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prof. dr. J.P.G. (Joost P.G.) Sluijter

prof. dr. J.P.G. (Joost P.G.) Sluijter

Full Professor
prof. dr. J.P.G. (Joost P.G.) Sluijter
  • Onderzoek Cardiovasculair Reg. Med.

Biography

Biography

Prof Joost Sluijter is a Medical Biologist and got his PhD in 2004 at the University Utrecht on “Collagen turnover in arterial disease”. After being a postdoctoral research fellow at Indiana University-Purdue University (IUPUI), he returned to the University Medical Centre Utrecht (the Netherlands) in 2006.  In his research group, they focus on stimulating cardiac regeneration, thereby using approaches that can lead to improved recovery of cardiac tissue upon injury. In recent years, they identified miRNAs that can push cell lineage specifications and how they could improve progenitor cell transplantation, specifically improving local delivery and cell retention. In this work, they have started to use 3D-bioprinting and advanced technologies of cardiac tissue engineering. His group substantially improved cell delivery to the myocardium, from which they also realized that most of the injected cell action was due to the potential paracrine actions. They therefore started to study the use of secreted vesicles by these cells as a novel approach to induce cardiac repair.

Prof Joost Sluijter is heading the Experimental Cardiology Laboratory and is nucleus member of the Regenerative Medicine program of the UMCU, he is nucleus member of the ESC working groups Cellular Biology of the Heart and Cardiovascular Regenerative & Reparative Medicine, has several editorial roles for journals, published >200 papers, and is awardee of an ERC consolidator grant.

Side Activities

  • Nucleus member working group on Cellular Biology of the Heart (European Society of Cardiology) 2010 - current

  • Chair working group on Cellular Biology of the Heart (European Society of Cardiology) 2016-2018
  • Immediate past-Chair working group on Cellular Biology of the Heart (European Society of Cardiology) 2018-2020

  • Nucleus member working group on Cardiovascular Regenerative & Reparative Medicine (European Society of Cardiology) 2020 - current

  • Board member of the Council on Basic Cardiovascular Science (European Society of Cardiology) 2018-2020

  • Associate editor of Journal of Cardiovascular Translational Research 2016 - current

  • Associate Editor Discovery Biology and Medicine 2012-2014

  • Editorial Board memeber of Clinical and Translational Physiology (Frontiers in Physiology)   2020 - current                                

  • Editorial Board member of Non-coding RNA Investigation 2018 - current

  • Scientific reviewer for journal (selected): Arterioslerosis, Thrombosis and Vascular biology (ATVB),   American Journal of Physiology, British Journal of Pharmacology, Cardiovascular research (Card Res), Circulation (Circ), Circulation research (Circ Res), Clinical Science, Current Pharmaceutical Design, European Heart Journal (EHJ), Journal of the American College of Cardiology (JACC), Journal of Cellular and Molecular Medicine (JCMM), New England Journal of Medicine (NEJoM), Physiological Genomics, Plos One, Stem Cells International, Science.

  • Scientific reviewer for grant providers (selected): Dutch Heart Foundation, NWO, Foundation de Cooperation Scientifique Campus Paris Saclay (FCS, France), Health and Medical Research Fund (China), Danish Council for Independent Research, National Center of Science and Technology Evaluation (Kazachstan), Medical Research Council (UK), Sir Henry Dale Fellowship (UK), Science foundation of Ireland

  • Member of the evaluation team for Ludwig Boltzman Institute for Cardiovascular Research, Vienna, September 2019.
  • Lecturer teaching program of undergraduate students at the Faculty of Medicine, Utrecht University.

  • University Utrecht - advisory board for ERC Starting and consolidator Grant-candidates

  • Advisory Board van de Graduate School of Life Sciences University Utrecht

Fellowship and Awards

  • 2004-2005 Interuniversity Institute of the Netherlands (ICIN)-fellowship

  • 2007-2009 Novartis Foundation for Cardiovascular Excellence Grant

  • 2008-2009 van Ruyvenstichting: 

  • 2009-2012 UMC Utrecht focus and mass area “cardiovascular research”

  • 2010-2014 BMM-YIC

  • 2011-2015 Translationeel Adult Stamcelonderzoek:

  • 2012-2017 HUMAN STem cells for CArdiac REpair (HUSTCARE)

  • 2014-2018 LSH Impuls: MIGRATE

  • 2015-2017: BMM Smartcare2 – Smart microtissues for cardiac regeneration

  • 2015-2019: Horizon 2020 – TECHNOBEAT (PHC-16-2015)

  • 2015-2018: CAS-NWO Program; Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathy

  • 2017-2022: Horizon 2020 - ERC-2016-CoG – 725229:  EVICARE: Extracellular Vesicle-Inspired CArdiac Repair

  • 2017-2019: Vrienden UMCU: “Innovatieve directe medicijnafgifte in het hart”

  • 2018-2022 – Horizon 2020 Marie S. Curie, COFUND programme RESCUE: Local Training Network on REgenerative medicine and Stem Cell technology in UtrEcht 

  • 2018-2021: Technology Of Protein delivery through Extracellular Vesicles to target PCSK9 (TOP-EV), Dutch Heart Foundation 

  • 2019-2024: RegMed XB Cardiovascular Moonshot 

  • 2019-2024: Horizon 2020 BRAV3 (SC1-BHC-07-2019)

  • 2020-2021: NL-PET - Next Level genome editing - efficient and precise correction of PLN/R14del using Prime Editing Technology. PLN foundation.

