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Prof.dr.Edward Nieuwenhuis
Prof.dr.Edward Nieuwenhuis

Pediatric gastroenterology lab

Members

Prof. dr. E.S. Nieuwenhuis, MD, PhD (Chair of pediatrics)

Sabine Middendorp, PhD (assistant professor)
Anke van Vugt (technician)
Caroline Wiegerinck, MD (PhD student)
Kerstin Schneeberger, MSc (PhD student)
Layla el Bouazzaoui (student)

Michal Mokry, MD, PhD (senior postdoc)
Claartje Meddens, MD (PhD student)
Sinisa Prelic (student)
Naoual van der Leur (student)

Sabine Fuchs, MD, PhD (pediatrician, fellow metabolic diseases)
Anke van Vugt (technician)
Anneke Monninkhof (student)
Imre Schene (student)

KEY PUBLICATIONS (to be updated)

• Adult stem cells in the small intestine are intrinsically programmed with their location-specific function.
Middendorp S, Schneeberger K, Wiegerinck CL, Mokry M, Akkerman RD, van Wijngaarden S, Clevers H, Nieuwenhuis EE.
Stem Cells. 2014 May;32(5):1083-91.

• Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.
Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H.
Cell Stem Cell. 2013 Dec 5;13(6):653-

• A functional CFTR assay using primary cystic fibrosis intestinal organoids.
Dekkers JF, Wiegerinck CL, de Jonge HR, Bronsveld I, Janssens HM, de Winter-de Groot KM, Brandsma AM, de Jong NW, Bijvelds MJ, Scholte BJ, Nieuwenhuis EE, van den Brink S, Clevers H, van der Ent CK, Middendorp S, Beekman JM.
Nat Med. 2013 Jul;19(7):939-45

• Van Lierop PP, de Haar C, Lindenbergh-Kortleve DJ, Simons-Oosterhuis Y,
van Rijt LS, Lambrecht BN, Escher JC, Samsom JN, Nieuwenhuis EE. T-cell
regulation of neutrophil infiltrate at the early stages of a murine colitis
model. Inflamm Bowel Dis. 2009.

• Brugman S, Liu KY, Lindenbergh-Kortleve D, Samsom JN, Furuta GT,
Renshaw SA, Willemsen R, Nieuwenhuis EE. Oxazolone-Induced
Enterocolitis in Zebrafish Depends on the Composition of the Intestinal
Microbiota. Gastroenterology. 2009.
 

SOCIAL IMPACT

At the crossroads of regenerative medicine and child health Nieuwenhuis aims to develop new treatments and diagnostics for cystic fibrosis and intestinal disease. Together with the Hubrecht Institute this has led to an organoid-based individual patient assay for testing new drugs for cystic fibrosis. The same researchers have succeeded in genetically ‘repairing’ minitiature intestines of cf patients. This holds great promise for innovative treatments for cystic fibrosis.

 

Read the extende press releases and watch the video

http://www.umcutrecht.nl/research/news/2013/12/utrecht-groups-repair-cystic-fibrosis.htm

http://www.hubrecht.eu/newsevents/news/2013/2013-12-05.html

http://www.umcutrecht.nl/zorg/nieuws/2013/05/behandeling-op-maat-voor-cf.htm

VIDEOS

Edward Nieuwenhuis explains the Child Health research program (Dutch with English subtitles)

https://www.youtube.com/watch?v=I2sP7kyT3n4

Research Lecture on Child Health by Edward Nieuwenhuis

http://vimeo.com/38038040