dr. M.L. (Marianne) Boes

dr. M.L. (Marianne) Boes

Associate Professor
dr. M.L. (Marianne) Boes
  • Center for Translational Immunology (CTI) Research
  • Onderzoek



Marianne Boes trained in the USA in immunology and cell biology research (1996-2008). She performed PhD research at Massachusetts Institute of Technology (MIT), at the Koch Institute for integrative Cancer Research under supervision of prof. Jianzhu Chen. Here she studied immunodeficiency mechanisms using mouse models. Postdoctoral work she performed at Harvard Medical School in the laboratory of prof. Hidde Ploegh, where she discovered the rapid and dynamic endosomal remodeling process in dendritic cells that occurs immediately upon antigen-specific T-cell contact (Boes et al, Nature 2002). In 2004, Dr. Boes started her independent research lab at Brigham and Women’s Hospital/Harvard Medical School, financed in part by an NWO-Veni grant in 2004 and a large NIH-RO1 grant that was awarded to her. In 2008, she moved her lab to the UMC-Utrecht. 


Boes heads the pediatric immunology laboratory at the UMC Utrecht, embedded in the Center for Translational Immunology. She published more than 120 articles (H-index approaching 40) in international journals, including Nature, Science, Immunity, J. Exp. Med., Nature Immunology and J. Clin. Invest. She and her group received numerous prestigious national and international grants and awards. Boes serves as editor for several peer-reviewed journals and is a regular reviewer for major journals in her field.


She is Chair of the Young Academy of the UMC Utrecht and board member of the Center for Unusual Collaborations (CUCo; working group of the Young Academies of the Strategic Alliance between TU-Eindhoven, Wageningen, Utrecht University and UMC-Utrecht). Boes is Faculty of Medicine-biomedical sciences member of the Education Committee of the Graduate School of Life Sciences (EC-LS), and serves as coordinator of the course 'Advanced Immunology' for PhD students, and the MSc course Logical Argumentation in Science: Publishing, Proposals and Pitching (co-coordinating with Eric Kalkhoven). She is current member of the I&I graduate school teaching committee. She thoroughly enjoys to meet and learn from researchers, patients and societal partners in different fields. She works actively to improve the involvement of patients and their perspectives in translational research.


The inadequate use of immune pathways can result in disease, such as exemplified in primary immunodeficiency patients. Boes focuses her translational research on the control of antigen-specific immune activation. Approaches include the study of immune cell function of patients suffering from autoimmune forms of arthritis, the study of immune tolerance mechanisms in hemophilia A patients receiving live-long supplementation therapy, and discovery of lymphoma-expressed neoantigens in primary tumor tissue to apply in therapeutic vaccination. The overarching goal is to develop new therapies for immune-mediated disorders such as psoriatic arthritis, of hemophilia A patients developing complications (to remove FVIII-neutralizing 'inhibitor' antibodies) and pediatric cancers.


Research in Boes lab is supported financially by grants from NWO, the European Research Council (ERC), the Lymph&co foundation, the strategic alliance TUe, WUR, UU, UMCU (The Power-Of-One project) and  industry partners. Boes collaborates across disciplines with investigators, societal partners and patientgroups at the UMC-Utrecht and beyond. Several collaborative projects exist with labs elsewhere in Europe and in the USA.

Side Activities

Board member of CUCo (working group of the Young Academies of the strategic alliance TUe, WUR, UU, UMCU), 2020- current

ZonMw member of evaluation and monitoring committee COVID19 studies, 2020 - current

ZonMw member of evaluation committee Clinical Fellows program since 2019

DSMB member IDSCOVA mRNA vaccination study LUMC (Establishing the tolerability, safety and immunogenicity of intradermal delivery of a mNRA SARS-CoV-2 vaccine in healthy adults), 2020-2021

GSLS staf member educational committee (Faculty of Medicine - Biomedical Sciences), 2017- current

Member of the NVVI and BSI, Dutch and British Society for Immunology, 2012- current

Editorial Board member: Immunotherapy Advances (Oxford Academic Press), 2019-current

Editorial Board member: Immunology Letters (Elsevier), 2020-current


2018/2021: member of numerous PhD thesis defense committees Radboud University, A-UMC (formerly VUMC, AMC) and UU

2016-2018: invited speaker: Boston Children's Hospital; FASEB conference (SRC Immunoreceptors, Colorado); Instituto Gulbenkian de Ciência, Portugal; Charles University Prague PhD conference; European Conference of Immunology; European B cell forum 2018 Landshut Germany, IUIS Beijing (also session chair)

2020-2022: invited speaker (live and webinar-based): Vienna Medical University, colloquium in pathophysiology, infectiology and immunology; 14th EFIS-EJI Tatra Immunology Conference, September 19-23, 2020; summer school Bonn University Cluster of Excellence; 50th anniversary meeting of the Scandinavian Society for Immunology; Immunometnet, SITC 2021 (annual meeting of the Society for Immuno Therapy of Cancer)


Fellowship and Awards


2022: EWUU-Unusual Collaboration grant; 154.990 euro (co-PI)

2021: Genentech grant 93K (PI)

2021: Actuate grant 200K dollar (PI)

2021: EWUU-Unusual Collaboration grant; 168K (co-PI) 

2021: ARGENX grant: 568K (PI)

2021: JMF-c.h.i.l.d.r.e.n. 50K (co-PI)