  • 2021-2024: NWO-OTP - HARVEY; Heart vector-mediated gene therapy: towards a clinically applicable cure for inherited cardiomyopathies.

  • 2021-2024: ZonMw - PSIDER - Multi-disciplimaire Consortia: From pluripotent stem cells to prime editing gene therapy for inherited cardiomyopathies.

  • 2022-2026: Horizon-HLTH-2021-TOOL-06-02; HEAL - HLA-homozygous IPSC-cardiomyocyte aggregate manufacturing technologies for allogenic cell therapy to the heart.

 

Research Output (291)

Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts

Peters Marijn C., Di Martino Sofia, Boelens Thomas, Qin Jiabin, van Mil Alain, Doevendans Pieter A., Chamuleau Steven A.J., Sluijter Joost P.G., Neef Klaus 9 Jun 2022, In: Molecular Therapy - Methods and Clinical Development. 25 , p. 3-16 14 p.

Circadian Dependence of the Acute Immune Response to Myocardial Infarction

Kilgallen Aoife B, van den Akker Frederieke, Feyen Dries A M, Crnko Sandra, Snijders Blok Christian J B, Gremmels Hendrik, du Pré Bastiaan C, Reijers Robin, Doevendans Pieter A, de Jager Saskia C A, Sluijter Joost P G, Sampaio-Pinto Vasco, van Laake Linda W 25 May 2022, In: Frontiers in Pharmacology. 13 , p. 1-13

Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study

Levy Sonja, Kilgallen Aoife B, Korse Catharina M, Oerlemans Marish I F J, Sluijter Joost P G, van Laake Linda W, Valk Gerlof D, Tesselaar Margot E T 1 May 2022, In: Cancers. 14 , p. 1-13

Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM 2.5 )-induced cardiac dysfunction via ACE2 signalling.

Wang Hongyun, Wang Tianhui, Rui Wei, Xie Jinxin, Xie Yuling, Zhang Xiao, Guan Longfei, Li Guoping, Lei Zhiyong, Schiffelers Raymond M, Sluijter Joost P G, Xiao Junjie May 2022, In: Journal of Extracellular Vesicles. 11 , p. 1-20

Pirfenidone Has Anti-fibrotic Effects in a Tissue-Engineered Model of Human Cardiac Fibrosis

Bracco Gartner Tom, Crnko S, Leiteris Laurynas, van Adrichem Iris, van Laake Linda W., Bouten Carlijn V. C., Goumans Marie-Jose, Suyker Willem, Sluijter Joost P.G., Hjortnaes Jesper 11 Mar 2022, In: Frontiers in Cardiovascular Medicine. 9 , p. 1-13

Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes

Yuan Qianliang, Maas Renee G.C., Brouwer Ellen C.J., Pei Jiayi, Blok Christian Snijders, Popovic Marko A., Paauw Nanne J., Bovenschen Niels, Hjortnaes Jesper, Harakalova Magdalena, Doevendans Pieter A., Sluijter Joost P.G., van der Velden Jolanda, Buikema Jan W. Feb 2022, In: Journal of Cardiovascular Development and Disease. 9 , p. 1-13

Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Evers Martijn J W, Du Wenjuan, Yang Qiangbing, Kooijmans Sander A A, Vink Arjan, van Steenbergen Mies, Vader Pieter, de Jager Saskia C A, Fuchs Sabine A, Mastrobattista Enrico, Sluijter Joost P G, Lei Zhiyong, Schiffelers Raymond 22 Jan 2022, In: Journal of controlled release : official journal of the Controlled Release Society. 343 , p. 207-216 10 p.

Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function

van de Wakker S. I., van Oudheusden J., Mol E. A., Roefs M. T., Zheng W., Görgens A., El Andaloussi S., Sluijter J. P.G., Vader P. Jan 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 170 , p. 59-69 11 p.

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel

van der Ven Casper F T, Tibbitt Mark W, Conde João, van Mil Alain, Hjortnaes Jesper, Doevendans Pieter A, Sluijter Joost P G, Aikawa Elena, Langer Robert S 28 Dec 2021, In: Nanoscale. 13 , p. 20451-20461 11 p.

Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction

Zhou Qiulian, Deng Jiali, Yao Jianhua, Song Jiaxin, Meng Danni, Zhu Yujiao, Xu Minjun, Liang Yajun, Xu Jiahong, Sluijter Joost PG, Xiao Junjie Dec 2021, In: EBioMedicine. 74

All research output

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