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prof. dr. J.M. Beekman

Full Professor
prof. dr. J.M. Beekman
  • Pulmonology Research 2
  • Onderzoek

Biography

Biography

Dr. J.M. Beekman obtained a PhD in molecular immunology in 2004, and performed multiple post docs in molecular and cell biology within various immunological settings. In October 2010, he became principle investigator at the UMC Utrecht, and started a novel translational research line focusing on developing novel therapeutic strategies for cystic fibrosis, a genetic disease characterized by aberrant ion and fluid homeostasis at mucosal surfaces leading to chronic infection and inflammation and early death around the 3rd to 4th decade of life.

 

‘People with chronic diseases living healthy lives: I strive to create breakthrough solutions for clinical needs of people with chronic diseases by scientific research that focuses on the development of novel diagnostic or therapeutic approaches. This requires a multidisciplinary approach in which basic and clinical research is aligned, and integrated with needs of patients, the private sector and regulatory authorities. Currently, I am particularly proud of leading a team that developed a highly innovative diagnostic assay that enables individualized therapy for people with cystic fibrosis that lead to direct clinical impact for people within 4 years after the initial discovery.’

Side Activities

Professional activities

2019-   Vice-president organizing committee European CF society conference 2022

2016 – European CF society basic science working group – vice coordinator

2013 –  Editorial board member of Rare Diseases

2013 –  Editorial board member of PlosOne

2013 –  Annual candidate selection committee for Eureka Institute of Translational Medicine

2010 –   Reviewer for various journals including Cell, Nature Medicine, Nature Communications, PlosOne, Journal of Immunological Methods, Journal of Leukocyte Biology, Molecular Immunology, Journal of Medical Genetics, Journal of Cystic Fibrosis

Memberships

2019-     UWE, collaboration Utrecht-Wageningen-Eindhoven

2019-     Membership transition-team for animal-free innovation Utrecht

2014 –    European Respiratory Society

2010 –    European Cystic Fibrosis Society

2011 –    Eureka Institute for Translational Medicine

2000 –    Dutch Society of Immunology (NVVI

Research Output (92)

Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation

Berkers Gitte, van der Meer Renske, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Suen Sylvia Wf, Heijerman Harry Gm, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Janssens Hettie M, de Rijke Yolanda B, Kemper E Marleen, Beekman Jeffrey M, van der Ent Cornelis K, de Jonge Hugo R nov 2020, In: Journal of Cystic Fibrosis. 19 , p. 955-961 7 p.

R117H-CFTR function and response to VX-770 correlate with mRNA and protein expression in intestinal organoids

Van Mourik Peter, van Haaren Paul, Kruisselbrink Evelien, Korkmaz Cemil, Janssens Hettie M., de Winter – de Groot Karin M., van der Ent Cornelis K., Hagemeijer Marne C., Beekman Jeffrey M. sep 2020, In: Journal of Cystic Fibrosis. 19 , p. 728-732 5 p.

Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids

Vonk Annelotte M, van Mourik Peter, Ramalho Anabela S, Silva Iris A L, Statia Marvin, Kruisselbrink Evelien, Suen Sylvia W F, Dekkers Johanna F, Vleggaar Frank P, Houwen Roderick H J, Mullenders Jasper, Boj Sylvia F, Vries Robert, Amaral Margarida D, de Boeck Kris, van der Ent Cornelis K, Beekman Jeffrey M 19 jun 2020, In: STAR protocols. 1 31 p.

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Geurts Maarten H., de Poel Eyleen, Amatngalim Gimano D., Oka Rurika, Meijers Fleur M., Kruisselbrink Evelien, van Mourik Peter, Berkers Gitte, de Winter-de Groot Karin M., Michel Sabine, Muilwijk Danya, Aalbers Bente L., Mullenders Jasper, Boj Sylvia F., Suen Sylvia W.F., Brunsveld Jesse E., Janssens Hettie M., Mall Marcus A., Graeber Simon Y., van Boxtel Ruben, van der Ent Cornelis K., Beekman Jeffrey M., Clevers Hans 2 apr 2020, In: Cell stem cell. 26 , p. 503-510.e7

Responsible use of organoids in precision medicine:The need for active participant involvement

Lensink Michael A., Jongsma Karin R., Boers Sarah N., Noordhoek Jacquelien J., Beekman Jeffrey M., Bredenoord Annelien L. apr 2020, In: Development (Cambridge). 147

Intestinal organoids for Cystic Fibrosis research

de Poel E., Lefferts J. W., Beekman J. M. mrt 2020, In: Journal of Cystic Fibrosis. 19 Suppl 1 , p. S60-S64 5 p.

Activating alternative chloride channels to treat CF:Friends or Foes?: Report on the Meeting of the Basic Science Working Group in Dubrovnik, Croatia

Amaral Margarida D., Beekman Jeffrey M. 1 jan 2020, In: Journal of Cystic Fibrosis. 19 , p. 11-15 5 p.

Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

de Winter-de Groot Karin M, Berkers Gitte, Marck-van der Wilt Rozemarijn E P, van der Meer Renske, Vonk Annelotte, Dekkers Johanna F, Geerdink Margot, Michel Sabine, Kruisselbrink Evelien, Vries Rob, Clevers Hans, Vleggaar Frank P, Elias Sjoerd G, Heijerman Harry G M, van der Ent Cornelis K, Beekman Jeffrey M 14 nov 2019, In: Journal of Cystic Fibrosis. 19 , p. 614-619 6 p.

Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids

Chen Kevin G., Zhong Pingyu, Zheng Wei, Beekman Jeffrey M. 1 nov 2019, In: Drug Discovery Today. 24 , p. 2126-2138 13 p.

A 'catch-and-release' receptor for the cholera toxin

Mahon Clare S., Wildsmith Gemma C., Haksar Diksha, De Poel Eyleen, Beekman Jeffrey M., Pieters Roland J., Webb Michael E., Turnbull W. Bruce 30 okt 2019, In: Faraday discussions. 219 , p. 112-127 16 p.

All research output

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