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prof. dr. M.C. (Marianne C.) Verhaar

prof. dr. M.C. (Marianne C.) Verhaar

Full Professor
prof. dr. M.C. (Marianne C.) Verhaar

Biography

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the relation between chronic kidney disease, microvascular dysfunction and heart failure, kidney organoids and their potential role in disease modeling and (materials-driven) kidney regeneration, vascular regeneration, development of a wearable artificial kidney.

Side Activities

Board activities

  • Scientific Forum of the Netherlands Heart Institute (2016-2019)
  • Wetenschappelijke Raad Nierstichting (2019- )
  • Scientific Advisory Board European Renal Association (ERA) (2019- )
  • ERA Continuing Medical Education Committee (chair) (2019- )
  • Scientific Committee ERA Scientific Congress (2019- )
  • Agence National de la Recherche (ANR), Selection Committee of University Hospital institutes (IHU) (chair) (2017- )
  • Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) (2019- )
  • Strategic Advisory Board Regenerative Medicine Crossing Borders (RegMedXB) (2020- )
  • Kidney Moonshot leader RegMedXB (2020- )
  • Nationaal Actieprogramma: Tafel 1 Regeneratieve Geneeskunde + Stamcel Therapie (2020- )
  • Advisory Board werkgroep Living Technologies Eindhoven-Wageningen-UU-UMC Utrecht (EWUU) Alliantie (2021- )

Memberships

  • Nederlandse Internisten Vereniging
  • Nederlandse Federatie voor Nefrologie
  • Dutch Cardio Vascular Alliance
  • Regenerative Medicine Crossing Borders
  • European Renal Association
  • ERA- EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group
  • American Society of Nephrology
  • American Heart Association

Fellowship and Awards

Dirkzwager-Assink Award

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)

Research Output (345)

Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease:a study protocol of an evidence map

Colombijn Julia M.T., Idema Demy L., van der Braak Kim, Spijker Rene, Meijvis Sabine C.A., Bots Michiel L., Hooft Lotty, Verhaar Marianne C., Vernooij Robin W.M. 12 Nov 2022, In: Systematic Reviews. 11

A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles

Nguyen Vivian V.T., Ye Shicheng, Gkouzioti Vasiliki, van Wolferen Monique E., Yengej Fjodor Yousef, Melkert Dennis, Siti Sofia, de Jong Bart, Besseling Paul J., Spee Bart, van der Laan Luc J.W., Horland Reyk, Verhaar Marianne C., van Balkom Bas W.M. 1 Nov 2022, In: Journal of Extracellular Vesicles. 11

Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids

Martinez-Silgado Adriana, Yousef Yengej Fjodor A., Puschhof Jens, Geurts Veerle, Boot Charelle, Geurts Maarten H., Rookmaaker Maarten B., Verhaar Marianne C., Beumer Joep, Clevers Hans 16 Sep 2022, In: STAR protocols. 3

A Uremic Pig Model for Peritoneal Dialysis

de Vries Joost C., van Gelder Maaike K., Monninkhof Anneke S., Ahmed Sabbir, Hazenbrink Diënty H.M., Nguyen Tri Q., de Kort Gèrard A.P., Vonken Evert Jan P.A., Vaessen Koen R.D., Joles Jaap A., Verhaar Marianne C., Gerritsen Karin G.F. 14 Sep 2022, In: Toxins. 14

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Lindoso Rafael Soares, Yousef Yengej Fjodor A., Voellmy Franziska, Altelaar Maarten, Mancheño Juncosa Estela, Tsikari Theano, Ammerlaan Carola M.E., Van Balkom Bas W.M., Rookmaaker Maarten B., Verhaar Marianne C., Masereeuw Rosalinde 15 Jul 2022, In: Journal of Nanobiotechnology. 20

Deep learning body-composition analysis of clinically acquired CT-scans estimates creatinine excretion with high accuracy in patients and healthy individuals

Pieters Tobias T., Veldhuis W. B., Moeskops P., de Vos B. D., Verhaar M. C., Haitjema S., Huitema A. D.R., Rookmaaker M. B. 30 May 2022, In: Scientific Reports. 12

Chronic kidney disease and atrial fibrillation:A dangerous combination

Ocak Gurbey, Khairoun Meriem, Khairoun Othman, Bos Willem Jan W, Fu Edouard L, Cramer Maarten J, Westerink Jan, Verhaar Marianne C, Visseren Frank L, Apr 2022, In: PLoS ONE. 17 , p. 1-13

Human bone marrow mononuclear cells do not improve limb perfusion in the hindlimb ischemia model

van Rhijn-Brouwer Femke Christina Ching-Chua, Gremmels Hendrik, den Ouden Krista, Teraa Martin, Fledderus Joost Ougust, Verhaar Marianne Christina 10 Mar 2022, In: Stem Cells and Development. 31 , p. 176-180 5 p.

Substrate Stiffness Determines the Establishment of Apical-Basal Polarization in Renal Epithelial Cells but Not in Tubuloid-Derived Cells

Hagelaars Maria J, Yousef Yengej Fjodor A, Verhaar Marianne C, Rookmaaker Maarten B, Loerakker Sandra, Bouten Carlijn V C 1 Mar 2022, In: Frontiers in bioengineering and biotechnology. 10 , p. 1-10

Nailfold Capillaroscopy in Patients with Peripheral Artery Disease of the Lower Limb (CAPAD study)

Wijnand Joep G J, van Rhijn-Brouwer Femke C C, Spierings Julia, Teraa Martin, de Borst Gert J, Verhaar Marianne C 22 Feb 2022, In: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 63 , p. 900-901 2 p.

All research output

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