prof. dr. M.L. (Michiel L.) Bots

prof. dr. M.L. (Michiel L.) Bots

Full Professor
prof. dr. M.L. (Michiel L.) Bots
  • Department of Epidemiology
  • Julius Center Research Program Cardiovascular Epidemiology

Research Programs

Circulatory Health




  • In 1986, Michiel Bots received his medical degree at the Erasmus University in Rotterdam. After working as a resident in Gynaecology and Obstetrics, at the Hospital Zonnegloren in Soest and as a resident in Surgery at the Juliana Hospital in Apeldoorn, he started in 1988 his training in cardiovascular epidemiology started at the Department of Epidemiology & Biostatistics of the Erasmus University Medical School in Rotterdam.
  • In 1993, he obtained his PhD degree on the thesis entitled 'Carotid wall thickness as indicator of generalised atherosclerosis'.
  • In 1996 he moved to the Julius Center for Health Sciences and Primary Care of the University Medical Center Utrecht in Utrecht.
  • Since 1997 he serves as Managing (up to 2001) and Scientific director of Vascular Imaging Center Utrecht, a vascular core laboratory on quantification of structural, dynamic and functional arterial characteristics.
  • In 2001 he was appointed associate professor in epidemiology
  • Since 2009 he is a professor in the Epidemiology of Cardiovascular Disease at the University Medical Center Utrecht, Utrecht, The Netherlands.
  • Since 2013 he is chariman of the steering committe of the Utrecht Cardiovascular Cohort: a multidisciplinary effort with physicians, patients and researchers of the UMC Utrecht, the UCC sets a benchmark for a learning cardiovascular healthcare system. UCC offers an invaluable resource for future high quality care as well as for first-class research for investigators.

 His research activities comprise observational studies and clinical trials

  • around the development of atherosclerosis, its physiological and environmental risk factors and its consequences. Non-invasive assessment of atherosclerotic abnormalities through imaging in both high risk and low risk populations by measurement of carotid intima-media thickness, carotid plaque, arterial stiffness, coronary calcifications, coronary stenosis and their progression over time are major topics in his studies.
  • around uncontrolled hypertension elevated blood pressure and treatment thereof
  • around kidney disease and its determinants and therapies, with a main focus on dialysis patients and treatment modalities
  • around facts and figure of cardiovascular disease in the Netherlands, with an emphasis on national data obtainable through linkage of registries.
  • around the creation of an infrastructure for uniform registration of cardiovascular information in routine clinical practice for patients referred for cardiovascular care at the University Medical Center Utrecht, the Netherlands

 His scientific output involves over 500 international peer reviewed publications.

 His teaching activities involve

  • Regular curricular lectures on cardiovascular and general clinical  epidemiology for biomedical and pharmaceutical bachelor and master students.
  • Coordinator of the annual MSc course 'Cardiovascular Epidemiology' (
  • Coordinator of the annual Blended MSc course ‘Epidemiology of Cardiovascular Disease’ (
  • Regularly a MSc course  'Clinical Epidemiology' outside the Netherlands (China, Germany, Malaysia) 


Side Activities

Member Scientific Committee on Senior POSTDOCs grants of the Netherlands Heart Foundation.

Advisory board for the working party on ‘Cardiovascular disease: figures and facts’ of the Dutch Heart Foundation,

Editor of European Journal of Preventive Cardiology.

Editorial board of Journal of Hypertension.

Member Medical Ethics Committee of the UMC Utrecht.

Incidental member on advisory boards of profit organizations on studies into imaging of atherosclerosis progression

Fellowship and Awards

Over the years Michiel Bots was involved in national and international collaborations that were successful in obtaining grants proposal from profit (pharmaceutical industry) and non profit organisations (ZonMw, Netherlands Heart Foundation, European Union, Dutch Kidney Foundation, CVON-HF).


Research Output (928)

Added value of cardiovascular calcifications for prediction of recurrent cardiovascular events and cardiovascular interventions in patients with established cardiovascular disease

van 't Klooster Cilie C, van der Graaf Yolanda, Nathoe Hendrik M, Bots Michiel L, de Borst Gert J, Visseren Frank L J, Leiner Tim, 12 feb 2021, In: The International Journal of Cardiovascular Imaging. 37 , p. 2051-2061 11 p.

Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations:an H3Africa AWI-Gen study

Nonterah Engelbert A, Crowther Nigel J, Oduro Abraham, Agongo Godfred, Micklesfield Lisa K, Boua Palwendé R, Choma Solomon S R, Mohamed Shukri F, Sorgho Herman, Tollman Stephen M, Norris Shane A, Raal Frederick J, Grobbee Diederick E, Ramsay Michelé, Bots Michiel L, Klipstein-Grobusch Kerstin, 10 feb 2021, In: BMC Medicine. 19 12 p.

