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prof. dr. M.C. (Marianne C.) Verhaar Full Professor

  • Nephrology

M.C. Verhaar

Contact

Research Programs

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the realation between chronic kidney disease, microvascular dysfunction and heart failure, the role of (bone marrow-derived) stem and progenitor cells or cellular products in vascular and renal regeneration and their therapeutic potential in patients with cardiovascular and chronic kidney disease; development of renal organoids and search for renal stem cells using specific stem cell markers; investigate the potential of induced pluripotent stem cells for renal regeneration; development of a wearable artificial kidney.

Side Activities

  • Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) 2019-

    Scientific board Dutch Kidney Foundation 2019-

    European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Continuous Education and Professional Development (CEPD) Committee (Chair) 2019-

    ERA-EDTA Scientific Advisory Board 2019-

    ERA-EDTA EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group 2015-2019

    Scientific Committee of the ERA-EDTA Berlin Meeting 2021

    Scientific Committee of the ERA-EDTA Milan Meeting 2020

    French National Research Agency (ANR) University Hospital institute Selection Committee (Chair) 2017-

    Scientific Forum of the Netherlands Heart Institute 2016-

    Science Europe Scientific Advisory Committee 2015-2018

    ZonMw Programme Committee Innovational Research Incentives Scheme Veni 2010-2018

    NWO Innovational Research Incentives Scheme Vidi (interdivisional) 2014

    ZonMw Programme Committee Translational Research 2010-2020

    International Review Board Academy of Finland, 2011 & 2015

    Review Committee Regenerative Medicine proposals European Committee, 2009

    Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. dr. M.S. Goligorsky) (2009)

Fellowship and Awards

  • NWO Vidi & ASPASIA grant (2008)

    NWO Veni grant (2002)

    Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)

Research Output (204)

Validation of randomized controlled trial-derived models for the prediction of postintervention outcomes in chronic limb-threatening ischemia

Wijnand Joep G J, van Koeverden Ian D, Teraa Martin, Spreen Marlon I, Mali Willem P T M, van Overhagen Hans, Pasterkamp Gerard, de Borst Gert J, Conte Michael S, Gremmels Hendrik, Verhaar Marianne C 1 mrt 2020, In: Journal of Vascular Surgery. 71 , p. 869-879 11 p.

Applicability of Transcutaneous Oxygen Tension Measurement in the Assessment of Chronic Limb-Threatening Ischemia

Leenstra Bernard, Wijnand Joep, Verhoeven Bart, Koning Olivier, Teraa Martin, Verhaar Marianne C, de Borst Gert J mrt 2020, In: Angiology. 71 , p. 208-216 9 p.

A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia

Gremmels Hendrik, Teraa Martin, de Jager Saskia C.A., Pasterkamp Gerard, de Borst Gert J., Verhaar Marianne C. 1 dec 2019, In: Scientific Reports. 9

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A, Hunault Claudine C, Van Maarseveen Erik M, Huitema Alwin D R, Van de Graaf Ed A, Kirkels Johannes H, Verhaar Marianne C, Grutters Jan C, Kesecioglu Jozef, De Lange Dylan W 19 nov 2019, In: European journal of drug metabolism and pharmacokinetics. 45 , p. 123-134 12 p.

The association between chronic kidney disease, falls, and fractures:a systematic review and meta-analysis

Goto N A, Weststrate A C G, Oosterlaan F M, Verhaar M C, Willems H C, Emmelot-Vonk M H, Hamaker M E 12 nov 2019, In: Osteoporosis International. 31 , p. 13-29 17 p.

Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation

Brandt Maarten M, van Dijk Christian G M, Maringanti Ranganath, Chrifi Ihsan, Kramann Rafael, Verhaar Marianne C, Duncker Dirk J, Mokry Michal, Cheng Caroline 30 okt 2019, In: Scientific Reports. 9

Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction:A Focus on Microcirculatory Factors and Therapeutic Targets

van de Wouw Jens, Broekhuizen Michelle, Sorop Oana, Joles JA, Verhaar Marianne C, Duncker Dirk J, Danser A H Jan, Merkus Daphne 4 sep 2019, In: Frontiers in Physiology. 10

Geriatric Assessment and the Relation with Mortality and Hospitalizations in Older Patients Starting Dialysis

van Loon Ismay N, Goto Namiko A, Boereboom Franciscus T J, Bots Michiel L, Hoogeveen Ellen K, Gamadia Laila, van Bommel E F H, van de Ven P J G, Douma Caroline E, Vincent H H, Schrama Yvonne C, Lips Joy, Siezenga Machiel A, Abrahams Alferso C, Verhaar Marianne C, Hamaker Marije E 13 aug 2019, In: Nephron. 143 , p. 108-119 12 p.

Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1

Pei Jiayi, Juni Rio, Harakalova Magdalena, Duncker Dirk J, Asselbergs Folkert W, Koolwijk Pieter, Hinsbergh Victor van, Verhaar Marianne C, Mokry Michal, Cheng Caroline 2 aug 2019, In: Toxins. 11

Reactivity of (Vicinal) Carbonyl Compounds with Urea

Jong Jacobus A W, Smakman Robert, Moret Marc-Etienne, Verhaar Marianne C, Hennink Wim E, Gerritsen Karin GF, Van Nostrum Cornelus F 31 jul 2019, In: ACS omega. 4 , p. 11928-11937 10 p.

All Research Output (204)
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