prof. dr. R.M. (Raymond) Schiffelers Full Professor

Department of Clinical Chemistry and Haematology

Contact

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015. In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles, and Founder of EXCYTEX-an extracellular vesicle-based company.

Side Activities

Without remuneration

Vice-president European Technology Platform Nanomedicine

Associate Editor Journal of Extracellular Vesicles

Associate Editor Pharmaceutical Research

Founder/Share holder (<5%)/Scientific Advisor Excytex bv

Member Scientific Advisory Board 20MED Therapeutics

Member Scientific Advisory Board EtheRNA

Member Scientific Advisory Board Anjurium

Member Scientific Advisory Board SentryX bv

Chairman NWO-STW Vidi-selection committee 2014-2015

Remuneration for department

Editor International Journal Pharmaceutics

Editor Journal Controlled Release

Research Output

Interfering with endolysosomal trafficking enhances release of bioactive exosomes

Ortega Francisco G., Roefs Marieke T., de Miguel Perez Diego, Kooijmans Sander A., de Jong Olivier G., Sluijter Joost P., Schiffelers Raymond M., Vader Pieter 1 Aug 2019 In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20

Red Blood Cells: Chasing Interactions

Pretini Virginia, Koenen Mischa H, Kaestner Lars, Fens Marcel H A M, Schiffelers Raymond M, Bartels Marije, Van Wijk Richard 31 Jul 2019 In: Frontiers in Physiology. 10

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Murphy Daniel E, de Jong Olivier G, Brouwer Maarten, Wood Matthew J, Lavieu Grégory, Schiffelers Raymond M, Vader Pieter 15 Mar 2019 In: Experimental & molecular medicine. 51

Routine Blood Tests Do Not Predict Survival in Patients with Glioblastoma—Multivariable Analysis of 497 Patients

Maas Sybren L.N., Draaisma Kaspar, Snijders Tom J., Senders Joeky T., Berendsen Sharon, Seute Tatjana, Schiffelers Raymond M., van Solinge Wouter W., Ten Berg Maarten J., Robe Pierre A., Broekman Marike L.D. 14 Mar 2019 In: World Neurosurgery. 126, p. e1081-e1091

Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma

Deshantri Anil K., Fens Marcel H., Ruiter Ruud W. J., Metselaar Josbert M., Storm Gert, van Bloois Louis, Varela-Moreira Aida, Mandhane Sanjay N., Mutis Tuna, Martens Anton C. M., Groen Richard W. J., Schiffelers Raymond M. 28 Feb 2019 In: Journal of Controlled Release. 296, p. 232-240

The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

Vorselen Daan, van Dommelen Susan M., Sorkin Raya, Piontek Melissa C., Schiller Jürgen, Döpp Sander T., Kooijmans Sander A.A., van Oirschot Brigitte A., Versluijs Birgitta A., Bierings Marc B., van Wijk Richard, Schiffelers Raymond M., Wuite Gijs J.L., Roos Wouter H. 23 Nov 2018 In: Nature Communications. 9

Thermosensitive liposomes for triggered release of cytotoxic proteins

de Matos Maria B.C., Beztsinna Nataliia, Heyder Christoph, Fens Marcel H.A.M., Mastrobattista Enrico, Schiffelers Raymond M., Leneweit Gero, Kok Robbert J. 1 Nov 2018 In: European Journal of Pharmaceutics and Biopharmaceutics. 132, p. 211-221 11 p.

Nanomedicines for the treatment of hematological malignancies

Deshantri Anil K., Varela Moreira Aida, Ecker Veronika, Mandhane Sanjay N., Schiffelers Raymond M., Buchner Maike, Fens Marcel H.A.M. 10 Oct 2018 In: Journal of Controlled Release. 287, p. 194-215 22 p.

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

Van der Jeught Kevin, De Koker Stefaan, Bialkowski Lukasz, Heirman Carlo, Joe Patrick Tjok, Perche Federico, Maenhout Sarah, Bevers Sanne, Broos Katrijn, Deswarte Kim, Malard Virginie, Hammad Hamida, Baril Patrick, Benvegnu Thierry, Jaffres Paul-Alain, Kooijmans Sander A. A., Schiffelers Raymond, Lienenklaus Stefan, Midoux Patrick, Pichon Chantal, Breckpot Karine, Thielemans Kris Oct 2018 In: ACS Nano. 12, p. 9815-9829

Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways

Sorkin Raya, Huisjes Rick, Bošković Filip, Vorselen Daan, Pignatelli Silvia, Ofir-Birin Yifat, Freitas Leal Joames K., Schiller Jürgen, Mullick Debakshi, Roos Wouter H., Bosman Giel, Regev-Rudzki Neta, Schiffelers Raymond M., Wuite Gijs J.L. 27 Sep 2018 In: Small. 14

All Research Output (129)

Fellowship and Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’