dr. G.J.M. (Maeike) Zijlmans Associate Professor - medical
- Neurology & Neurosurgery
Maeike Zijlmans finished her PhD with honors in May 2011 (prof van Huffelen and prof Gotman). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients. She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery. Another part of the thesis concerns quality of life and coping style in epilepsy. In 2013 she started her work as clinical researcher at the RMI together with a combined clinical and research position at Epilepsy Institute in the Netherlands Foundation (SEIN). Her research group, consisting of a post-doctoral fellow, 4 PhD students (+1 finished) and several master students, studies HFOs in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and she started up a prospective randomized controlled two-center trial comparing the use of visually identified HFOs to spikes during surgery (the HFO trial). In the mean time the group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis. Her ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Another part of the research group works on the non-invasive identification of HFOs with EEG and MEG so the biomarker can help understand several epileptic disorders and help with finding the diagnosis and treatment in people with epilepsy.
Diagnostics in epilepsy surgery
Most recent key publications
1: van 't Klooster MA, van Klink NEC, Zweiphenning WJEM, Leijten FSS, Zelmann R, Ferrier CH, van Rijen PC, Otte WM, Braun KPJ, Huiskamp GJM, Zijlmans M. Tailoring epilepsy surgery with fast ripples in the intraoperative electrocorticogram. Ann Neurol. 2017 May;81(5):664-676
2: van 't Klooster MA, van Klink NE, Leijten FS, Zelmann R, Gebbink TA, Gosselaar PH, Braun KP, Huiskamp GJ, Zijlmans M. Residual fast ripples in the intraoperative corticogram predict epilepsy surgery outcome. Neurology 2015;85:120-8.
3: Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.
4: Zijlmans M, Jacobs J, Zelmann R, Dubeau F, Gotman J. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology. 2009
5: Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53.
Fellowship and Awards
1: ZonMW veni personal grant
2: BCRM young talent grant and prize
3: Dutch Epilepsy Foundation research grant (2011, 2015)
4: Hersenstichting Prize for scientific work
5: Amsterdam Neurologists Prize for clinical research
6: Dutch Epilepsy Foundation Reseach prize