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prof. dr. G.J.M. (Maeike) Zijlmans

prof. dr. G.J.M. (Maeike) Zijlmans

Full Professor
prof. dr. G.J.M. (Maeike) Zijlmans
  • Neurology & Neurosurgery

Research Programs

Brain

Biography

Biography

Maeike Zijlmans is a neurologist and principle investigator at the UMC Utrecht Brain Center and Stichting Epilepsie Instellingen Nederland (SEIN). She finished her PhD with honors in May 2011 (prof van Huffelen, Utrecht, and prof Gotman, Montreal). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients.  She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery. This work ultimately led to the conduct of a prospective randomized controlled trial 'the HFO trial' comparing the use of HFOs to spikes as electrical biomarkers for epileptic tissue during epilepsy surgery. Results are expected to be published in 2022. Another part of the thesis concerned quality of life and coping style in epilepsy.  In 2013 she started her work as clinical researcher. She is now leading the 'epilab' which focusses on advanced technologies to recognize epileptic brain tissue. Her research group consists of a post-doctoral fellow, 7 PhD students (+3 finished) and several master students. She obtained an ERC starting grant in 2019 for the project 'the Core and Effects of Epilepsy'. The group studies how to delineate epileptic brain tissue from healthy cortex with optimal signal recording and analysis in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and by prospectively recording high denisity electrocorticography. The group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis and machine learning. Her ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Part of the research group works on related issues like the non-invasive identification of HFOs with EEG and MEG, and finding alterative biomarkers with metabolic MRI. Allied research focuses on stress-related epilepsy, psychogenic non-epileptic seizures and effect of surgery on patient well being.

Research line

Advance diagnostics for epilepsy surgery

Most recent key publications

1: Zijlmans M, Zweiphenning WJEM, van Klink NEC. Changing concepts in presurgical assessment for epilepsy surgery. Nat Rev Neurol 2019;15:594-606.

2: van 't Klooster MA, van Klink NEC, Zweiphenning WJEM, Leijten FSS, Zelmann R, Ferrier CH, van Rijen PC, Otte WM, Braun KPJ, Huiskamp GJM, Zijlmans M. Tailoring epilepsy surgery with fast ripples in the intraoperative electrocorticogram. Ann Neurol. 2017 May;81(5):664-676

3: Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.

4: Zijlmans M, Jacobs J, Zelmann R, Dubeau F, Gotman J. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology. 2009

5: Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53.

Side Activities

Neurologist at Stichting Epilepsie Instellingen Nederland (SEIN)

Advisor scientific board of EpilepsieNL

Fellowship and Awards

1: ILAE European Young investigators award 2022

2: ERC starting grant 803880

3: For-woman-in-science award LÓreal UNESCO

4: ZonMW veni personal grant

5: BCRM young talent grant and prize

6: Dutch Epilepsy Foundation research grant (2011, 2015)

7: Hersenstichting Prize for scientific work

8: Amsterdam Neurologists Prize for clinical research

9: Dutch Epilepsy Foundation Reseach prize

Research Output (105)

7T metabolic MRI in focal epilepsy

Jacobs S. M., Shams Z., Wiegers E. C., Wijnen J. P., Klomp D. W., Versteeg E., Siero J. C. W., Muhlebner A., Van Hecke W., Robe P. A., Zijlmans M., Van der Kolk A. G. Sep 2022, In: Epilepsia. 63 , p. 34-35

Deep learning and electrocorticography to tailor epilepsy surgery

Hoogteijling S., Schaft E., Huiskamp G., Straumann S., Smits P., Demuru M., van Rijen P., Leijten F., Gebbink T., van Putten M., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 104-104

Dynamic properties of HFOs and spikes in the intra-operative electrocortigram in patients with focal cortical dysplasia

Schaft E., Sun D., van't Klooster M., van Blooijs D., Smits P., Zweiphenning W., Gosselaar P., Ferrier C., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 103-103

Tailored epilepsy surgery with high frequency oscillations versus spikes in intra-operative electrocorticography: Results of the RCT HFO trial

Klooster M. Van ' T., Zweiphenning W., Van Klink N., Leijten F., Ferrier C., Gebbink T., Huiskamp G., Van Zandvoort M., Van Schooneveld M., Bourez M., Goemans S., Straumann S., Van Rijen P., Gosselaar P., Van Eijsden P., Otte W., Van Diessen E., Braun K., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 19-20

The analogy between structural networks obtained from diffusion weighted imaging and effective networks derived from single pulse electrical stimulation in people with epilepsy

Jelsma S., Van Blooijs D., Van Putten M., Raemaekers M., Zijlmans M., Van Klink N. Sep 2022, In: Epilepsia. 63 , p. 50-50

High-frequency oscillations in scalp EEG:A systematic review of methodological choices and clinical findings

Noorlag Lotte, van Klink Nicole E.C., Kobayashi Katsuhiro, Gotman Jean, Braun Kees P.J., Zijlmans Maeike 20 Jan 2022, In: Clinical Neurophysiology. 137 , p. 46-58 13 p.

Deep learning for epileptogenic zone delineation from the invasive EEG:challenges and lookouts

Hoogteijling Sem, Zijlmans Maeike 4 Jan 2022, In: Brain communications. 4 , p. 1-4

Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy:Can They Predict the Success Chance of Hippocampus-Sparing Resections?

Maccabeo Alessandra, van 't Klooster Maryse A, Schaft Eline, Demuru Matteo, Zweiphenning Willemiek, Gosselaar Peter, Gebbink Tineke, Otte Wim M, Zijlmans Maeike 2022, In: Frontiers in Neurology. 13

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse, van Huffelen Alexander, van Klink Nicole, Benders Manon, de Vries Linda, Leijten Frans, Jansen Floor E., Braun Kees, Zijlmans Maeike Nov 2021, In: Epilepsia. 62 , p. 114-115

Editorial:High-Frequency Oscillations in the Hippocampus as Biomarkers of Pathology and Healthy Brain Function

Sarnthein Johannes, Jacobs Julia, Zijlmans Maeike 29 Sep 2021, In: Frontiers in Human Neuroscience. 15 , p. 1-3

All research output

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