prof. dr. M.J.M. (Marc ) Bonten

Full Professor
prof. dr. M.J.M. (Marc ) Bonten
  • Department of Epidemiology
  • Department of Medical Microbiology
  • Julius Center Research Program Infectious Diseases

Research Programs

Infection & Immunity



Marc Bonten earned his MD (1991) and PhD (“the role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia, 1994) at the Maastricht University Medical School, the Netherlands. He registered as internist in 2000, as infectious disease specialist in 2002 and as clinical microbiologist in 2008, all at the University Medical Center Utrecht, the Netherlands. Since August 2008 he is head of the Department of Medical Microbiology and leading the research group of infectious Disease Epidemiology of the Julius Center of Health Sciences and Primary Care, both at the UMC Utrecht, where he is professor of molecular epidemiology of infectious diseases since 2002. He has been a principal investigator in many large scale epidemiologic studies and investigator-initiated randomized trials of prevention and treatment of infectious diseases. His experience covers the full range of epidemiologic study designs including clinical trials, cohorts, case-control studies and mathematical modelling to study antibiotic resistance and infection prevention. Specific research interests include the epidemiology of antibiotic-resistant bacteria such as VRE, MRSA and MDR Enterobacteriaceae, selective decontamination in intensive care unit patients, prevention of ventilator-associated pneumonia, treatment of community-acquired pneumonia, and prevention and treatment of community-acquired pneumonia, including COVID-19.

Since 2016 he is the Scientific Director of the research theme "Tackling Antimicrobial Resistance" of the Netherlands Centre for One Health (NCOH;

Since 2017 he is the chairman of the focus area Infection & Immunity at the UMC Utrecht, and board member of the Netherlands Antibiotic Development Platform (NADP;

Side Activities

  • He acts as paid consultant for Janssen Vaccines (payments to UMC Utrecht) and Merck Sharp & Dohme B.V. (payments to UMC Utrecht).

    He has received speakers fee from Takeda (Nov 2019).

    He is a member of the Expertpanel of the Stichting Dierenautoriteit Nederland.

    He is a member of the cluster Infectieziektenbestrijding from ZorgOnderzoek Nederland. 

    He is a member of the Scientific Advisory Board of GARDP (Global Antibiotic Research & Development Platform).

    He is a member of the Independent Data Monitoring Committee of the PSK008 and PSK009 studies on pneumococcal conjugate vaccines from Sanofi Pasteur. 

Fellowship and Awards

  • He has been (co-)applicant of a large number of national and international research grants. He is a VICI laureate (2006) from the Dutch Science Association, Principal Investigator of the CAPiTA study, coordinator of the EU-funded project R-GNOSIS, scientific coordinator of the IMI-funded consortiums COMBACTE-NET, COMBACTE-CARE and COMBACTE-MAGNET, and Work Package leader of the REMAP-CAP ICU study in PREPARE.

    In 2015 he received the ESCMID 2015 Award for Excellence in Clinical Microbiology and Infectious Diseases.

    In 2017 he received a honorary fellowship of the Royal College of Physicians of Ireland, and was awarded the ESCMID fellowship.

Research Output (724)

Evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics

Janssen Axel B, Doorduijn Dennis J, Mills Grant, Rogers Malbert R C, Bonten Marc J M, Rooijakkers Suzan H M, Willems Rob J L, Bengoechea Jose A, van Schaik Willem 2 nov 2020, In: Antimicrobial Agents and Chemotherapy. 65

The burden of bacteremic and non-bacteremic Gram-negative infections:a prospective multicenter cohort study in a low-resistance country

Deelen J W Timotëus, Rottier Wouter C, van Werkhoven Cornelis H, Woudt Sjoukje H S, Buiting Anton G M, Dorigo-Zetsma J Wendelien, Kluytmans Jan A J W, van der Linden Paul D, Thijsen Steven F T, Vlaminckx Bart J M, Weersink Annemarie J L, Ammerlaan Heidi S M, Bonten Marc J M 5 okt 2020, In: The Journal of Infection. 81 , p. 895-901 7 p.

