dr. M.G. (Matthijs) Bossong

Assistant Professor

  • Psychiatry

Research Programs


Curriculum Vitae


Matthijs Bossong studied Biomedical Sciences at Utrecht University. After completing his PhD in Utrecht on the role of the endocannabinoid system in human brain functions relevant for psychiatric disorders, he started his first postdoc position in September 2011 at the Institute of Psychiatry of King’s College London. Here, supported by an NWO Rubicon fellowship, Matthijs worked on two multimodal neuroimaging studies with people at an ultra-high risk for developing psychosis. One of these projects involved a treatment with the cannabinoid compound cannabidiol. In September 2014, he started his second postdoc at the Department of Psychiatry of the UMC Utrecht, where he coordinated a large-scale international multicenter study in which the potential of omega-3 fatty acids in the prevention of psychosis was examined in adolescent at-risk individuals. Supported by both an NWO Veni fellowship and a Rudolf Magnus Young Talent Fellowship, Matthijs is currently working as Assistant Professor on a pharmacological neuroimaging study investigating the impact of cannabidiol treatment on brain function of patients with a psychotic disorder. 



Key Publications


Bossong M.G., Antoniades M., Azis M., Samson C., Quinn B., Bonoldi I., Modinos G., Pérez J., Howes O.D., Stone J., Allen P., McGuire P. (2019) Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis. JAMA Psychiatry 76, 199-207.


Bhattacharyya S., Wilson R., Appiah-Kusi E., O'Neill A., Brammer M., Perez J., Murray R., Allen P., Bossong M.G., McGuire P. (2018) Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial. JAMA Psychiatry 75, 1107-17.


Iseger T.A., Bossong M.G. (2015) A systematic review of the antipsychotic properties of cannabidiol in humans. Schizophrenia Research 162 (1-3), 153 - 161.


Bossong M.G., Jansma J.M., Van Hell H.H., Jager G., Oudman E., Saliasi E., Kahn R.S., Ramsey N.F. (2012) Effects of Δ9-tetrahydrocannabinol on human working memory function. Biological Psychiatry 71 (8), 693 - 699.


Bossong M.G., Niesink R.J. (2010) Adolescent brain maturation, the endogenous cannabinoid system and cannabis-induced schizophrenia. Progress in Neurobiology 92 (3), 370 - 385.


Bossong M.G., Van Berckel B.N.M., Boellaard R., Zuurman L., Schuit R.C., Windhorst A.D., Van Gerven J.M.A., Ramsey N.F., Lammertsma A.A., Kahn R.S. (2009) ∆9-Tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology 34 (3), 759 - 766.


Van Berckel B.N.M., Bossong M.G., Van Haaren N., Boellaard R., Comans E.F.I., Kloet R., Schuitemaker A., Caspers E., Luurtsema G., Windhorst A.D., Cahn W., Lammertsma A.A., Kahn R.S. (2008) Microglia activation in recent onset schizophrenia: a quantitative (R)-[11C]PK11195 PET study. Biological Psychiatry 64 (9), 820 - 822

Fellowship and Awards

  • Bossong M.G. Examining synaptic density in the living brain of schizophrenia patients. Rudolf Magnus Young Talent Fellowship, 01/10/2017 - 01/01/2020, €200,000 


    Bossong M.G. Endocannabinoid control of microglia activation as a new therapeutic target in the treatment of schizophrenia. Netherlands Organisation for Scientific Research, Fellowship (VENI grant), 01/01/2016 - 01/01/2019, €250,000 


    Bossong M.G. Towards prevention of schizophrenia: the potential of a cannabidiol as a novel antipsychotic agent. Netherlands Organisation for Scientific Research, Fellowship (Rubicon grant), 01/05/2012 - 01/05/2014, €144,937 

Research Output (36)

Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis

Wilson Robin, Bossong Matthijs G, Appiah-Kusi Elizabeth, Petros Natalia, Brammer Michael, Perez Jesus, Allen Paul, McGuire Philip, Bhattacharyya Sagnik 22 aug 2019, In: Translational Psychiatry. 9

The Potential of Cannabidiol as a Treatment for Psychosis and Addiction:Who Benefits Most? A Systematic Review

Batalla Albert, Janssen Hella, Gangadin Shiral S, Bossong Matthijs G 19 jul 2019, In: Journal of Clinical medicine. 8

Acute effects of Delta 9-tetrahydrocannabinol (THC) on resting state brain function and their modulation by COMT genotype

Bossong Matthijs G., van Hell Hendrika H., Schubart Chris D., van Saane Wesley, Iseger Tabitha A., Jager Gerry, van Osch Matthias J.P., Jansma J. Martijn, Kahn René S., Boks Marco P., Ramsey Nick F. 1 jun 2019, In: European Neuropsychopharmacology. 29 , p. 766-776 11 p.


Gangadin Shiral, Cahn Wiepke, Scheeuwe Thomas, Pol Hilleke Hulshoff, Bossong Matthijs apr 2019, In: Schizophrenia Bulletin. 45 , p. S288-S288

The neuropsychopharmacology of cannabis:A review of human imaging studies

Bloomfield Michael A P, Hindocha Chandni, Green Sebastian F, Wall Matthew B, Lees Rachel, Petrilli Katherine, Costello Harry, Ogunbiyi M Olabisi, Bossong Matthijs G, Freeman Tom P mrt 2019, In: Pharmacology & Therapeutics. 195 , p. 132-161 30 p.

Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis

Bossong Matthijs G, Antoniades Mathilde, Azis Matilda, Samson Carly, Quinn Beverley, Bonoldi Ilaria, Modinos Gemma, Perez Jesus, Howes Oliver D, Stone James M, Allen Paul, McGuire Philip 1 feb 2019, In: JAMA Psychiatry. 76 , p. 199-207 9 p.

Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultra-High Risk for Psychosis

Bonoldi Ilaria, Allen Paul, Madeira Luis, Tognin Stefania, Bossong Matthijs G, Azis Mathilda, Samson Carly, Quinn Beverly, Calem Maria, Valmaggia Lucia, Modinos Gemma, Stone James, Perez Jesus, Howes Oliver, Politi Pierluigi, Kempton Matthew J, Fusar-Poli Paolo, McGuire Philip 1 jan 2019, In: Frontiers in Psychiatry. 10 11 p.

Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis:Replication in a Second Cohort

Allen Paul, Azis Matilda, Modinos Gemma, Bossong MG, Bonoldi Ilaria , Samson Carly, Quinn Beverly, Kempton Matthew, Howes Oliver, Stone James, Calem Maria, Perez Jesus, Bhattacharyya Sagnik , Broome Matthew, Grace Anthony, Zelaya Fernando, McGuire Philip nov 2018, In: Schizophrenia Bulletin. 44 , p. 1323–1331 9 p.

Human striatal response to reward anticipation linked to hippocampal glutamate levels

Bossong MG, Wilson Robin, Appiah-Kusi Elizabeth, McGuire Philip, Bhattacharyya Sagnik jul 2018, In: International Journal of Neuropsychopharmacology. 21 , p. 623-630

Cortical GABA in Subjects at Ultra-High Risk of Psychosis: Relationship to Negative Prodromal Symptoms

Modinos Gemma, Simsek Fatma, Horder Jamie, Bossong MG, Bonoldi Ilaria , Azis Matilda, Perez Jesus, Broome Matthew, Lythgoe David , Stone James, Howes Oliver, Murphy Declan, Grace Anthony , Allen Paul, McGuire Philip 2018, In: International Journal of Neuropsychopharmacology. 21 , p. 114-119

All Research Output (36)