dr. G.J.M. (Maeike) Zijlmans

Associate Professor - medical

  • Neurology & Neurosurgery

dr. G.J.M. (Maeike) Zijlmans


Maeike Zijlmans finished her PhD with honors in May 2011 (prof van Huffelen and prof Gotman). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients.  She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery. Another part of the thesis concerns quality of life and coping style in epilepsy.  In 2013 she started her work as clinical researcher at the RMI together with a combined clinical and research position at Epilepsy Institute in the Netherlands Foundation (SEIN). Her research group, consisting of a post-doctoral fellow, 4 PhD students (+1 finished) and several master students, studies HFOs in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and she started up a prospective randomized controlled two-center trial comparing the use of visually identified HFOs to spikes during surgery (the HFO trial). In the mean time the group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis. Her ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Another part of the research group works on the non-invasive identification of HFOs with EEG and MEG so the biomarker can help understand several epileptic disorders and help with finding the diagnosis and treatment in people with epilepsy.

Research line

Diagnostics in epilepsy surgery

Most recent key publications

1: van 't Klooster MA, van Klink NEC, Zweiphenning WJEM, Leijten FSS, Zelmann R, Ferrier CH, van Rijen PC, Otte WM, Braun KPJ, Huiskamp GJM, Zijlmans M. Tailoring epilepsy surgery with fast ripples in the intraoperative electrocorticogram. Ann Neurol. 2017 May;81(5):664-676

2: van 't Klooster MA, van Klink NE, Leijten FS, Zelmann R, Gebbink TA, Gosselaar PH, Braun KP, Huiskamp GJ, Zijlmans M. Residual fast ripples in the intraoperative corticogram predict epilepsy surgery outcome. Neurology 2015;85:120-8.
3: Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.
4: Zijlmans M, Jacobs J, Zelmann R, Dubeau F, Gotman J. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology. 2009
5: Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53.

Fellowship and Awards

  • 1: ZonMW veni personal grant
    2: BCRM young talent grant and prize
    3: Dutch Epilepsy Foundation research grant (2011, 2015)
    4: Hersenstichting Prize for scientific work
    5: Amsterdam Neurologists Prize for clinical research
    6: Dutch Epilepsy Foundation Reseach prize

Research Output (85)

High frequency oscillations in MEG:next steps in source imaging for focal epilepsy

van Klink Nicole, Zijlmans Maeike 1 nov 2019, In: Brain : a journal of neurology. 142 , p. 3318-3320 3 p.

Changing concepts in presurgical assessment for epilepsy surgery

Zijlmans Maeike, Zweiphenning Willemiek, van Klink Nicole okt 2019, In: Nature Reviews Neurology. 15 , p. 594-606 13 p.

Increased gamma and decreased fast ripple connections of epileptic tissue:A high-frequency directed network approach

Zweiphenning Willemiek J E M, Keijzer Hanneke M, van Diessen Eric, van 't Klooster Maryse A, van Klink Nicole E C, Leijten Frans S S, van Rijen Peter C, van Putten Michel J A M, Braun Kees P J, Zijlmans Maeike 22 jul 2019, In: Epilepsia. 60 , p. 1908-1920 13 p.

Simultaneous MEG and EEG to detect ripples in people with focal epilepsy

van Klink Nicole, Mooij Anne, Huiskamp Geertjan, Ferrier Cyrille, Braun Kees, Hillebrand Arjan, Zijlmans Maeike 1 jul 2019, In: Clinical Neurophysiology. 130 , p. 1175-1183 9 p.

Electrocorticographic high gamma language mapping:Mind the pitfalls of comparison with electrocortical stimulation

Mooij A. H., Sterkman L. C.M., Zijlmans M., Huiskamp G. J.M. mei 2018, In: Epilepsy and Behavior. 82 , p. 196-199 4 p.

The relation between cortisol and functional connectivity in people with and without stress-sensitive epilepsy

den Heijer Jonas M., Otte Willem M., van Diessen Eric, van Campen Jolien S., Lorraine Hompe E., Jansen Floor E., Joels Marian, Braun Kees P.J., Sander Josemir W., Zijlmans Maeike 1 jan 2018, In: Epilepsia. 59 , p. 179-189 11 p.

Beamforming applied to surface EEG improves ripple visibility

van Klink Nicole, Mol Arjen, Ferrier Cyrille, Hillebrand Arjan, Huiskamp Geertjan, Zijlmans Maeike 9 nov 2017, In: Clinical Neurophysiology. 129 , p. 101-111 11 p.

Post traumatic stress-sensitive epilepsy

Zijlmans Maeike, van Campen Jolien S., de Weerd A. 1 nov 2017, In: Seizure : the Journal of the British Epilepsy Association. 52 , p. 20-21 2 p.

Physiological Ripples (± 100 Hz) in Spike-Free Scalp EEGs of Children With and Without Epilepsy

Mooij Anne H., Raijmann Renee C.M.A., Jansen Floor E., Braun Kees P.J., Zijlmans Maeike nov 2017, In: Brain Topography. 30 , p. 739-746 8 p.

How to record high-frequency oscillations in epilepsy:A practical guideline

Zijlmans Maeike, Worrell Gregory A., Dümpelmann Matthias, Stieglitz Thomas, Barborica Andrei, Heers Marcel, Ikeda Akio, Usui Naotaka, Le Van Quyen Michel 1 aug 2017, In: Epilepsia. 58 , p. 1305-1315 11 p.

All Research Output (85)