prof. dr. J.M. Beekman

Full Professor

  • Pulmonology Research 2
  • Onderzoek

prof. dr. J.M. Beekman


Dr. J.M. Beekman obtained a PhD in molecular immunology in 2004, and performed multiple post docs in molecular and cell biology within various immunological settings. In October 2010, he became principle investigator at the UMC Utrecht, and started a novel translational research line focusing on developing novel therapeutic strategies for cystic fibrosis, a genetic disease characterized by aberrant ion and fluid homeostasis at mucosal surfaces leading to chronic infection and inflammation and early death around the 3rd to 4th decade of life.


‘People with chronic diseases living healthy lives: I strive to create breakthrough solutions for clinical needs of people with chronic diseases by scientific research that focuses on the development of novel diagnostic or therapeutic approaches. This requires a multidisciplinary approach in which basic and clinical research is aligned, and integrated with needs of patients, the private sector and regulatory authorities. Currently, I am particularly proud of leading a team that developed a highly innovative diagnostic assay that enables individualized therapy for people with cystic fibrosis that lead to direct clinical impact for people within 4 years after the initial discovery.’

Side Activities

  • Professional activities

    2019-   Vice-president organizing committee European CF society conference 2022

    2016 – European CF society basic science working group – vice coordinator

    2013 –  Editorial board member of Rare Diseases

    2013 –  Editorial board member of PlosOne

    2013 –  Annual candidate selection committee for Eureka Institute of Translational Medicine

    2010 –   Reviewer for various journals including Cell, Nature Medicine, Nature Communications, PlosOne, Journal of Immunological Methods, Journal of Leukocyte Biology, Molecular Immunology, Journal of Medical Genetics, Journal of Cystic Fibrosis


    2019-     UWE, collaboration Utrecht-Wageningen-Eindhoven

    2019-     Membership transition-team for animal-free innovation Utrecht

    2014 –    European Respiratory Society

    2010 –    European Cystic Fibrosis Society

    2011 –    Eureka Institute for Translational Medicine

    2000 –    Dutch Society of Immunology (NVVI

Research Output (85)

Intestinal organoids for Cystic Fibrosis research

de Poel E., Lefferts J. W., Beekman J. M. mrt 2020, In: Journal of Cystic Fibrosis. 19 Suppl 1 , p. S60-S64 5 p.

Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids

Chen Kevin G., Zhong Pingyu, Zheng Wei, Beekman Jeffrey M. 1 nov 2019, In: Drug Discovery Today. 24 , p. 2126-2138 13 p.

A 'catch-and-release' receptor for the cholera toxin

Mahon Clare S., Wildsmith Gemma C., Haksar Diksha, De Poel Eyleen, Beekman Jeffrey M., Pieters Roland J., Webb Michael E., Turnbull W. Bruce 30 okt 2019, In: Faraday discussions. 219 , p. 112-127 16 p.

High-resolution 3D imaging of fixed and cleared organoids

Dekkers Johanna F., Alieva Maria, Wellens Lianne M., Ariese Hendrikus C.R., Jamieson Paul R., Vonk Annelotte M., Amatngalim Gimano D., Hu Huili, Oost Koen C., Snippert Hugo J.G., Beekman Jeffrey M., Wehrens Ellen J., Visvader Jane E., Clevers Hans, Rios Anne C. 1 jun 2019, In: Nature Protocols. 14 , p. 1756-1771 16 p.

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

Sun Xingshen, Yi Yaling, Yan Ziying, Rosen Bradley H., Liang Bo, Winter Michael C., Evans T. Idil Apak, Rotti Pavana G., Yang Yu, Gray Jaimie S., Park Soo Yeun, Zhou Weihong, Zhang Yulong, Moll Shashanna R., Woody Lisa, Tran Dao M., Jiang Licong, Vonk Annelotte M., Beekman Jeffrey M., Negulescu Paul, Van Goor Fred, Fiorino Dennis F., Gibson-Corley Katherine N., Engelhardt John F. 27 mrt 2019, In: Science Translational Medicine. 11

FcγRIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4

Golebski K., Hoepel W., van Egmond D., de Groot E. J., Amatngalim G. D., Beekman J. M., Fokkens W. J., van Drunen C. M., den Dunnen J. 1 mrt 2019, In: Mucosal immunology. 12 , p. 425-433 9 p.

The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids:a basis for read-through therapies in cystic fibrosis

Clarke Luka A., Awatade Nikhil T., Felício Veronica M., Silva Iris A., Calucho Maite, Pereira Luisa, Azevedo Pilar, Cavaco José, Barreto Celeste, Bertuzzo Carmen, Gartner Silvia, Beekman Jeffrey, Amaral Margarida D. 1 mrt 2019, In: Human Mutation. 40 , p. 326-334 9 p.

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Schutgens Frans, Rookmaaker Maarten B, Margaritis Thanasis, Rios Anne, Ammerlaan Carola, Jansen Jitske, Gijzen Linda, Vormann Marianne, Vonk Annelotte, Viveen Marco, Yengej Fjodor Yousef, Derakhshan Sepide, de Winter-de Groot Karin M, Artegiani Benedetta, van Boxtel Ruben, Cuppen Edwin, Hendrickx Antoni P A, van den Heuvel-Eibrink Marry M, Heitzer Ellen, Lanz Henriette, Beekman Jeffrey, Murk Jean-Luc, Masereeuw Rosalinde, Holstege Frank, Drost Jarno, Verhaar Marianne C, Clevers Hans mrt 2019, In: Nature Biotechnology. 37 , p. 303-313 11 p.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers Gitte, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Dekkers Johanna F, de Winter-de Groot Karin M, Arets Hubertus G M, Marck-van der Wilt Rozemarijn E P, Dijkema Jasper S, Vanderschuren Maaike M, Houwen Roderick H J, Heijerman Harry G M, van de Graaf Eduard A, Elias Sjoerd G, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Bakker Marleen, Janssens Hettie M, van der Meer Renske, Vries Robert G J, Clevers Hans C, de Jonge Hugo R, Beekman Jeffrey M, van der Ent Cornelis K 12 feb 2019, In: Cell Reports. 26 , p. 1701-1708.e3

Strong inhibition of cholera toxin B subunit by affordable, polymer-based multivalent inhibitors

Haksar Diksha, de Poel Eyleen, Quarles van Ufford Linda H C, Bhatia Sumati, Haag Rainer, Beekman Jeffrey M, Pieters Roland J 10 jan 2019, In: Bioconjugate Chemistry. 30 , p. 785-792 8 p.

All Research Output (85)