dr. ir. J.J.M. (Jaco J.M.) Zwanenburg

dr. ir. J.J.M. (Jaco J.M.) Zwanenburg

Associate Professor
dr. ir. J.J.M. (Jaco J.M.) Zwanenburg



Jaco Zwanenburg studied Applied Physics at the Delft University of Technology (1995 - 2001). He concluded his study with a research project in MRI at Philips Medical Systems, Best. In this project he developed a patented method to use sensitivity encoding from multiple receive coils to reduce artifacts in the reconstructed image caused by the field inhomogeneity and gradient non-linearity of the MR system.

From 2001 until 2005, he did his PhD research at the VU University Medical Center, Amsterdam, with a project on MRI and myocardial tagging to study the dyssynchrony in the mechanical contraction of the human heart.

His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he has developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients.

Side Activities


Fellowship and Awards

ERC starting grant 'Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)' (2013, ERC grant agreement n°337333).

Research Output (139)

Targeting Cerebral Small Vessel Disease With MRI

Zwanenburg Jaco J M, van Osch Matthias J. P. Nov 2017, In: Stroke. 48 , p. 3175-3182 8 p.

Detecting Intracranial Vessel Wall Lesions With 7T-Magnetic Resonance Imaging:Patients With Posterior Circulation Ischemia Versus Healthy Controls

Harteveld Anita A, van der Kolk Anja G, van der Worp H Bart, Dieleman Nikki, Zwanenburg Jaco J M, Luijten Peter R, Hendrikse Jeroen Sep 2017, In: Stroke. 48 , p. 2601-2604

Seven tesla MRI improves detection of focal cortical dysplasia in patients with refractory focal epilepsy

Veersema Tim J, Ferrier Cyrille H, van Eijsden Pieter, Gosselaar Peter H, Aronica Eleonora, Visser Fredy, Zwanenburg Jaco M, de Kort Gerard A P, Hendrikse Jeroen, Luijten Peter R, Braun Kees P J Jun 2017, In: Epilepsia Open. 2 , p. 162-171 10 p.

High-resolution intracranial vessel wall MRI in an elderly asymptomatic population:comparison of 3T and 7T

Harteveld Anita A, van der Kolk Anja G, van der Worp HB, Dieleman Nikki, Siero JCW, Kuijf Hugo J, Frijns CJM, Luijten Peter R, Zwanenburg Jaco J M, Hendrikse J Apr 2017, In: European Radiology. 27 , p. 1585–1595

Endogenous assessment of diffuse myocardial fibrosis in patients with T1ρ -mapping

van Oorschot Joep W M, Güçlü Fatih, de Jong Sanne, Chamuleau Steven A J, Luijten Peter R., Leiner Tim, Zwanenburg Jaco J M 1 Jan 2017, In: Journal of Magnetic Resonance Imaging. 45 , p. 132-138 7 p.

Quantitative T1 mapping under precisely controlled graded hyperoxia at 7T

Bhogal Alex A, Siero JCW, Zwanenburg Jaco, Luijten Peter R, Philippens Marielle EP, Hoogduin Hans 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37 , p. 1461–1469

Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease:A Pilot Study

Bouvy Willem H, Kuijf Hugo J, Zwanenburg Jaco J M, Koek Huiberdina L, Kappelle L Jaap, Luijten Peter R, Ikram M Kamran, Biessels Geert Jan, 2017, In: Journal of Alzheimer's Disease. 57 , p. 705-710 6 p.

Perivascular spaces on 7 Tesla brain MRI are related to markers of small vessel disease but not to age or cardiovascular risk factors

Bouvy Willem H., Zwanenburg Jaco J M, Reinink Rik, Wisse Laura E M, Luijten Peter R., Kappelle L. Jaap, Geerlings Mirjam I., Biessels Geert Jan 1 Oct 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36 , p. 1708-1717 10 p.

Quantification of deep medullary veins at 7 T brain MRI

Kuijf Hugo J., Bouvy Willem H., Zwanenburg Jaco J M, Schultz Tom B Razoux, Viergever Max A., Vincken Koen L., Biessels Geert Jan Oct 2016, In: European Radiology. 26 , p. 3412-3418 7 p.

Cover Image, Volume 29, Issue 9

Bouvy W. H., Geurts L. J., Kuijf H. J., Luijten P. R., Kappelle L. J., Biessels G. J., Zwanenburg J. J M 1 Sep 2016, In: NMR in Biomedicine. 29 , p. 1 1 p.

All research output

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