2020: travel award Beijing IUIS conference 2K (PI)

2020: Actuate grant 100K dollar (PI)

2019: Lymph&co 385K (PI)

2019: Nutricia 47.5K (co-PI)

2018: Child Health focus grant 15K (co-PI) 

2018: Nutricia 47.5K (co-PI)

2017: Sobi 42.6K (co-PI)

2015: UU Life Sciences Seed grant 100K (co-PI)

2015: Fonds NutsOhra 67K (co-PI)

2014: NWO-PhD grant 250K (I&I graduate school UU)

2014: WKZ Research Foundation 38K (PI)

2014: Diabetes Fonds Nederland 250K (co-PI)

2013: Bayer 574K (co-PI)

2012: NWO investment subsidy medium 586K (co-PI)

2012: Fonds NutsOhra 100K (co-PI)

2011: MedImmune research grant 75K (PI)

2011: Baxalta (now part of Takeda) 273K (co-PI)

2010: ERC-Marie Curie 80K (PI)

2009 WKZ Research Foundation 150K (PI)

2009 UMCU Talent incentive 250K (PI)

2008 WKZ Research Foundation 125K (PI)

2008 Baxalta (now part of Takeda)  230K (co-PI)

2007: NIH-RO1 grant 750K (PI)

2006: Harvard Skin Disease Research Center grant 25K (PI)

2004: NWO-Veni 250K (PI)

2001: Cancer Research Institute/ Irvington fellowship 300K (PI)

1997: Boehringer Ingelheim PhD fellowship 250K (PI)












Research Output (165)

Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells

Pouw Juliëtte N, Olde Nordkamp Michel A M, O'Toole Tom G, Radstake Timothy R D J, Leijten Emmerik F A, Boes Marianne 16 Mar 2022, In: Lupus science & medicine. 9 , p. 1-3

Harnessing immunometabolism for cardiovascular health and cancer therapy

Markovska Angela, Schipper Henk, Boes Marianne 9 Nov 2021, In: Immunotherapy Advances. 1 , p. 1-3

A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections

Koenen Mischa, Bosma Marleen, Roorda Udo, Wopereis Fabienne, Roos Anja, van der Vries Erhard, Bogaert D, Sanders Elisabeth , Boes Marianne, Heidema Jojanneke, van Montfrans JM, Balemans Walter A F, van Holten Thijs C, Verhagen Lilly 29 Oct 2021, In: Clinical and Translational Immunology. 10 10 p.

Immunometabolic factors in adolescent chronic disease are associated with Th1 skewing of invariant Natural Killer T cells

Ververs Francesca, Engelen Suzanne, Nuboer Roos, Vastert SJ, van der Ent Kors , van 't Land Belinda, Garssen Johan, Monaco Claudia, Boes Marianne, Schipper Henk 11 Oct 2021, In: Scientific Reports. 11 11 p.

Role of Regulatory Cells in Immune Tolerance Induction in Hemophilia A

Schep Sarah, Schutgens Roger E, Fischer Kathelijn, Voorberg Jan, Boes Marianne May 2021, In: Hemasphere. 5 9 p.

Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity

Clark Chantal C., Jukema Bernard N., Barendrecht Arjan D., Spanjaard Judith S., Jorritsma Nikita K.N., Smits Simone, de Maat Steven, Seinen Cor W., Verhoef Sandra, Parr Naomi M.J., Sebastian Silvie A.E., Koekman Arnold C., van Wesel Annet C.W., van Goor Harriet M.R., Spijkerman Roy, Bongers Suzanne H., van der Vries Erhard, Nierkens Stefan, Boes Marianne, Koenderman Leo, Kaasjager Karin A.H., Maas Coen, 22 Apr 2021, In: Frontiers in medicine. 8 , p. 1-11

Tissue-resident memory CD8+ T cells from skin differentiate psoriatic arthritis from psoriasis

Leijten Emmerik F, van Kempen Tessa S, Olde Nordkamp Michel A, Pouw Juliette N, Kleinrensink Nienke J, Vincken Nanette L, Mertens Jorre, Balak Deepak M W, Verhagen Fleurieke H, Hartgring Sarita A, Lubberts Erik, Tekstra Janneke, Pandit Aridaman, Radstake Timothy R, Boes Marianne 16 Jan 2021, In: Arthritis & Rheumatology. 73 , p. 1220-1232 13 p.

Upcoming immunotherapeutic combinations for B-cell lymphoma

Greve Patrick, Meyer Wentrup Friederike, Peperzak Victor, Boes Marianne Jan 2021, In: Immunotherapy Advances. 1 14 p.

Revisiting B cell tolerance and autoantibodies in seropositive and seronegative autoimmune rheumatic disease (AIRD)

Pouw J N Juliëtte, Leijten E F A Emmerik, van Laar J M Jacob, Boes M Marianne 15 Nov 2020, In: Clinical and Experimental Immunology. 203 , p. 160-173 14 p.

CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cellsin vitro

Silva-Cardoso Sandra C., Tao Weiyang, Angiolilli Chiara, Lopes Ana P., Bekker Cornelis P. J., Devaprasad Abhinandan, Giovannone Barbara, van Laar Jaap, Cossu Marta, Marut Wioleta, Hack Erik, de Boer Rob J., Boes Marianne, Radstake Timothy R. D. J., Pandit Aridaman 17 Sep 2020, In: Frontiers in Immunology. 11

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet