prof. dr. I.H.M. Borel Rinkes
prof. dr. I.H.M. Borel Rinkes
- Department of Surgical Oncology
Research Programs
Biography
Biography
Inne Borel Rinkes attended medical School (Leiden University) from 1976-1984 (MD-degree cum laude) while working as donor-allocation-coordinator for Eurotransplant. From 1984-1986 he was resident in surgery Red Cross Hospital,The Hague (supervisor dr. J. Hamming). He had his formal surgical training from 1986-1993 in Rotterdam (Zuiderziekenhuis, dr. G. Olthuis; University Hospital Dijkzigt, Prof. J. Jeekel). His training was interrupted for 1.5 years for doctoral research at Massachusetts General Hospital/Harvard University, Center for Engineering in Medicine (Profs. Toner, Yarmush and Tompkins). Inne Borel Rinkes obtained his PhD degree in 1993 on the dissertation “Hepatocytes in the development of liver support systems”.
In 1993 he became surgeon in the Dr. Daniel den Hoed Cancer Center in Rotterdam. In 1995 he became staff surgeon in the University Medical Center in Utrecht, where he was appointed full professor of Surgical Oncology in 2002. Between 2001 and 2012 he was director of the residency program in surgery and chairman of the Concilium Chirurgicum. From 2006 to 2012 he was member of the scientific council of the Dutch Cancer Society (KWF) and chairman of the translational research-committee. In 2012 he received the Catharijne Prize for outstanding translational research and clinical work. His main topics of interest include HPB-surgery and Endocrine surgery. His research focus involves (targeting) the development of liver metastases.
Side Activities
Bestuurslid Stichting Michael van Vloten Fonds (Onderzoeksbeurzen chirurgisch onderzoek buitenland)
Voorzitter Regenten Hippocrates Studiefonds (Onderzoeksprijzen med studenten)
Bestuurslid Netherlands Society for International Surgery
Bestuurslid Stichting Hanarth Fonds
[alle onbezoldigd]
Fellowship and Awards
2013 Catharijne Award for outstanding translational research & surgical oncology patient care
Effects of anti-angiogenic therapy on physiological and pathological angiogenesis; Dutch Society for Scientific Research (NWO)-920-03-102; AGIKO E.A. te Velde
Angiogenesis and the liver: role of angiogenesis in liver regeneration and cirrhosis; Private fund and Vanderes foundation; J.M. Vogten
Anti-angiogenic effects of photodynamic therapy in experimental cancer; Dutch Cancer Foundation
Implenting stereotactic large-core needle biopsy for non-palpable breast cancer lesions; Dutch Society for Scientific Research (NWO -920-03-159 and Stichting Centraal Fonds Vrijwillige Reserves; AGIKO L.E. Hoorntje
Early effects of liver metastases on hepatic microcirculation; Vanderes foundation – 2001/63
Is angiogenesis the key to more effective local thermal ablation of colorectal liver metastases?; Dutch Society for Scientific Research (NWO)-920-03-159; AGIKO L.M. Veenendaal
Surgery-induced hypoxia, angiogenesis, and tumor growth; Private Fund.
Reovirus oncolysis of colorectal liver metastases (2004); Dutch Society for Scientific Research (NWO)-920-03-313; AGIKO: J.D.W. van der Bilt
Long term effects of short term ischemia on metastatic colorectal cancer cells; Dutch Cancer Foundation 2006-3711 (1year research grant for clinical assistants to M. Nijkamp)
Anti-tumor therapy with an adeno-associated virus (AAV) suppressing the K-Ras oncogene by RNA interference; Dutch Society for Scientific Research (NWO)-920-03-382; AGIKO W. van Houdt
Apoptosis control in metastases of colorectal cancer (2006); Private fund
Identification of metastasis genes activated by oncogenic Kras (G12D); Association for International Cancer Research (AICR) 2007-552
Identification of metastasis stimulating genes activated by oncogenic Kras; Vanderes foundation 2007-177
A gene expression signature for prediction of disease free survival after Ro resection of colorectal liver metastasis; Dutch Cancer Foundation (KWF) 2007-3923
Radioguided occult lesion localisation in patients with non-palpable breast cancer (ROLL); Dutch Society for Scientific Research (ZonW) 17088.2101
The Role of sprituality in the adjustment of patients with cancer; Dutch Cancer Foundation (KWF) HDI 2008-4076
The secretome of colon cancer stem cells; Dutch Cancer Foundation (KWF) UU 2009-4367 (research grant for B.L. Emmink)
Death receptor signaling in liver metastasis formation; Dutch Cancer Foundation (KWF) UU 2009-4379 (research grant for E.J.A. Steller)
Preventing recurrence of colorectal liver metastases following liver surgery by hypoxia-activated pro-drugs (KWF) UU 2010-4608 (research grant for K. Govaert)
Wijnand M. Pon Foundation Het volgen van kankerstamcel tot leveruitzaaiing
Prevention of Breast Cancer by Monitoring Gene Promoter Methylation in Nipple Aspirates; Dutch Cancer Foundation (KWF) UU 2008-4217
Killing hypoxic colorectal cancer stam cells; Dutch Cancer Foundation (KWF) UU 2013-5865 (research grant for J.M.J. Jongen)
Targeting cancer stem cells in colon cancer. Stichting Vrienden UMC Utrecht 2013, 217.000 euro.
