dr. A.M.E. (Annelies) Bos

dr. A.M.E. (Annelies) Bos

Associate Professor - medical
dr. A.M.E. (Annelies) Bos
  • Reproductive Medicine & Gynecology - Medical

Research Programs




Doctorate                        5th of March, 2003

                                             Thesis: Optimizing conventional chemotherapy approaches.                                                                              Studies on feasibility and pharmacokinetics.

                                             Promotores: Prof. dr. E.G.E. de Vries and Prof. dr. A.G.J. van der                                                         Zee, co-promotor: Dr. P.H.B. Willemse

                                             Department Medical Oncology/Gynaecology-Oncology UMC Groningen


Current position           July 2010-now: Consultant, Fertility and Gynecology department, University Medical Center Utrecht


Prior positions              -1988-1995: Medicine Study, Rijksuniversiteit Groningen


                                             -Aug 1995-Okt 1995: Resident Internal Medicine

                                             De Weezenlanden Hospital, Zwolle


                                             -Okt 1995-May 1997: Resident Gynecology/Obstetrics

                                             De Weezenlanden Hospital, Zwolle


                                             May 1997- Febr 1998: Resident Gynecology/Obstetrics

                                             Martini Hospital, Groningen


                                             Febr 1998- July 2000: Resident and researcher Medical Oncology & Gynaecology Oncology, University Medical Center Groningen


                                             July 2000-July 2006: Traineeship  Gynecology and                                                                                   Obstetrics:  Isala Klinieken Zwolle, University Medical Center                                                                            Groningen and Medical Center Leeuwarden.


                                             2006-2010: Consultant, Fertility and Gynecology department, University Medical Center Groningen


                                             2008-July 2010: Consultant and Subspecialisation                                                                                    Fertility and Endocrinology, University Medical Center                                                                          Groningen


Side Activities

Current Professional memberships

Member of the Dutch Network Gynaecology and Obstetrics (NVOG) >2000


Member European Society Human Reproduction and Endocrinology (ESHRE) >2008


Member Dutch Working party Gynaecological Endoscopy (WGE) (>2012)


Member of the oncologic Mamma Team in the UMC Utrecht (>2011)


Member and secretary (since May 2015) of the Dutch Special Interest Group Fertility preservation (NVOG)


Member of the Special Interest Group Gamete donation (NVOG) >2016


Secretary and vice-president of the Medical Ethical Board of the Department Fertility UMC Utrecht, since April 2015


Member of the Dutch Society of Gender and Health (NVG&G) >2018 (before member of the Alliance Gender and Health)


Chair of the working group Fertility patients in children with cancer in the Prinses Maxima Center.  (>June 2018)



Guideline development committees:


- Member of the Dutch Alliance of Gender and Health care (>2012), 2014-2016 making the ‘Kennisagenda Gender and Health’ by estimating knowledge gaps and aims for future research in the field of genderspecific medicine.


-2015-2016 Member of the working group of modern families (NVOG/cie Herijking Ouderschap)


- member of Dutch guideline group: Fertility preservation for women with cancer (2015-2016),


-Initiator and member of the Dutch working group SKION agreement Fertility Preservation for girls and adolescents 0-18 yrs (2016) (gynecologist and pediatric oncologists)


-Modelreglement Embryowet (NVOG and KLEM) Advisory board August 2018


-Member of the working group for development of fertility preservation guidelines in female cancer patients (0-18 years) as part of the IGHG project/PancareLife European project (>2016-2018).



Fellowship and Awards

Child Health Boost grant, sept 2017. 15K euro for the start-up of the EXOTiC project (Exploring the feasibility of EXcellent fertility counseling care for girls with cancer and the safety of Ovarian Tissue Cryopreservation on a national level).

Research team: Annelies Bos, Marry van den Heuvel-Eibrink, Marc Wijnen, Birgitta Versluijs, Simone Broer en Frank Broekmans

The proposed EXOTiC project will be the start of an integral part of the joint clinical and research program on fertility preservation care for children up to 19 years of age in the Princess Máxima Center for Pediatric Oncology and the Department of Reproductive Medicine, UMC Utrecht.


Research Output (38)

Reproductive Outcomes of Women with Turner Syndrome Undergoing Oocyte Vitrification:A Retrospective Multicenter Cohort Study

Nadesapillai Sapthami, Mol Femke, Broer Simone L, Stevens Brentjens Linda B P M, Verhoeven Marieke O, Heida Karst Y, Goddijn Mariëtte, van Golde Ron J T, Bos Annelies M E, van der Coelen Sanne, Peek Ronald, Braat Didi D M, van der Velden Janielle A E M, Fleischer Kathrin 13 Oct 2023, In: Journal of Clinical medicine. 12 15 p.

