prof. dr. P.J. (Paul J.) van Diest

prof. dr. P.J. (Paul J.) van Diest

Full Professor
prof. dr. P.J. (Paul J.) van Diest
  • Department of Pathology

Research Programs

Strategic Program Cancer



Paul J van Diest has been a dedicated cancer researcher since the start of his career, obtaining numerous grants a.o. from the NIH and the Dutch Cancer Society. He studied Medicine, did his PhD and pathology residency at the VU University medical center (VUMC) in Amsterdam. After obtaining his Board certification in Pathology in 1996, he became Consultant Pathologist at the Department of Pathology of the VUMC. In 1999 he was appointed Associate Professor and in 2001 to full Professor. In 2003 he moved to Utrecht to become Head of the Department of Pathology at the University Medical Center Utrecht (UMCU) where he is currently still working. He is Adjunct Professor of Oncology at the Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA. He serves on the editorial board of >20 international journals. He has been active in the board as secretary and president of several international societies. He has published >700 papers in peer reviewed journals, personally supervised 70 PhD theses, and has an H-index of 66. The main theme of his research is finding ways for prevention, optimized diagnosis and cure of breast cancer, both the male and female forms. He is also active in the field of implementing digital pathology.

Side Activities

From all these activitites for the UMC Utrecht  there never is personal income, or - if there is a fee - it is for the department of pathology of Utrecht.


Adjunct Professor of Oncology, Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA

Member of the Breast Cancer Working Group of the University Medical Center Utrecht.

Member of the European Working Group for Breast Screening Pathology

Member of the expert panel quality indicators breast cancer

Member of the Digital Pathology advisory board of Philips and Sectra.

Member of the Board of the Dutch Federation for Medical Scientific Societies

Member of the Program Committee of the Breast Screening Program.

President elect of the European Association of Pathology Chairs and Program Directors

Vice-director of the Pathology Residency Program of the UMC Utrecht

Head of the Utrecht Training program for Experimental Pathobiology


Editorial board activities

World Journal of Surgical Procedures      

Member of the Editorial Board of Recent Patents on Biomarkers

Member of the Editorial Board of the Chinese Journal of Clinicians

Associate editor of BMC Cancer

Member of the Editorial Board of Pathology Research International

Member of the Editorial Board of The Open Plastic Surgery Journal

Member of the Editorial Board of The Open Prostate Journal

Member of the Editorial Board of Laboratory Investigation

Member of the Editorial Board of the Journal of Experimental & Clinical Cancer Research

Member of the Editorial Board of Biotechnic and Histochemistry

Member of the Editorial Board of Analytical and Quantitative Cytology and Histology

Academic Editor of PlosOne

Associate editor of the Journal of Case Reports in Medicine

Member of the Editorial Board of World Journal of Medical Genetics

Member of the Editorial Board of World Journal of Clinical Urology

Member of the Editorial Board of World Journal of Surgical Procedures

Member of the Editorial Board of Current Biomarker Findings


Advisory boards


2005-               Member of the breast cancer advisory board of Astra Zenica

2008-               Member of the Digital Pathology advisory board of Philips.

2013-               Member of the Advisory Council of the Breast Cancer Society Netherlands (BVN)

2014-               Member of the advisory board of PathXL

2015-               Member of the advisory board of Sectra

Invited Speaker on (Inter)National Meetings 121 in 2003-2019: 1 only 2018-9 below for brevity reasons



  1. Sol Goldman Think-Tank Meeting on Artificial Intelligence as Applied to Pancreatic Cancer. Baltimore, MD, USA, April 16, 2018. Invited speaker.

  2. 11th joint meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland. Maastricht, The Netherlands, June 19-22 2018. Invited speaker.

  3. 30th European Congress of Pathology, Bilbao, Spain, September 8-12, 2018. Invited speaker.

  4. Hans Peterse Lecture at the NKI breast cancer symposium 2018. Amsterdam, The Netherlands, October 31, 2018. Invited speaker.

  5. Digital pathology in daily practice: The current status and the future. Utrecht, The Netherlands, November 2 2018. Organizer, speaker.

  6. 84th Annual Meeting of the Swiss Society of Pathology. Lugano, Switzerland, November 10, 2018. Invited speaker.




  7. European Congress of Radiology. Vienna, Austria, Febuary 27-March 3, 2019. Invited speaker.

  8. Artificial Intelligence in 2019: Where we are now. London UK, March 22, 2019. Invited speaker.

  9. 1e Wad 'n Workshop: Mammacarcinoom, Terschelling, The Netherlands, March 24-26. Invited speaker.

