dr. ir. J.J.M. (Jaco J.M.) Zwanenburg

Associate Professor
dr. ir. J.J.M. (Jaco J.M.) Zwanenburg



Jaco Zwanenburg studied Applied Physics at the Delft University of Technology (1995 - 2001). He concluded his study with a research project in MRI at Philips Medical Systems, Best. In this project he developed a patented method to use sensitivity encoding from multiple receive coils to reduce artifacts in the reconstructed image caused by the field inhomogeneity and gradient non-linearity of the MR system.

From 2001 until 2005, he did his PhD research at the VU University Medical Center, Amsterdam, with a project on MRI and myocardial tagging to study the dyssynchrony in the mechanical contraction of the human heart.

His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he has developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients.

Side Activities


Fellowship and Awards

ERC starting grant 'Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)' (2013, ERC grant agreement n°337333).

Research Output (129)

Assessment of blood flow velocity and pulsatility in cerebral perforating arteries with 7-T quantitative flow MRI

Bouvy W. H., Geurts L. J., Kuijf H. J., Luijten P. R., Kappelle L. J., Biessels G. J., Zwanenburg J. J M 1 sep 2016, In: NMR in Biomedicine. 29 , p. 1295-1304 10 p.

7 tesla T<sub>2</sub>-weighted MRI as a tool to improve detection of focal cortical dysplasia

Veersema Tim J., van Eijsden Pieter, Gosselaar PH, Hendrikse J, Zwanenburg Jaco J M, Spliet Wim G M, Aronica Eleonora, Braun Kees P J, Ferrier Cyrille H. 1 sep 2016, In: Epileptic Disorders. 18 , p. 315-323 9 p.

Myelin contrast across lamina at 7T, ex-vivo and in-vivo dataset

Fracasso Alessio, van Veluw Susanne J, Visser Fredy, Luijten Peter R, Spliet Wim, Zwanenburg Jaco J M, Dumoulin Serge O, Petridou Natalia sep 2016, In: Data in Brief. 8 , p. 990-1003 14 p.

Qualitative evaluation of a high-resolution 3D multi-sequence intracranial vessel wall protocol at 3 tesla MRI

Dieleman Nikki, Yang Wenjie, Van Der Kolk Anja G., Abrigo Jill, Lee Ka Lok, Chu Winnie Chiu Wing, Zwanenburg Jaco J M, Siero JCW, Wong Ka Sing, Hendrikse J, Chen Fiona Xiang Yan 1 aug 2016, In: PLoS ONE [E]. 11

Single Breath-Hold T1ρ-Mapping of the Heart for Endogenous Assessment of Myocardial Fibrosis

Van Oorschot Joep W M, Visser Fredy, Eikendal Anouk L M, Vonken Evert Jan P A, Luijten Peter R., Chamuleau Steven A J, Leiner Tim, Zwanenburg Jaco J M 1 aug 2016, In: Investigative Radiology. 51 , p. 505-512 8 p.

Thinner regions of intracranial aneurysm wall correlate with regions of higher wall shear stress:A 7T MRI study

Blankena R., Kleinloog R., Verweij B. H., Van Ooij P., Ten Haken B., Luijten P. R., Rinkel G. J E, Zwanenburg J. J M 1 jul 2016, In: American Journal of Neuroradiology. 37 , p. 1310-1317 8 p.

Relations between location and type of intracranial atherosclerosis and parenchymal damage

Dieleman Nikki, van der Kolk Anja G, Zwanenburg Jaco Jm, Brundel Manon , Harteveld Anita A, Biessels Geert J, Visser Fredy, Luijten Peter R, Hendrikse J jul 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36 , p. 1271-1280

Automated hippocampal subfield segmentation at 7T MRI

Wisse L. E M, Kuijf H. J., Honingh A. M., Wang H., Pluta J. B., Das S. R., Wolk D. A., Zwanenburg J. J M, Yushkevich P. A., Geerlings M. I. 1 jun 2016, In: American Journal of Neuroradiology. 37 , p. 1050-1057 8 p.

Lines of baillarger in vivo and ex vivo:Myelin contrast across lamina at 7T MRI and histology

Fracasso Alessio, van Veluw Susanne J, Visser Fredy, Luijten Peter R, Spliet Wim, Zwanenburg Jaco J M, Dumoulin Serge O, Petridou Natalia jun 2016, In: NeuroImage. 133 , p. 163–175

Quantitative intracranial atherosclerotic plaque characterization at 7T MRI:An ex vivo study with histologic validation

Harteveld A. A., Denswil N. P., Siero J. C W, Zwanenburg J. J M, Vink A., Pouran B., Spliet W. G M, Klomp D. W J, Luijten P. R., Daemen M. J., Hendrikse J., Van Der Kolk A. G. 1 mei 2016, In: American Journal of Neuroradiology. 37 , p. 802-810 9 p.

All research output

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