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dr. Y.M. (Ynte) Ruigrok Assistant Professor - medical

  • Neurology & Neurosurgery

Y.M. Ruigrok

Contact

Research Programs

Biography

Ynte Ruigrok obtained her medical degree in Utrecht in 1999. After that she started working as a resident in Neurology at the Department of Neurology and Neurosurgery of the University Medical Center Utrecht. She combined her residency with a PhD project on the genetics of intracranial aneurysm and aneurysmal subarachnoid hemorrhage. She has contributed to the identification of genetic risk factors of intracranial aneurysms using different approaches such as candidate gene studies, linkage studies, genome wide association studies (GWAS) and genome wide expression (GWE) studies. She has participated in three GWAS on intracranial aneurysms published in Nature Genetics. In 2006 she obtained her PhD degree cum laude. In 2010 she registered as a neurologist and continued working as a neurologist at the Department of Neurology and Neurosurgery of the University Medical Center Utrecht. 

Her current research focuses on the identification of 1) genetic determinants and biomarkers in the development and rupture of intracranial aneurysms and 2) first-degree relatives of aneurysm patients who are at high risk of developing aneurysms.  Her research interest is on the identification of 1) genetic determinants and biomarkers in the development and rupture of intracranial aneurysms and 2) first-degree relatives of aneurysm patients who are at high risk of developing aneurysms. Her ambition is to increase insight in underlying disease processes, improve detection of aneurysms in high risk patients and optimize treatment. She aspires to translate findings in her research to clinical applications. Her expertise receives international recognition which has allowed her to establish international collaborations. Among others, she has initiated a consortium on the genetics of IAs of the international stroke genetics consortium (ISGC).

Research line

Genetic riks of stroke

Most recent key publications

1: van 't Hof FN, Vaucher J, Holmes MV, de Wilde A, Baas AF, Blankensteijn JD, Hofman A, Kiemeney LA, Rivadeneira F, Uitterlinden AG, Vermeulen SH, Rinkel GJ, de Bakker PI, Ruigrok YM. Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms. Eur J Hum Genet. 2017 Jun;25(6):758-762. 

2: van 't Hof FN, Ruigrok YM, et al. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc. 2016 Jul 14;5(7). pii: e002603.

3: Kleinloog R, Verweij BH, van der Vlies P, Deelen P, Swertz MA, de Muynck L, Van Damme P, Giuliani F, Regli L, van der Zwan A, Berkelbach van der Sprenkel JW, Han KS, Gosselaar P, van Rijen PC, Korkmaz E, Post JA, Rinkel GJ, Veldink JH, Ruigrok YM. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture. Stroke. 2016 May;47(5):1286-93.

4: Rasing I, Ruigrok YM, Greebe P, Velthuis BK, Witkamp TD, Wermer MJ, Roos YB, Vandertop WP, Rinkel GJ. Long-term risk of aneurysmal subarachnoid hemorrhage after a negative aneurysm screen. Neurology. 2015 Mar 3;84(9):912-7.

5: Sijtsma LC, Rinkel GJ, Ruigrok YM. Sex-related clustering of intracranial aneurysms within families. Stroke. 2015 Apr;46(4):1107-9.

Fellowship and Awards

  • 1: 2014 Clinical fellowship, Netherlands Organization for Scientific Research (NWO)
    2: 2010 Rudolf Magnus Young Talent Fellowship from the Rudolf Magnus Institute of the University Medical Center Utrecht
    3: 2009 ‘Vernieuwingsimpuls Veni’ grant from the Netherlands Organization for Scientific Research (NWO) for the research project entitled ‘Genetic variation and the risk of developing intracranial aneurysms’ (project no. 91610016)
    4: 2008 ‘Amsterdamse Neurologenvereeniging’ prize for thesis (cum laude)
    5: 2007 Girard de Mielet van Coehoorn prize for thesis (cum laude) (University Medical Center Utrecht)
    5: 2005 grant from the Netherlands Brain Foundation for the research project entitled 'the role of the extracellular matrix in intracranial aneurysms' (project no. 13F05.13)

Research Output (91)

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis:The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 dec 2019, In: American Journal of Neuroradiology. 40 , p. 2016-2022 7 p.

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies

Laarman Melanie D., Kleinloog Rachel, Bakker Mark K., Rinkel Gabriël J.E., Bakkers Jeroen, Ruigrok Ynte M. 1 okt 2019, In: Stroke. 50 , p. 2933-2936 4 p.

The Dutch Parelsnoer Institute Cerebrovascular Disease Initiative:A retrospective study of the effects of integrating clinical care and research on costs and quality of care in patients with ischaemic stroke

Mensing Liselore A., Kappelle Jaap, Buijs Julie E., Luijckx Gert Jan, Koffijberg Hendrik, Zielhuis Gerhard A., Ruigrok Ynte M. 27 aug 2019, In: BMJ Open. 9

Histological differences of the Vascular wall between sites with high and low prevalence of intracranial aneurysm

Laarman Melanie D., Ruigrok Ynte M., Nierstrasz Renske C.S., Spliet Wim G.M., Van Hecke Wim, Algra Ale, Rinkel Gabriël J.E. 1 jul 2019, In: Journal of Neuropathology and Experimental Neurology. 78 , p. 648-654 7 p.

Correlation of age at time of aneurysmal subarachnoid hemorrhage within families

Dalemans Diana J.Z., Mensing Liselore A., Bourcier Romain, Aggour Mohamed, Ben Hassen Wagih, Lindgren Antti E., Koivisto Timo, Jääskeläinen Juha E., Rinkel Gabriel J.E., Ruigrok Ynte M. jul 2019, In: International Journal of Stroke. 14 , p. NP15-NP16

Comparison of Rupture Risk of Intracranial Aneurysms Between Familial and Sporadic Patients

Mensing Liselore A, Greving Jacoba P, Verhoeff Tessa A, Rinkel Gabriel J E, Ruigrok Ynte M jun 2019, In: Stroke. 50 , p. 1380-1383 4 p.

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

Laarman Melanie D., Geeven Geert, Barnett Phil, Rinkel Gabriël J.E., de Laat Wouter, Ruigrok Ynte M., Bakkers Jeroen, 7 mei 2019, In: Journal of the American Heart Association. 8

Association of hippocampal calcification and cardiovascular risk factors in two patient cohorts

van der Knaap Marije J.A., Peters Melissa E.M., Lucci Carlo, Geerlings Mirjam I., de Jong Pim A., Ruigrok Ynte M., van der Graaf Y., Grobbee D. E., Rutten G. E.H.M., Visseren F. L.J., de Borst G. J., Kappelle L. J., Leiner T., Doevendans P. A., 1 mei 2019, In: Atherosclerosis: X. 1

Concordance in Aneurysm Size at Time of Rupture in Familial Intracranial Aneurysms

Bourcier Romain, Lindgren Antti, Desal Hubert, L'Allinec Vincent, Januel Anne Christine, Koivisto Timo, Jääskeläinen Juha E., Slot Emma M.H., Mensing Liselore, Zuithoff Nicolaas P.A., Milot Geneviève, Algra Ale, Rinkel Gabriël J.E., Ruigrok Ynte 3 jan 2019, In: Stroke. 50 , p. 504-506 3 p.

Patient and aneurysm characteristics in familial intracranial aneurysms:A systematic review and meta-analysis

Slot Emma M H, Rinkel Gabriel J E, Algra Ale, Ruigrok Ynte M 2019, In: PLoS ONE. 14

All Research Output (91)
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