prof. dr. R.M. (Raymond) Schiffelers Full Professor

Department of Clinical Chemistry and Haematology

Contact

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015. In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles, and Founder of EXCYTEX-an extracellular vesicle-based company.

Side Activities

Without remuneration

Vice-president European Technology Platform Nanomedicine

Associate Editor Journal of Extracellular Vesicles

Associate Editor Pharmaceutical Research

Founder/Share holder (<5%)/Scientific Advisor Excytex bv

Member Scientific Advisory Board 20MED Therapeutics

Member Scientific Advisory Board EtheRNA

Member Scientific Advisory Board Anjurium

Member Scientific Advisory Board SentryX bv

Chairman NWO-STW Vidi-selection committee 2014-2015

Remuneration for department

Editor International Journal Pharmaceutics

Editor Journal Controlled Release

Research Output

Routine Blood Tests Do Not Predict Survival in Patients with Glioblastoma—Multivariable Analysis of 497 Patients

Maas Sybren L.N., Draaisma Kaspar, Snijders Tom J., Senders Joeky T., Berendsen Sharon, Seute Tatjana, Schiffelers Raymond M., van Solinge Wouter W., Ten Berg Maarten J., Robe Pierre A., Broekman Marike L.D. 1 Jun 2019 In: World Neurosurgery. 126, p. e1081-e1091

Squeezing for life - Properties of red blood cell deformability

Huisjes Rick, Bogdanova Anna, van Solinge Wouter W., Schiffelers Raymond M., Kaestner Lars, van Wijk Richard 1 Jun 2018 In: Frontiers in Physiology. 9 22 p.

Extracellular vesicles for drug delivery

Vader Pieter, Mol Emma A, Pasterkamp Gerard, Schiffelers Raymond M Nov 2016 In: Advanced Drug Delivery Reviews. 106, p. 148-156

Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment

Kooijmans Sander A A, Schiffelers Raymond M., Zarovni Natasa, Vago Riccardo 1 Sep 2016 In: Pharmacological Research. 111, p. 487-500 14 p.

Comparison of pharmaceutical nanoformulations for curcumin: Enhancement of aqueous solubility and carrier retention

Allijn Iris E., Schiffelers Raymond M., Storm Gert 15 Jun 2016 In: International Journal of Pharmaceutics. 506, p. 407-413 7 p.

Cetuximab treatment alters the content of extracellular vesicles released from tumor cells

van Dommelen Susan M, van der Meel Roy, van Solinge Wouter W, Coimbra Maria, Vader Pieter, Schiffelers Raymond M Apr 2016 In: Nanomedicine (Lond). 11, p. 881-90 10 p.

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

Kooijmans S. A A, Fliervoet L. A L, Van Der Meel R., Fens M. H A M, Heijnen H. F G, Van Bergen En Henegouwen P. M P, Vader P., Schiffelers R. M. 28 Feb 2016 In: Journal of Controlled Release. 224, p. 77-85 9 p.

Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Kooijmans Sander A A, Aleza Clara Gómez, Roffler Steve R, van Solinge Wouter W, Vader Pieter, Schiffelers Raymond M 2016 In: Journal of Extracellular Vesicles. 5

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Sork Helena, Nordin Joel Z, Turunen Janne J, Wiklander Oscar Pb, Bestas Burcu, Zaghloul Eman M, Margus Helerin, Padari Kärt, Duru Adil D, Corso Giulia, Bost Jeremy, Vader Pieter, Pooga Margus, Smith Ci Edvard, Wood Matthew Ja, Schiffelers Raymond M, Hällbrink Mattias, Andaloussi Samir El 2016 In: Molecular therapy. Nucleic acids. 5 11 p.

An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAs

Borgheti-Cardoso Lívia Neves, Depieri Lívia Vieira, Kooijmans Sander, Diniz Henrique, Calzzani Ricardo Alexandre Junqueira, De Carvalho Vicentini Fabiana Testa Moura, van der Meel Roy, De Abreu Fantini Márcia Carvalho, Iyomasa Mamie Mizusaki, Schiffelers Raymond, Bentley Maria Vitória Lopes Badra 10 Jul 2015 In: European Journal of Pharmaceutical Sciences. 74, p. 103-117 15 p.

All Research Output (65)

Fellowship and Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’