Seven projects in the Organ-on-Chip Showcases call have been awarded with a grant by Top Sector Life Sciences & Health (LSH). The Top Sector is thus stimulating the development of early phase Organ-on-Chip technology with 2.76 million euros in Public-Private Partnership Allowance. This substantial investment brings together knowledge institutions and companies from the Netherlands and abroad in joint projects. Among these seven projects is the Nano+ project in which the UMC Utrecht Brain Center participates.

The Nano+ project is a public private partnership between TU/e, UMC Utrecht (Jeroen Pasterkamp and Elly Hol) and InnoSer Nederland BV and aims to develop bioreactor technology for measuring electrophysiological activity in ALS patient cell-derived brain organoids. Pasterkamp: “Brain organoids are an important upcoming cellular model for studying brain disease, but measuring neuronal activity in these three-dimensional structures is difficult. With the proposed brain-on-a-chip technology Nano+ will be able to assess changes in brain activity that underlie neurodegenerative diseases such as ALS and that ultimately may be used for drug screening.”

Read more about this project on the Health Holland website.