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prof. dr. I.H.M. Borel Rinkes

prof. dr. I.H.M. Borel Rinkes

Full Professor
prof. dr. I.H.M. Borel Rinkes
  • Department of Surgical Oncology

Biography

Biography

Inne Borel Rinkes attended medical School (Leiden University) from 1976-1984 (MD-degree cum laude) while working as donor-allocation-coordinator for Eurotransplant. From 1984-1986 he was resident in surgery Red Cross Hospital,The Hague (supervisor dr. J. Hamming). He had his formal surgical training from 1986-1993 in Rotterdam (Zuiderziekenhuis, dr. G. Olthuis; University Hospital Dijkzigt, Prof. J. Jeekel). His training was interrupted for 1.5 years for doctoral research at Massachusetts General Hospital/Harvard University, Center for Engineering in Medicine (Profs. Toner, Yarmush and Tompkins). Inne Borel Rinkes obtained his PhD degree in 1993 on the dissertation “Hepatocytes in the development of liver support systems”.
In 1993 he became surgeon in the Dr. Daniel den Hoed Cancer Center in Rotterdam. In 1995 he became staff surgeon in the University Medical Center in Utrecht, where he was appointed full professor of Surgical Oncology in 2002. Between 2001 and 2012 he was director of the residency program in surgery and chairman of the Concilium Chirurgicum. From 2006 to 2012 he was member of the scientific council of the Dutch Cancer Society (KWF) and chairman of the translational research-committee. In 2012 he received the Catharijne Prize for outstanding translational research and clinical work. His main topics of interest include HPB-surgery and Endocrine surgery. His research focus involves (targeting) the development of liver metastases.

Side Activities

Bestuurslid Stichting Michael van Vloten Fonds (Onderzoeksbeurzen chirurgisch onderzoek buitenland)

 

Voorzitter Regenten Hippocrates Studiefonds (Onderzoeksprijzen med studenten)

 

Bestuurslid Netherlands Society for International Surgery

 

Bestuurslid Stichting Hanarth Fonds

 

[alle onbezoldigd]

Fellowship and Awards

2013 Catharijne Award for outstanding translational research & surgical  oncology patient care
Effects of anti-angiogenic therapy on physiological and pathological angiogenesis; Dutch Society for Scientific Research (NWO)-920-03-102; AGIKO E.A. te Velde
Angiogenesis and the liver: role of angiogenesis in liver regeneration and cirrhosis; Private fund and Vanderes foundation; J.M. Vogten
Anti-angiogenic effects of photodynamic therapy in experimental cancer; Dutch Cancer Foundation 
Implenting stereotactic large-core needle biopsy for non-palpable breast cancer lesions; Dutch Society for Scientific Research (NWO -920-03-159 and Stichting Centraal Fonds Vrijwillige Reserves; AGIKO L.E. Hoorntje
Early effects of liver metastases on hepatic microcirculation; Vanderes foundation – 2001/63
Is angiogenesis the key to more effective local thermal ablation of colorectal liver metastases?; Dutch Society for Scientific Research (NWO)-920-03-159; AGIKO L.M. Veenendaal 
Surgery-induced hypoxia, angiogenesis, and tumor growth; Private Fund.
Reovirus oncolysis of colorectal liver metastases (2004); Dutch Society for Scientific Research (NWO)-920-03-313; AGIKO: J.D.W. van der Bilt
Long term effects of short term ischemia on metastatic colorectal cancer cells; Dutch Cancer Foundation 2006-3711 (1year research grant for clinical assistants to M. Nijkamp) 
Anti-tumor therapy with an adeno-associated virus (AAV) suppressing the K-Ras oncogene by RNA interference; Dutch Society for Scientific Research (NWO)-920-03-382; AGIKO W. van Houdt
Apoptosis control in metastases of colorectal cancer (2006); Private fund
Identification of metastasis genes activated by oncogenic Kras (G12D); Association for International Cancer Research (AICR) 2007-552
Identification of metastasis stimulating genes activated by oncogenic Kras; Vanderes foundation 2007-177
A gene expression signature for prediction of disease free survival after Ro resection of colorectal liver metastasis; Dutch Cancer Foundation (KWF) 2007-3923
Radioguided occult lesion localisation in patients with non-palpable breast cancer (ROLL); Dutch Society for Scientific Research (ZonW) 17088.2101
The Role of sprituality in the adjustment of patients with cancer; Dutch Cancer Foundation (KWF) HDI 2008-4076
The secretome of colon cancer stem cells; Dutch Cancer Foundation (KWF) UU 2009-4367 (research grant for B.L. Emmink)
Death receptor signaling in liver metastasis formation; Dutch Cancer Foundation (KWF) UU 2009-4379 (research grant for E.J.A. Steller)
Preventing recurrence of colorectal liver metastases following liver surgery by hypoxia-activated pro-drugs (KWF) UU 2010-4608 (research grant for K. Govaert)
Wijnand M. Pon Foundation Het volgen van kankerstamcel tot leveruitzaaiing
Prevention of Breast Cancer by Monitoring Gene Promoter Methylation in Nipple Aspirates; Dutch Cancer Foundation (KWF) UU 2008-4217
Killing hypoxic colorectal cancer stam cells; Dutch Cancer Foundation (KWF) UU 2013-5865 (research grant for J.M.J. Jongen)
Targeting cancer stem cells in colon cancer. Stichting Vrienden UMC Utrecht 2013, 217.000 euro.
Platelet-derived growth factor receptor inhibition in mesenchymal-type colorectal cancer. Dutch Cancer Foundation (KWF) UU 2014-6617 (research grant for I. Ubink).
PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymaltype colon cancer: a widow trial. ZonMw (95104001) 93.300 euro
What is the best treatment for MEN1 patients with duodenopancreatic neuroendocrine tumors? Twenty-two years of survival to be gained.
Dutch Cancer Foundation (KWF) UU 2014-7102 (research grant for S. Nell) 152.421,- euro. (2e PI)

Research Output (390)

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Heinz Maria C, Peters Niek A, Oost Koen C, Lindeboom Rik G H, van Voorthuijsen Lisa, Fumagalli Arianna, van der Net Mirjam C, de Medeiros Gustavo, Hageman Joris H, Verlaan-Klink Ingrid, Borel Rinkes Inne H M, Liberali Prisca, Gloerich Martijn, van Rheenen Jacco, Vermeulen Michiel, Kranenburg Onno, Snippert Hugo J G 15 May 2022, In: Cancer Research. 82 , p. 1953-1968 16 p.

