prof. dr. M.C. (Marianne C.) Verhaar Full Professor

Nephrology

Contact

m.c.verhaar@umcutrecht.nl

Research programs

Biography
Side Activities
Research Output
Fellowship and Awards

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the realation between chronic kidney disease, microvascular dysfunction and heart failure, the role of (bone marrow-derived) stem and progenitor cells or cellular products in vascular and renal regeneration and their therapeutic potential in patients with cardiovascular and chronic kidney disease; development of renal organoids and search for renal stem cells using specific stem cell markers; investigate the potential of induced pluripotent stem cells for renal regeneration; development of a wearable artificial kidney.

Side Activities

Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) 2019-

Scientific board Dutch Kidney Foundation 2019-

European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Continuous Education and Professional Development (CEPD) Committee (Chair) 2019-

ERA-EDTA Scientific Advisory Board 2019-

ERA-EDTA EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group 2015-2019

Scientific Committee of the ERA-EDTA Berlin Meeting 2021

Scientific Committee of the ERA-EDTA Milan Meeting 2020

French National Research Agency (ANR) University Hospital institute Selection Committee (Chair) 2017-

Scientific Forum of the Netherlands Heart Institute 2016-

Science Europe Scientific Advisory Committee 2015-2018

ZonMw Programme Committee Innovational Research Incentives Scheme Veni 2010-2018

NWO Innovational Research Incentives Scheme Vidi (interdivisional) 2014

ZonMw Programme Committee Translational Research 2010-2020

International Review Board Academy of Finland, 2011 & 2015

Review Committee Regenerative Medicine proposals European Committee, 2009

Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. dr. M.S. Goligorsky) (2009)

Research Output

Histological characteristics of Acute Tubular Injury during Delayed Graft Function predict renal function after renal transplantation

Pieters Tobias T, Falke Lucas L, Nguyen Tri Q, Verhaar Marianne C, Florquin Sandrine, Bemelman Frederike J, Kers Jesper, Vanhove Thomas, Kuypers Dirk, Goldschmeding Roel, Rookmaaker Maarten B Mar 2019 In: Physiological Reports [E]. 7

Quality of life as indicator of poor outcome in hemodialysis: relation with mortality in different age groups

van Loon I N, Bots M L, Boereboom Frans T J, Grooteman Muriel P C, Blankestijn P J, van den Dorpel Marinus A., Nubé Menso J., ter Wee Pieter M., Verhaar M C, Hamaker M. E. 6 Jul 2017 In: BMC Nephrology [E]. 18

Corrigendum: A closer look at the trajectory of physical functioning in chronic hemodialysis [Age and Ageing (2017) 594-599] doi.org/10.1093/ageing/afx006

Loon Ismay Van, Hamaker Marije E., Boereboom Franciscus T.J., Grooteman Muriel P.C., Blankestijn Peter J., Van Den Dorpel Rene M.A., Nubé Menso J., Ter Wee Piet M., Verhaar Marianne C., Bots Michiel L. 1 Jul 2017 In: Age and Ageing. 47 1 p.

The Transcription Factor Nrf2 Protects Angiogenic Capacity of Endothelial Colony-Forming Cells in High-Oxygen Radical Stress Conditions

Gremmels Hendrik, De Jong Olivier G., Hazenbrink Diënty H., Fledderus Joost O., Verhaar Marianne C. 2017 In: Stem Cells International. 2017 11 p.

High-Normal Estimated Glomerular Filtration Rate in Early-Onset Preeclamptic Women 10 Years Postpartum

Paauw Nina D., Joles Jaap A., Drost José T., Verhaar Marianne C., Franx Arie, Navis Gerjan, Maas Angela H E M, Lely A. Titia 1 Dec 2016 In: Hypertension. 68, p. 1407-1414 8 p.

Pluripotent stem cell-derived kidney organoids: An in vivo-like in vitro technology

Schutgens Frans, Verhaar Marianne C., Rookmaaker Maarten B. 5 Nov 2016 In: European Journal of Pharmacology. 790, p. 12-20 9 p.

Diabetes Mellitus Is Associated With Decreased Limb Survival in Patients With Critical Limb Ischemia: Pooled Data From Two Randomized Controlled Trials

Spreen Marlon I, Gremmels Hendrik, Teraa Martin, Sprengers Ralf W, Verhaar Marianne C, Statius van Eps Randolph G, de Vries Jean-Paul P M, Mali Willem P.Th.M. , van Overhagen Hans, 9 Sep 2016 In: Diabetes Care. 39, p. 2058-2064

How can we reduce costs of solid-phase multiplex-bead assays used to determine anti-HLA antibodies?

Kamburova E. G., Wisse B. W., Joosten I., Allebes W. A., van der Meer A., Hilbrands L. B., Baas M. C., Spierings E., Hack C. E., van Reekum F. E., van Zuilen A. D., Verhaar M., Bots M. L., Drop A. C A D, Plaisier L., Seelen M. A J, Sanders J. S F, Hepkema B. G., Lambeck A. J., Bungener L. B., Roozendaal C., Tilanus M. G J, Vanderlocht J., Voorter C. E., Wieten L., van Duijnhoven E. M., Gelens M., Christiaans M. H L, van Ittersum F. J., Nurmohamed A., Lardy N. M., Swelsen W., van der Pant K. A., van der Weerd N. C., ten Berge I. J M, Bemelman F. J., Hoitsma A., van der Boog P. J M, de Fijter J. W., Betjes M. G H, Heidt S., Roelen D. L., Claas F. H., Otten H. G. 1 Sep 2016 In: HLA. 88, p. 110-119 10 p.

Plasma CTGF is independently related to an increased risk of cardiovascular events and mortality in patients with atherosclerotic disease: the SMART study

Gerritsen Karin G, Falke Lucas L, van Vuuren Stefan H, Leeuwis Jan W, Broekhuizen Roel, Nguyen Tri Q, de Borst Gert Jan, Nathoe Hendrik M, Verhaar Marianne C, Kok Robbert J, Goldschmeding Roel, Visseren Frank L, Aug 2016 In: Growth factors. 34, p. 149-58 10 p.

Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy

Louzao-Martinez Laura, Vink Aryan, Harakalova Magdalena, Asselbergs Folkert W, Verhaar Marianne C, Cheng Caroline 27 Jun 2016 In: International Journal of Cardiology. 220, p. 634-646 13 p.

All Research Output (120)

Fellowship and Awards

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)