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dr. Y.M. (Ynte) Ruigrok

dr. Y.M. (Ynte) Ruigrok

Associate Professor - medical
dr. Y.M. (Ynte) Ruigrok
  • Neurologen

Research Programs

Biography

Biography

My name is Ynte Ruigrok and I work as a stroke neurologist and an associate professor at the department of Neurology and Neurosurgery. Both in my clinical work and my research I focus on intracranial aneurysms. Intracranial aneurysms are present in 3% of the population and usually go undetected until rupture occurs leading to an often fatal aneurysmal subarachnoid hemorrhage (ASAH). The overall aim of my research is to identify the patients who are at high risk of developing aneurysms and a subsequent ASAH. It is my ambition to increase insight in underlying disease processes, improve detection of aneurysms in high risk patients and optimize treatment. My research has a strong translational view in which I combine genetics, epidemiology and imaging of intracranial aneurysms.

 For my research I have received several prestigious grants, including an ERC starting grant in 2019 for my research project PRYSM: Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage. This  project concerns translational research in which I integrate genetic and environmental risk factors with imaging markers and combine these factors in an aneurysm prediction risk model. This will lead to precision medicine in early aneurysm detection to reduce the burden of ASAH.

 To advance aneurysm genetic research I have initiated the intracranial aneurysm working group within the international stroke genetics consortium. This cohort enables me to provide insight in which genetic variants and/or genes are associated with intracranial aneurysms and thus make a major contribution to unravelling the genetic architecture of the disease. Recently a large scale genome wide association study (GWAS) on intracranial aneurysms was performed. Based on its findings now more than half of the disease heritability can be explained (Bakker et al, Nature Genetics 2020). Currently my group is performing translational research studies for understanding the biological mechanisms of genetic variants for intracranial aneurysms identified and for exploiting genetics for drug discovery. In addition, observational clinical studies are being performed which provide important insights into causality, mechanisms and consequences of genetic findings.

Research line

Genetic riks of stroke

Most recent key publications

1.  Zuurbier CC, ... , Ruigrok YM. Difference in Rupture Risk Between Familial and Sporadic Intracranial Aneurysms: An Individual Patient Data Meta-analysis. Neurology. 2021 Oct 20:10.1212/WNL.0000000000012885. doi: 10.1212/WNL.0000000000012885

2. Bakker MK, Ruigrok YM. Genetics of Intracranial Aneurysms. Stroke. 2021 Aug;52(9):3004-3012. doi: 10.1161/STROKEAHA.120.032621. Epub 2021 Aug 17.

3. Bakker MK, … , Ruigrok YM. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Nat Genet. 2020 Dec;52(12):1303-1313. doi: 10.1038/s41588-020-00725-7. Epub 2020 Nov 16.PMID: 33199917 

4. Bakker MK, Ettema RA, Klostermann M, Rinkel GJE, Veldink JH, Ruigrok YM. Role of Rare Genetic Variants Found in Families With Intracranial Aneurysms in the General Dutch and UK Population. Stroke. 2021 Aug;52(9):e540-e541. doi: 10.1161/STROKEAHA.121.035492. Epub 2021 Jun 25.PMID: 34167329

5. van 't Hof FNG, Lai D, van Setten J, Bots ML, Vaartjes I, Broderick J, Woo D, Foroud T, Rinkel GJE, de Bakker PIW, Ruigrok YM.Exome-chip association analysis of intracranial aneurysms. Neurology. 2020 Feb 4;94(5):e481-e488. doi: 10.1212/WNL.0000000000008665. Epub 2019 Nov 15.PMID: 31732565 

Fellowship and Awards

2020 Michele Sale award for Women in Stroke Genetics, an internationally competitive mid-career award of the Internation Stroke Genetics Consortium (ISGC)

2019 ERC starting grant from the European Research Council for the research project ‘Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid haemorrhage (PRYSM)

2014 ZonMW Clinical Fellowship for the research project ‘Towards therapeutic strategies for intracranial aneurysms through deep re-sequencing of genetic risk loci and comprehensive functional characterisation’ 

2010 Rudolf Magnus Young Talent Fellowship from the Rudolf Magnus Institute of the University Medical Center Utrecht

2009 ‘Vernieuwingsimpuls Veni’ grant from the Netherlands Organization for Scientific Research (NWO) for the research project entitled ‘Genetic variation and the risk of developing intracranial aneurysms’

2008 ‘Amsterdamse Neurologenvereeniging’ prize for thesis (cum laude)

2007 Girard de Mielet van Coehoorn prize for thesis (cum laude) (University Medical Center Utrecht)

2005 personal grant from the Dr. E. Dekker program of the Duth Heart Foundation  for the research project 'The role of the extracellular matrix in intracranial aneurysms’ 

2000 personal grant from the program ‘AGIKO-stipendia’ of NWO for the PhD project on the genetic background of intracranial aneurysms and aneurysmal subarachnoid hemorrhage

Research Output (117)

Does the Internal Carotid Artery Attenuate Blood-Flow Pulsatility in Small Vessel Disease?:A 7 T 4D-Flow MRI Study

van Tuijl Rick J, Ruigrok Ynte M, Geurts Lennart J, van der Schaaf Irene C, Biessels Geert Jan, Rinkel Gabriël J E, Velthuis Birgitta K, Zwanenburg Jaco J M 2022, In: Journal of Magnetic Resonance Imaging.