Anticoagulant interventions in hospitalized patients with COVID-19:A scoping review of randomized controlled trials and call for international collaboration

Tritschler Tobias, Mathieu Marie-Eve, Skeith Leslie, Rodger Marc, Middeldorp Saskia, Brighton Timothy, Sandset Per Morten, Kahn Susan R, Angus Derek C, Blondon Marc, Bonten Marc J, Cattaneo Marco, Cushman Mary, Derde Lennie P G, DeSancho Maria T, Diehl Jean-Luc, Goligher Ewan, Jilma Bernd, Jüni Peter, Lawler Patrick R, Marietta Marco, Marshall John C, McArthur Colin, Miranda Carlos Henrique, Mirault Tristan, Morici Nuccia, Perepu Usha, Schörgenhofer Christian, Sholzberg Michelle, Spyropoulos Alex C, Webb Steve A, Zarychanski Ryan, Zuily Stéphane, Le Gal Grégoire, 5 sep 2020, In: Journal of thrombosis and haemostasis : JTH. 18 , p. 2958-2967 10 p.

Clonal transmission of multidrug-resistant Acinetobacter baumannii harbouring blaOXA-24-like and blaOXA-23-like genes in a tertiary hospital in Albania

Tafaj Silva, Kostyanev Tomislav, Xavier Basil B, Fluit Ad C, Rodrigues Célia F, Lammens Christine, Osmalli Damiana, Raka Lul, Goossens Herman, Malhotra-Kumar Surbhi, Bonten Marc J M 2 sep 2020, In: Journal of global antimicrobial resistance. 23 , p. 79-81 3 p.

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19:The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

Angus Derek C, Derde Lennie, Al-Beidh Farah, Annane Djillali, Arabi Yaseen, Beane Abigail, van Bentum-Puijk Wilma, Berry Lindsay, Bhimani Zahra, Bonten Marc, Bradbury Charlotte, Brunkhorst Frank, Buxton Meredith, Buzgau Adrian, Cheng Allen C, de Jong Menno, Detry Michelle, Estcourt Lise, Fitzgerald Mark, Goossens Herman, Green Cameron, Haniffa Rashan, Higgins Alisa M, Horvat Christopher, Hullegie Sebastiaan J, Kruger Peter, Lamontagne Francois, Lawler Patrick R, Linstrum Kelsey, Litton Edward, Lorenzi Elizabeth, Marshall John, McAuley Daniel, McGlothin Anna, McGuinness Shay, McVerry Bryan, Montgomery Stephanie, Mouncey Paul, Murthy Srinivas, Nichol Alistair, Parke Rachael, Parker Jane, Rowan Kathryn, Sanil Ashish, Santos Marlene, Saunders Christina, Seymour Christopher, Turner Anne, van de Veerdonk Frank, Venkatesh Balasubramanian, 2 sep 2020, In: JAMA - The Journal of The American Medical Association. 324 , p. 1317-1329 13 p.

Association of Staphylococcus aureus Colonization and Pneumonia in the Intensive Care Unit

Paling Fleur P, Hazard Derek, Bonten Marc J M, Goossens Herman, Jafri Hasan S, Malhotra-Kumar Surbhi, Sifakis Frangiscos, Weber Susanne, Kluytmans Jan A J W, 1 sep 2020, In: JAMA network open. 3 , p. e2012741

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG:a Retrospective Cohort Study

Moorlag Simone J C F M, van Deuren Rosanne C, van Werkhoven Cornelis H, Jaeger Martin, Debisarun Priya, Taks Esther, Mourits Vera P, Koeken Valerie A C M, de Bree L Charlotte J, Ten Doesschate Thijs, Cleophas Maartje C, Smeekens Sanne, Oosting Marije, van de Veerdonk Frank L, Joosten Leo A B, Ten Oever Jaap, van der Meer Jos W M, Curtis Nigel, Aaby Peter, Stabell-Benn Christine, Giamarellos-Bourboulis Evangelos J, Bonten Marc, van Crevel Reinout, Netea Mihai G 25 aug 2020, In: Cell reports. Medicine. 1 , p. 100073

Carbapenem-alternative strategies for complicated urinary tract infections:a systematic review of randomized controlled trials

Ten Doesschate T, van der Vaart T W, Damen J A A, Bonten M J M, van Werkhoven C H 11 aug 2020, In: The Journal of Infection. 81 , p. 499-509 11 p.

Microevolution of acquired colistin resistance in Enterobacteriaceae from ICU patients receiving selective decontamination of the digestive tract

Janssen Axel B, van Hout Denise, Bonten Marc J M, Willems Rob J L, van Schaik Willem 26 jul 2020, In: The Journal of antimicrobial chemotherapy. 75 , p. 3135-3143 9 p.

Impact of delays on effectiveness of contact tracing strategies for COVID-19:a modelling study

Kretzschmar Mirjam E, Rozhnova Ganna, Bootsma Martin C J, van Boven Michiel, van de Wijgert Janneke H H M, Bonten Marc J M 16 jul 2020, In: The Lancet Public Health. 5 , p. e452-e459

All research output