prof. dr. M.J.M. (Marc ) Bonten

Full Professor

  • Department of Epidemiology
  • Department of Medical Microbiology
  • Julius Center Research Program Infectious Diseases

prof. dr. M.J.M. (Marc ) Bonten

Research Programs


Marc Bonten earned his MD (1991) and PhD (“the role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia, 1994) at the Maastricht University Medical School, the Netherlands. He registered as internist in 2000, as infectious disease specialist in 2002 and as clinical microbiologist in 2008, all at the University Medical Center Utrecht, the Netherlands. Since August 2008 he is head of the Department of Medical Microbiology and leading the research group of infectious Disease Epidemiology of the Julius Center of Health Sciences and Primary Care, both at the UMC Utrecht, where he is professor of molecular epidemiology of infectious diseases since 2002. He has been a principal investigator in many large scale epidemiologic studies and investigator-initiated randomized trials of prevention and treatment of infectious diseases. His experience covers the full range of epidemiologic study designs including clinical trials, cohorts, case-control studies and mathematical modelling to study antibiotic resistance and infection prevention. Specific research interests include the epidemiology of antibiotic-resistant bacteria such as VRE, MRSA and MDR Enterobacteriaceae, selective decontamination in intensive care unit patients, prevention of ventilator-associated pneumonia, treatment of community-acquired pneumonia, and prevention and treatment of community-acquired pneumonia.

Since 2016 he is the Scientific Director of the research theme "Tackling Antimicrobial Resistance" of the Netherlands Centre for One Health (NCOH;

Since 2017 he is the chairman of the focus area Infection & Immunity at the UMC Utrecht, and board member of the Netherlands Antibiotic Development Platform (NADP;

Side Activities

  • He acts as paid consultant for Janssen Vaccines (payments to UMC Utrecht) and Merck Sharp & Dohme B.V. (payments to UMC Utrecht).

    He has received speakers fee from Takeda (Nov 2019).

    He is a member of the Expertpanel of the Stichting Dierenautoriteit Nederland.

    He is a member of the cluster Infectieziektenbestrijding from ZorgOnderzoek Nederland. 

    He is a member of the Scientific Advisory Board of GARDP (Global Antibiotic Research & Development Platform).


Fellowship and Awards

  • He has been (co-)applicant of a large number of national and international research grants. He is a VICI laureate (2006) from the Dutch Science Association, Principal Investigator of the CAPiTA study, coordinator of the EU-funded project R-GNOSIS, scientific coordinator of the IMI-funded consortiums COMBACTE-NET, COMBACTE-CARE and COMBACTE-MAGNET, and Work Package leader of the REMAP-CAP ICU study in PREPARE.

    In 2015 he received the ESCMID 2015 Award for Excellence in Clinical Microbiology and Infectious Diseases.

    In 2017 he received a honorary fellowship of the Royal College of Physicians of Ireland, and was awarded the ESCMID fellowship.

Research Output (699)

Trained Immunity:a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Netea Mihai G, Giamarellos-Bourboulis Evangelos J, Domínguez-Andrés Jorge, Curtis Nigel, van Crevel Reinout, van de Veerdonk Frank L, Bonten Marc 4 mei 2020, In: Cell. 181 , p. 969-977 9 p.

Impact of antimicrobial de-escalation on mortality: a literature review of study methodology and recommendations for observational studies

Van Heijl Inger, Schweitzer Valentijn A., van der Linden Paul D., Bonten Marc J. M., Van Werkhoven Cornelis H. 3 mei 2020, In: Expert review of Anti-infective Therapy. 18 , p. 405-413 9 p.

Selective Decontamination Is Safe and Efficacious for Critically Ill Patients

Bonten Marc J mei 2020, In: Critical care medicine. 48 , p. 736-738 3 p.

Contact isolation versus standard precautions to decrease acquisition of extended-spectrum β-lactamase-producing Enterobacterales in non-critical care wards:a cluster-randomised crossover trial

Maechler Friederike, Schwab Frank, Hansen Sonja, Fankhauser Carolina, Harbarth Stephan, Huttner Benedikt D., Diaz-Agero Cristina, Lopez Nieves, Canton Rafael, Ruiz-Garbajosa Patricia, Blok Hetty, Bonten Marc J., Kloosterman Fieke, Schotsman Joost, Cooper Ben S., Behnke Michael, Golembus Jennifer, Kola Axel, Gastmeier Petra mei 2020, In: The Lancet Infectious Diseases. 20 , p. 575-584 10 p.

Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017

Vincent Jean-Louis, Sakr Yasser, Singer Mervyn, Martin-Loeches Ignacio, Machado Flavia R, Marshall John C, Finfer Simon, Pelosi Paolo, Brazzi Luca, Aditianingsih Dita, Timsit Jean-François, Du Bin, Wittebole Xavier, Máca Jan, Kannan Santhana, Gorordo-Delsol Luis A, De Waele Jan J, Mehta Yatin, Bonten Marc J M, Khanna Ashish K, Kollef Marin, Human Mariesa, Angus Derek C, 24 mrt 2020, In: JAMA - The Journal of The American Medical Association. 323 , p. 1478-1487 10 p.

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

Janssen Axel B., Bartholomew Toby L., Marciszewska Natalia P., Bonten Marc J.M., Willems Rob J.L., Bengoechea Jose A., van Schaik Willem 11 mrt 2020, In: mSphere. 5 13 p.

Seasonality in carriage of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in the general population:a pooled analysis of nationwide cross-sectional studies

Wielders C C H, van Duijkeren E, van den Bunt G, Meijs A P, Dierikx C M, Bonten M J M, van Pelt W, Franz E, de Greeff S C 21 feb 2020, In: Epidemiology and Infection. 148 17 p.

Occurrence and Risk Factors of Chronic Pain After Critical Illness

Koster-Brouwer Maria E., Rijsdijk Mienke, Van Os Wouter K.M., Soliman Ivo W., Slooter Arjen J.C., De Lange Dylan W., Van Dijk Diederik, Bonten Marc J.M., Cremer Olaf L. 10 feb 2020, In: Critical Care Medicine. 48 , p. 680-687 8 p.

Correction to:Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study

Klein Klouwenberg Peter M C, Spitoni Cristian, van der Poll Tom, Bonten Marc J, Cremer Olaf L, 6 feb 2020, In: Critical care (London, England). 24

Extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli isolates causing bacteremia in the Netherlands (2014 - 2016) differ in clonal distribution, antimicrobial resistance gene and virulence gene content

van Hout Denise, Verschuuren Tess D, Bruijning-Verhagen Patricia C J, Bosch Thijs, Schürch Anita C, Willems Rob J L, Bonten Marc J M, Kluytmans Jan A J W 1 jan 2020, In: PLoS ONE. 15 14 p.

All Research Output (699)