External Validation of Two Established Clinical Risk Scores Predicting Outcome after Local Treatment of Colorectal Liver Metastases in a Nationwide Cohort

Bolhuis Karen, Wensink G. Emerens, Elferink Marloes A.G., Bond Marinde J.G., Dijksterhuis Willemieke P.M., Fijneman Remond J.A., Kranenburg Onno W., Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Elias Sjoerd G., Roodhart Jeanine M.L. 10 May 2022, In: Cancers. 14 , p. 1-17

Liver lymphatic drainage patterns follow segmental anatomy

van den Bent Lotte, Frenkel Nicola C, Poghosyan Susanna, Molenaar I Quintus, Padera Timothy P, Kranenburg Onno, Borel Rinkes Inne H M, Hagendoorn Jeroen 30 Mar 2022, In: The British journal of surgery. 109 , p. 559-560

Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity

Laoukili Jamila, Constantinides Alexander, Wassenaar Emma C E, Elias Sjoerd G, Raats Danielle A E, van Schelven Susanne J, van Wettum Jonathan, Volckmann Richard, Koster Jan, Huitema Alwin D R, Nienhuijs Simon W, de Hingh Ignace H J T, Wiezer René J, van Grevenstein Helma M U, Rinkes Inne H M Borel, Boerma Djamila, Kranenburg Onno 22 Feb 2022, In: British Journal of Cancer. 126 , p. 1824-1833 10 p.

Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy

Poghosyan Susanna, Frenkel Nicola, Lentzas Aristeidis, Laoukili Jamila, Rinkes Inne Borel, Kranenburg Onno, Hagendoorn Jeroen 1 Feb 2022, In: Cancers. 14 , p. 1-18

Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism

van der Vaart Jelte, Bosmans Lynn, Sijbesma Stijn F, Knoops Kèvin, van de Wetering Willine J, Otten Henny G, Begthel Harry, Borel Rinkes Inne H M, Korving Jeroen, Lentjes Eef G W M, Lopez-Iglesias Carmen, Peters Peter J, van Santen Hanneke M, Vriens Menno R, Clevers Hans 21 Dec 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118 , p. 1-11

Radiofrequency ablation and chemotherapy versus chemotherapy alone for locally advanced pancreatic cancer (PELICAN):study protocol for a randomized controlled trial

Walma M. S., Rombouts S. J., Brada L. J.H., Borel Rinkes I. H., Bosscha K., Bruijnen R. C., Busch O. R., Creemers G. J., Daams F., van Dam R. M., van Delden O. M., Festen S., Ghorbani P., de Groot D. J., de Groot J. W.B., Haj Mohammad N., van Hillegersberg R., de Hingh I. H., D’Hondt M., Kerver E. D., van Leeuwen M. S., Liem M. S., van Lienden K. P., Los M., de Meijer V. E., Meijerink M. R., Mekenkamp L. J., Nio C. Y., Oulad Abdennabi I., Pando E., Patijn G. A., Polée M. B., Pruijt J. F., Roeyen G., Ropela J. A., Stommel M. W.J., de Vos-Geelen J., de Vries J. J., van der Waal E. M., Wessels F. J., Wilmink J. W., van Santvoort H. C., Besselink M. G., Molenaar I. Q., Dec 2021, In: Trials. 22 , p. 1-12

Outcomes of Minimally Invasive Thyroid Surgery - A Systematic Review and Meta-Analysis

de Vries Lisa H, Aykan Dilay, Lodewijk Lutske, Damen Johanna A A, Borel Rinkes Inne H M, Vriens Menno R Aug 2021, In: Frontiers in Endocrinology. 12 16 p.

Complications After Major Surgery for Duodenopancreatic Neuroendocrine Tumors in Patients with MEN1:Results from a Nationwide Cohort

van Beek Dirk Jan, Nell Sjoerd, Vorselaars Wessel M.C.M., Bonsing Bert A., van Eijck Casper H.J., van Goor Harry, Nieveen van Dijkum Elisabeth J., Dejong Cornelis H.C., Valk Gerlof D., Bisschop P. H., Dekkers O. M., Drent M. L., Havekes B., de Herder W. W., van der Horst-Schrivers A. N.A., Pieterman C. R.C., van de Ven A. C., Borel Rinkes Inne H.M., Vriens Menno R., Aug 2021, In: Annals of Surgical Oncology. 28 , p. 4387-4399 13 p.

Long-lived human lymphatic endothelial cells to study lymphatic biology and lymphatic vessel/tumor coculture in a 3D microfluidic model

Frenkel Nicola, Poghosyan Susanna, Alarcón Carmen Rubio, García Silvia Bonilla, Queiroz Karla, Van Den Bent Lotte, Laoukili Jamila, Rinkes Inne Borel, Vulto Paul, Kranenburg Onno, Hagendoorn Jeroen 12 Jul 2021, In: ACS Biomaterials Science and Engineering. 7 , p. 3030-3042 13 p.

All research output

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