. 8

Sensory processing in autism spectrum disorders and Fragile X syndrome—From the clinic to animal models

Sinclair David, Oranje B., Razak K. A., Siegel S. J., Schmid S. 1 mei 2017, In: Neuroscience & Biobehavioral Reviews. 76 , p. 235-253 19 p.

Enlarged temporal integration window in schizophrenia indicated by the double-flash illusion

Haß Katharina, Sinke Christopher, Reese Tanya, Roy Mandy, Wiswede Daniel, Dillo Wolfgang, Oranje Bob, Szycik Gregor R. 4 mrt 2017, In: Cognitive Neuropsychiatry. 22 , p. 145-158 14 p.

All Research Output (85)
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