dr. M.G. (Matthijs) Bossong

dr. M.G. (Matthijs) Bossong

Assistant Professor
  • Psychiatry

Research Programs




Curriculum Vitae


Matthijs Bossong studied Biomedical Sciences at Utrecht University. After completing his PhD in Utrecht on the role of the endocannabinoid system in human brain functions relevant for psychiatric disorders, he started his first postdoc position in September 2011 at the Institute of Psychiatry of King’s College London. Here, supported by an NWO Rubicon fellowship, Matthijs worked on two multimodal neuroimaging studies with people at an ultra-high risk for developing psychosis. One of these projects involved a treatment with the cannabinoid compound cannabidiol. In September 2014, he started his second postdoc at the Department of Psychiatry of the UMC Utrecht, where he coordinated a large-scale international multicenter study in which the potential of omega-3 fatty acids in the prevention of psychosis was examined in adolescent at-risk individuals. Supported by both an NWO Veni fellowship and a Rudolf Magnus Young Talent Fellowship, Matthijs is currently working as Assistant Professor on a pharmacological neuroimaging study investigating the impact of cannabidiol treatment on brain function of patients with a psychotic disorder. 



Key Publications


Bossong M.G., Antoniades M., Azis M., Samson C., Quinn B., Bonoldi I., Modinos G., Pérez J., Howes O.D., Stone J., Allen P., McGuire P. (2019) Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis. JAMA Psychiatry 76, 199-207.


Bhattacharyya S., Wilson R., Appiah-Kusi E., O'Neill A., Brammer M., Perez J., Murray R., Allen P., Bossong M.G., McGuire P. (2018) Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial. JAMA Psychiatry 75, 1107-17.


Iseger T.A., Bossong M.G. (2015) A systematic review of the antipsychotic properties of cannabidiol in humans. Schizophrenia Research 162 (1-3), 153 - 161.


Bossong M.G., Jansma J.M., Van Hell H.H., Jager G., Oudman E., Saliasi E., Kahn R.S., Ramsey N.F. (2012) Effects of Δ9-tetrahydrocannabinol on human working memory function. Biological Psychiatry 71 (8), 693 - 699.


Bossong M.G., Niesink R.J. (2010) Adolescent brain maturation, the endogenous cannabinoid system and cannabis-induced schizophrenia. Progress in Neurobiology 92 (3), 370 - 385.


Bossong M.G., Van Berckel B.N.M., Boellaard R., Zuurman L., Schuit R.C., Windhorst A.D., Van Gerven J.M.A., Ramsey N.F., Lammertsma A.A., Kahn R.S. (2009) ∆9-Tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology 34 (3), 759 - 766.


Van Berckel B.N.M., Bossong M.G., Van Haaren N., Boellaard R., Comans E.F.I., Kloet R., Schuitemaker A., Caspers E., Luurtsema G., Windhorst A.D., Cahn W., Lammertsma A.A., Kahn R.S. (2008) Microglia activation in recent onset schizophrenia: a quantitative (R)-[11C]PK11195 PET study. Biological Psychiatry 64 (9), 820 - 822

Fellowship and Awards

Bossong M.G. Examining synaptic density in the living brain of schizophrenia patients. Rudolf Magnus Young Talent Fellowship, 01/10/2017 - 01/01/2020, €200,000 


Bossong M.G. Endocannabinoid control of microglia activation as a new therapeutic target in the treatment of schizophrenia. Netherlands Organisation for Scientific Research, Fellowship (VENI grant), 01/01/2016 - 01/01/2019, €250,000 


Bossong M.G. Towards prevention of schizophrenia: the potential of a cannabidiol as a novel antipsychotic agent. Netherlands Organisation for Scientific Research, Fellowship (Rubicon grant), 01/05/2012 - 01/05/2014, €144,937 

Research Output (48)

Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients

Gangadin Shiral S, Cahn Wiepke, Scheewe Thomas W, Hulshoff Pol Hilleke E, Bossong Matthijs G 26 mrt 2021, In: Journal of Psychiatric Research. 138 , p. 83-88 6 p.

The Impact of Cannabidiol on Human Brain Function:A Systematic Review

Batalla Albert, Bos Julian, Postma Amber, Bossong Matthijs G. 21 jan 2021, In: Frontiers in Pharmacology. 11 15 p.

A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

Davies Cathy, Wilson Robin, Appiah-Kusi Elizabeth, Blest-Hopley Grace, Brammer Michael, Perez Jesus, Murray Robin M, Allen Paul, Bossong Matthijs G, McGuire Philip, Bhattacharyya Sagnik 13 sep 2020, In: Translational Psychiatry. 10 , p. 1-12

Glutamate in schizophrenia:Neurodevelopmental perspectives and drug development

Egerton Alice, Grace Anthony A, Stone James, Bossong Matthijs G, Sand Michael, McGuire Philip sep 2020, In: Schizophrenia Research. 223 , p. 59-70 12 p.

Do the effects of cannabis on the hippocampus and striatum increase risk for psychosis?

Daniju Y, Bossong M G, Brandt K, Allen P mei 2020, In: Neuroscience and Biobehavioral Reviews. 112 , p. 324-335 12 p.

Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome

Modinos Gemma, Allen Paul, Zugman Andre, Dima Danai, Azis Matilda, Samson Carly, Bonoldi Ilaria, Quinn Beverly, Gifford George W. G., Smart Sophie E., Antoniades Mathilde, Bossong Matthijs G., Broome Matthew R., Perez Jesus, Howes Oliver D., Stone James M., Grace Anthony A., McGuire Philip 10 apr 2020, In: Schizophrenia bulletin. 46 , p. 670-679 10 p.

Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis

Appiah-Kusi E, Petros N, Wilson R, Colizzi M, Bossong M G, Valmaggia L, Mondelli V, McGuire P, Bhattacharyya S apr 2020, In: Psychopharmacology. 237 , p. 1121-1130 10 p.

Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis:a multi-modal PET-magnetic resonance brain imaging study

Howes Oliver D, Bonoldi Ilaria, McCutcheon Robert A, Azis Matilda, Antoniades Mathilde, Bossong Matthijs, Modinos Gemma, Perez Jesus, Stone James M, Santangelo Barbara, Veronese Mattia, Grace Anthony, Allen Paul, McGuire Philip K 1 mrt 2020, In: Neuropsychopharmacology. 45 , p. 641-648 8 p.

Factors Moderating the Association Between Cannabis Use and Psychosis Risk:A Systematic Review

van der Steur Sanne J, Batalla Albert, Bossong Matthijs G 12 feb 2020, In: Brain sciences. 10 , p. 1-17

Structural brain volumes of individuals at clinical high risk for psychosis: a meta-analysis

Vissink C. E., Bossong M. G., Winter-van Rossum I., Cannon T. D., Kahn R. S. dec 2019, In: European Neuropsychopharmacology. 29 , p. S65-S66

All research output

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