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Surendran Praveen, Feofanova Elena V., Lahrouchi Najim, Ntalla Ioanna, Karthikeyan Savita, Cook James, Chen Lingyan, Mifsud Borbala, Yao Chen, Kraja Aldi T., Cartwright James H., Hellwege Jacklyn N., Giri Ayush, Tragante Vinicius, Thorleifsson Gudmar, Liu Dajiang J., Prins Bram P., Stewart Isobel D., Cabrera Claudia P., Eales James M., Akbarov Artur, Auer Paul L., Bielak Lawrence F., Bis Joshua C., Braithwaite Vickie S., Brody Jennifer A., Daw E. Warwick, Warren Helen R., Drenos Fotios, Nielsen Sune Fallgaard, Faul Jessica D., Fauman Eric B., Fava Cristiano, Ferreira Teresa, Foley Christopher N., Franceschini Nora, Gao He, Giannakopoulou Olga, Giulianini Franco, Gudbjartsson Daniel F., Guo Xiuqing, Harris Sarah E., Havulinna Aki S., Helgadottir Anna, van der Harst Pim, Vaartjes Ilonca, Asselbergs Folkert W., Bots Michiel L., van der Harst Pim, van der Meer Peter, , , , , dec 2020, In: Nature Genetics. 52 , p. 1314-1332 19 p.

Evaluating a cardiovascular disease risk management care continuum within a learning healthcare system:a prospective cohort study

Groenhof T Katrien J, Lely A Titia, Haitjema Saskia, Nathoe Hendrik M, Kortekaas Marlous F, Asselbergs Folkert W, Bots Michiel L, Hollander Monika, 17 nov 2020, In: BJGP Open. 4 , p. 1-10 10 p.

Measuring effects on intima-media thickness:an evaluation of rosuvastatin in Chinese subjects with subclinical atherosclerosis—design, rationale, and methodology of the METEOR-China study

Wang Yilong, Wang Anxin, Li Hongwei, Li Zhanquan, Hu Bo, Li Xiaogang, Zheng Huaguang, Fu Lu, Hu Hongtao, Nie Zhiyu, Qin Yulin, Zhao Bilian, Wei Di, Karlson Björn W., Bots Michiel L., Chen Yundai, Wang Yongjun 11 nov 2020, In: Trials. 21

The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium:Design and Rationale

Tschiderer Lena, Seekircher Lisa, Klingenschmid Gerhard, Izzo Raffaele, Baldassarre Damiano, Iglseder Bernhard, Calabresi Laura, Liu Jing, Price Jackie F., Bae Jang Ho, Brouwers Frank P., De Groot Eric, Schmidt Caroline, Bergström Göran, Aşçi Gülay, Gresele Paolo, Okazaki Shuhei, Kapellas Kostas, Landecho Manuel F., Sattar Naveed, Agewall Stefan, Zou Zhi Yong, Byrne Christopher D., Nanayakkara Prabath W.B., Papagianni Aikaterini, Witham Miles D., Bernal Enrique, Ekart Robert, Van Agtmael Michiel A., Neves Mario F., Sato Eiichi, Ezhov Marat, Walters Matthew, Olsen Michael H., Stolić Radojica, Zozulińska-Ziółkiewicz Dorota A., Hanefeld Markolf, Staub Daniel, Nagai Michiaki, Nieuwkerk Pythia T., Huisman Menno V., Kato Akihiko, Honda Hirokazu, Parraga Grace, Magliano Dianna, Gabriel Rafael, Rundek Tatjana, Espeland Mark A., Beulens Joline W.J., Bots Michiel L. 1 sep 2020, In: Gerontology. 66 , p. 447-459 13 p.

Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk:Meta-Analysis of 119 Clinical Trials Involving 100,667 Patients

Willeit Peter, Tschiderer Lena, Allara Elias, Reuber Kathrin, Seekircher Lisa, Gao Lu, Liao Ximing, Lonn Eva, Gerstein Hertzel C, Yusuf Salim, Brouwers Frank P, Asselbergs Folkert W, van Gilst Wiek, Anderssen Sigmund A, Grobbee Diederick E, Kastelein John J P, Visseren Frank L J, Ntaios George, Hatzitolios Apostolos I, Savopoulos Christos, Nieuwkerk Pythia T, Stroes Erik, Walters Matthew, Higgins Peter, Dawson Jesse, Gresele Paolo, Guglielmini Giuseppe, Migliacci Rino, Ezhov Marat, Safarova Maya, Balakhonova Tatyana, Sato Eiichi, Amaha Mayuko, Nakamura Tsukasa, Kapellas Kostas, Jamieson Lisa M, Skilton Michael, Blumenthal James A, Hinderliter Alan, Sherwood Andrew, Smith Patrick J, van Agtmael Michiel A, Reiss Peter, van Vonderen Marit G A, Kiechl Stefan, Klingenschmid Gerhard, Sitzer Matthias, Stehouwer Coen D A, Blankestijn Peter J, Bots Michiel L, 17 jun 2020, In: Circulation. 142 , p. 621-642 22 p.

Sex Differences in Symptom Presentation in Acute Coronary Syndromes:A Systematic Review and Meta-analysis

van Oosterhout Roos E M, de Boer Annemarijn R, Maas Angela H E M, Rutten Frans H, Bots Michiel L, Peters Sanne A E 5 mei 2020, In: Journal of the American Heart Association. 9 72 p.

A prediction model for one- and three-year mortality in dementia:results from a nationwide hospital-based cohort of 50,993 patients in the Netherlands

van de Vorst Irene E., Golüke Nienke M.S., Vaartjes Ilonca, Bots Michiel L., Koek Huiberdina L. mei 2020, In: Age and ageing. 49 , p. 361-367 7 p.

All research output

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