Platelet-derived growth factor receptor inhibition in mesenchymal-type colorectal cancer. Dutch Cancer Foundation (KWF) UU 2014-6617 (research grant for I. Ubink).
PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymaltype colon cancer: a widow trial. ZonMw (95104001) 93.300 euro
What is the best treatment for MEN1 patients with duodenopancreatic neuroendocrine tumors? Twenty-two years of survival to be gained.
Dutch Cancer Foundation (KWF) UU 2014-7102 (research grant for S. Nell) 152.421,- euro. (2e PI)
Research Output (419)
Dayton Talya L, Alcala Nicolas, Moonen Laura, den Hartigh Lisanne, Geurts Veerle, Mangiante Lise, Lap Lisa, Dost Antonella F M, Beumer Joep, Levy Sonja, van Leeuwaarde Rachel S, Hackeng Wenzel M, Samsom Kris, Voegele Catherine, Sexton-Oates Alexandra, Begthel Harry, Korving Jeroen, Hillen Lisa, Brosens Lodewijk A A, Lantuejoul Sylvie, Jaksani Sridevi, Kok Niels F M, Hartemink Koen J, Klomp Houke M, Borel Rinkes Inne H M, Dingemans Anne-Marie, Valk Gerlof D, Vriens Menno R, Buikhuisen Wieneke, van den Berg José, Tesselaar Margot, Derks Jules, Speel Ernst Jan, Foll Matthieu, Fernández-Cuesta Lynnette, Clevers Hans 11 Dec 2023, In: Cancer Cell. 41 , p. 2083-2099.e9
Zwart Maurice J.W., Van Den Broek Bram, De Graaf Nine, Suurmeijer José A., Augustinus Simone, Te Riele Wouter W., Van Santvoort Hjalmar C., Hagendoorn Jeroen, Borel Rinkes Inne H.M., Van Dam Jacob L., Takagi Kosei, Tran Khé T.C., Schreinemakers Jennifer, Van Der Schelling George, Wijsman Jan H., De Wilde Roeland F., Festen Sebastiaan, Daams Freek, Luyer Misha D., De Hingh Ignace H.J.T., Mieog Jan S.D., Bonsing Bert A., Lips Daan J., Abu Hilal Mohamed, Busch Olivier R., Saint-Marc Olivier, Zeh Herbert J., Zureikat Amer H., Hogg Melissa E., Koerkamp Bas G., Molenaar Isaac Q., Besselink Marc G. 1 Dec 2023, In: Annals of surgery. 278 , p. E1232-E1241
Farmer Diana L., O'Connell P. Ronan, Pugh Carla M., Lang Hauke, Greenberg Caprice C., Borel-Rinkes Inne Hm, Mellinger John D., Pinto-Marques Hugo 1 Nov 2023, In: Annals of surgery. 278 , p. 642-646 5 p.
Andel Daan, Lam Marnix G.E.H., de Bruijne Joep, Smits Maarten L.J., Braat Arthur J.A.T., Moelker Adriaan, Vegt Erik, Ruiter Simeon J.S., Noordzij Walter, Grazi Gianluca, Vallati Giulio E., Bennink Roel J., van Delden Otto M., Kranenburg Onno W., Ijzermans Jan N.M., Nijkamp Maarten W., Erdmann Joris I., Sciuto Rosa, Hagendoorn Jeroen, Borel Rinkes Inne H.M. 18 Aug 2023, In: BMC Cancer. 23 , p. 1-9
Sousa Da Silva Richard X et al. 19 Jul 2023, In: Annals of surgery. 278 , p. 748-755 8 p.
Küçükköse Emre, Laoukili Jamila, Gorelick Alexander N., Degner Sebastian, Laclé Miangela M., van den Bent Lotte, Peters Niek A., Verheem André, Hung Wei Ting, Frenkel Nicola C., Wassenaar Emma C.E., Lansu Nico, Lenos Kristiaan J., Vermeulen Louis, Koopman Miriam, Roodhart Jeanine M.L., Kops Geert J.P.L., Borel Rinkes Inne H.M., Hagendoorn Jeroen, Naxerova Kamila, Kranenburg Onno 10 Mar 2023, In: Gastroenterology. 165 , p. 429-444.e15
Wensink G. E., Bolhuis Karen, Elferink Marloes A.G., Fijneman Remond J.A., Kranenburg Onno, Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Roodhart Jeanine M.L., Elias Sjoerd G. 1 Mar 2023, In: British Journal of Surgery. 110 , p. 362-371 10 p.
Müller Philip C, Borel Rinkes Inne H M, Clavien Pierre Alain Mar 2023, In: Annals of surgery open : perspectives of surgical history, education, and clinical approaches. 4 , p. 1-1
Andel Daan, Hagendoorn Jeroen, Alsultan Ahmed Aziz, Lacle Miangela Marie, Smits Maarten Leonard Johannes, Braat Arthur Johannes Anthonius Theodorus, Kranenburg Onno, Lam Marnix Gerard Ernest Hendrik, Borel Rinkes Inne Hilbrand Max 2023, In: International Hepato-Pancreato Biliary Association.. 25 , p. 1345-1353 9 p.
Frenkel Nicola, Poghosyan Susanna, van Wijnbergen Jan Willem, van den Bent Lotte, Wijler Liza, Verheem André, Borel Rinkes Inne, Kranenburg Onno, Hagendoorn Jeroen 2023, In: Frontiers in oncology. 13 10 p.