dr. P.A.M. (Paul) Smeets

Associate Professor

  • Image Sciences Institute

dr. P.A.M. (Paul) Smeets

Research Programs


Paul Smeets is associate professor at the UMC Utrecht and has a background in Behavioral Biology. His PhD work, at the Image Sciences Institute (ISI), aimed at finding biomarkers of satiety in the human brain, using functional MRI. Currently, he works at ISI / UMC Utrecht and at the Division of Human Nutrition and Health of Wageningen University. The central theme in his research is the decision to eat, which is taken in the brain on the basis of multiple neural as well as hormonal signals. Research topics include the neural correlates of taste, satiety and (un)healthy food choice, gut-brain interactions, effects of personality characteristics on food-induced brain responses and functional neuroimaging in anorexia nervosa. In recent years he has been using MRI techniques to study (gastric) digestion.

Research line

Nutritional and Translational Neuroscience

Most recent key publications

1: Charbonnier L, van Meer F, Johnstone AM, Crabtree D, Buosi W, Manios Y, Androutsos O, Giannopoulou A, Viergever MA, Smeets PAM; Full4Health consortium. Effects of hunger state on the brain responses to food cues across the life span. Neuroimage. 2018 May 1;171:246-255. doi: 10.1016/j.neuroimage.2018.01.012.

2: van Meer F, van der Laan LN, Viergever MA, Adan RAH, Smeets PAM; I.Family Consortium. Considering healthiness promotes healthier choices but modulates medial prefrontal cortex differently in children compared with adults. Neuroimage. 2017 Oct 1;159:325-333. doi: 10.1016/j.neuroimage.2017.08.007.

3: van Meer F, van der Laan LN, Charbonnier L, Viergever MA, Adan RA, Smeets PA; I.Family Consortium. Developmental differences in the brain response to unhealthy food cues: an fMRI study of children and adults. Am J Clin Nutr. 2016 Dec;104(6):1515-1522.

4: Camps G, Mars M, de Graaf C, Smeets PA. Empty calories and phantom fullness: a randomized trial studying the relative effects of energy density and viscosity on gastric emptying determined by MRI and satiety. Am J Clin Nutr. 2016 Jul;104(1):73-80. doi:10.3945/ajcn.115.129064.

5: Sanders N, Smeets PA, van Elburg AA, Danner UN, van Meer F, Hoek HW, Adan RA. Altered food-cue processing in chronically ill and recovered women with anorexia nervosa. Front Behav Neurosci. 2015 Feb 27;9:46. doi: 10.3389/fnbeh.2015.00046. eCollection 2015.

6: van Meer F, van der Laan LN, Adan RA, Viergever MA, Smeets PA. What you see is what you eat: an ALE meta-analysis of the neural correlates of food viewing in children and adolescents. Neuroimage. 2015 Jan 1;104:35-43. doi:10.1016/j.neuroimage.2014.09.069.

Research Output (84)

The influence of acute partial sleep deprivation on liking, choosing and consuming high- and low-energy foods

Benjamins Jeroen S., Hooge Ignace T.C., Benedict Christian, Smeets Paul A.M., van der Laan Laura N. mrt 2021, In: Food Quality and Preference. 88

The importance of swelling for in vitro gastric digestion of whey protein gels

Deng Ruoxuan, Mars Monica, Van Der Sman Ruud G.M., Smeets Paul A.M., Janssen Anja E.M. 15 nov 2020, In: Food chemistry. 330 7 p.

Distraction decreases rIFG-putamen connectivity during goal-directed effort for food rewards

Duif Iris, Wegman Joost, de Graaf Kees, Smeets Paul A M, Aarts Esther 4 nov 2020, In: Scientific Reports. 10 , p. 19072

Deep Learning-Based Regression and Classification for Automatic Landmark Localization in Medical Images

Noothout Julia M H, De Vos Bob D, Wolterink Jelmer M, Postma Elbrich M, Smeets Paul A M, Takx Richard A P, Leiner Tim, Viergever Max A, Isgum Ivana 13 jul 2020, In: IEEE transactions on medical imaging. 39 , p. 4011-4022 12 p.

Endocrine Cephalic Phase Responses to Food Cues:A Systematic Review

Lasschuijt Marlou P, Mars Monica, de Graaf Cees, Smeets Paul A M 9 jun 2020, In: Advances in nutrition (Bethesda, Md.). 11 , p. 1364-1383 20 p.

How oro-sensory exposure and eating rate affect satiation and associated endocrine responses-a randomized trial

Lasschuijt Marlou, Mars Monica, de Graaf Cees, Smeets Paul A M 22 apr 2020, In: American Journal of Clinical Nutrition. 111 , p. 1137-1149 13 p.

Effects of distraction on taste-related neural processing:a cross-sectional fMRI study

Duif Iris, Wegman Joost, Mars Monica M, de Graaf Cees, Smeets Paul A M, Aarts Esther 16 mrt 2020, In: American Journal of Clinical Nutrition. 111 , p. 950-961 12 p.

Exploring in vitro gastric digestion of whey protein by time-domain nuclear magnetic resonance and magnetic resonance imaging

Deng Ruoxuan, Janssen Anja E.M., Vergeldt Frank J., Van As Henk, de Graaf Cees, Mars Monica, Smeets Paul A.M. 1 feb 2020, In: Food Hydrocolloids. 99 9 p.

Grab to eat! Eating motivation dynamics measured by effort exertion depend on hunger state

Pirc Matjaž, Čad E. M., Jager G., Smeets Paul A.M. 1 dec 2019, In: Food Quality and Preference. 78

Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice

van Meer Floor, van der Laan Laura N, Eiben Gabriele, Lissner Lauren, Wolters Maike, Rach Stefan, Herrmann Manfred, Erhard Peter, Molnar Denes, Orsi Gergely, Viergever Max A, Adan Roger A H, Smeets Paul A M, 1 nov 2019, In: NeuroImage. 201

All Research Output (84)