prof. dr. M.C. (Marianne C.) Verhaar Full Professor

Nephrology

Contact

m.c.verhaar@umcutrecht.nl

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the realation between chronic kidney disease, microvascular dysfunction and heart failure, the role of (bone marrow-derived) stem and progenitor cells or cellular products in vascular and renal regeneration and their therapeutic potential in patients with cardiovascular and chronic kidney disease; development of renal organoids and search for renal stem cells using specific stem cell markers; investigate the potential of induced pluripotent stem cells for renal regeneration; development of a wearable artificial kidney.

Side Activities

ZonMw Programme Committee Innovational Research Incentives Scheme Veni

NWO Innovational Research Incentives Scheme Vidi (interdivisional)

ZonMw Programme Committee Translational Research

International Review Board Academy of Finland, 2011 & 2015

Review Committee Regenerative Medicine proposals European Committee, 2009

Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. dr. M.S. Goligorsky) (2009)

Research Output

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Heidt Sebastiaan, Haasnoot Geert W., Witvliet Marian D., van der Linden-van Oevelen Marissa J.H., Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Marielle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries, van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Otten Henny G., Roelen Dave L., Claas Frans H.J. Oct 2019 In: American Journal of Transplantation. 19, p. 2926-2933 8 p.

Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1

Pei Jiayi, Juni Rio, Harakalova Magdalena, Duncker Dirk J, Asselbergs Folkert W, Koolwijk Pieter, Hinsbergh Victor van, Verhaar Marianne C, Mokry Michal, Cheng Caroline 2 Aug 2019 In: Toxins. 11

Exhaustion of the bone marrow progenitor cell reserve is associated with major events in severe limb ischemia

Gremmels Hendrik, van Rhijn-Brouwer Femke C C, Papazova Diana A, Fledderus Joost O, Teraa Martin, Verhaar Marianne C, 30 Mar 2019 In: Angiogenesis.

Quality of life after the initiation of dialysis or maximal conservative management in elderly patients: a longitudinal analysis of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study

van Loon I N, Goto N A, Boereboom F T J, Verhaar M C, Bots M L, Hamaker M E 29 Mar 2019 In: BMC Nephrology. 20

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Schutgens Frans, Rookmaaker Maarten B, Margaritis Thanasis, Rios Anne, Ammerlaan Carola, Jansen Jitske, Gijzen Linda, Vormann Marianne, Vonk Annelotte, Viveen Marco, Yengej Fjodor Yousef, Derakhshan Sepide, de Winter-de Groot Karin M, Artegiani Benedetta, van Boxtel Ruben, Cuppen Edwin, Hendrickx Antoni P A, van den Heuvel-Eibrink Marry M, Heitzer Ellen, Lanz Henriette, Beekman Jeffrey, Murk Jean-Luc, Masereeuw Rosalinde, Holstege Frank, Drost Jarno, Verhaar Marianne C, Clevers Hans Mar 2019 In: Nature Biotechnology. 37, p. 303-313 11 p.

Histological characteristics of Acute Tubular Injury during Delayed Graft Function predict renal function after renal transplantation

Pieters Tobias T, Falke Lucas L, Nguyen Tri Q, Verhaar Marianne C, Florquin Sandrine, Bemelman Frederike J, Kers Jesper, Vanhove Thomas, Kuypers Dirk, Goldschmeding Roel, Rookmaaker Maarten B Mar 2019 In: Physiological Reports [E]. 7

Effect of Donor Variation on Osteogenesis and Vasculogenesis in Hydrogel Co-cultures

Pennings I, van Dijk L A, van Huuksloot J, Fledderus J O, Schepers K, Braat A K, Hsiao E C, Barruet E, Morales B M, Verhaar M C, Rosenberg A J W P, Gawlitta D 16 Jan 2019 In: Journal of Tissue Engineering and Regenerative Medicine.

Performance of bleeding risk scores in dialysis patients

Ocak Gurbey, Ramspek Chava, Rookmaaker Maarten B, Blankestijn Peter J, Verhaar Marianne C, Bos Willem Jan W, Dekker Friedo W, van Diepen Merel 4 Jan 2019 In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients

Michielsen Laura A, van Zuilen Arjan D, Verhaar Marianne C, Wisse Bram W, Kamburova Elena G, Joosten Irma, Allebes Wil A, van der Meer Arnold, Baas Marije C, Spierings Eric, Hack Cornelis E, van Reekum Franka E, Bots Michiel L, Drop Adriaan C A D, Plaisier Loes, Seelen Marc A J, Sanders Jan-Stephan F, Hepkema Bouke G, Lambeck Annechien J, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christien E, Wieten Lotte, van Duijnhoven Elizabeth M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Shaikh A, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A, van der Weerd Neelke C, Ten Berge Ineke J M, Bemelman Frederike J, Hoitsma Andries, van der Boog Paul J M, de Fijter Johan W, Betjes Michiel G H, Heidt Sebastiaan, Roelen Dave L, Claas Frans H, Otten Henderikus G, Hilbrands Luuk B 15 Dec 2018 In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Pretransplant C3D-fixing donor-specific anti-HLA antibodies are not associated with increased risk for kidney graft failure

Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., Van Der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., Van Reekum Franka E., Van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, Van Duijnhoven Elly M., Gelens Mariëlle A.C.J., Christiaans Maarten H.L., Van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, Van Der Pant Karlijn A.M.I., Van Der Weerd Neelke C., Ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries J., Van Der Boog Paul J.M., De Fijter Johan W., Betjes Michiel G.H., Heidt Sebastiaan, Roelen Dave L., Claas Frans H., Otten Henny G. 1 Sep 2018 In: Journal of the American Society of Nephrology. 29, p. 2279-2285 7 p.

All Research Output (202)

Fellowship and Awards

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)