dr. M.L. (Marianne) Boes Associate Professor
- Laboratory for Translational Immunology (LTI)
- Immunology research 1
Marianne Boes trained in the USA in immunology and cell biology research (1996-2008). She performed PhD research at Massachusetts Institute of Technology (MIT), at the Koch Institute for integrative Cancer Research under supervision of prof. Jianzhu Chen. Here she studied immunodeficiency mechanisms using mouse models. Postdoctoral work she performed at Harvard Medical School in the laboratory of prof. Hidde Ploegh, where she discovered the rapid and dynamic endosomal remodeling process in dendritic cells that occurs immediately upon antigen-specific T-cell contact (Boes et al, Nature 2002). In 2004, Dr. Boes started her independent research lab at Brigham and Women’s Hospital/Harvard Medical School, financed in part by an NWO-Veni grant in 2004 and a large NIH-RO1 grant that was awarded to her. In 2008, she moved her lab to the UMC-Utrecht.
Boes heads the immunodeficiency laboratory in the pediatrics department and Laboratory of Translational Immunology. She published over 100 articles (H-index 36) in international journals, including Nature, Science, Immunity, J. Exp. Med., Nature Immunology and J. Clin. Invest. She and her group received numerous prestigious national and international grants and awards. Boes serves as associate editor for several journals and is a regular reviewer for most major journals in her field. She is Faculty of Medicine-biomedical sciences member of the Education Committee of the Graduate School of Life Sciences (EC-LS), and serves as coordinator of the course 'Advanced Immunology' for PhD students. She is also current member of the I&I graduate school teaching committee, where she chairs the I&I Eijkman seminar committee.
The inadequate use of immune pathways can result in disease, such as exemplified in immunodeficiency patients. Boes focuses research on immune pathways that control leukocyte function. Approaches include the genetic screening of primary immunodeficiency patients and study of hemophilia patients receiving live-long supplementation therapy. The goal is to develop new immune tolerance induction protocols, and to apply new immunotherapies for auto inflammatory and autoimmune disorders such as Juvenile idiopathic arthritis (JIA), and pediatric cancers.
Research in Boes lab is supported financially by grants from NWO, the European Research Council (ERC), the Lymph&co foundation and various industry partners. Boes collaborates with both basic and clinically oriented investigators at the UMC-Utrecht. Several collaborative projects exist with labs elsewhere in Europe and in the USA.
ZonMw member of programma evaluation committee, 2019- current
ZonMw member of scientific evaluation committee, 2020 - current
GSLS staf member educational committee (Faculty of Medicine - Biomedical Sciences), 2017- current
ZonMw member scientific evaluation committee Horizon 2020 grants ERA-NET 2015 and 2016
NVVI member financial committee 'kascommissie' (Dutch Society for Immunology)
AAI member (American Association of Immunologists)
associate editor and frequent reviewer of various immunology and cancer-related journals
2018/2019: member of various PhD thesis defense committees Radboud University, VUMC, AMC and UU
2016-2019: invited speaker: Boston Children's Hospital; FASEB conference (SRC Immunoreceptors, Colorado); Instituto Gulbenkian de Ciência, Portugal; Charles University Prague PhD conference; European Conference of Immunology; European B cell forum 2018 Landshut Germany, IUIS Beijing (also chair).
2020: invited speaker: Vienna Medical University, colloquium in pathophysiology, infectiology and immunology; 14th EFIS-EJI Tatra Immunology Conference, September 19-23, 2020; summer school Bonn University Cluster of Excellence; 50th anniversary meeting of the Scandinavian Society for Immunology
Fellowship and Awards
Boehringer Ingelheim PhD fellowship 1997
Cancer Research Institute Postdoc fellowship 2001
NWO-Veni senior-postdoc fellowship 2004
Harvard Skin Disease Research Center grant 2006
NIH-RO1 grant AR052810 2007
ERC-Marie Curie 2010
MedImmune grant 2011
Fonds NutsOhra 2012
NWO investment subsidy medium 2012
Diabetes Fonds Nederland 2014
NWO-PhD grant (I&I graduate school UU) 2014
Fonds NutsOhra 2015
UU Life Sciences Seed grant 2015
Child Health focus grant 2018
travel awared Beijing IUIS conference 2020