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dr. ir. J.P. (Jannie) Wijnen

Associate Professor

  • 7T Group

dr. ir. J.P. (Jannie) Wijnen

Biography

The mission of my research is to use metabolic imaging in the diagnosis and treatment planning of metabolic disorders and cancer. I believe that direct measurement of tissue metabolism in the patient will lead to better understanding of the disease in the individual patient and can therefore faster translate to a change in diagnosis and consequently treatment, to better help the patient. I strive to invent and make available advanced metabolic imaging methods to aid diagnosis and treatment of the most vulnerable group of patients; children with metabolic diseases and solid tumours, who may greatly benefit from non-invasive metabolic characterisation of their disease.

 

I have a background in Biomedical Engineering and obtained my PhD in biomedicine on the topic of magnetic resonance spectroscopy (MRS) of human brain tumours at the Radboud University Nijmegen-Medical Centre. After a short post-doc position at the University Medical Centre Utrecht (UMCU) (Marina van Damma Grant), I obtained the Niels Stensen fellowship which enabled me to work as a postdoc to learn about pre-clinical research in oncology in the In-vivo Cellular and Molecular Imaging Center (ICMIC) from the department of radiology in the Johns Hopkins Medical Institutions, (Baltimore, USA) in 2011. I continued my post-doctoral research on advanced metabolic imaging methods at high magnetic field for human applications in the brain and body in the Leiden University Medical Centre and UMCU in 2012, and since 2014 as Assistant Professor in the high field MR research group in the UCMU. Being part of this group, I have access to a large multidisciplinary team of experts on MRI and unique MRI equipment (7 Tesla MR system, MetaScanner). I guide and supervise master and PhD students in projects that make use of this equipment to study neurological diseases, metabolic diseases and cancer both in adults and children.

Fellowship and Awards

  • Eurostars VM Biopsy! (2019) "Rapid virtual metabolic biopsy for neuroscience and clinical diagnosis"

    other partners:MR Shim GmbH, Multiwave Technologies SA, Wavetronica

    WKZ Research fund 'Non-invasive characterization of paediatric brain tumours using metabolic imaging at high magnetic field' (2018)

    In collaboration with dr. M.H. Lequin, Paediatric (Neuro)Radiologist, Department of Radiology, WKZ/UMCU, dr. J.M. de Bont, Paediatric Neurologist, Department of Neurology, WKZ, dr. S.L.A. Plasschaert, Paediatric Oncologist, PMC

    Eurostars IMAGINE! (2018) 'Real time Intraoperative Head-optimised Magnetic Resonance Imaging (hiMRI) forbrain surgery'

    Other partners: MRCoils, Multiwave Technologies SA, Tesla Engineering Ltd, Princes Maxima Center.

    Alpe d'Huzes grant 'Saving breast cancer patients from ineffective cytotoxic treatment' (2014)
    Other applicants: Prof. dr. M.A.A.J. van den Bosch (department of Radiology UMCU), Prof. dr. H.W.M. van Laarhoven (department of Oncology AMC)

    VENI (NWO) 'Towards non-invasive metabolic imaging of breast cancer staging at 7 Tesla to guide treatments' (2013)
    Momenteel zijn er nauwelijks technieken om effecten van chemotherapie direct in de patiënt te kunnen meten. De onderzoekers gaan impact van therapie bestuderen met Magnetische Resonantie Spectroscopie, zodat vroegtijdig, zonder operaties, de therapie op individuele basis gestuurd kan worden.

    Marina van Damme grant (2010)
    This award has been made possible by a donation from Mrs dr.ir. Marina van Damme (1953). She is a Delft engineering graduate and the first female to gain a PhD at the University of Twente. She has had a distinguished career in science and industry. Marina van Damme wants to enable young female engineering graduates of TU/e to develop and boost their job and career prospects.

