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prof. dr. J.P.G. (Joost P.G.) Sluijter

Full Professor

  • Onderzoek Cardiovasculair Reg. Med.

prof. dr. J.P.G. (Joost P.G.) Sluijter

Biography

Prof Joost Sluijter is a Medical Biologist and got his PhD in 2004 at the University Utrecht on “Collagen turnover in arterial disease”. After being a postdoctoral research fellow at Indiana University-Purdue University (IUPUI), he returned to the University Medical Centre Utrecht (the Netherlands) in 2006.  In his research group, they focus on stimulating cardiac regeneration, thereby using approaches that can lead to improved recovery of cardiac tissue upon injury. In recent years, they identified miRNAs that can push cell lineage specifications and how they could improve progenitor cell transplantation, specifically improving local delivery and cell retention. In this work, they have started to use 3D-bioprinting and advanced technologies of cardiac tissue engineering. His group substantially improved cell delivery to the myocardium, from which they also realized that most of the injected cell action was due to the potential paracrine actions. They therefore started to study the use of secreted vesicles by these cells as a novel approach to induce cardiac repair.

Prof Joost Sluijter is heading the Experimental Cardiology Laboratory and is nucleus member of the Regenerative Medicine program of the UMCU, he is the current past-chair of the ESC working group Cellular Biology of the Heart, has several editorial roles for journals, published >170 papers, and is awardee of an ERC consolidator grant.

Side Activities

  • -Nucleus member working group on Cellular Biology of the Heart (European Society of Cardiology)

    - Immediate past-Chair working group on Cellular Biology of the Heart (European Society of Cardiology)

    - Board member of the Council on Basic Cardiovascular Science (European Society of Cardiology)

    - Associate editor of Journal of Cardiovascular Translational Research

    - Associate Editor Discovery Biology and Medicine 

    - Editorial Board memeber of Clinical and Translational Physiology (Frontiers in Physiology)                                   

    - Editorial Board member of Non-coding RNA Investigation

    - Scientific reviewer for journal (selected): Arterioslerosis, Thrombosis and Vascular biology (ATVB),   American Journal of Physiology, British Journal of Pharmacology, Cardiovascular research (Card Res), Circulation (Circ), Circulation research (Circ Res), Clinical Science, Current Pharmaceutical Design, European Heart Journal (EHJ), Journal of the American College of Cardiology (JACC), Journal of Cellular and Molecular Medicine (JCMM), New England Journal of Medicine (NEJoM), Physiological Genomics, Plos One, Stem Cells International, Science.

    - Scientific reviewer for grant providers (selected): Dutch Heart Foundation, NWO, Foundation de Cooperation Scientifique Campus Paris Saclay (FCS, France), Health and Medical Research Fund (China), Danish Council for Independent Research, National Center of Science and Technology Evaluation (Kazachstan), Medical Research Council (UK), Sir Henry Dale Fellowship (UK), Science foundation of Ireland

     - Lecturer teaching program of undergraduate students at the Faculty of Medicine, Utrecht University.

    - University Utrecht - advisory board for ERC Starting and consolidator Grant-candidates

    - Advisory Board van de Graduate School of Life Sciences University Utrecht

Fellowship and Awards

  • 2004-2005 Interuniversity Institute of the Netherlands (ICIN)-fellowship
    2007-2009 Novartis Foundation for Cardiovascular Excellence Grant
    2008-2009 van Ruyvenstichting
    2009-2012 UMC Utrecht focus and mass area “cardiovascular research”
    2010-2014 BMM-YIC
    2011-2015 Translationeel Adult Stamcelonderzoek:
    2012-2017 HUMAN STem cells for CArdiac REpair (HUSTCARE)
    2014-2018 LSH Impuls: MIGRATE
    2015-2017: BMM Smartcare2 – Smart microtissues for cardiac regeneration
    2015-2019: Horizon 2020 – TECHNOBEAT (PHC-16-2015)
    2015-2018: CAS-NWO Program; Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathy
    2017-2022: Horizon 2020 - ERC-2016-CoG – 725229:  EVICARE: Extracellular Vesicle-Inspired CArdiac Repair
    2017-2019: Vrienden UMCU: “Innovatieve directe medicijnafgifte in het hart”
    2018-2022 – Horizon 2020 Marie S. Curie, COFUND programme RESCUE: Local Training Network on REgenerative medicine and Stem Cell technology in UtrEcht 
    2018-2021: Technology Of Protein delivery through Extracellular Vesicles to target PCSK9 (TOP-EV), Dutch Heart Foundation 
    2019-2024: RegMed XB Cardiovascular Moonshot 
    2019-2024: Horizon 2020 BRAV3 (SC1-BHC-07-2019)
    2020-2021: NL-PET - Next Level genome editing - efficient and precise correction of PLN/R14del using Prime Editing Technology. PLN foundation

