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prof. dr. R.A.H. (Roger) Adan

prof. dr. R.A.H. (Roger) Adan

Full Professor
  • Translational Neuroscience

Research Programs

Brain

Biography

Biography

Roger Adan was trained as a molecular neurobiologist and received his PhD in 1992 on the regulation of vasopressin and oxytocin gene expression. Since 2002 he is full professor in molecular pharmacology. Via his work on melanocortin receptors he became an expert in molecular and neural pathways underlying feeding behavior, obesity and eating disorders. His lab has a strong multidisciplinary character. A variety of strategies (pharmacogenetics, viral vector technology, in vivo electrophysiology, optogenetics and automated behavioral and physiological analysis) is used to unravel mechanism underlying behavior.  The main focus is on feeding, since this is a natural behavior ideally suited to dissect neural circuits that underlie decision making, anxiety, anhedonia, impulsivity and reward seeking.

Personal fellowships and awards

1: NWO-VIDI grant (016.036.322): Role of neuropeptides in disorders of energy balance
2: ZOnMW-TOP grant (40-00812-98-14093): Shining light on loss of control over substance and food intake
3: co-applicant of 4 granted FP7 programs (Nudge-IT, NeuroFast, Full4Health and I.Family)
4: Recipient of the Rudolf Magnus Research Prize 2003
5: Recipient of the Organon prize for pharmacology 2004

Research line

Neural circuits of feeding and related behaviors

Side Activities

Visiting professor University of Gothenburg, Sweden.

Scientific advisor/professor at Rintveld-Altrecht, Zeist

Expert European Autority for Foof safety in Parma, Italy.

Fellowship and Awards

1: NWO-VIDI grant (016.036.322): Role of neuropeptides in disorders of energy balance
2: TI pharma grant T5-210 Rapid in vivo CNS drug target validation and therapeutic potential by RNA-interference PI (and co-applicant on 2 other TI pharma grants)
3:co-applicant of 3 granted FP7 programs (NeuroFast, Full4Health and I.Family)
4: Recipient of the Rudolf Magnus Research Prize 2003
5: Recipient of the Organon prize for pharmacology 2004

Research Output (223)

The continued need for animals to advance brain research

Homberg Judith R et al. 4 aug 2021, In: Neuron. 109 , p. 2374-2379 6 p.

Optimization of whole-brain rabies virus tracing technology for small cell populations

Roelofs Theresia J.M., Menting-Henry Shanice, Gol Lieke M., Speel Annelijn M., Wielenga Vera H., Garner Keith M., Luijendijk Mieneke C.M., Hennrich Alexandru A., Conzelmann Karl Klaus, Adan Roger A.H. 17 mei 2021, In: Scientific Reports. 11

How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020):How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030))

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen J.J.P., Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., van Dam Anne Marie, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernhard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes J.A.G., Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer Jaap, Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi M.B., Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 2 nov 2020, In: Current Biology. 30 , p. 4328-4328 1 p.

How the COVID-19 pandemic highlights the necessity of animal research

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen, Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., Dam Anne Marie van, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes, Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer J., Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi, Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 21 sep 2020, In: Current Biology. 30 , p. R1014-R1018

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Bryois Julien, Skene Nathan G., Hansen Thomas Folkmann, Kogelman Lisette J.A., Watson Hunna J., Liu Zijing, Adan Roger, Alfredsson Lars, Ando Tetsuya, Andreassen Ole, Baker Jessica, Bergen Andrew, Berrettini Wade, Birgegård Andreas, Boden Joseph, Boehm Ilka, Boni Claudette, Boraska Perica Vesna, Brandt Harry, Breen Gerome, Bryois Julien, Buehren Katharina, Bulik Cynthia, Burghardt Roland, Cassina Matteo, Cichon Sven, Clementi Maurizio, Coleman Jonathan, Cone Roger, Courtet Philippe, Crawford Steven, Crow Scott, Crowley James, Danner Unna, Davis Oliver, de Zwaan Martina, Dedoussis George, Degortes Daniela, DeSocio Janiece, Dick Danielle, Dikeos Dimitris, Dina Christian, Dmitrzak-Weglarz Monika, Docampo Martinez Elisa, Duncan Laramie, Kas Martien, Lin Bochao Danae, Luykx Jurjen, Ophoff Roel, de Boer Irene, , , 1 mei 2020, In: Nature Genetics. 52 , p. 482-493 12 p.

Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies

Munn-Chernoff Melissa A., Johnson Emma C., Chou Yi Ling, Coleman Jonathan R.I., Thornton Laura M., Walters Raymond K., Yilmaz Zeynep, Baker Jessica H., Hübel Christopher, Gordon Scott, Medland Sarah E., Watson Hunna J., Gaspar Héléna A., Bryois Julien, Hinney Anke, Leppä Virpi M., Mattheisen Manuel, Ripke Stephan, Yao Shuyang, Giusti-Rodríguez Paola, Hanscombe Ken B., Adan Roger A.H., Alfredsson Lars, Ando Tetsuya, Andreassen Ole A., Berrettini Wade H., Boehm Ilka, Boni Claudette, Boraska Perica Vesna, Buehren Katharina, Burghardt Roland, Cassina Matteo, Cichon Sven, Clementi Maurizio, Cone Roger D., Courtet Philippe, Crow Scott, Crowley James J., Danner Unna N., Davis Oliver S.P., de Zwaan Martina, Dedoussis George, Degortes Daniela, DeSocio Janiece E., Dick Danielle M., Dikeos Dimitris, Kas Martien J.H., Lin Bochao Danae, Luykx Jurjen, Ophoff Roel A., 1 jan 2020, In: Addiction Biology. 26 20 p.

Good taste or gut feeling?:A new method in rats shows oro-sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns

Roelofs Theresia J M, Luijendijk Mieneke C M, van der Toorn Annette, Camps Guido, Smeets Paul A M, Dijkhuizen Rick M, Adan Roger A H 2020, In: International Journal of Eating Disorders. 54 , p. 1116-1126 11 p.

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Lee Phil H., Anttila Verneri, Won Hyejung, Feng Yen-Chen A., Rosenthal Jacob, Zhu Zhaozhong, Tucker-Drob Elliot M., Nivard Michel G., Grotzinger Andrew D., Posthuma Danielle, Wang Meg M-J, Yu Dongmei, Stahl Eli A., Walters Ray-mond K., Anney Richard J. L., Duncan Laramie E., Ge Tian, Adolfsson Rolf, Banaschewski Tobias, Belangero Sintia, Cook Edwin H., Coppola Giovanni, Derks Eske M., Hoekstra Pieter J., Kaprio Jaakko, Keski-Rahkonen Anna, Kirov George, Kranzler Henry R., Luykx Jurjen J., Rohde Luis A., Zai Clement C., Agerbo Esben, Arranz M. J., Asherson Philip, Baekvad-Hansen Marie, Baldursson Gisli, Bellgrove Mark, Belliveau Richard A., Jr., Buitelaar Jan, Burton Christie L., Bybjerg-Grauholm Jonas, Casas Miguel, Cerrato Felecia, Chambert Kimberly, Churchhouse Claire, Gormand Bru, Ophoff Roel A., Adan Roger A. H., Kas Martien J. H., van Os Jim, 12 dec 2019, In: Cell. 179 , p. 1469-1482.e11

Limbic control over the homeostatic need for sodium

Verharen Jeroen P H, Roelofs Theresia J M, Menting-Henry Shanice, Luijendijk Mieneke C M, Vanderschuren Louk J M J, Adan Roger A H 1 dec 2019, In: Scientific Reports. 9

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