dr. M.A.G. van der Heyden Associate Professor

Department of Medical Physiology

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Circulatory Health

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Biography

Marcel is associate professor in the department of Medical Physiology at the University Medical Center Utrecht, The Netherlands. He obtained his PhD in the field of cancer research at the Utrecht University in 1995. Thereafter he performed two post-docs on stem cell biology and connexins at the Netherlands Institute of Developmental Biology. He entered the field of cardiac arrhythmias in 2000.
Currently, his focus is on cardiac potassium ion channel pharmacology and ion channel trafficking. His research group combines functional electrophysiological methods with cellular and molecular biology, and biochemical methods. He authored more than 120 peer reviewed papers, most of which deal with membrane protein biology and pharmacology including ion channels.

Marcel teaches and writes on scientific integrity and is member of several advisory panels on this subject. Marcel is associate editor on four peer review physiology journals and was secretary of the Dutch Society of Physiology for five years. In 2017/18 he worked as guest-professor at the Department of Pharmacology and Toxicology at Vienna University. Marcel is a passionate teacher of physiology. He obtained his Senior Teaching Qualification in 2018 and is currently coordinator and examiner in the Medical curriculum in the course Circulation 1 and the bachelor Honours Program for medical students.

Keywords:

Cardiac physiology

Potassium ion channels

Cardiac arrhythmia

Ion channel trafficking

Scientific integrity

Research Output

Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents

Houtman Marien J C, Chen Xingyu, Qile Muge, Duran Karen, van Haaften Gijs, Stary-Weinzinger Anna, van der Heyden Marcel A G 1 Aug 2019 In: Journal of Cellular and Molecular Medicine. 23, p. 4962-4969 8 p.

LUF7244, an allosteric modulator/activator of K _v11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

Qile Muge, Beekman Henriette D M, Sprenkeler David J, Houtman Marien J C, van Ham W B, Stary-Weinzinger Anna, Beyl Stanislav, Hering Steffen, van den Berg Dirk-Jan, de Lange Elizabeth C M, Heitman Laura H, IJzerman Ad P, Vos Marc A, van der Heyden Marcel A G 24 Jul 2019 In: British Journal of Pharmacology. 176, p. 3871-3885 15 p.

Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification

Qile Muge, Ji Yuan, Houtman Marien J C, Veldhuis Marlieke, Romunde Fee, Kok Bart, van der Heyden Marcel A G 5 Jul 2019 In: Frontiers in Physiology. 10

Sex hormones and jumping heart beats

van der Heyden Marcel A G, Vos Marc A Jun 2019 In: Journal of Cardiovascular Electrophysiology. 30, p. 950-951 2 p.

Computational Identification of Novel Kir6 Channel Inhibitors

Chen Xingyu, Garon Arthur, Wieder Marcus, Houtman Marien J C, Zangerl-Plessl Eva-Maria, Langer Thierry, van der Heyden Marcel A G, Stary-Weinzinger Anna 24 May 2019 In: Frontiers in Pharmacology. 10

Commentary: Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the Trans-Golgi Network in COS-7 Cells

Zangerl-Plessl Eva-Maria, van der Heyden Marcel A G 5 Oct 2018 In: Frontiers in Physiology. 9

Editorial: Ion Channel Trafficking and Cardiac Arrhythmias

van der Heyden Marcel A G, Delisle Brian P, Abriel Hugues 25 Sep 2018 In: Frontiers in Physiology. 9

Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation

Szatmári Viktor, Ji Yuan, Herwijnen Bianca van, Feng Mei, Wang Michael Zhou, Bossu Alexandre, van der Heyden Marcel A.G. 1 Sep 2018 In: Journal of Veterinary Internal Medicine. 32, p. 1549-1554 6 p.

Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs

Bossu Alexandre, Kostense Amée, Beekman Henriette D M, Houtman Marien J C, van der Heyden Marcel A G, Vos Marc A Jul 2018 In: Pharmacological Research. 133, p. 132-140 9 p.

Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Bossu Alexandre, Houtman Marien J C, Meijborg Veronique M F, Varkevisser Rosanne, Beekman Henriette D M, Dunnink Albert, de Bakker Jacques M T, Mollova Nevena, Rajamani Sridharan, Belardinelli Luiz, van der Heyden Marcel A G, Vos Marc A Jun 2018 In: British Journal of Pharmacology. 175, p. 2470-2482 13 p.

All Research Output (125)

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