prof. dr. J.A.M. (José) Borghans

prof. dr. J.A.M. (José) Borghans

Full Professor
prof. dr. J.A.M. (José) Borghans
  • Center for Translational Immunology (CTI) Research

Research Programs

Infection & Immunity



José Borghans runs an interdisciplinary research group, with a main focus on the quantification of leukocyte dynamics. She was originally trained as a theoretical immunologist at Utrecht University, and obtained her PhD in 2000 on studies of lymphocyte and MHC diversity. After her PhD, she started to work in experimental immunology laboratories, aiming to bridge the gap between wet lab experiments and mathematical modelling. Funded by a Marie-Curie Fellowship, she worked as a post-doctoral fellow at the Institut Pasteur in Paris studying lymphocyte homeostasis. During another postdoctoral period, funded by an NWO Veni grant, she worked at Sanquin Research in Amsterdam to study lymphocyte dynamics in HIV infection. She has been working at UMCU since 2004, funded by several NWO grants, and was appointed Associate Professor in 2009 and Full Professor of Quantitative Immunology in 2021. She has formed an interdisciplinary research group with Kiki Tesselaar, which facilitates the close integration of experimental and mathematical immunology. Using state of the art immunological techniques, including in vivo stable isotope labeling in mice and men, the group studies the dynamics of different types of leukocytes in homeostasis, during healthy aging and in different diseases, including leukemia, HIV infection, and post-stem cell transplantation. In addition, she is heading the Computational Immunology Core of the CTI, which brings together all researchers using computational techniques to study the immune system.

Side Activities

Grant reviewer for:

  • NWO-ENW Open competition
  • NWO Replication Studies
  • Israel Science Foundation
  • Center for AIDS Research
  • Medical Research Council
  • Wellcome Investigator Award in Science

Associate Editor of Frontiers Immunology.

Member of the International Network on Quantitative T-cell Immunology and Immunotherapy (QuanTII), funded by the Horizon 2020 programme of the European Union.

Fellowship and Awards

NWO Aspasia grant 2021

NWO Vici grant 2020

NVVI Thesis Award 2014 for the thesis of Liset Westera, under her supervision

NWO Aspasia grant 2009

NWO Vidi grant 2008

NWO Meervoud grant 2007

NWO Veni grant 2002

Marie-Curie Fellowship, EU, 2000

Young Researcher's Award, Unilever, 1996

Research Output (74)

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Baliu Piqué Mariona, van Hoeven Vera, Drylewicz Julia, van der Wagen Lotte E, Janssen Anke, Otto Sigrid A, van Zelm Menno C, de Boer Rob J, Kuball Jürgen Jhe, Borghans Jose Am, Tesselaar Kiki 4 feb 2021, In: eLife. 10 22 p.

Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

Connell Bridgette J., Hermans Lucas E., Wensing Annemarie M.J., Schellens Ingrid, Schipper Pauline J., van Ham Petra M., de Jong Dorien T.C.M., Otto Sigrid, Mathe Tholakele, Moraba Robert, Borghans José A.M., Papathanasopoulos Maria A., Kruize Zita, Venter Francois W.D., Kootstra Neeltje A., Tempelman Hugo, Tesselaar Kiki, Nijhuis Monique 28 sep 2020, In: Scientific Reports. 10 , p. 1-10

Functional categories of immune inhibitory receptors

Rumpret Matevž, Drylewicz Julia, Ackermans Laura J.E., Borghans José A.M., Medzhitov Ruslan, Meyaard Linde 1 jan 2020, In: Nature Reviews. Immunology. 20 , p. 771-780 10 p.

Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study

Samson Leonard Daniel, van den Berg Sara P. H., Engelfriet Peter, Boots Annemieke M. H., Hendriks Marion, de Rond Lia G. H., de Zeeuw-Brouwer Mary-Iene, Verschuren W. M. Monique, Borghans Jose A. M., Buisman Anne-Marie, van Baarle Debbie 2020, In: Clinical & Translational Immunology (CTI) . 9 , p. 1-18

Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination:a systematic review and meta-analysis

van den Berg S. P.H., Warmink K., Borghans J. A.M., Knol M. J., van Baarle D. 1 aug 2019, In: Medical Microbiology and Immunology. 208 , p. 305-321 17 p.

In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow

Baliu-Piqué Mariona, Otto Sigrid A, Borghans José A M, Tesselaar Kiki jun 2019, In: Immunology Letters. 210 , p. 29-32 4 p.

Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats

Baliu-Piqué Mariona, Kurniawan Henry, Ravesloot Lars, Verheij Myrddin W., Drylewicz Julia, Lievaart-Peterson Karianne, Borghans José A.M., Koets Ad, Tesselaar Kiki 1 apr 2019, In: Developmental and Comparative Immunology. 93 , p. 1-10 10 p.

Short lifespans of memory T-cells in bone marrow, blood, and lymph nodes suggest that T-cell memory is maintained by continuous self-renewal of recirculating cells

Baliu-Piqué Mariona, Verheij Myrddin W., Drylewicz Julia, Ravesloot Lars, de Boer Rob J., Koets Ad, Tesselaar Kiki, Borghans José A.M. 11 sep 2018, In: Frontiers in Immunology. 9

Current best estimates for the average lifespans of mouse and human leukocytes:reviewing two decades of deuterium-labeling experiments

Borghans José A M, de Boer Rob J, Tesselaar Kiki sep 2018, In: Immunological Reviews. 285 , p. 233-248 16 p.

Potential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy

Scheltema Nienke M, Kavelaars Xynthia M, Thorburn Kentigern, Hennus Marije P, van Woensel Job B, van der Ent Cornelis K, Borghans José A M, Bont Louis J, Drylewicz Julia 25 jul 2018, In: Vaccine. 36 , p. 4693-4700 8 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet