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prof. dr. R. (Rene) Bernards

prof. dr. R. (Rene) Bernards

Full Professor

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Research Output (41)

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer

Huijberts Sanne C F A, van Geel Robin M J M, van Brummelen Emilie M J, Opdam Frans L, Marchetti Serena, Steeghs Neeltje, Pulleman Saskia, Thijssen Bas, Rosing Hilde, Monkhorst Kim, Huitema Alwin D R, Beijnen Jos H, Bernards René, Schellens Jan H M 1 May 2020, In: Cancer Chemotherapy and Pharmacology. 85 , p. 917-930 14 p.

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

van Geel Robin M J M, van Brummelen Emilie M J, Eskens Ferry A L M, Huijberts Sanne C F A, de Vos Filip Y F L, Lolkema Martijn P J K, Devriese Lot A, Opdam Frans L, Marchetti Serena, Steeghs Neeltje, Monkhorst Kim, Thijssen Bas, Rosing Hilde, Huitema Alwin D R, Beijnen Jos H, Bernards René, Schellens Jan H M 9 Mar 2020, In: British Journal of Cancer. 122 , p. 1166-1174 9 p.

POSEIDON trial phase 1B results:Safety, efficacy and circulating tumor DNA response of the beta isoform-sparing PI3K inhibitor taselisib (GDC-0032) combined with tamoxifen in hormone receptor positive metastatic breast cancer patients

Baird Richard D., van Rossum Annelot G.J., Oliveira Mafalda, Beelen Karin, Gao Meiling, Schrier Mariette, Mandjes Ingrid A.M., Garcia-Corbacho Javier, Vallier Anne Laure, Dougall Greig, van Werkhoven Erik, Linossi Constanza, Kumar Sanjeev, van Tinteren Harm, Callari Maurizio, Beddowes Emma, Perez-Garcia Jose Manuel, Rosing Hilde, Platte Else, Nederlof Petra, Schot Margaret, de Vries Schultink Aurelia, Bernards Rene, Saura Cristina, Gallagher William, Cortes Javier, Caldas Carlos, Linn Sabine C. 15 Nov 2019, In: Clinical Cancer Research. 25 , p. 6598-6605 8 p.

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells

Ressa Anna, Bosdriesz Evert, de Ligt Joep, Mainardi Sara, Maddalo Gianluca, Prahallad Anirudh, Jager Myrthe, de la Fonteijne Lisanne, Fitzpatrick Martin, Groten Stijn, Altelaar A. F. Maarten, Bernards Rene, Cuppen Edwin, Wessels Lodewyk, Heck Albert J. R. Oct 2018, In: Molecular & Cellular Proteomics. 17 , p. 1892-1908

The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

Severson Tesa M, Wolf Denise M., Yau Christina, Peeters Justine K, Wehkam Diederik, Schouten Philip C, Chin Suet-Feung, Majewski Ian J, Michaut Magali, Bosma Astrid J, Pereira Bernard, Bismeijer Tycho, Wessels Lodewyk F A, Caldas Carlos, Bernards René, Simon Iris M, Glas Annuska M., Linn Sabine, Van't Veer Laura J. 25 Aug 2017, In: Breast Cancer Research. 19

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo Carla S, Overmeer René M, Ponsioen Bas, Drost Jarno, Mertens Sander, Verlaan-Klink Ingrid, Gerwen Bastiaan van, van der Ven Marieke, van de Wetering Marc , Egan David A, Bernards René, Clevers Hans, Bos Johannes L, Snippert Hugo J 15 Nov 2016, In: eLife. 5

Loss of ARID1A activates ANXA1, which serves as a predictive biomarker for trastuzumab resistance

Berns Katrien, Sonnenblick Amir, Gennissen Annemiek, Brohée Sylvain, Hijmans E. Marielle, Evers Bastiaan, Fumagalli Debora, Desmedt Christine, Loibl Sibylle, Denkert Carsten, Neven Patrick, Guo Wei, Zhang Fan, Knijnenburg Theo A., Bosse Tjalling, Van Der Heijden Michiel S., Hindriksen Sanne, Nijkamp Wouter, Wessels Lodewyk F A, Joensuu Heikki, Mills Gordon B., Beijersbergen Roderick L., Sotiriou Christos, Bernards René 1 Nov 2016, In: Clinical Cancer Research. 22 , p. 5238-5248 11 p.

FGFR1 is a potential prognostic biomarker and therapeutic target in head and neck squamous cell carcinoma

Koole Koos, Brunen Diede, Van Kempen Pauline M W, Noorlag Rob, De Bree Remco, Lieftink Cor, Van Es Robert J J, Bernards Rene, Willems Stefan M. 1 Aug 2016, In: Clinical Cancer Research. 22 , p. 3884-3893 10 p.

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione Loredana, Gambino Valentina, Raaijmakers Jonne, Schlicker Andreas, Fumagalli Arianna, Russo Mariangela, Villanueva Alberto, Beerling Evelyne, Bartolini Alice, Mollevi David G., El-Murr Nizar, Chiron Marielle, Calvet Loreley, Nicolazzi Céline, Combeau Cécile, Henry Christophe, Simon Iris M., Tian Sun, In 'T Veld Sjors, D'Ario Giovanni, Mainardi Sara, Beijersbergen Roderick L., Lieftink Cor, Linn Sabine, Rumpf-Kienzl Cornelia, Delorenzi Mauro, Wessels Lodewyk, Salazar Ramon, Di Nicolantonio Federica, Bardelli Alberto, Van Rheenen Jacco, Medema René H., Tejpar Sabine, Bernards René 7 Apr 2016, In: Cell. 165 , p. 317-330 14 p.

Equivalence of MammaPrint array types in clinical trials and diagnostics

Beumer Inès, Witteveen Anke, Delahaye Leonie, Wehkamp Diederik, Snel Mireille, Dreezen Christa, Zheng John, Floore Arno, Brink Guido, Chan Bob, Linn Sabine, Bernards Rene, van 't Veer Laura, Glas Annuska M. 22 Mar 2016, In: Breast Cancer Research and Treatment. 156 , p. 279-287 9 p.

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