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dr. M.L. (Marianne) Boes

Associate Professor

  • Laboratory for Translational Immunology (LTI)
  • Immunology research 1
  • Onderzoek

dr. M.L. (Marianne) Boes

Biography

Marianne Boes trained in the USA in immunology and cell biology research (1996-2008). She performed PhD research at Massachusetts Institute of Technology (MIT), at the Koch Institute for integrative Cancer Research under supervision of prof. Jianzhu Chen. Here she studied immunodeficiency mechanisms using mouse models. Postdoctoral work she performed at Harvard Medical School in the laboratory of prof. Hidde Ploegh, where she discovered the rapid and dynamic endosomal remodeling process in dendritic cells that occurs immediately upon antigen-specific T-cell contact (Boes et al, Nature 2002). In 2004, Dr. Boes started her independent research lab at Brigham and Women’s Hospital/Harvard Medical School, financed in part by an NWO-Veni grant in 2004 and a large NIH-RO1 grant that was awarded to her. In 2008, she moved her lab to the UMC-Utrecht. 

  

Boes heads the pediatric immunology laboratory at the Center for Translational Immunology. She published more than 120 articles (H-index approaching 40) in international journals, including Nature, Science, Immunity, J. Exp. Med., Nature Immunology and J. Clin. Invest. She and her group received numerous prestigious national and international grants and awards. Boes serves as associate editor for several journals and is a regular reviewer for most major journals in her field. She is Chair of the Young Academy of the UMC Utrecht and board member of the Center for Unusual Collaborations (as part of the strategic alliance between TU-Eindhoven, Wageningen, Utrecht University and UMC-Utrecht). Boes is Faculty of Medicine-biomedical sciences member of the Education Committee of the Graduate School of Life Sciences (EC-LS), and serves as coordinator of the course 'Advanced Immunology' for PhD students. She is also current member of the I&I graduate school teaching committee, where she chairs the I&I Eijkman seminar committee. She thoroughly enjoys to meet and learn from researchers and societal partners in different fields.

 

The inadequate use of immune pathways can result in disease, such as exemplified in immunodeficiency patients. Boes focuses research on immune pathways that control leukocyte function. Approaches include the genetic screening of primary immunodeficiency patients and study of hemophilia patients receiving live-long supplementation therapy. The goal is to develop new immune tolerance induction protocols, and to apply new immunotherapies for auto inflammatory and autoimmune disorders such as Juvenile idiopathic arthritis (JIA), and pediatric cancers.

 

Research in Boes lab is supported financially by grants from NWO, the European Research Council (ERC), the Lymph&co foundation and various industry partners. Boes collaborates with both basic and clinically oriented investigators at the UMC-Utrecht. Several collaborative projects exist with labs elsewhere in Europe and in the USA.

Side Activities

  • ZonMw member of programma evaluation committee, 2019- current

    ZonMw member of scientific evaluation committee, 2020 - current

    GSLS staf member educational committee (Faculty of Medicine - Biomedical Sciences), 2017- current

    ZonMw member scientific evaluation committee Horizon 2020 grants ERA-NET 2015 and 2016

    NVVI member financial committee 'kascommissie' (Dutch Society for Immunology)

    AAI  member (American Association of Immunologists)

    associate editor and frequent reviewer of  various immunology and cancer-related journals

    2018/2019: member of various PhD thesis defense committees Radboud University, VUMC, AMC and UU

    2016-2019: invited speaker: Boston Children's Hospital; FASEB conference (SRC Immunoreceptors, Colorado); Instituto Gulbenkian de Ciência, Portugal; Charles University Prague PhD conference; European Conference of Immunology; European B cell forum 2018 Landshut Germany, IUIS Beijing (also chair).

