prof. dr. A.J.C. (Arjen) Slooter

Full Professor

  • Intensive Care Medicine

prof. dr. A.J.C. (Arjen) Slooter

Research Programs


Arjen Slooter studied Medicine at the Vrije Universiteit, Amsterdam (1986-1994) and worked subsequently as a resident in Neurology in Sint Lucas Hospital, Amsterdam (1994). He was research fellow in Neuro-Epidemiology at the G.H. Sergievsky Center, Columbia University, New York (1996) and received a PhD in Epidemiology from Erasmus University, Rotterdam (1998), on a thesis on dementia. During his residency in Neurology in the UMC Utrecht (1999-2004), he became enthusiastic for Neurocritical Care. After a fellowship in Intensive Care Medicine (AMC Amsterdam, 2004-2006), he rejoined the UMC Utrecht where he is currently working as consultant neurologist-intensivist at the Department of Intensive Care Medicine. In 2016, he was appointed as Professor in Intensive Care Neuropsychiatry at Utrecht University.

The research focus of Arjen Slooter is on delirium and on neuropsychiatric outcome after anesthesia/surgery or critical illness. He currently works on an EEG-based device to detect delirium, functional connectivity in delirium, drug side-effects and delirium, postoperative delirium, and long-term outcome after ICU admission. He is President of the European Delirium Association and was chairman of the delirium section of the Society of Critical Care Medicine (SCCM) 2018 guideline on pain, agitation, delirium, early mobilization and sleep.

The clinical focus of Arjen Slooter is on Intensive Care of neurological- and neurosurgical patients, and on neurological complications of critical illness. He is responsible for training of ICU nurses, residents and fellows in Neuro-Intensive Care in the UMC Utrecht. Arjen lives with wife Barbara, daughter Pien (2001) and son Bas (2004) in beautiful Utrecht.

Research line

Delirium and (neuropsychiatric) outcome of critical illness

Most recent key publications

1. Van den Boogaard M, Slooter AJC, Brüggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P; REDUCE Study Investigators. Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA 2018;319:680-90 (IF=47.7).

2. Klein Klouwenberg PMC, Zaal IJ, Spitoni C, Ong DSY, van der Kooi AW, Bonten MJM, Slooter AJC, Cremer OL. The attributable mortality of delirium in critically ill patients. BMJ 2014;349:g6652 (IF=23.6).

3. Slooter AJC. Critical illness, delirium and cognitive impairment. Nature Rev Neurol 2013;9:666-7 (IF=20.3). 

4. Van den Boogaard M, Pickkers P, Slooter AJ, Kuiper MA, Spronk PE, van der Voort PH, van der Hoeven JG, Donders R, van Achterberg T, Schoonhoven L. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ 2012;344:e420 (IF=23.6).

5. Van Eijk MMJ, Roes KCB, Honing MLH, Kuiper MA, Karakus A, van der Jagt M, Spronk PE, van Gool WA, van der Mast RC, Kesecioglu J, Slooter AJC. Rivastigmine does not decrease duration of delirium and may increase mortality in critically ill patients: a multicentre, double-blind, randomized, placebo-controlled add-on trial. Lancet 2010;376:1829-37 (IF=53.3).

Fellowship and Awards

  • ‘Public private partnership to revolutionize delirium care in hospitals’. European Union (H2020-EIC-FTI-2018-2020-820555, co-applicant and principal clinical investigator, principal investigator).

    ‘Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: a prospective randomised multicentre double-blind placebo-controlled clinical trial’. ZonMW GGG (80-84800-98-41 023, co-applicant).

    ‘Delirium Monitor: reducing the burden of delirium’. Technology Foundation STW, Take-off phase 2 (14066; co-applicant).

    ‘Objective delirium detection with an innovative EEG-based spot monitor’. European Union (H2020-PHC-12-2014-672974; co-applicant).

    ‘Delirium Monitor: reducing the burden of delirium’. Technology Foundation STW (2015-14066, principal investigator).

    ‘Objective delirium monitoring for routine critical care’. European Society of Intensive Care Medicine, Clinical Research Award (2014, principal investigator).

    Annual Scientific Award, Society of Critical Care Medicine (2014, principal investigator).

