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prof. dr. M.J.M. (Marc ) Bonten

Full Professor
prof. dr. M.J.M. (Marc ) Bonten
  • Department of Epidemiology
  • Julius Center Research Program Infectious Diseases

Research Programs

Infection & Immunity

Biography

Biography

Marc Bonten earned his MD (1991) and PhD (“the role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia, 1994) at the Maastricht University Medical School, the Netherlands. He registered as internist in 2000, as infectious disease specialist in 2002 and as clinical microbiologist in 2008, all at the University Medical Center Utrecht, the Netherlands. From 2008 till March 2021 he was head of the Department of Medical Microbiology. Since 2003 he is head of the research group of Infectious Disease Epidemiology of the Julius Center of Health Sciences and Primary Care and professor of molecular epidemiology of infectious diseases. He has been a principal investigator in many large scale epidemiologic studies and investigator-initiated randomized trials of prevention and treatment of infectious diseases. His experience covers the full range of epidemiologic study designs including clinical trials, cohorts, case-control studies and mathematical modelling to study antibiotic resistance and infection prevention. Specific research interests include the epidemiology of antibiotic-resistant bacteria such as VRE, MRSA and MDR Enterobacteriaceae, selective decontamination in intensive care unit patients, prevention of ventilator-associated pneumonia, treatment of community-acquired pneumonia, and prevention and treatment of community-acquired pneumonia, including COVID-19.

Since March 2021 he is coordinator of the H2020-funded project ECRAID-Base. 

Since 2016 he is the Scientific Director of the research theme "Tackling Antimicrobial Resistance" of the Netherlands Centre for One Health (NCOH; www.ncoh.nl).

Since 2017 he is the chairman of the focus area Infection & Immunity at the UMC Utrecht, and board member of the Netherlands Antibiotic Development Platform (NADP; www.nadp.nl).

Side Activities

He acts as paid consultant for Janssen Vaccines (payments to UMC Utrecht) and Merck Sharp & Dohme B.V. (payments to UMC Utrecht).

He has received speakers fee from Takeda (Nov 2019).

He is a member of the expert panel of Netherlands Veterinary Medicines Institute (SDa).

He is a member of the cluster Infectieziektenbestrijding from ZorgOnderzoek Nederland. 

He is a member of the Scientific Advisory Board of GARDP (Global Antibiotic Research & Development Platform).

He is a member of the Independent Data Monitoring Committee of the PSK008 and PSK009 studies on pneumococcal conjugate vaccines from Sanofi Pasteur. 

Since March 2020 he is a member of the national Outbreak Management Team for COVID-19. 

Het UMC Utrecht coordineert voor Nederland de uitvoering van de HERALD studie; A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older een fase2/3 studie. Bonten is principal investigator voor Nederland.

Het UMC Utrecht was van 2008-2014 uitvoerder van de CAPiTA studie en 3 aanverwante observationele studies met een pneumokokkenvaccin. Bonten heeft tot en met 2016 op verzoek van Pfizer voordrachten gehouden over de resultaten van dit onderzoek. Honorering ging naar UMC Utrecht.

Bonten is, namens UMC Utrecht, coordinator van 4 publiek-private samenwerkingen gefinancierd door het Innovative Medicines Initiative (COMBACTE-NET, CARE, MAGNET en CDI) met als doel het klinisch onderzoek van nieuwe geneesmiddelen te verbeteren. Hierin wordt samengewerkt met AstraZeneca, Pfizer, GSK, Basilea, AiCuris, DaVolterra, Janssen, Sanofi, BioMerieux en MSD (www.combacte.com).

Bonten is, namens UMC Utrecht, coordinator van de publieke-private samenwerking gefinancierd door het Innovative Medicine Initiative (VITAL) waarin het effect van leeftijd op vaccin effectiviteit onderzocht wordt. Hierin wordt samengewerkt met Pfizer, GSK, Janssen, Sanofi, BioMerieux en MSD (https://vital-imi.eu/).