    2020: invited speaker: Vienna Medical University, colloquium in pathophysiology, infectiology and immunology; 14th EFIS-EJI Tatra Immunology Conference, September 19-23, 2020; summer school Bonn University Cluster of Excellence; 50th anniversary meeting of the Scandinavian Society for Immunology

     

Fellowship and Awards

  • Boehringer Ingelheim PhD fellowship   1997

    Cancer Research Institute Postdoc   fellowship 2001

    NWO-Veni senior-postdoc fellowship   2004

    Harvard Skin Disease Research Center   grant 2006

    NIH-RO1 grant   AR052810 2007

    ERC-Marie Curie 2010

    MedImmune grant 2011

    Fonds NutsOhra 2012

    NWO investment subsidy medium 2012

    Bayer 2013

    Diabetes Fonds Nederland 2014

    NWO-PhD grant (I&I graduate school UU) 2014

    Fonds NutsOhra 2015

    UU Life Sciences Seed grant 2015

    Bayer 2016

    Sobi 2017

    Nutricia 2018

    Child Health focus grant 2018

    Nutricia 2019

    Lymph&co 2019

    travel awared Beijing IUIS conference 2020

     

     

Research Output (148)

Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity

Jansen AJ Gerard, Spaan Thom, Low Hui Zhi, Di lorio Daniele , van den Brand Judith M A, Tieke Malte, Barendrecht Arjan , Rohn Kerstin, van Amerongen Geert, Stittelaar Koert, Baumgartner Wolfgang , Osterhaus Albert D M E, Kuiken Thijs, Boons Geert-Jan, Huskens Jurriaan , Boes Marianne, Maas Coen, van der Vries Erhard 14 jul 2020, In: Blood Advances. 4 , p. 2967-2978 12 p.

Emerging molecular biomarkers for predicting therapy response in psoriatic arthritis:A review of literature

Pouw Juliëtte, Leijten Emmerik, Radstake Timothy, Boes Marianne 26 nov 2019, In: Clinical Immunology. 211 8 p.

CXCL4 is a driver of cytokine mRNA stability in monocyte-derived dendritic cells

Silva-Cardoso Sandra C., Bekker Cornelis P.J., Boes Marianne, Radstake Timothy R.D.J., Angiolilli Chiara 10 sep 2019, In: Molecular Immunology. 114 , p. 524-534 11 p.

Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation

Rakhshandehroo Maryam, van Eijkeren Robert J., Gabriel Tanit L., de Haar Colin, Gijzel Sanne M.W., Hamers Nicole, Ferraz Maria J., Aerts Johannes M.F.G., Schipper Henk S., van Eijk Marco, Boes Marianne, Kalkhoven Eric 30 apr 2019, In: Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1864 , p. 1157-1167 11 p.

An update on the ‘danger theory’ in inhibitor development in hemophilia A

Schep Sarah J, Boes Marianne L, Schutgens Roger E G, van Vulpen Lize F D 5 apr 2019, In: Expert Review of Hematology. 12 , p. 335-344 10 p.

Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) controls immune synapse stability in human T cells

Janssen Willemijn J.M., Grobarova Valeria, Leleux Jardin, Jongeneel Lieneke, van Gijn Marielle, van Montfrans Joris M., Boes Marianne dec 2018, In: Journal of Allergy and Clinical Immunology. 142 , p. 1947-1955

Nedd4 Binding Protein 1 (N4BP1) and TNFAIP3 Interacting Protein 1 (TNIP1) control MHC-1 display in neuroblastoma

Spel Lotte, Nieuwenhuis Joppe, Haarsma Rianne, Stickel Elmer, Bleijerveld Onno B, Altelaar Maarten, Boelens Jaap Jan, Brummelkamp Thijn R, Nierkens Stefan, Boes Marianne dec 2018, In: Cancer Research. 78 , p. 6621-6631

Cancer immunotherapy:Moving beyond checkpoint inhibition

Boes Marianne 27 nov 2018, In: Oncotarget. 9 , p. 36545-36546 2 p.

NFκB and MHC-1 Interplay in Neuroblastoma and Immunotherapy

Spel Lotte, Schiepers Ariën, Boes Marianne 1 nov 2018, In: Trends in Cancer. 4 , p. 715-717 3 p.

Review of immune tolerance induction in hemophilia A

Schep S J, Schutgens R E G, Fischer K, Boes M L 1 jul 2018, In: Blood Reviews. 32 , p. 326-338

All Research Output (148)