prof. dr. M.C. (Marianne C.) Verhaar Full Professor

Nephrology

Contact

m.c.verhaar@umcutrecht.nl

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the realation between chronic kidney disease, microvascular dysfunction and heart failure, the role of (bone marrow-derived) stem and progenitor cells or cellular products in vascular and renal regeneration and their therapeutic potential in patients with cardiovascular and chronic kidney disease; development of renal organoids and search for renal stem cells using specific stem cell markers; investigate the potential of induced pluripotent stem cells for renal regeneration; development of a wearable artificial kidney.

Side Activities

Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) 2019-

Scientific board Dutch Kidney Foundation 2019-

European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Continuous Education and Professional Development (CEPD) Committee (Chair) 2019-

ERA-EDTA Scientific Advisory Board 2019-

ERA-EDTA EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group 2015-2019

Scientific Committee of the ERA-EDTA Berlin Meeting 2021

Scientific Committee of the ERA-EDTA Milan Meeting 2020

French National Research Agency (ANR) University Hospital institute Selection Committee (Chair) 2017-

Scientific Forum of the Netherlands Heart Institute 2016-

Science Europe Scientific Advisory Committee 2015-2018

ZonMw Programme Committee Innovational Research Incentives Scheme Veni 2010-2018

NWO Innovational Research Incentives Scheme Vidi (interdivisional) 2014

ZonMw Programme Committee Translational Research 2010-2020

International Review Board Academy of Finland, 2011 & 2015

Review Committee Regenerative Medicine proposals European Committee, 2009

Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. dr. M.S. Goligorsky) (2009)

Research Output

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 Dec 2019 In: American Journal of Neuroradiology. 40, p. 2016-2022 7 p.

Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation

Brandt Maarten M, van Dijk Christian G M, Maringanti Ranganath, Chrifi Ihsan, Kramann Rafael, Verhaar Marianne C, Duncker Dirk J, Mokry Michal, Cheng Caroline 30 Oct 2019 In: Scientific Reports. 9

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Heidt Sebastiaan, Haasnoot Geert W., Witvliet Marian D., van der Linden-van Oevelen Marissa J.H., Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Marielle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries, van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Otten Henny G., Roelen Dave L., Claas Frans H.J. Oct 2019 In: American Journal of Transplantation. 19, p. 2926-2933 8 p.

Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction: A Focus on Microcirculatory Factors and Therapeutic Targets

van de Wouw Jens, Broekhuizen Michelle, Sorop Oana, Joles JA, Verhaar Marianne C, Duncker Dirk J, Danser A H Jan, Merkus Daphne 4 Sep 2019 In: Frontiers in Physiology. 10

The Small RNA Repertoire of Small Extracellular Vesicles Isolated From Donor Kidney Preservation Fluid Provides a Source for Biomarker Discovery for Organ Quality and Posttransplantation Graft Function

Gremmels Hendrik, de Jong Olivier G, Toorop Raechel J, Michielsen Laura, van Zuilen Arjan D, Vlassov Alexander V, Verhaar Marianne C, van Balkom Bas W M Sep 2019 In: Transplantation direct. 5

Epoetin Beta and C-Terminal Fibroblast Growth Factor 23 in Patients With Chronic Heart Failure and Chronic Kidney Disease

Eisenga Michele F, Emans Mireille E, van der Putten Karien, Cramer Maarten J, Diepenbroek Adry, Velthuis Birgitta K, Doevendans Pieter A, Verhaar Marianne C, Joles JA, Bakker Stephan J L, Nolte Ilja M, Braam Branko, Gaillard Carlo A J M 20 Aug 2019 In: Journal of the American Heart Association. 8

Geriatric Assessment and the Relation with Mortality and Hospitalizations in Older Patients Starting Dialysis

van Loon Ismay N, Goto Namiko A, Boereboom Franciscus T J, Bots Michiel L, Hoogeveen Ellen K, Gamadia Laila, van Bommel E F H, van de Ven P J G, Douma Caroline E, Vincent H H, Schrama Yvonne C, Lips Joy, Siezenga Machiel A, Abrahams Alferso C, Verhaar Marianne C, Hamaker Marije E 13 Aug 2019 In: Nephron. 143, p. 108-119 12 p.

Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1

Pei Jiayi, Juni Rio, Harakalova Magdalena, Duncker Dirk J, Asselbergs Folkert W, Koolwijk Pieter, Hinsbergh Victor van, Verhaar Marianne C, Mokry Michal, Cheng Caroline 2 Aug 2019 In: Toxins. 11

Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction

Brandt Maarten M, Nguyen Isabel T N, Krebber Merle M, van de Wouw Jens, Mokry Michal, Cramer Maarten J, Duncker Dirk J, Verhaar Marianne C, Joles Jaap A, Cheng Caroline 31 Jul 2019 In: Journal of Cellular and Molecular Medicine. 23, p. 6666-6678 13 p.

De draagbare kunstnier: hoe staan de zaken?

Wester Maarten, van Gelder Maaike K., Joles Jaap A., Verhaar Marianne C., Koeman Jeroen P., Gerritsen Karin G.F. 9 Jul 2019 In: Nederlands Tijdschrift voor Geneeskunde. 163, p. 1-3 3 p.

All Research Output (250)

Fellowship and Awards

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)