Het UMC Utrecht is partner in de publieke-private samenwerking gefinancierd door het Innovative Medicine Initiative (VALUE-Dx) waarin het effect van diagnostiek in de behandeling van luchtweginfecties onderzocht wordt. Hierin wordt samengewerkt met BioMerieux, Abbot, Janssen, BioRad en BD (https://vital-imi.eu/). Bonten is onderzoeksleider van de ADEQUATE studie waarin wordt samengewerkt met BioMerieux.

Het UMC Utrecht heeft samengewertk Atox Bio (2018-2019), Merck (2016-2018), Shionogi (2015) en Summit Therapies (2019-2020) voor site selections voor klinische studies. 

Het UMC Utrecht heeft samengewerkt met Sanofi in de uitvoering van een klinische studie met influenza vaccinatie (2018-2019).

Het UMC Utrecht coordineert de PNEUMO studie, gefinancierd door Merck; een observationele studie om de incidentie van LWI veroorzaakt door pneumokokken in verschillende Europese landen vast te stellen.

 

Fellowship and Awards

He has been (co-)applicant of a large number of national and international research grants. He is a VICI laureate (2006) from the Dutch Science Association, Principal Investigator of the CAPiTA study, coordinator of the EU-funded project R-GNOSIS, scientific coordinator of the IMI-funded consortiums COMBACTE-NET, COMBACTE-CARE and COMBACTE-MAGNET. He is member of the International Trial Steering Committee of the REMAP-CAP study, and coordinator of ECRAID-Base.  


In 2015 he received the ESCMID 2015 Award for Excellence in Clinical Microbiology and Infectious Diseases.

In 2017 he received a honorary fellowship of the Royal College of Physicians of Ireland, and was awarded the ESCMID fellowship.

Research Output (728)

Glycoproteoform Profiles of Individual Patients' Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

Čaval Tomislav, Lin Yu-Hsien, Varkila Meri, Reiding Karli R, Bonten Marc J M, Cremer Olaf L, Franc Vojtech, Heck Albert J R 14 jan 2021, In: Frontiers in Immunology. 11

O-serotype distribution of Escherichia coli bloodstream infection isolates in critically ill patients in The Netherlands

Verboom D M, Varkila M R J, Morrow B, Davies T, Ibarra de Palacios P, Poolman J, Hermans P W M, Dudley E G, Roberts E, Cremer O L, Bonten M J M 2021, In: Vaccine. 39 , p. 1670-1674 5 p.

The leukocyte non-coding RNA landscape in critically ill patients with sepsis

Scicluna Brendon P, Uhel Fabrice, van Vught Lonneke A, Wiewel Maryse A, Hoogendijk Arie J, Baessman Ingelore, Franitza Marek, Nürnberg Peter, Horn Janneke, Cremer Olaf L, Bonten Marc J, Schultz Marcus J, van der Poll Tom, 11 dec 2020, In: eLife. 9 , p. 1-23 23 p.

Evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics

Janssen Axel B, Doorduijn Dennis J, Mills Grant, Rogers Malbert R C, Bonten Marc J M, Rooijakkers Suzan H M, Willems Rob J L, Bengoechea Jose A, van Schaik Willem 2 nov 2020, In: Antimicrobial Agents and Chemotherapy. 65 , p. 1-15

The burden of bacteremic and non-bacteremic Gram-negative infections:a prospective multicenter cohort study in a low-resistance country

Deelen J W Timotëus, Rottier Wouter C, van Werkhoven Cornelis H, Woudt Sjoukje H S, Buiting Anton G M, Dorigo-Zetsma J Wendelien, Kluytmans Jan A J W, van der Linden Paul D, Thijsen Steven F T, Vlaminckx Bart J M, Weersink Annemarie J L, Ammerlaan Heidi S M, Bonten Marc J M 5 okt 2020, In: The Journal of Infection. 81 , p. 895-901 7 p.