    EU-FP7 grant: ‘Biomarker development for postoperative cognitive impairment in the elderly’ (FP7-HEALTH-2013-Innovation-1, co-applicant).

    Netherlands Heart Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’ (2009, principal investigator).

    Netherlands Brain Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’ (2008, principal investigator).

    ZonMW doelmatigheid: ‘Rivastigmine for delirium in Intensive Care patients, a multicentre, double-blind, randomised placebo-controlled add-on trial’ (ZonMW 170881003, principal investigator).

Research Output (213)

Psychotropic medication use in former ICU patients with mental health problems:A prospective observational follow-up study

Janssen Debbie G A, Jonker Joep, van Dijk Diederik, Heerdink Eibert R, Egberts Toine C G, Slooter Arjen J C okt 2020, In: Journal of Critical Care. 59 , p. 112-117 6 p.

Updated nomenclature of delirium and acute encephalopathy:statement of ten Societies

Slooter Arjen J C, Otte Wim M, Devlin John W, Arora Rakesh C, Bleck Thomas P, Claassen Jan, Duprey Matthew S, Ely E Wesley, Kaplan Peter W, Latronico Nicola, Morandi Alessandro, Neufeld Karin J, Sharshar Tarek, MacLullich Alasdair M J, Stevens Robert D mei 2020, In: Intensive Care Medicine. 46 , p. 1020-1022 3 p.

Hallucinations after Cardiac Surgery:A Prospective Observational Study

Ottens Thomas H, Sommer Iris E C, Begemann Marieke J, Schutte Maya, Cramer Maarten Jan, Suyker Willem J, Van Dijk Diederik, Slooter Arjen J C 2 mrt 2020, In: Medicina (Kaunas, Lithuania). 56 9 p.

Occurrence and Risk Factors of Chronic Pain After Critical Illness

Koster-Brouwer Maria E., Rijsdijk Mienke, Van Os Wouter K.M., Soliman Ivo W., Slooter Arjen J.C., De Lange Dylan W., Van Dijk Diederik, Bonten Marc J.M., Cremer Olaf L. 10 feb 2020, In: Critical Care Medicine. 48 , p. 680-687 8 p.

fMRI network correlates of predisposing risk factors for delirium:A cross-sectional study

van Montfort S J T, Slooter A J C, Kant I M J, van der Leur R R, Spies C, de Bresser J, Witkamp T D, Hendrikse J, van Dellen E 2020, In: NeuroImage. Clinical. 27 9 p.

Neuropsychiatric outcome in subgroups of Intensive Care Unit survivors:Implications for after-care

Dijkstra-Kersten Sandra M A, Kok Lotte, Kerckhoffs Monika C, Cremer Olaf L, de Lange Dylan W, van Dijk Diederik, Needham Dale M, Slooter Arjen J C 12 nov 2019, In: Journal of Critical Care. 55 , p. 171-176 6 p.

The association between frailty and MRI features of cerebral small vessel disease

Kant Ilse M J, Mutsaerts Henri J M M, van Montfort Simone J T, Jaarsma-Coes Myriam G, Witkamp Theodoor D, Winterer Georg, Spies Claudia D, Hendrikse Jeroen, Slooter Arjen J C, de Bresser Jeroen, 5 aug 2019, In: Scientific Reports. 9

External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment

Wassenaar Annelies, Schoonhoven Lisette, Devlin John W, van Haren Frank M P, Slooter Arjen J C, Jorens Philippe G, van der Jagt Mathieu, Simons Koen S, Egerod Ingrid, Burry Lisa D, Beishuizen Albertus, Matos Joaquim, Donders A Rogier T, Pickkers Peter, van den Boogaard Mark 15 jul 2019, In: Critical Care Medicine. 47 , p. e827-e835

Pharmacological Management of Delirium

Neerland Bjørn Erik, Neufeld Karin J, Slooter Arjen J C 3 jul 2019, In: JAMA Psychiatry. 76 , p. 983-983 1 p.

Defining perioperative neurocognitive disorders:still more to clarify

Çizmeci Elif A, Slooter Arjen J C 24 jun 2019, In: British Journal of Anaesthesia. 123 , p. e468-e468 1 p.

All Research Output (213)