     

Research Output (236)

Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients

Crnko Sandra, Printezi Markella I, Jansen Tijn P J, Leiteris Laurynas, van der Meer Manon G, Schutte Hilde, van Faassen Martijn, du Pré Bastiaan C, de Jonge Nicolaas, Asselbergs Folkert W, Gaillard Carlo A J M, Kemperman Hans, Doevendans Pieter A, Sluijter Joost P G, van Laake Linda W 31 mrt 2020, In: ESC heart failure. 7 , p. 1224-1233 10 p.

Polymeric siRNA gene delivery- transfection efficiency versus cytotoxicity

Sluijter Joost P.G., Kargaard A, Klumperman B. 28 dec 2019, In: Journal of Controlled Release. 316 , p. 263-291 29 p.

Biofabrication of Cell-Derived Nanovesicles: A Potential Alternative to Extracellular Vesicles for Regenerative Medicine

Ilahibaks Nazma, Lei Zhiyong, Deshantri AK, Jiang L, Schiffelers Raymond, Vader Pieter, Sluijter Joost P.G., Mol Emma nov 2019, In: Cells. 8

Fiber Scaffold Patterning for Mending Hearts:3D Organization Bringing the Next Step

Kristen Marleen, Ainsworth Madison J., Chirico Nino, van der Ven Casper F.T., Doevendans Pieter A., Sluijter Joost P.G., Malda Jos, van Mil Alain, Castilho Miguel 11 okt 2019, In: Advanced Healthcare Materials. 9 21 p.

Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics

Mol Emma A, Lei Zhiyong, Roefs Marieke T, Bakker Maarten H, Goumans Marie-José, Doevendans Pieter A, Dankers Patricia Y W, Vader Pieter, Sluijter Joost P G okt 2019, In: Advanced Healthcare Materials. 8

Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure

van den Hoogen Patricia, de Jager Saskia C.A., Huibers Manon M.H., Schoneveld Arjan H., Puspitasari Yustina M., Valstar Gideon B., Oerlemans Marish I.F.J., de Weger Roel A., Doevendans Pieter A., den Ruijter Hester M., Laman Jon D., Vink Aryan, Sluijter Joost P.G. 26 sep 2019, In: Journal of Cellular and Molecular Medicine. 23 , p. 7505-7516 12 p.

Interfering with endolysosomal trafficking enhances release of bioactive exosomes

Ortega Francisco G., Roefs Marieke T., de Miguel Perez Diego, Kooijmans Sander A., de Jong Olivier G., Sluijter Joost P., Schiffelers Raymond M., Vader Pieter 1 aug 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen Jitske, Jansen Katja, Neven Ellen, Poesen Ruben, Othman Amr, van Mil Alain, Sluijter Joost, Torano Javier Sastre, Zaal Esther A., Berkers Celia R., Esser Diederik, Wichers Harry J., van Ede Karin, van Duursen Majorie, Burtey Stéphane, Verhaar Marianne C., Meijers Björn, Masereeuw Rosalinde 24 jul 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 16105-16110 6 p.

Circadian rhythms and the molecular clock in cardiovascular biology and disease

Crnko Sandra, Du Pré Bastiaan C, Sluijter Joost P G, Van Laake Linda W jul 2019, In: Nature Reviews Cardiology. 16 , p. 437-447 11 p.

Integrated analysis of transcriptional regulation in PLN R14del cardiomyopathy

Pei J., Harakalova M., Nagyova E., Gho J. M. I. H., Sepehrkhouy S., van Dinter J., van Mil A., Buijsrogge M. P., de Jonge N., Huibers M. M., Nieuwenhuis E. E. S., den Ruijter H. M., Pasterkamp G., Doevendans P. A., Hajjar R., Mercola M., Sluijter J. P. G., de Weger R. A., Cheng C., Vink A., Mokry M., Asselbergs F. W. jul 2019, In: European Journal of Human Genetics. 27 , p. 790-791

All Research Output (236)