dr. M. (Marco) Boks

dr. M. (Marco) Boks

Associate Professor - medical
dr. M. (Marco) Boks
  • Psychiatry

Research Programs




Genetic, epigenetic and epidemiological studies of Gene- Environment interplay

The main theme of my research is how our genetic background shapes the influence of the environmental risk for bipolar disorder and schizophrenia. 

 The idea that psychiatric disorders develop as a result of the interaction between genes and environment is generally supported. However methodological challenges of such studies have limited large scale genome wide efforts. Therefore studies that focus on the interaction between environmental risk and genetic background remain timely and necessary.

 However such genetic studies do not take into account  a more subtle but highly relevant molecular mechanisms of interactions between environment and genes that recently is identified as a key mechanism of adaptation. These mechanisms, referred to as epigenetics, are extensive and complex and to date not fully understood. Central to our understanding is that epigenetic mechanisms influences transcription of DNA by modifying access to the DNA sequences. What makes this line of research extra interesting is the potential for pharmaceutical manipulation.

To focus these studies we have chosen cannabis and trauma as a main environmental exposure. 

Specialties: Psychiatry, epigenetics, genetics, bio-informatics


Fellowship and Awards

1:  NARSAD Young Investigator Award 2010
2: Semel Institute of Neuroscience, 2009 Phenomics Travel Award

Research Output (254)

An international research agenda for clozapine-resistant schizophrenia

Luykx Jurjen J, Gonzalez-Diaz Jairo M, Guu Ta-Wei, van der Horst Marte Z, van Dellen Edwin, Boks Marco P, Guloksuz Sinan, DeLisi Lynn E, Sommer Iris E, Cummins Russel, Shiers David, Lee Jimmy, Every-Palmer Susanna, Mhalla Ahmed, Chadly Zohra, Chan Sherry K W, Cotes Robert O, Takahashi Shun, Benros Michael E, Wagner Elias, Correll Christoph U, Hasan Alkomiet, Siskind Dan, Endres Dominique, MacCabe James, Tiihonen Jari 14 Jun 2023, In: The lancet. Psychiatry. 10 , p. 644-652 9 p.

Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders

Boltz Toni, Schwarz Tommer, Bot Merel, Hou Kangcheng, Caggiano Christa, Lapinska Sandra, Duan Chenda, Boks Marco P, Kahn Rene S, Zaitlen Noah, Pasaniuc Bogdan, Ophoff Roel 25 May 2023,

Changes in perfusion, and structure of hippocampal subfields related to cognitive impairment after ECT:A pilot study using ultra high field MRI

Van der A Julia, De Jager Jesca E., van Dellen Edwin, Mandl René C.W., Somers Metten, Boks Marco P.M., Sommer Iris E.C., Nuninga Jasper O. 15 Mar 2023, In: Journal of Affective Disorders. 325 , p. 321-328 8 p.

In vitro modeling of the neurobiological effects of glucocorticoids:A review

Bassil Katherine, Krontira Anthi C., Leroy Thomas, Escoto Alana I.H., Snijders Clara, Pernia Cameron D., Pasterkamp R. Jeroen, de Nijs Laurence, van den Hove Daniel, Kenis Gunter, Boks Marco P., Vadodaria Krishna, Daskalakis Nikolaos P., Binder Elisabeth B., Rutten Bart P.F. Mar 2023, In: Neurobiology of stress. 23 20 p.

Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults

Marchi Mattia, Elkrief Laurent, Alkema Anne, van Gastel Willemijn, Schubart Chris D, van Eijk Kristel R, Luykx Jurjen J, Branje Susan, Mastrotheodoros Stefanos, Galeazzi Gian M, van Os Jim, Cecil Charlotte A, Conrod Patricia J, Boks Marco P Dec 2022, In: Translational Psychiatry. 12 , p. 1-10

Powerful eQTL mapping through low-coverage RNA sequencing

Schwarz Tommer, Boltz Toni, Hou Kangcheng, Bot Merel, Duan Chenda, Loohuis Loes Olde, Boks Marco P, Kahn René S, Ophoff Roel A, Pasaniuc Bogdan 14 Jul 2022, In: HGG advances. 3 , p. 1-12

A computational solution for bolstering reliability of epigenetic clocks:implications for clinical trials and longitudinal tracking

Higgins-Chen Albert T., Thrush Kyra L., Wang Yunzhang, Minteer Christopher J., Kuo Pei Lun, Wang Meng, Niimi Peter, Sturm Gabriel, Lin Jue, Moore Ann Zenobia, Bandinelli Stefania, Vinkers Christiaan H., Vermetten Eric, Rutten Bart P.F., Geuze Elbert, Okhuijsen-Pfeifer Cynthia, van der Horst Marte Z., Schreiter Stefanie, Gutwinski Stefan, Luykx Jurjen J., Picard Martin, Ferrucci Luigi, Crimmins Eileen M., Boks Marco P., Hägg Sara, Hu-Seliger Tina T., Levine Morgan E. Jul 2022, In: Nature Aging. 2 , p. 644-661 18 p.

Samenspel tussen genetische achtergrond en omgevingsfactoren in de psychiatrie:stand van zaken en toekomstperspectief

Rutten B P F, Guloksuz S, Boks M, van Os J, Luykx J J, van Winkel R 10 May 2022, In: Tijdschrift voor Psychiatrie. 64 , p. 321-326 6 p.

Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model

Berdenis van Berlekom Amber, Kübler Raphael, Hoogeboom Jeske W, Vonk Daniëlle, Sluijs Jacqueline A, Pasterkamp R Jeroen, Middeldorp Jinte, Kraneveld Aletta D, Garssen Johan, Kahn René S, Hol Elly M, de Witte Lot D, Boks Marco P 2 May 2022, In: Nutrients. 14 , p. 1-19

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

Gumbs Stephanie B.H., Berdenis van Berlekom Amber, Kübler Raphael, Schipper Pauline J., Gharu Lavina, Boks Marco P., Ormel Paul R., Wensing Annemarie M.J., de Witte Lot D., Nijhuis Monique 16 Apr 2022, In: Viruses. 14 , p. 1-20

All research output

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