Minimal Infiltrative Disease Identification in Cryopreserved Ovarian Tissue of Girls with Cancer for Future Use:A Systematic Review

Grubliauskaite Monika, van der Perk M E Madeleine, Bos Annelies M E, Meijer Annelot J M, Gudleviciene Zivile, van den Heuvel-Eibrink Marry M, Rascon Jelena Sep 2023, In: Cancers. 15 , p. 1-26

Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis:A Systematic Review

Clasen Nikita H Z, van der Perk M E Madeleine, Neggers Sebastian J C M M, Bos Annelies M E, van den Heuvel-Eibrink Marry M Apr 2023, In: Cancers. 15

Evaluation of oncofertility care in childhood cancer patients:the EU-Horizon 2020 twinning project TREL initiative

Stukaite-Ruibiene Egle, van der Perk M E Madeleine, Vaitkeviciene Goda Elizabeta, Bos Annelies M E, Bumbuliene Zana, van den Heuvel-Eibrink Marry M, Rascon Jelena 2023, In: Frontiers in Pediatrics. 11

Fertility preservation for women with breast cancer:a multicentre randomized controlled trial on various ovarian stimulation protocols

Balkenende Eva M E, Dahhan Taghride, Beerendonk Catharina C M, Fleischer Kathrin, Stoop Dominic, Lambalk Cornelis B, Bos Annelies M E, Schats Roel, Smeenk Jesper M J, Louwé Leonie A, Cantineau Astrid E P, Bruin Jan Peter de, Linn Sabine C, van der Veen Fulco, van Wely Madelon, Goddijn Mariëtte 1 Jul 2022, In: Human Reproduction. 37 , p. 1786-1794 9 p.

Development of a questionnaire to evaluate female fertility care in pediatric oncology, a TREL initiative

van der Perk M E Madeleine, Stukaitė-Ruibienė Eglė, Bumbulienė Žana, Vaitkevičienė Goda Elizabeta, Bos Annelies M E, van den Heuvel-Eibrink Marry M, Rascon Jelena 25 Apr 2022, In: BMC Cancer. 22

White paper:Onco-fertility in pediatric patients with Wilms tumor

van der Perk M E Madeleine, Cost Nicholas G, Bos Annelies M E, Brannigan Robert, Chowdhury Tanzina, Davidoff Andrew M, Daw Najat C, Dome Jeffrey S, Ehrlich Peter, Graf Norbert, Geller James, Kalapurakal John, Kieran Kathleen, Malek Marcus, McAleer Mary F, Mullen Elizabeth, Pater Luke, Polanco Angela, Romao Rodrigo, Saltzman Amanda F, Walz Amy L, Woods Andrew D, van den Heuvel-Eibrink Marry M, Fernandez Conrad V 28 Mar 2022, In: International Journal of Cancer. 151 , p. 843-858 16 p.

Oncofertility Perspectives for Girls with Cancer

van der Perk M. E.Madeleine, van der Kooi Anne Lotte L.F., Bos Annelies M.E., Broer Simone L., Veening Margreet A., van Leeuwen Jeanette, van Santen Hanneke M., van Dorp Wendy, van den Heuvel-Eibrink Marry M. 28 Mar 2022, In: JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY. 35 , p. 523-526 4 p.

An unconventional path to conventional motherhood:A qualitative study of women's motivations and experiences regarding social egg freezing in the Netherlands

Kanters N T J, Brokke K E, Bos A M E, Benneheij S H, Kostenzer J, Ockhuijsen H D L 23 Nov 2021, In: Journal of gynecology obstetrics and human reproduction. 51 , p. 1-8

Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach:Results from the PanCareLIFE Study

van der Perk M E Madeleine, Broer Linda, Yasui Yutaka, Robison Leslie L, Hudson Melissa M, Laven Joop S E, van der Pal Helena J, Tissing Wim J E, Versluys Birgitta, Bresters Dorine, Kaspers Gertjan J L, de Vries Andrica C H, Lambalk Cornelis B, Overbeek Annelies, Loonen Jacqueline J, Beerendonk Catharina C M, Byrne Julianne, Berger Claire, Clemens Eva, Dirksen Uta, Falck Winther Jeanette, Fosså Sophie D, Grabow Desiree, Muraca Monica, Kaiser Melanie, Kepák Tomáš, Kruseova Jarmila, Modan-Moses Dalit, Spix Claudia, Zolk Oliver, Kaatsch Peter, Krijthe Jesse H, Kremer Leontien C M, Brooke Russell J, Baedke Jessica L, van Schaik Ron H N, van den Anker John N, Uitterlinden André G, Bos Annelies M E, van Leeuwen Flora E, van Dulmen-den Broeder Eline, van der Kooi Anne-Lotte L F, van den Heuvel-Eibrink Marry M, On Behalf Of The PanCareLIFE Consortium 13 Sep 2021, In: Cancers. 13

All research output

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