dr. M.A.G. van der Heyden Associate Professor

Department of Medical Physiology

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Circulatory Health

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Biography

Marcel is associate professor in the department of Medical Physiology at the University Medical Center Utrecht, The Netherlands. He obtained his PhD in the field of cancer research at the Utrecht University in 1995. Thereafter he performed two post-docs on stem cell biology and connexins at the Netherlands Institute of Developmental Biology. He entered the field of cardiac arrhythmias in 2000.
Currently, his focus is on cardiac potassium ion channel pharmacology and ion channel trafficking. His research group combines functional electrophysiological methods with cellular and molecular biology, and biochemical methods. He authored more than 120 peer reviewed papers, most of which deal with membrane protein biology and pharmacology including ion channels.

Marcel teaches and writes on scientific integrity and is member of several advisory panels on this subject. Marcel is associate editor on four peer review physiology journals and was secretary of the Dutch Society of Physiology for five years. In 2017/18 he worked as guest-professor at the Department of Pharmacology and Toxicology at Vienna University. Marcel is a passionate teacher of physiology. He obtained his Senior Teaching Qualification in 2018 and is currently coordinator and examiner in the Medical curriculum in the course Circulation 1 and the bachelor Honours Program for medical students.

Keywords:

Cardiac physiology

Potassium ion channels

Cardiac arrhythmia

Ion channel trafficking

Scientific integrity

Research Output

The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on I_K1

Goversen Birgit, van der Heyden Marcel A.G., van Veen Toon A.B., de Boer Teun P. Mar 2018 In: Pharmacology & Therapeutics. 183, p. 127-136

Response to the letter from Warren et al.

Takanari Hiroki, Fontes Magda S.C., Van Der Heyden Marcel A.G., Vos Marc A., Van Veen Toon A.B. 1 Dec 2017 In: Cardiovascular Research. 113, p. 1799-1800 2 p.

High-potency block of Kir4.1 channels by pentamidine: Molecular basis

Aréchiga-Figueroa Iván A, Marmolejo-Murillo Leticia G, Cui Meng, Delgado-Ramírez Mayra, van der Heyden Marcel A G, Sánchez-Chapula José A, Rodríguez-Menchaca Aldo A 15 Nov 2017 In: European Journal of Pharmacology. 815, p. 56-63 8 p.

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function K_IR2.1 channels, but increases channel protein expression

Ji Yuan, Veldhuis Marlieke G., Zandvoort Jantien, Romunde Fee L, Houtman Marien J C, Duran Karen, Van Haaften Gijs, Zangerl-Plessl Eva Maria, Takanari Hiroki, Stary-Weinzinger Anna, Van Der Heyden Marcel A.G. 15 Jul 2017 In: Journal of Biomedical Science. 24

Commentary: Autonomic modulation in patients with heart failure increases beat-to-beat variability of ventricular action potential duration

Van Weperen Valerie Y.H., Vos Marc A., Van der Heyden Marcel A.G. 30 Jun 2017 In: Frontiers in Physiology [E]. 8

Short-term variability of repolarization is superior to other repolarization parameters in the evaluation of diverse antiarrhythmic interventions in the chronic atrioventricular block dog

Bossu Alexandre, Varkevisser Rosanne, Beekman Henriette D.M. , Houtman Marien J C, Van Der Heyden Marcel A.G., Vos Marc A. 1 Jun 2017 In: Journal of Cardiovascular Pharmacology. 69, p. 398-407 10 p.

A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology

Takanari Hiroki, Miwa Keiko, Fu Xian Ming, Nakai Junichi, Ito Akira, Ino Kousuke, Honda Hiroyuki, Tonomura Wataru, Konishi Satoshi, Opthof Tobias, van der Heyden Marcel A G, Kodama Itsuo, Lee Jong Kook 1 Oct 2016 In: Journal of Cellular Physiology. 231, p. 2249-2256 8 p.

Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent

Takanari Hiroki, Bourgonje Vincent J A, Fontes Magda S C, Raaijmakers Antonia J A, Driessen Helen, Jansen John A., Van Der Nagel Roel, Kok Bart, Van Stuijvenberg Leonie, Boulaksil Mohamed, Takemoto Yoshio, Yamazaki Masatoshi, Tsuji Yukiomi, Honjo Haruo, Kamiya Kaichiro, Kodama Itsuo, Anderson Mark E., Van Der Heyden Marcel A G, Van Rijen Harold V M, van Veen AAB, Vos Marc A. 1 Sep 2016 In: Cardiovascular Research. 111, p. 410-421 12 p.

Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation

van der Heyden MAG, Jespersen Thomas 15 Jan 2016 In: European Journal of Pharmacology. 771, p. 56-64 9 p.

Beat-to-beat variability in preload unmasks latent risk of Torsade de Pointes in anesthetized chronic atrioventricular block dogs

Stams Thom R G, Oosterhoff Peter, Heijdel Atty, Dunnink Albert, Beekman Jet D M , van der Nagel Roel, van Rijen Harold V. M. , van der Heyden Marcel A.G. , Vos Marc A. 2016 In: Circulation journal. 80, p. 1336-1345 10 p.

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