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prof. dr. W.A. (Wilton A.) van Klei Full Professor

  • Division of Anesthesiology, Intensive Care and Emergency Medicine
  • Anesthesiology
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Research programs

Biography

Wilton van Klei received his PhD in 2002 and completed his postgraduate training as anesthesiologist in the Netherlands (2006. After that he did a clinical and research fellowship in perioperative medicine (Ottawa, Ontario, 2007). He returned to the Netherlands to complete a fellowship in cardiothoracic anesthesia (2009), including training in TEE. From 2007 till 2012, he was the Medical Director of the Outpatient Preoperative Evaluation Clinic of the UMC Utrecht.
Currently, he is the Chair of the Department of Anesthesiology and the Director Research and Education of the Division of Anesthesiology, Intensive Care and Emergency Medicine of the UMC Utrecht. His interests focus on improving care for high-risk surgical patients, and involve collaborations with cardiologists, surgeons, clinical chemists, and epidemiologists within the UMC Utrecht’s Circulatory Health research programme. He is supervising several PhD students on clinical research projects in the field of cardiovascular perioperative medicine. Most projects aim to unravel further the etiology, detection and treatment of asymptomatic myocardial injury after surgery. He considers hisself a specialist in perioperative medicine.
Perioperative medicine starts before surgery with a preanesthesia assessment and currently often ends with the patient leaving the recovery room, except for a responsibility for postoperative pain management. However, anesthesiologists should be involved not only in pain management, but also in providing postoperative care on general wards, monitoring vital functions and monitoring for complications likely to be related to surgery and anesthesia. In fact, anesthesiologists should extend what they are doing in the operating room to the surgical floor in order to improve patient outcomes. He is working towards this goal by initiating research in those areas where evidence for optimal treatment is absent.

Research Output

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis

Barnes Jonathan, Hunter Jennifer, Harris Steve, Shankar-Hari Manu, Diouf Elisabeth, Jammer Ib, Kalkman Cor, Klein Andrew A., Corcoran Tomas, Dieleman Stefan, Grocott Michael P.W., Mythen Michael G., Myles Paul, Gan Tang Joon, Kurz Andrea, Peyton Phil, Sessler Dan, Tramèr Martin, Cyna Alan, De Oliveira Gildasio S., Wu Christopher, Jensen Mark, Kehlet Henrik, Botti Mari, Boney Oliver, Haller Guy, Grocott Mike, Cook Tim, Fleisher Lee, Neuman Mark, Story David, Gruen Russell, Bampoe Sam, Evered Lis, Scott David, Silbert Brendan, van Dijk Diederik, Chan Matthew, Grocott Hilary, Eckenhoff Rod, Rasmussen Lars, Eriksson Lars, Beattie Scott, Wijeysundera Duminda, Landoni Giovanni, Leslie Kate, Biccard Bruce, Howell Simon, Nagele Peter, van Klei Wilton, Apr 2019 In: British Journal of Anaesthesia. 122, p. 500-508

Association of Overlapping Surgery with Perioperative Outcomes

Sun Eric, Mello Michelle M., Rishel Chris A., Vaughn Michelle T., Kheterpal Sachin, Saager Leif, Fleisher Lee A., Damrose Edward J., Kadry Bassam, Jena Anupam B., Kooij Fabian, Wilczak Janet, Soto Roy, Berris Joshua, Price Zachary, Urman Richard D., Lins Steven, Harris John M., Cummings Kenneth C., Berman Mitchell F., Nanamori Masakatsu, Adelman Bruce T., Wedeven Christopher, Bittner Edward A., LaGorio John, McCormick Patrick J., Tom Simon, Aziz Michael F., Coffman Traci, Ellis Terri A., Molina Susan, Peterson William, Mackey Sean C., Van Klei Wilton A., Mahajan Aman, Jameson Leslie C., Biggs Daniel A., Neuman Mark D., Craft Robert M., Pace Nathan L., Paganelli William C., Durieux Marcel E., Nair Bala J., Wanderer Jonathan P., Miller Scott A., Helsten Daniel L., Turnbull Zachary A., Schonberger Robert B., 26 Feb 2019 In: JAMA - Journal of the American Medical Association. 321, p. 773-785 13 p.

Different methods of modelling intraoperative hypotension and their association with postoperative complications in patients undergoing non-cardiac surgery

Vernooij L. M., van Klei W. A., Machina M., Pasma W., Beattie W. S., Peelen L. M. 1 May 2018 In: British Journal of Anaesthesia. 120, p. 1080-1089 10 p.

Kinetics of troponin I in patients with myocardial injury after noncardiac surgery

Van Waes Judith A R, Peelen Linda M., Kemperman Hans, Grobben Remco B., Nathoe Hendrik M., Van Klei Wilton A. Mar 2017 In: Clinical Chemistry and Laboratory Medicine. 55, p. 586-594 9 p.

Validation of non-invasive arterial pressure monitoring during carotid endarterectomy

Heusdens J F, Lof S, Pennekamp C W A, Specken-Welleweerd J C, de Borst G J, van Klei W A, van Wolfswinkel L, Immink R V 1 Sep 2016 In: British Journal of Anaesthesia. 117, p. 316-323 8 p.

Transforming the learning outcomes of anaesthesiology training into entrustable professional activities

Wisman-Zwarter Nienke, van der Schaaf Marieke, Ten Cate Olle, Jonker Gersten, van Klei Wilton A, Hoff Reinier G 1 Aug 2016 In: European Journal of Anaesthesiology. 33, p. 559-567 9 p.

Re: 'Lost in Translation: Time to Re-evaluate Our Definitions'

Grobben R. B., Nathoe H. M., van Klei W. A., de Borst G. J. Aug 2016 In: European Journal of Vascular and Endovascular Surgery. 52, p. 270 1 p.

One-Year Mortality, Causes of Death, and Cardiac Interventions in Patients with Postoperative Myocardial Injury

van Waes Judith A R, Grobben Remco B, Nathoe Hendrik M , Kemperman Hans, de Borst Gert Jan, Peelen Linda M, van Klei Wilton A, Jul 2016 In: Anesthesia and Analgesia. 123, p. 29-37 9 p.

Clinical Relevance of Cardiac Troponin Assessment in Patients Undergoing Carotid Endarterectomy

Grobben R. B., Vrijenhoek J. E P, Nathoe H. M., Den Ruijter H. M., van Waes J. A R, Peelen L. M., van Klei W. A., de Borst G. J. Apr 2016 In: European Journal of Vascular and Endovascular Surgery. 51, p. 473-480

Response to 'Re: Clinical Relevance of Cardiac Troponin Assessment in Patients Undergoing Carotid Endarterectomy'

Grobben R B, Nathoe H M, van Klei W A, de Borst G J Apr 2016 In: European Journal of Vascular and Endovascular Surgery. 51, p. 607

Fellowship and Awards

2011 Research Award of the International Anesthesia Research Society (IARS)

© 2019  

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