Pulsatility attenuation along the carotid siphon in pseudoxanthoma elasticum

Bartstra J. W., van Tuijl R. J., de Jong P. A., Mali W. P.T.M., van der Schaaf I. C., Ruigrok Y. M., Rinkel G. J.E., Velthuis B. K., Spiering W., Zwanenburg J. J.M. 1 nov 2021, In: American Journal of Neuroradiology. 42 , p. 2030-2033 4 p.

Reliability and Agreement of 2D and 3D Measurements on MRAs for Growth Assessment of Unruptured Intracranial Aneurysms

Timmins Kimberley, Kuijf Hugo, Vergouwen Mervyn, Otten Maarten, Ruigrok Ynte, Velthuis BK, van der Schaaf Irene 1 sep 2021, In: American Journal of Neuroradiology. 42 , p. 1598-1603 6 p.

Comparing methods of detecting and segmenting unruptured intracranial aneurysms on TOF-MRAS: The ADAM challenge

Timmins Kimberley, van der Schaaf Irene, Bennink E, Ruigrok Ynte, Velthuis BK, Kuijf Hugo sep 2021, In: NeuroImage. 238 21 p.

Predicting 10-year risk of recurrent cardiovascular events andcardiovascular interventions in patients with established cardiovascular disease:results from UCC-SMART and REACH

Klooster C. C.van t., Bhatt D. L., Steg P. G., Massaro J. M., Dorresteijn J. A.N., Westerink J., Ruigrok Y. M., de Borst G. J., Asselbergs F. W., van der Graaf Y., Visseren F. L.J., 15 feb 2021, In: International Journal of Cardiology. 325 , p. 140-148 9 p.

Variational Autoencoders with a Structural Similarity Loss in Time of Flight MRAs

Timmins Kimberley, van der Schaaf Irene, Velthuis BK, Ruigrok Ynte, Kuijf Hugo 15 feb 2021, 11596

Automatic Cerebral Vessel Extraction in TOF-MRA Using Deep Learning

de Vos Vera, Timmins Kimberley, van der Schaaf Irene, Ruigrok Ynte, Velthuis BK, Kuijf Hugo 2021,

Genetic basis of lacunar stroke:a pooled analysis of individual patient data and genome-wide association studies

Traylor Matthew, Persyn Elodie, Tomppo Liisa, Klasson Sofia, Abedi Vida, Bakker Mark K., Torres Nuria, Li Linxin, Bell Steven, Rutten-Jacobs Loes, Tozer Daniel J., Griessenauer Christoph J., Zhang Yanfei, Pedersen Annie, Sharma Pankaj, Jimenez-Conde Jordi, Rundek Tatjana, Grewal Raji P., Lindgren Arne, Meschia James F., Salomaa Veikko, Havulinna Aki, Kourkoulis Christina, Crawford Katherine, Marini Sandro, Mitchell Braxton D., Kittner Steven J., Rosand Jonathan, Dichgans Martin, Jern Christina, Strbian Daniel, Fernandez-Cadenas Israel, Zand Ramin, Ruigrok Ynte, Rost Natalia, Lemmens Robin, Rothwell Peter M., Anderson Christopher D., Wardlaw Joanna, Lewis Cathryn M., Markus Hugh S., , , , 2021, In: The Lancet Neurology. 20 , p. 351-361 11 p.

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Bakker Mark K., van der Spek Rick A.A., van Rheenen Wouter, Morel Sandrine, Bourcier Romain, Hostettler Isabel C., Alg Varinder S., van Eijk Kristel R., Koido Masaru, Akiyama Masato, Terao Chikashi, Matsuda Koichi, Walters Robin, Lin Kuang, Li Liming, Millwood Iona Y., Chen Zhengming, Rouleau Guy A., Zhou Sirui, Rannikmäe Kristiina, Sudlow Cathie L.M., Houlden Henry, van den Berg Leonard H., Dina Christian, Naggara Olivier, Gentric Jean Christophe, Shotar Eimad, Eugène François, Desal Hubert, Winsvold Bendik S., Børte Sigrid, Johnsen Marianne Bakke, Brumpton Ben M., Sandvei Marie Søfteland, Willer Cristen J., Hveem Kristian, Zwart John Anker, Verschuren W. M.Monique, Friedrich Christoph M., Hirsch Sven, Schilling Sabine, Dauvillier Jérôme, Martin Olivier, Bian Zheng, Chen Junshi, Klijn Catharina J.M., Rinkel Gabriel J.E., Lindgren Antti, Veldink Jan H., Ruigrok Ynte M., , , , , , , dec 2020, In: Nature Genetics. 52 , p. 1303-1313 11 p.

Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Patients With a History of Migraine

van Os Hendrikus J A, Ruigrok Ynte M, Verbaan Dagmar, Dennesen Paul, Müller Marcella C A, Coert Bert A, Algra Ale, Vergouwen Mervyn D I, Wermer Marieke J H 1 sep 2020, In: Stroke. 51 , p. 3039-3044 6 p.

All research output

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