prof. dr. J.M. Beekman

prof. dr. J.M. Beekman

Full Professor
prof. dr. J.M. Beekman
  • Pulmonology Research 2
  • Onderzoek



Dr. J.M. Beekman obtained a PhD in molecular immunology in 2004, and performed multiple post docs in molecular and cell biology within various immunological settings. In October 2010, he became principle investigator at the UMC Utrecht, and started a novel translational research line focusing on developing novel therapeutic strategies for cystic fibrosis, a genetic disease characterized by aberrant ion and fluid homeostasis at mucosal surfaces leading to chronic infection and inflammation and early death around the 3rd to 4th decade of life.


‘People with chronic diseases living healthy lives: I strive to create breakthrough solutions for clinical needs of people with chronic diseases by scientific research that focuses on the development of novel diagnostic or therapeutic approaches. This requires a multidisciplinary approach in which basic and clinical research is aligned, and integrated with needs of patients, the private sector and regulatory authorities. Currently, I am particularly proud of leading a team that developed a highly innovative diagnostic assay that enables individualized therapy for people with cystic fibrosis that lead to direct clinical impact for people within 4 years after the initial discovery.’

Side Activities

Professional activities

2021        Co-founder Fair Therapeutics 

2020        Member selection committee for “3V-stimuleringsfonds” UU and UMCU     

2019    Vice-president organizing committee European CF society conference 2022  

2018    PhD Committee and opponent of Franz Shan Brunel, University of Aberdeen, UK 

2017     PhD Committee and opponent of Karen Schelde, University of Aarhus, Denmark 

2017    Consultant at CFF Theratyping workshop  

2016     European CF society basic science working group – vice coordinator 

2016    Grant reviewer Canadian Foundation for Innovation 

2016    Grant reviewer Cystic Fibrosis Research, Inc. (CFRI) 

2016    Grant reviewer German CF society 

2016    Advisor for future funding of UK Cystic Fibrosis Trust (Research Sandpit Workshop, 8-9 Feb) 

2015        Grant reviewer SRC grant application Cystic Fibrosis Trust (UK) 

2015        Avicenna Roadmap Authoring Team – A strategy for in silico clinical trials 

2013 –  Editorial board member of Rare Diseases

2013 –  Editorial board member of PlosOne

2013 –  Annual candidate selection committee for Eureka Institute of Translational Medicine

2010 –   Reviewer for various journals including Cell, Nature Medicine, Nature Communications, PlosOne, Journal of Immunological Methods, Journal of Leukocyte Biology, Molecular Immunology, Journal of Medical Genetics, Journal of Cystic Fibrosis


2019-     UWE, collaboration Utrecht-Wageningen-Eindhoven

2019-     Membership transition-team for animal-free innovation Utrecht

2014 –    European Respiratory Society

2010 –    European Cystic Fibrosis Society

2011 –    Eureka Institute for Translational Medicine

2000 –    Dutch Society of Immunology (NVVI

Research Output (95)

Prediction of Real-World Long-Term Outcomes of People with CF Homozygous for the F508del Mutation Treated with CFTR Modulators

Muilwijk Danya, Bierlaagh Marlou, van Mourik Peter, Kraaijkamp Jasmijn, van der Meer Renske, van den Bor Rutger, Heijerman Harry, Eijkemans René, Beekman Jeffrey, van der Ent Kors 16 dec 2021, In: Journal of Personalized Medicine. 11

Breast development in a 7 year old girl with CF treated with ivacaftor:An indication for personalized dosing?

Jeyaratnam Joshena, van der Meer Renske, Berkers Gitte, Heijerman Harry Gm, Beekman Jeffrey M, van der Ent Cornelis K 23 jun 2021, In: Journal of Cystic Fibrosis. 20 , p. e63-e66

Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation

Berkers Gitte, van der Meer Renske, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Suen Sylvia Wf, Heijerman Harry Gm, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Janssens Hettie M, de Rijke Yolanda B, Kemper E Marleen, Beekman Jeffrey M, van der Ent Cornelis K, de Jonge Hugo R nov 2020, In: Journal of Cystic Fibrosis. 19 , p. 955-961 7 p.

R117H-CFTR function and response to VX-770 correlate with mRNA and protein expression in intestinal organoids

Van Mourik Peter, van Haaren Paul, Kruisselbrink Evelien, Korkmaz Cemil, Janssens Hettie M., de Winter – de Groot Karin M., van der Ent Cornelis K., Hagemeijer Marne C., Beekman Jeffrey M. sep 2020, In: Journal of Cystic Fibrosis. 19 , p. 728-732 5 p.

Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids

Vonk Annelotte M, van Mourik Peter, Ramalho Anabela S, Silva Iris A L, Statia Marvin, Kruisselbrink Evelien, Suen Sylvia W F, Dekkers Johanna F, Vleggaar Frank P, Houwen Roderick H J, Mullenders Jasper, Boj Sylvia F, Vries Robert, Amaral Margarida D, de Boeck Kris, van der Ent Cornelis K, Beekman Jeffrey M 19 jun 2020, In: STAR protocols. 1 31 p.

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Geurts Maarten H., de Poel Eyleen, Amatngalim Gimano D., Oka Rurika, Meijers Fleur M., Kruisselbrink Evelien, van Mourik Peter, Berkers Gitte, de Winter-de Groot Karin M., Michel Sabine, Muilwijk Danya, Aalbers Bente L., Mullenders Jasper, Boj Sylvia F., Suen Sylvia W.F., Brunsveld Jesse E., Janssens Hettie M., Mall Marcus A., Graeber Simon Y., van Boxtel Ruben, van der Ent Cornelis K., Beekman Jeffrey M., Clevers Hans 2 apr 2020, In: Cell stem cell. 26 , p. 503-510.e7

Responsible use of organoids in precision medicine:The need for active participant involvement

Lensink Michael A., Jongsma Karin R., Boers Sarah N., Noordhoek Jacquelien J., Beekman Jeffrey M., Bredenoord Annelien L. apr 2020, In: Development (Cambridge). 147

Intestinal organoids for Cystic Fibrosis research

de Poel E., Lefferts J. W., Beekman J. M. mrt 2020, In: Journal of Cystic Fibrosis. 19 Suppl 1 , p. S60-S64 5 p.

Activating alternative chloride channels to treat CF:Friends or Foes?: Report on the Meeting of the Basic Science Working Group in Dubrovnik, Croatia

Amaral Margarida D., Beekman Jeffrey M. 1 jan 2020, In: Journal of Cystic Fibrosis. 19 , p. 11-15 5 p.

Lumacaftor/ivacaftor in people with cystic fibrosis with an A455E-CFTR mutation

Berkers Gitte, van der Meer Renske, Heijerman Harry, Beekman Jeffrey M, Boj Sylvia F, Vries Robert G J, van Mourik Peter, Doyle Jamie R, Audhya Paul, Yuan Zheng Jason, Kinnman Nils, van der Ent C Kors 2020, In: Journal of Cystic Fibrosis. 20 , p. 761-767 7 p.

All research output

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