Anticoagulant interventions in hospitalized patients with COVID-19:A scoping review of randomized controlled trials and call for international collaboration

Tritschler Tobias, Mathieu Marie-Eve, Skeith Leslie, Rodger Marc, Middeldorp Saskia, Brighton Timothy, Sandset Per Morten, Kahn Susan R, Angus Derek C, Blondon Marc, Bonten Marc J, Cattaneo Marco, Cushman Mary, Derde Lennie P G, DeSancho Maria T, Diehl Jean-Luc, Goligher Ewan, Jilma Bernd, Jüni Peter, Lawler Patrick R, Marietta Marco, Marshall John C, McArthur Colin, Miranda Carlos Henrique, Mirault Tristan, Morici Nuccia, Perepu Usha, Schörgenhofer Christian, Sholzberg Michelle, Spyropoulos Alex C, Webb Steve A, Zarychanski Ryan, Zuily Stéphane, Le Gal Grégoire, 5 sep 2020, In: Journal of thrombosis and haemostasis : JTH. 18 , p. 2958-2967 10 p.

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19:The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

Angus Derek C, Derde Lennie, Al-Beidh Farah, Annane Djillali, Arabi Yaseen, Beane Abigail, van Bentum-Puijk Wilma, Berry Lindsay, Bhimani Zahra, Bonten Marc, Bradbury Charlotte, Brunkhorst Frank, Buxton Meredith, Buzgau Adrian, Cheng Allen C, de Jong Menno, Detry Michelle, Estcourt Lise, Fitzgerald Mark, Goossens Herman, Green Cameron, Haniffa Rashan, Higgins Alisa M, Horvat Christopher, Hullegie Sebastiaan J, Kruger Peter, Lamontagne Francois, Lawler Patrick R, Linstrum Kelsey, Litton Edward, Lorenzi Elizabeth, Marshall John, McAuley Daniel, McGlothin Anna, McGuinness Shay, McVerry Bryan, Montgomery Stephanie, Mouncey Paul, Murthy Srinivas, Nichol Alistair, Parke Rachael, Parker Jane, Rowan Kathryn, Sanil Ashish, Santos Marlene, Saunders Christina, Seymour Christopher, Turner Anne, van de Veerdonk Frank, Venkatesh Balasubramanian, 2 sep 2020, In: JAMA - The Journal of The American Medical Association. 324 , p. 1317-1329 13 p.

Clonal transmission of multidrug-resistant Acinetobacter baumannii harbouring blaOXA-24-like and blaOXA-23-like genes in a tertiary hospital in Albania

Tafaj Silva, Kostyanev Tomislav, Xavier Basil B, Fluit Ad C, Rodrigues Célia F, Lammens Christine, Osmalli Damiana, Raka Lul, Goossens Herman, Malhotra-Kumar Surbhi, Bonten Marc J M 2 sep 2020, In: Journal of global antimicrobial resistance. 23 , p. 79-81 3 p.

Association of Staphylococcus aureus Colonization and Pneumonia in the Intensive Care Unit

Paling Fleur P, Hazard Derek, Bonten Marc J M, Goossens Herman, Jafri Hasan S, Malhotra-Kumar Surbhi, Sifakis Frangiscos, Weber Susanne, Kluytmans Jan A J W, 1 sep 2020, In: JAMA network open. 3 , p. 1-12

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG:a Retrospective Cohort Study

Moorlag Simone J C F M, van Deuren Rosanne C, van Werkhoven Cornelis H, Jaeger Martin, Debisarun Priya, Taks Esther, Mourits Vera P, Koeken Valerie A C M, de Bree L Charlotte J, Ten Doesschate Thijs, Cleophas Maartje C, Smeekens Sanne, Oosting Marije, van de Veerdonk Frank L, Joosten Leo A B, Ten Oever Jaap, van der Meer Jos W M, Curtis Nigel, Aaby Peter, Stabell-Benn Christine, Giamarellos-Bourboulis Evangelos J, Bonten Marc, van Crevel Reinout, Netea Mihai G 25 aug 2020, In: Cell reports. Medicine. 1 , p. 1-15

All research output

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