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prof. dr. J.M. Beekman

Full Professor

  • Pulmonology Research 2
  • Onderzoek

Research Output (85)

Intestinal organoids for Cystic Fibrosis research

de Poel E., Lefferts J. W., Beekman J. M. mrt 2020, In: Journal of Cystic Fibrosis. 19 Suppl 1 , p. S60-S64 5 p.

Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids

Chen Kevin G., Zhong Pingyu, Zheng Wei, Beekman Jeffrey M. 1 nov 2019, In: Drug Discovery Today. 24 , p. 2126-2138 13 p.

A 'catch-and-release' receptor for the cholera toxin

Mahon Clare S., Wildsmith Gemma C., Haksar Diksha, De Poel Eyleen, Beekman Jeffrey M., Pieters Roland J., Webb Michael E., Turnbull W. Bruce 30 okt 2019, In: Faraday discussions. 219 , p. 112-127 16 p.

High-resolution 3D imaging of fixed and cleared organoids

Dekkers Johanna F., Alieva Maria, Wellens Lianne M., Ariese Hendrikus C.R., Jamieson Paul R., Vonk Annelotte M., Amatngalim Gimano D., Hu Huili, Oost Koen C., Snippert Hugo J.G., Beekman Jeffrey M., Wehrens Ellen J., Visvader Jane E., Clevers Hans, Rios Anne C. 1 jun 2019, In: Nature Protocols. 14 , p. 1756-1771 16 p.

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

Sun Xingshen, Yi Yaling, Yan Ziying, Rosen Bradley H., Liang Bo, Winter Michael C., Evans T. Idil Apak, Rotti Pavana G., Yang Yu, Gray Jaimie S., Park Soo Yeun, Zhou Weihong, Zhang Yulong, Moll Shashanna R., Woody Lisa, Tran Dao M., Jiang Licong, Vonk Annelotte M., Beekman Jeffrey M., Negulescu Paul, Van Goor Fred, Fiorino Dennis F., Gibson-Corley Katherine N., Engelhardt John F. 27 mrt 2019, In: Science Translational Medicine. 11

FcγRIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4

Golebski K., Hoepel W., van Egmond D., de Groot E. J., Amatngalim G. D., Beekman J. M., Fokkens W. J., van Drunen C. M., den Dunnen J. 1 mrt 2019, In: Mucosal immunology. 12 , p. 425-433 9 p.

The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids:a basis for read-through therapies in cystic fibrosis

Clarke Luka A., Awatade Nikhil T., Felício Veronica M., Silva Iris A., Calucho Maite, Pereira Luisa, Azevedo Pilar, Cavaco José, Barreto Celeste, Bertuzzo Carmen, Gartner Silvia, Beekman Jeffrey, Amaral Margarida D. 1 mrt 2019, In: Human Mutation. 40 , p. 326-334 9 p.

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Schutgens Frans, Rookmaaker Maarten B, Margaritis Thanasis, Rios Anne, Ammerlaan Carola, Jansen Jitske, Gijzen Linda, Vormann Marianne, Vonk Annelotte, Viveen Marco, Yengej Fjodor Yousef, Derakhshan Sepide, de Winter-de Groot Karin M, Artegiani Benedetta, van Boxtel Ruben, Cuppen Edwin, Hendrickx Antoni P A, van den Heuvel-Eibrink Marry M, Heitzer Ellen, Lanz Henriette, Beekman Jeffrey, Murk Jean-Luc, Masereeuw Rosalinde, Holstege Frank, Drost Jarno, Verhaar Marianne C, Clevers Hans mrt 2019, In: Nature Biotechnology. 37 , p. 303-313 11 p.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers Gitte, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Dekkers Johanna F, de Winter-de Groot Karin M, Arets Hubertus G M, Marck-van der Wilt Rozemarijn E P, Dijkema Jasper S, Vanderschuren Maaike M, Houwen Roderick H J, Heijerman Harry G M, van de Graaf Eduard A, Elias Sjoerd G, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Bakker Marleen, Janssens Hettie M, van der Meer Renske, Vries Robert G J, Clevers Hans C, de Jonge Hugo R, Beekman Jeffrey M, van der Ent Cornelis K 12 feb 2019, In: Cell Reports. 26 , p. 1701-1708.e3

Strong inhibition of cholera toxin B subunit by affordable, polymer-based multivalent inhibitors

Haksar Diksha, de Poel Eyleen, Quarles van Ufford Linda H C, Bhatia Sumati, Haag Rainer, Beekman Jeffrey M, Pieters Roland J 10 jan 2019, In: Bioconjugate Chemistry. 30 , p. 785-792 8 p.