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prof. dr. J.L. (Johannes L. (Hans)) Bos

prof. dr. J.L. (Johannes L. (Hans)) Bos

Professor Emeritus

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Research Output (173)

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Ponsioen Bas, Post Jasmin B, Buissant des Amorie Julian R, Laskaris Dimitrios, van Ineveld Ravian L, Kersten Simone, Bertotti Andrea, Sassi Francesco, Sipieter François, Cappe Benjamin, Mertens Sander, Verlaan-Klink Ingrid, Boj Sylvia F, Vries Rob G J, Rehmann Holger, Vandenabeele Peter, Riquet Franck B, Trusolino Livio, Bos Johannes L, Snippert Hugo J G 1 apr 2021, In: Nature Cell Biology. 23 , p. 377-390 14 p.

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Kopper Oded, de Witte Chris J, Lõhmussaar Kadi, Valle-Inclan Jose Espejo, Hami Nizar, Kester Lennart, Balgobind Anjali Vanita, Korving Jeroen, Proost Natalie, Begthel Harry, van Wijk Lise M, Revilla Sonia Aristín, Theeuwsen Rebecca, van de Ven Marieke, van Roosmalen Markus J, Ponsioen Bas, Ho Victor W H, Neel Benjamin G, Bosse Tjalling, Gaarenstroom Katja N, Vrieling Harry, Vreeswijk Maaike P G, van Diest Paul J, Witteveen Petronella O, Jonges Trudy, Bos Johannes L, van Oudenaarden Alexander, Zweemer Ronald P, Snippert Hugo J G, Kloosterman Wigard P, Clevers Hans mei 2019, In: Nature Medicine. 25 , p. 838-849 12 p.

A two-tiered mechanism enables localized Cdc42 signaling during enterocyte polarization

Bruurs Lucas J.M., Zwakenberg Susan, van der Net Mirjam C., Zwartkruis Fried J., Bos Johannes L. apr 2017, In: Molecular and Cellular Biology. 37

Ras Association-Domain Dimers Bring Proteins Together

Rehmann Holger, Bos Johannes L 6 dec 2016, In: Structure. 24 , p. 2039-2040 2 p.

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo Carla S, Overmeer René M, Ponsioen Bas, Drost Jarno, Mertens Sander, Verlaan-Klink Ingrid, Gerwen Bastiaan van, van der Ven Marieke, van de Wetering Marc , Egan David A, Bernards René, Clevers Hans, Bos Johannes L, Snippert Hugo J 15 nov 2016, In: eLife. 5

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization

Bruurs Lucas J M, Donker Lisa, Zwakenberg Susan, Zwartkruis Fried J, Begthel Harry, Knisely A S, Posthuma George, van de Graaf Stan F J, Paulusma Coen C, Bos Johannes L 28 sep 2015, In: Journal of Cell Biology. 210 , p. 1055-63 9 p.

Quantitative imaging of focal adhesion dynamics and their regulation by HGF and Rap1 signaling

Spanjaard Emma, Smal Ihor, Angelopoulos Nicos, Verlaan Ingrid, Matov Alexandre, Meijering Erik, Wessels Lodewyk, Bos Hans, de Rooij Johan 15 jan 2015, In: Experimental Cell Research. 330 , p. 382-397 16 p.

Rap1 spatially controls ArhGAP29 to inhibit Rho signaling during endothelial barrier regulation

Post A., Pannekoek W. J., Ponsioen B., Vliem M. J., Bos J. L. 1 jan 2015, In: Molecular and Cellular Biology. 35 , p. 2495-2502 8 p.

Structure-Guided Design of Selective Epac1 and Epac2 Agonists

Schwede Frank, Bertinetti Daniela, Langerijs Carianne N., Hadders Michael A., Wienk Hans, Ellenbroek Johanne H., de Koning Eelco J P, Bos Johannes L., Herberg Friedrich W., Genieser Hans Gottfried, Janssen Richard A J, Rehmann Holger 1 jan 2015, In: PLoS Biology. 13 26 p.

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