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prof. dr. J.M. Beekman

prof. dr. J.M. Beekman

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Research Output (125)

Targeted Locus Amplification and Haplotyping

Lefferts Juliet W., Boersma Vera, Hagemeijer Marne C., Hajo Karima, Beekman Jeffrey M., Splinter Erik 2023, 2590 , p. 31-48 18 p.

FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes

de Poel E., Spelier S., Hagemeijer M. C., van Mourik P., Suen S. W.F., Vonk A. M., Brunsveld J. E., Ithakisiou G. N., Kruisselbrink E., Oppelaar H., Berkers G., de Winter de Groot K. M., Heida-Michel S., Jans S. R., van Panhuis H., Bakker M., van der Meer R., Roukema J., Dompeling E., Weersink E. J.M., Koppelman G. H., Blaazer A. R., Muijlwijk-Koezen J. E., van der Ent C. K., Beekman J. M. 2023, In: Journal of Cystic Fibrosis. 22 , p. 548-559 12 p.

Redefining Hypo- and Hyper-Responding Phenotypes of CFTR Mutants for Understanding and Therapy

Hillenaar Tamara, Beekman Jeffrey, van der Sluijs Peter, Braakman Ineke Dec 2022, In: International Journal of Molecular Sciences. 23

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

Amatngalim Gimano D, Rodenburg Lisa W, Aalbers Bente L, Raeven Henriette Hm, Aarts Ellen M, Sarhane Dounia, Spelier Sacha, Lefferts Juliet W, Silva Iris Al, Nijenhuis Wilco, Vrendenbarg Sacha, Kruisselbrink Evelien, Brunsveld Jesse E, van Drunen Cornelis M, Michel Sabine, de Winter-de Groot Karin M, Heijerman Harry G, Kapitein Lukas C, Amaral Magarida D, van der Ent Cornelis K, Beekman Jeffrey M Dec 2022, In: Life Science Alliance. 5 , p. 1-14

The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion

Jo Sungwoo, Centeio Raquel, Park Jinhong, Ousingsawat Jiraporn, Jeon Dong kyu, Talbi Khaoula, Schreiber Rainer, Ryu Kunhi, Kahlenberg Kristin, Somoza Veronika, Delpiano Livia, Gray Michael A., Amaral Margarida D., Railean Violeta, Beekman Jeffrey M., Rodenburg Lisa W., Namkung Wan, Kunzelmann Karl Nov 2022, In: FASEB Journal. 36

Drug Repurposing for Cystic Fibrosis:Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids

Rodenburg Lisa W., Delpiano Livia, Railean Violeta, Centeio Raquel, Pinto Madalena C., Smits Shannon M.A., van der Windt Isabelle S., van Hugten Casper F.J., van Beuningen Sam F.B., Rodenburg Remco N.P., van der Ent Cornelis K., Amaral Margarida D., Kunzelmann Karl, Gray Michael A., Beekman Jeffrey M., Amatngalim Gimano D. 21 Oct 2022, In: International Journal of Molecular Sciences. 23

Recurrent respiratory syncytial virus infection in a CD14 deficient patient

Besteman Sjanna B, Phung Emily, Raeven Henriette H M, Amatngalim Gimano D, Rumpret Matevž, Crabtree Juliet, Schepp Rutger M, Rodenburg Lisa W, Siemonsma Susanna G, Verleur Nile, van Slooten Rianne, Duran Karen, van Haaften Gijs, Beekman Jeffrey M, Chang Lauren A, Meyaard Linde, van der Bruggen Tjomme, Berbers Guy A M, Derksen Nicole, Nierkens Stefan, Morabito Kaitlyn M, Ruckwardt Tracy J, Kurt-Jones Evelyn A, Golenbock Douglas, Graham Barney S, Bont Louis J 16 Apr 2022, In: The Journal of infectious diseases. 226 , p. 258-269 12 p.

A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases

Ghigo Alessandra, Murabito Alessandra, Sala Valentina, Pisano Anna Rita, Bertolini Serena, Gianotti Ambra, Caci Emanuela, Montresor Alessio, Premchandar Aiswarya, Pirozzi Flora, Ren Kai, Sala Angela Della, Mergiotti Marco, Richter Wito, de Poel Eyleen, Matthey Michaela, Caldrer Sara, Cardone Rosa A., Civiletti Federica, Costamagna Andrea, Quinney Nancy L., Butnarasu Cosmin, Visentin Sonja, Ruggiero Maria Rosaria, Baroni Simona, Crich Simonetta Geninatti, Ramel Damien, Laffargue Muriel, Tocchetti Carlo G., Levi Renzo, Conti Marco, Lu Xiao Yun, Melotti Paola, Sorio Claudio, De Rose Virginia, Facchinetti Fabrizio, Fanelli Vito, Wenzel Daniela, Fleischmann Bernd K., Mall Marcus A., Beekman Jeffrey, Laudanna Carlo, Gentzsch Martina, Lukacs Gergely L., Pedemonte Nicoletta, Hirsch Emilio 30 Mar 2022, In: Science translational medicine. 14

Mutation-specific reporter for optimization and enrichment of prime editing

Schene I F, Joore I P, Baijens J H L, Stevelink R, Kok G, Shehata S, Ilcken E F, Nieuwenhuis E E S, Bolhuis D P, van Rees R C M, Spelier S A, van der Doef H P J, Beekman J M, Houwen R H J, Nieuwenhuis E E S, Fuchs S A 1 Mar 2022, In: Nature Communications. 13

Forskolin induced swelling (FIS) assay in intestinal organoids to guide eligibility for compassionate use treatment in a CF patient with a rare genotype

Aalbers B L, Brunsveld J E, van der Ent C K, van den Eijnden J C, Beekman J M, Heijerman H G M 30 Jan 2022, In: Journal of Cystic Fibrosis. 21 , p. 254-257 4 p.

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