prof. dr. I.H.M. Borel Rinkes
prof. dr. I.H.M. Borel Rinkes
- Department of Surgical Oncology
Research Programs
Biography
Biography
Inne Borel Rinkes attended medical School (Leiden University) from 1976-1984 (MD-degree cum laude) while working as donor-allocation-coordinator for Eurotransplant. From 1984-1986 he was resident in surgery Red Cross Hospital,The Hague (supervisor dr. J. Hamming). He had his formal surgical training from 1986-1993 in Rotterdam (Zuiderziekenhuis, dr. G. Olthuis; University Hospital Dijkzigt, Prof. J. Jeekel). His training was interrupted for 1.5 years for doctoral research at Massachusetts General Hospital/Harvard University, Center for Engineering in Medicine (Profs. Toner, Yarmush and Tompkins). Inne Borel Rinkes obtained his PhD degree in 1993 on the dissertation “Hepatocytes in the development of liver support systems”.
In 1993 he became surgeon in the Dr. Daniel den Hoed Cancer Center in Rotterdam. In 1995 he became staff surgeon in the University Medical Center in Utrecht, where he was appointed full professor of Surgical Oncology in 2002. Between 2001 and 2012 he was director of the residency program in surgery and chairman of the Concilium Chirurgicum. From 2006 to 2012 he was member of the scientific council of the Dutch Cancer Society (KWF) and chairman of the translational research-committee. In 2012 he received the Catharijne Prize for outstanding translational research and clinical work. His main topics of interest include HPB-surgery and Endocrine surgery. His research focus involves (targeting) the development of liver metastases.
Side Activities
Bestuurslid Stichting Michael van Vloten Fonds (Onderzoeksbeurzen chirurgisch onderzoek buitenland)
Voorzitter Regenten Hippocrates Studiefonds (Onderzoeksprijzen med studenten)
Bestuurslid Netherlands Society for International Surgery
Bestuurslid Stichting Hanarth Fonds
[alle onbezoldigd]
Fellowship and Awards
2013 Catharijne Award for outstanding translational research & surgical oncology patient care
Effects of anti-angiogenic therapy on physiological and pathological angiogenesis; Dutch Society for Scientific Research (NWO)-920-03-102; AGIKO E.A. te Velde
Angiogenesis and the liver: role of angiogenesis in liver regeneration and cirrhosis; Private fund and Vanderes foundation; J.M. Vogten
Anti-angiogenic effects of photodynamic therapy in experimental cancer; Dutch Cancer Foundation
Implenting stereotactic large-core needle biopsy for non-palpable breast cancer lesions; Dutch Society for Scientific Research (NWO -920-03-159 and Stichting Centraal Fonds Vrijwillige Reserves; AGIKO L.E. Hoorntje
Early effects of liver metastases on hepatic microcirculation; Vanderes foundation – 2001/63
Is angiogenesis the key to more effective local thermal ablation of colorectal liver metastases?; Dutch Society for Scientific Research (NWO)-920-03-159; AGIKO L.M. Veenendaal
Surgery-induced hypoxia, angiogenesis, and tumor growth; Private Fund.
Reovirus oncolysis of colorectal liver metastases (2004); Dutch Society for Scientific Research (NWO)-920-03-313; AGIKO: J.D.W. van der Bilt
Long term effects of short term ischemia on metastatic colorectal cancer cells; Dutch Cancer Foundation 2006-3711 (1year research grant for clinical assistants to M. Nijkamp)
Anti-tumor therapy with an adeno-associated virus (AAV) suppressing the K-Ras oncogene by RNA interference; Dutch Society for Scientific Research (NWO)-920-03-382; AGIKO W. van Houdt
Apoptosis control in metastases of colorectal cancer (2006); Private fund
Identification of metastasis genes activated by oncogenic Kras (G12D); Association for International Cancer Research (AICR) 2007-552
Identification of metastasis stimulating genes activated by oncogenic Kras; Vanderes foundation 2007-177
A gene expression signature for prediction of disease free survival after Ro resection of colorectal liver metastasis; Dutch Cancer Foundation (KWF) 2007-3923
Radioguided occult lesion localisation in patients with non-palpable breast cancer (ROLL); Dutch Society for Scientific Research (ZonW) 17088.2101
The Role of sprituality in the adjustment of patients with cancer; Dutch Cancer Foundation (KWF) HDI 2008-4076
The secretome of colon cancer stem cells; Dutch Cancer Foundation (KWF) UU 2009-4367 (research grant for B.L. Emmink)
Death receptor signaling in liver metastasis formation; Dutch Cancer Foundation (KWF) UU 2009-4379 (research grant for E.J.A. Steller)
Preventing recurrence of colorectal liver metastases following liver surgery by hypoxia-activated pro-drugs (KWF) UU 2010-4608 (research grant for K. Govaert)
Wijnand M. Pon Foundation Het volgen van kankerstamcel tot leveruitzaaiing
Prevention of Breast Cancer by Monitoring Gene Promoter Methylation in Nipple Aspirates; Dutch Cancer Foundation (KWF) UU 2008-4217
Killing hypoxic colorectal cancer stam cells; Dutch Cancer Foundation (KWF) UU 2013-5865 (research grant for J.M.J. Jongen)
Targeting cancer stem cells in colon cancer. Stichting Vrienden UMC Utrecht 2013, 217.000 euro.
