dr. P. (Pieter) Vader
dr. P. (Pieter) Vader
- Central Diagnostic Laboratory
Research Programs
Biography
Biography
Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.
From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.
In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), NWO Vidi Grant (2020) and ERC Consolidator Grant (2023). In 2021, Pieter was awarded the Prix Galien Research Award for his work on drug delivery.
Fellowship and Awards
- 2023 ERC Consolidator Grant for the project: "Unravelling extracellular vesicle heterogeneity to inspire improved therapeutic RNA delivery systems"
- 2020 NWO Vidi grant for the project: "Molecular drivers of extracellular vesicle targeting and RNA transfer – towards improved delivery"
- 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles"
- 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
- 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms”
- 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"
Research Output (84)
Görgens André, Corso Giulia, Hagey Daniel W., Jawad Wiklander Rim, Gustafsson Manuela O., Felldin Ulrika, Lee Yi, Bostancioglu R. Beklem, Sork Helena, Liang Xiuming, Zheng Wenyi, Mohammad Dara K., van de Wakker Simonides I., Vader Pieter, Zickler Antje M., Mamand Doste R., Ma Li, Holme Margaret N., Stevens Molly M., Wiklander Oscar P.B., EL Andaloussi Samir Jun 2022, In: Journal of Extracellular Vesicles. 11 , p. 1-27
Salomon Carlos, Das Saumya, Erdbrügger Uta, Kalluri Raghu, Kiang Lim Sai, Olefsky Jerrold M., Rice Gregory E., Sahoo Susmita, Andy Tao W., Vader Pieter, Wang Qun, Weaver Alissa M. Jun 2022, In: Endocrine reviews. 43 , p. 441-468 28 p.
van Niel Guillaume, Carter David R.F., Clayton Aled, Lambert Daniel W., Raposo Graça, Vader Pieter May 2022, In: Nature reviews molecular cell biology. 23 , p. 369-382 14 p.
Rodríguez Diego A., Vader Pieter Feb 2022, In: Pharmaceutics. 14
Evers Martijn J W, Du Wenjuan, Yang Qiangbing, Kooijmans Sander A A, Vink Arjan, van Steenbergen Mies, Vader Pieter, de Jager Saskia C A, Fuchs Sabine A, Mastrobattista Enrico, Sluijter Joost P G, Lei Zhiyong, Schiffelers Raymond 22 Jan 2022, In: Journal of controlled release : official journal of the Controlled Release Society. 343 , p. 207-216 10 p.
Saludas Laura, Garbayo Elisa, Ruiz-Villalba Adrián, Hernández Silvia, Vader Pieter, Prósper Felipe, Blanco-Prieto María J. Jan 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 170 , p. 187-196 10 p.
van de Wakker S. I., van Oudheusden J., Mol E. A., Roefs M. T., Zheng W., Görgens A., El Andaloussi S., Sluijter J. P.G., Vader P. Jan 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 170 , p. 59-69 11 p.
Raes Laurens, Pille Melissa, Harizaj Aranit, Goetgeluk Glenn, Van Hoeck Jelter, Stremersch Stephan, Fraire Juan C., Brans Toon, de Jong Olivier Gerrit, Maas-Bakker Roel, Mastrobattista Enrico, Vader Pieter, De Smedt Stefaan C., Vandekerckhove Bart, Raemdonck Koen, Braeckmans Kevin 3 Sep 2021, In: Molecular Therapy - Nucleic Acids. 25 , p. 696-707 12 p.
de Voogt Willemijn S., Tanenbaum Marvin E., Vader Pieter Jul 2021, In: Advanced Drug Delivery Reviews. 174 , p. 250-264 15 p.
Sork Helena, Conceicao Mariana, Corso Giulia, Nordin Joel, Lee Yi Xin Fiona, Krjutskov Kaarel, Orzechowski Westholm Jakub, Vader Pieter, Pauwels Marie, Vandenbroucke Roosmarijn E., Wood Matthew Ja, El Andaloussi Samir, Mäger Imre 18 Jun 2021, In: Cells. 10 , p. 1-17