Circulatory Health nieuws

Circulatory Health nieuws

First patient-specific zebrafish model for arrhythmogenic cardiomyopathy

The research groups of Jeroen Bakkers and Toon van Veen bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM). They were able to recapitulate the human form of this disease by introducing a genetic mutation called Phospholamban (PLN) p.Arg14del in zebrafish. The cellular changes resulting from the mutation could be recovered using the drug istaroxime. Eventually, the findings – published on 9 December in Nature Communications – may contribute to the understanding of the molecular mechanisms of the PLN mutation and the ways in which the symptoms of ACM can be relieved in patients.

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UMC Utrecht the first hospital in the Netherlands to implant a completely artificial heart

In early November, a patient with severe heart failure was implanted with a total artificial heart at the UMC Utrecht for the first time in The Netherlands.

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Healthcare data offer more knowledge on male-female differences in cardiovascular disease

Men and women may react differently to medication for cardiovascular disease.

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Hugo Kuijf receives Heart Foundation grant for innovative machine learning model

Hugo Kuijf

Hugo Kuijf today receives the Dekker Senior Scientist 2021 grant from the Dutch Heart Foundation for his research that uses self-learning computer algorithms to image damage to the small blood vessels in the brain.

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Gene Tbx5 essential for getting the heart in correct shape during embryonic development

Researchers from the group of Jeroen Bakkers, in collaboration with Leiden University and the Amsterdam UMC, provide a detailed description of cardiac looping during zebrafish embryonic development.

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Bart van der Worp Professor of Acute Neurology

Bart van der Worp has been appointed Professor of Acute Neurology, with a special interest in cerebrovascular diseases, at the Faculty of Medicine of Utrecht University with effect from 1 March 2021.

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Two grants (NWO and ZonMW) for Utrecht researchers


Utrecht researchers Magdalena Harakalova, Frank van Steenbeek, Folkert Asselbergs and Jeroen Bakkers have obtained prestigious funding to further build infrastructure on genetic cardiomyopathies (severe diseases of the cardiac muscle).

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Launch of European research into radiotherapy for cardiac arrhythmias

On June 15th and 16th, the STOPSTORM consortium coordinated by the UMC Utrecht met virtually to discuss early project progress. The project, which officially started on May 1st, will begin researching the use of radiotherapy in treating cardiac arrhythmias. Patients who suffer from life-threatening ventricular tachycardia (VT) are often treated with medication and the implantation of an implantable cardioverter defibrillator that can correct a rapid heart rate with an electric shock.

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Collaborative project of researchers from UMC Utrecht, Hubrecht Institute and Amsterdam UMC receives funding from ZonMw Open Competition

Researchers from the groups of Folkert Asselbergs and Magdalena Harakalova (UMC Utrecht), Jeroen Bakkers (Hubrecht Institute) and Frédéric Vaz (Amsterdam UMC) receive €936.000 from the ZonMw Open Competition for their CONTRACT project. They will study how mutations in the PLN gene affect the energy supply of the heart. The results will contribute to the development of new treatment strategies for heart muscle diseases.

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First successful DCD heart donations in the Netherlands

The UMC Utrecht is the first to have performed DCD heart donation procedures in the Netherlands. This helps more waiting heart patients.

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Working at UMC Utrecht





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