    Niels Stensen Fellowship 'Monitoring of response to breast cancer therapy by 31P Magnetic Resonance Spectroscopy' (2010)

    Since the 1960s, the Niels Stensen Fellowship has been awarded annually to outstanding researchers who recently received their PhD to enable them to gain research experience at a top university or institute abroad.The aim of the Niels Stensen Fellowship is to encourage these talented young researchers by means of facilitating their academic research abroad. The Niels Stensen Fellowship Committee would like to be introduced to candidates who have shown academic excellence as well as social commitment. The fellowship is open to all academic disciplines

Research Output (51)

Advanced single voxel <sup>1</sup>H magnetic resonance spectroscopy techniques in humans:Experts' consensus recommendations

Öz Gülin, Deelchand Dinesh K., Wijnen Jannie P., Mlynárik Vladimír, Xin Lijing, Mekle Ralf, Noeske Ralph, Scheenen Tom W.J., Tkáč Ivan, 10 jan 2020, In: NMR in Biomedicine. 18 p.

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Annink Kim, V, Groenendaal Floris, Cohen Daan, van der Aa Niek E., Alderliesten Thomas, Dudink Jeroen, Benders Manon J. N. L., Wijnen Jannie P. 1 jan 2020, In: Pediatric Research. 6 p.

Shortening of apparent transverse relaxation time of inorganic phosphate as a breast cancer biomarker

van der Kemp Wybe J.M., van der Velden Tijl A., Schmitz Alexander M., Gilhuijs Kenneth G., Luijten Peter R., Klomp Dennis W.J., Wijnen Jannie P. 1 okt 2019, In: NMR in Biomedicine. 32 , p. e4011

Contradiction between amide-CEST signal and pH in breast cancer explained with metabolic MRI

Krikken Erwin, van der Kemp Wybe J.M., Khlebnikov Vitaliy, van Dalen Thijs, Los Maartje, van Laarhoven Hanneke W.M., Luijten Peter R., van den Bosch Maurice A.A.J., Klomp Dennis W.J., Wijnen Jannie P. 1 aug 2019, In: NMR in Biomedicine. 32 , p. e4110

Early detection of changes in phospholipid metabolism during neoadjuvant chemotherapy in breast cancer patients using phosphorus magnetic resonance spectroscopy at 7T

Krikken Erwin, van der Kemp Wybe J M, van Diest Paul J, van Dalen Thijs, van Laarhoven Hanneke W M, Luijten Peter R, Klomp Dennis W J, Wijnen Jannie P jun 2019, In: NMR in Biomedicine. 32

Homogeneous B<sub>1 </sub><sup>+</sup> for bilateral breast imaging at 7 T using a five dipole transmit array merged with a high density receive loop array

Krikken Erwin, Steensma Bart R., Voogt Ingmar J., Luijten Peter R., Klomp Dennis W.J., Raaijmakers Alexander J.E., Wijnen Jannie P. feb 2019, In: NMR in Biomedicine. 32 , p. e4039

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

Rumping Lynne, Tessadori Federico, Pouwels Petra J.W., Vringer Esmee, Wijnen Jannie P., Bhogal Alex A., Savelberg Sanne M.C., Duran Karen J., Bakkers Mark J.G., Ramos Rúben J.J., Schellekens Peter A.W., Kroes Hester Y., Klomp Dennis W.J., Black Graeme C.M., Taylor Rachel L., Bakkers Jeroen P.W., Prinsen Hubertus C.M.T., van der Knaap Marjo S., Dansen Tobias B., Rehmann Holger, Zwartkruis Fried J.T., Houwen Roderick H.J., van Haaften Gijs, Verhoeven-Duif Nanda M., Jans Judith J.M., van Hasselt Peter M. 1 jan 2019, In: Human Molecular Genetics. 28 , p. 96-104 9 p.

Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells

Shah Tariq, Krishnamachary Balaji, Wildes Flonne, Wijnen Jannie P., Glunde Kristine, Bhujwalla Zaver M. 1 aug 2018, In: NMR in Biomedicine. 31 , p. e3936

<sup>31</sup>P T<sub>2</sub>s of phosphomonoesters, phosphodiesters, and inorganic phosphate in the human brain at 7T

van der Kemp Wybe J M, Klomp Dennis W J, Wijnen Jannie P 1 jul 2018, In: Magnetic Resonance in Medicine. 80 , p. 29-35 7 p.

Amide chemical exchange saturation transfer at 7T:A possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients

Krikken Erwin, Khlebnikov Vitaliy, Zaiss Moritz, Jibodh Rajni A., van Diest Paul J., Luijten Peter R., Klomp Dennis W.J., van Laarhoven Hanneke W.M., Wijnen Jannie P. 14 jun 2018, In: Breast Cancer Research. 20 , p. 51

All Research Output (51)