Platelet-derived growth factor receptor inhibition in mesenchymal-type colorectal cancer. Dutch Cancer Foundation (KWF) UU 2014-6617 (research grant for I. Ubink).
PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymaltype colon cancer: a widow trial. ZonMw (95104001) 93.300 euro
What is the best treatment for MEN1 patients with duodenopancreatic neuroendocrine tumors? Twenty-two years of survival to be gained.
Dutch Cancer Foundation (KWF) UU 2014-7102 (research grant for S. Nell) 152.421,- euro. (2e PI)
Research Output (406)
Küçükköse Emre, Heesters Balthasar A, Villaudy Julien, Verheem André, Cercel Madalina, van Hal Susan, Boj Sylvia F, Borel Rinkes Inne H M, Punt Cornelis J A, Roodhart Jeanine M L, Laoukili Jamila, Koopman Miriam, Spits Hergen, Kranenburg Onno Dec 2022, In: Journal for ImmunoTherapy of Cancer. 10
Laoukili Jamila, van Schelven Susanne, Küçükköse Emre, Verheem André, Goey Kaitlyn, Koopman Miriam, Borel Rinkes Inne, Kranenburg Onno 29 Nov 2022, In: Cell Reports. 41 , p. 1-22
Bargon Claudia A, Huibers Anne, Young-Afat Danny A, Jansen Britt A M, Borel-Rinkes Inne H M, Lavalaye Jules, van Slooten Henk-Jan, Verkooijen Helena M, van Swol Christiaan F P, Doeksen Annemiek 1 Nov 2022, In: Annals of surgery. 276 , p. 913-920 8 p.
Suurd Diederik P D, Vorselaars Wessel M C M, Van Beek Dirk-Jan, Borel Rinkes Inne H M, Spiering Wilko, Valk Gerlof D, Vriens Menno R Nov 2022, In: Annals of surgery. 276 , p. 929-934 6 p.
van Beek Dirk-Jan, Pieterman Carolina R C, Wessels Frank J, van de Ven Annenienke C, de Herder Wouter W, Dekkers Olaf M, Zandee Wouter T, Drent Madeleine L, Bisschop Peter H, Havekes Bas, Borel Rinkes Inne H M, Vriens Menno R, Valk Gerlof D 7 Oct 2022, In: Frontiers in Endocrinology. 13 , p. 1-12
Hoek Vincent T., Edomskis Pim P., Stark Pieter W., Lambrichts Daniel P.V., Draaisma Werner A., Consten Esther C.J., Lange Johan F., Bemelman Willem A., Hop W. C., Opmeer B. C., Reitsma J. B., Scholte R. A., Waltmann E. W.H., Legemate A., Bartelsman J. F., Meijer D. W., de Brouwer M., van Dalen J., Durbridge M., Geerdink M., Ilbrink G. J., Mehmedovic S., Middelhoek P., Boom M. J., Consten E. C.J., van der Bilt J. D.W., van Olden G. D.J., Stam M. A.W., Verweij M. S., Vennix Sandra, Musters Gijsbert D., Swank Hilko A., Boermeester Marja A., Busch O. R.C., Schijven M. P., Steller E. P., de Graaf E. J.R., Vermaas M., de Vries M. R., Prins H. A., Vermeulen J., Hendriks E. R., Wiezer M. J., Hazebroek E. J., Smits A. B., Lange J. F., van Grevenstein W. M.U., Vriens M. R., Borel Rinkes I. H.M., Witkamp A. J., Oct 2022, In: Surgical endoscopy. 36 , p. 7764-7774 11 p.
de Vries Lisa H, Lodewijk Lutske, de Keizer Bart, Borel Rinkes Inne Hm, Vriens Menno R 7 Sep 2022, In: Future Oncology. 18 , p. 3493-3499 7 p.
Peters Niek A., Constantinides Alexander, Ubink Inge, van Kuik Joyce, Bloemendal Haiko J., van Dodewaard Joyce M., Brink Menno A., Schwartz Thijs P., Lolkema Martijn P.J.K., Lacle Miangela M., Moons Leon M., Geesing Joost, van Grevenstein Wilhelmina M.U., Roodhart Jeanine M.L., Koopman Miriam, Elias Sjoerd G., Borel Rinkes Inne H.M., Kranenburg Onno 6 Sep 2022, In: Frontiers in oncology. 12
Strating Esther, Elias Sjoerd, van Scharrenburg Guus, Luoto Kaisa, Verheem André, Borel Rinkes Inne, Steen Herman, Kranenburg Onno Sep 2022, In: Cancers. 14
Korenblik R et al. Sep 2022, In: Cardiovascular and Interventional Radiology. 45 , p. 1391-1398 8 p.