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Circulatory Health nieuws

Circulatory Health nieuws

Global digital health leaders propose framework to enhance research using real-world data

Infographic CODE-EHR

Routinely-collected healthcare data has the potential to improve the lives and wellbeing of patients across the world, through better understanding of disease, and research on existing and new treatments. Presented today at ESC Congress and simultaneously published in The BMJ, Lancet Digital Health and European Heart Journal, an international team propose a framework to improve the integrity and quality of studies using healthcare data, and boost confidence in using the results for clinical decision support.

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Bart Steensma receives prestigious Dekker grant

Bart Steensma

The Heart Foundation has awarded a prestigious Dekker grant to researcher Bart Steensma of UMC Utrecht for research on a radio stethoscope that can be used to measure whether the heart is deteriorating from the outside.

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NWO grant for MRI-guided heart radiotherapy

NWO grant for MRI-guided heart radiotherapy

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Single cell RNA sequensing uncovers new mechanisms of heart disease

Hypertrophic cardiomyopathy is a heart disease that leads to a stressed, swollen heart muscle. Due to a poor understanding of underlying mechanisms, effective clinical treatments are not available. Patients receive generic heart medication and sometimes need open-heart surgery to remove excess tissue. Researchers at the Hubrecht Institute have now successfully applied a new revolutionary technology (scRNA-seq) to uncover underlying disease mechanisms, including specifically those causing the swelling. The extensive “big data” set is a treasure trove of novel observations that give insight in hypertrophic cardiomyopathy and potential new therapeutic venues. The results from this study, done by researchers in the group of Eva van Rooij, were published in the journal Cell Reports on the 10th of May.

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Opening Circulatory health research center with Irene Schouten

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Horizon Europe Project LiverTarget gets funded

Horizon Europe project LiverTarget gets funded

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HEAL - Cardiomyocyte transplantation to induce myocardial regeneration

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First patient-specific zebrafish model for arrhythmogenic cardiomyopathy

The research groups of Jeroen Bakkers and Toon van Veen bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM). They were able to recapitulate the human form of this disease by introducing a genetic mutation called Phospholamban (PLN) p.Arg14del in zebrafish. The cellular changes resulting from the mutation could be recovered using the drug istaroxime. Eventually, the findings – published on 9 December in Nature Communications – may contribute to the understanding of the molecular mechanisms of the PLN mutation and the ways in which the symptoms of ACM can be relieved in patients.

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UMC Utrecht the first hospital in the Netherlands to implant a completely artificial heart

In early November, a patient with severe heart failure was implanted with a total artificial heart at the UMC Utrecht for the first time in The Netherlands.

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Healthcare data offer more knowledge on male-female differences in cardiovascular disease

Men and women may react differently to medication for cardiovascular disease.

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