Epidemiology of sepsis and inflammation
Epidemiology of sepsis and inflammation


This group combines expertise on infections and inflammation in critically ill patients with a strong focus on epidemiological aspects of clinical research, including innovative trial design. Advanced statistical techniques are used to study risk factors and attributable mortality related to (nosocomial) infections as well as specific complications of sepsis. In addition, novel molecular markers are used together with state-of-the-art epidemiological approaches to distinguish true infection from sterile inflammation, allowing for faster and more accurate diagnosis of infection as well as improved prognostication of critically ill patients in the ICU and/or postoperative setting.

Research program

Infection and Immunity


Olaf Cremer


Research interests

We aim to improve understanding of (the epidemiology of) infections occurring in critically ill and/or postoperative patients by advanced mathematical modeling and the use of novel biomarkers.

Specific research topics include:
  • Diagnostic uncertainty and early detection of sepsis
  • Attributable morbidity and mortality of (nosocomial) infections
  • Decision support for diagnosis and treatment of sepsis

Key publications

  1. de Jong, E., et al. (2016). "Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial." Lancet Infect Dis 16(7): 819-827. View
  2. Koster-Brouwer, M. E., et al. (2018). "Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure." Crit Care Med 46(3): 368-374. View
  3. Derde, L. P. G., et al. (2014). "Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial." Lancet Infect Dis 14(1): 31-39. View
  4. Klein Klouwenberg, P. M., et al. (2014). "Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation." Am J Respir Crit Care Med 189(8): 947-955. View
  5. Klein Klouwenberg, P. M., et al. (2013). "Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients." Crit Care Med 41(10): 2373-2378. View

PhD theses

Societal impact of sepsis and inflammation in the ICU and beyond

Marlies Koster-Brouwer

Studying the etiology of complications in sepsis: secondary infections and myocardial injury

Jos Frencken

> See all theses




The Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE) (#602525)

Canadian Institute of Health Research, Strategy for Patient-Oriented Research (CIHR-SPOR)

Innovative Clinical Trials Program (#158584)

Center for Translational Molecular Medicine

MARS & More




European Society of Intensive Care Medicine (ESICM)

Epimed Solutions Award 2019



Molecular Diagnosis and Risk Stratification of Sepsis (MARS) consortium
VIP-study group 
REMAP-CAP study group