dr. G.J.M. (Maeike) Zijlmans

Associate Professor
dr. G.J.M. (Maeike) Zijlmans
  • Neurology & Neurosurgery



Maeike Zijlmans finished her PhD with honors in May 2011 (prof van Huffelen and prof Gotman). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients.  She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery. Another part of the thesis concerns quality of life and coping style in epilepsy.  In 2013 she started her work as clinical researcher at the RMI together with a combined clinical and research position at Epilepsy Institute in the Netherlands Foundation (SEIN). Her research group, consisting of a post-doctoral fellow, 4 PhD students (+1 finished) and several master students, studies HFOs in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and she started up a prospective randomized controlled two-center trial comparing the use of visually identified HFOs to spikes during surgery (the HFO trial). In the mean time the group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis. Her ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Another part of the research group works on the non-invasive identification of HFOs with EEG and MEG so the biomarker can help understand several epileptic disorders and help with finding the diagnosis and treatment in people with epilepsy.

Research line

Diagnostics in epilepsy surgery

Most recent key publications

1: van 't Klooster MA, van Klink NEC, Zweiphenning WJEM, Leijten FSS, Zelmann R, Ferrier CH, van Rijen PC, Otte WM, Braun KPJ, Huiskamp GJM, Zijlmans M. Tailoring epilepsy surgery with fast ripples in the intraoperative electrocorticogram. Ann Neurol. 2017 May;81(5):664-676

2: van 't Klooster MA, van Klink NE, Leijten FS, Zelmann R, Gebbink TA, Gosselaar PH, Braun KP, Huiskamp GJ, Zijlmans M. Residual fast ripples in the intraoperative corticogram predict epilepsy surgery outcome. Neurology 2015;85:120-8.
3: Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.
4: Zijlmans M, Jacobs J, Zelmann R, Dubeau F, Gotman J. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology. 2009
5: Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53.

Fellowship and Awards

1: ZonMW veni personal grant
2: BCRM young talent grant and prize
3: Dutch Epilepsy Foundation research grant (2011, 2015)
4: Hersenstichting Prize for scientific work
5: Amsterdam Neurologists Prize for clinical research
6: Dutch Epilepsy Foundation Reseach prize

Research Output (91)

HFO to Measure Seizure Propensity and Improve Prognostication in Patients With Epilepsy

Jacobs Julia, Zijlmans Maeike 22 okt 2020, In: Epilepsy Currents. 20 , p. 338-347 10 p.

Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery

Demuru Matteo, Zweiphenning Willemiek, van Blooijs Dorien, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Kalitzin Stiliyan 21 okt 2020, In: Journal of Neural Engineering. 17 , p. 1-10

The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery:from group-level to patient-level analysis

Demuru Matteo, Kalitzin Stiliyan, Zweiphenning Willemiek, van Blooijs Dorien, van’t Klooster Maryse, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Braun Kees, Ferrier Cyrille, Gebbink Tineke, Gosselaar Peter, Huiskamp Geertjan, van Klink Nicole, Ophorst Janine, van Rijen Peter, van der Salm Sandra, Winter Anouk Velders de, 4 sep 2020, In: Scientific Reports. 10

High frequency oscillations relate to cognitive improvement after epilepsy surgery in children

Sun Dongqing, van 't Klooster Maryse A., van Schooneveld Monique M.J., Zweiphenning Willemiek J.E.M., van Klink Nicole E.C., Ferrier Cyrille H., Gosselaar Peter H., Braun Kees P.J., Zijlmans Maeike 1 mei 2020, In: Clinical Neurophysiology. 131 , p. 1134-1141 8 p.

The resolution revolution:Comparing spikes and high frequency oscillations in high-density and standard intra-operative electrocorticography of the same patient

Zweiphenning Willemiek J E M, van Diessen Eric, Aarnoutse Erik J, Leijten Frans S S, van Rijen Peter C, Braun Kees P J, Zijlmans Maeike 2 mrt 2020, In: Clinical Neurophysiology. 131 , p. 1040-1043 4 p.

High frequency oscillations in MEG:next steps in source imaging for focal epilepsy

van Klink Nicole, Zijlmans Maeike 1 nov 2019, In: Brain : a journal of neurology. 142 , p. 3318-3320 3 p.

What are you looking at? Unrippling terminology for high frequency activity

Noorlag Lotte, van Klink Nicole, Huiskamp Geertjan, Zijlmans Maeike nov 2019, In: Clinical Neurophysiology. 130 , p. 2132-2133 2 p.

Changing concepts in presurgical assessment for epilepsy surgery

Zijlmans Maeike, Zweiphenning Willemiek, van Klink Nicole okt 2019, In: Nature Reviews Neurology. 15 , p. 594-606 13 p.

Increased gamma and decreased fast ripple connections of epileptic tissue:A high-frequency directed network approach

Zweiphenning Willemiek J E M, Keijzer Hanneke M, van Diessen Eric, van 't Klooster Maryse A, van Klink Nicole E C, Leijten Frans S S, van Rijen Peter C, van Putten Michel J A M, Braun Kees P J, Zijlmans Maeike 22 jul 2019, In: Epilepsia. 60 , p. 1908-1920 13 p.

Simultaneous MEG and EEG to detect ripples in people with focal epilepsy

van Klink Nicole, Mooij Anne, Huiskamp Geertjan, Ferrier Cyrille, Braun Kees, Hillebrand Arjan, Zijlmans Maeike 1 jul 2019, In: Clinical Neurophysiology. 130 , p. 1175-1183 9 p.

All research output

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