  10. European Working Group of Breast Screening Pathologists. Dublin, Ireland, March 29 2019. Invited speaker.

  11. Pathology week. Veenendaal, The Netherlands, April 9-12. Invited speaker.

  12. 5th Digital Pathology & AI congress: USA. NYC, NY, USA. June 13-14, 2019. Invited speaker

Yearly lectures 

1 NVvO Dutch Society of Oncology

2 ODDP, Oncology Drug Development in Practice

3 University of Siena

Contract research

OncoMark Ltd. Dublin, Ireland, Euro 15,000

Samantree Medical SA, Lausanne, Switzerland, Euro 18.000

Fellowship and Awards

Dutch Cancer Society (KWF)

Health Care Efficiency Research Programme of The Netherlands Organization for Health Research and Development (ZonMw)

Research Output (944)

Can automatic image analysis replace the pathologist in cardiac allograft rejection diagnosis?

Veta Mitko, van Diest Paul J, Vink Aryan 21 jun 2021, In: European heart journal. 42 , p. 2370-2372 3 p.

The increasing importance of histologic grading in tailoring adjuvant systemic therapy in 30,843 breast cancer patients

van Dooijeweert C., Baas I. O., Deckers I. A.G., Siesling S., van Diest P. J., van der Wall E. jun 2021, In: Breast Cancer Research and Treatment. 187 , p. 577-586 10 p.

Supplemental Breast MRI for Women with Extremely Dense Breasts:Results of the Second Screening Round of the DENSE Trial

Veenhuizen Stefanie G A, de Lange Stéphanie V, Bakker Marije F, Pijnappel Ruud M, Mann Ritse M, Monninkhof Evelyn M, Emaus Marleen J, de Koekkoek-Doll Petra K, Bisschops Robertus H C, Lobbes Marc B I, de Jong Mathijn D F, Duvivier Katya M, Veltman Jeroen, Karssemeijer Nico, de Koning Harry J, van Diest Paul J, Mali Willem P T M, van den Bosch Maurice A A J, van Gils Carla H, Veldhuis Wouter B, 16 mrt 2021, In: Radiology. 299 , p. 278-286 9 p.

Histopathologische gradering van het mammacarcinoom:GROTE VARIATIE MET GROTE GEVOLGEN?

van Dooijeweert C., Baas I. O., Deckers I. A.G., van der Wall E., van Diest P. J. 19 jan 2021, In: Nederlands Tijdschrift voor Geneeskunde. 164 4 p.

The association of socioeconomic status on treatment strategy in patients with stage I and II breast cancer in the Netherlands

Filipe M. D., Siesling S., Vriens M. R., van Diest P., Witkamp A. J. 2021, In: Breast Cancer Research and Treatment. 189 , p. 541-550 10 p.

Twist activates miR-22 to suppress estrogen receptor alpha in breast cancer

Vesuna Farhad, Lisok Ala, van Diest Paul, Raman Venu 2021, In: Molecular and Cellular Biochemistry. 476 , p. 2295-2306 12 p.

Meta-analysis and cost-effectiveness of ductoscopy, duct excision surgery and MRI for the diagnosis and treatment of patients with pathological nipple discharge

Filipe M D, Patuleia S I S, Vriens M R, van Diest P J, Witkamp A J 2021, In: Breast Cancer Research and Treatment. 186 , p. 285-293 9 p.

Deep learning-based grading of ductal carcinoma in situ in breast histopathology images

Wetstein Suzanne C., Stathonikos Nikolas, Pluim Josien P.W., Heng Yujing J., ter Hoeve Natalie D., Vreuls Celien P.H., van Diest Paul J., Veta Mitko 2021, In: Laboratory Investigation. 101 , p. 525-533 9 p.

Tumor-Infiltrating Lymphocytes in Low-Risk Patients With Breast Cancer Treated With Single-Dose Preoperative Partial Breast Irradiation

Vasmel Jeanine E, Vreuls Celien Ph, Manson Quirine F, Charaghvandi Ramona K, van Gorp Joost, van Leeuwen Am Gijs, van Diest Paul J, Verkooijen Helena M, Desiree van den Bongard H J G 15 dec 2020, In: International Journal of Radiation Oncology Biology Physics. 109 , p. 1325-1331 7 p.

Variation in breast cancer grading:the effect of creating awareness through laboratory-specific and pathologist-specific feedback reports in 16 734 patients with breast cancer

van Dooijeweert Carmen, van Diest Paul J, Baas Inge O, van der Wall Elsken, Deckers Ivette A 1 dec 2020, In: Journal of Clinical Pathology. 73 , p. 793-799 7 p.

All research output

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